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The map label for this gene is nuoF [H]

Identifier: 148284884

GI number: 148284884

Start: 1583362

End: 1584630

Strand: Direct

Name: nuoF [H]

Synonym: OTBS_1632

Alternate gene names: 148284884

Gene position: 1583362-1584630 (Clockwise)

Preceding gene: 148284883

Following gene: 148284886

Centisome position: 74.44

GC content: 36.41

Gene sequence:

>1269_bases
ATGTTAAATATTGAGGATAAAATTTTTACCAATTTATCTGGGGCTATGGCCGTTGACCTTGCCAGCGCAAAAAAGCGTGG
TGACTGGTATACAACGAAAAATTTAATATTAAATAGTCGAGAATGGATTATTGAAGAAATTAAAAGCTCTGGCTTACGTG
GTCGAGGTGGAGCAGGATTTCCTACAGGTTTAAAATGGTCTTTTATGCCTAAAAACTCTGAAAAGGCAACTTATCTAGTT
GTTAATGCTGATGAATCAGAACCAGGGACATGTAAAGATAGGGATATAATTCGTTATGAACCTCATAAATTAATTGAAGG
GTGCTTACTCGCAGCATATGCCATTGGAGCTCAAACATGTTATATATATATACGTGGCGAATATTATAATGAAGCCTTAA
TATTACAAAATGCAATTCAAGAAGCCTATGGTGCTAGGCTTATAGGACTAAATGCATGTGGCACAGACTTTAACTTCAAT
CTTTATCTGCATAGAGGAGCTGGAGCATATATTTGTGGAGAGGAAACAGCTCTTCTTGAAAGCTTAGAAGGAAAAAAGGG
AATGCCGCGTTTAAAACCTCCATTTCCAGCTAATACTGGATTATATGGATGCCCTACTACTATTAATAATGTTGAATCTA
TAGCCGTAGTTCCAACAATACTCAGAAGGGGGGCAAAATGGTTCGCTAGTATTGGCAAACCAAACAATACAGGAACTAAA
ATTTTTAGCATTTCAGGACATGTTAATAATCCTTGTAATATTGAAGAAGCGATGGGAGTTCCGCTTAAATATCTAATAGA
AAAATATGCTGGAGGAGTACGTGGTGGATGGGATAATCTTAAAGCTATTATTCCAGGTGGATCATCTGTTCCACTGATTC
CTAAAAATATCTGTGATACAGTAGAAATGGACTTTGATAGCTTAAAAGCAGTAGGTTCAGGATTAGGAACAGGTGGTATT
ATAGTAATGGATAATAATACTGATATCATTTACGCTATCGCCAGGCTAAGTAAGTTTTATATGCATGAATCATGTGGCCA
ATGTACACCATGCCGAGAAGGAACAGGCTGGATGTGGCGAATTATGATGAGACTAGTAGAAGGAAATGCATCAGTAAGCG
ATATAGACATGATATTAGATGTTACTAAGCAAATAGAAGGAAATACTATATGCGCATTAGGTGATGCAGCAGCTTGGCCT
ATTCAAGGGTTAATAAAGCATTTTAGGCATGAAATTGAAGATCGTATAAAAAACTTTAATATTCAATAA

Upstream 100 bases:

>100_bases
TCAAAGAAATTATCAATAACTTGCATGCTAAAGATTTACAAAAAAAATCTGAACTAAAACCTGATAATAAAGCTGACTTA
TCACTCAAGAGTAATTATAA

Downstream 100 bases:

>100_bases
TATTGCAAGCTTAACTAAGAATTAAATCACTAAGAACAACTACTCTTTTGTGAATATAATTTACTACTTTCTAGAACTCA
TAGTGTAAGCCTTGTAATAA

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLNIEDKIFTNLSGAMAVDLASAKKRGDWYTTKNLILNSREWIIEEIKSSGLRGRGGAGFPTGLKWSFMPKNSEKATYLV
VNADESEPGTCKDRDIIRYEPHKLIEGCLLAAYAIGAQTCYIYIRGEYYNEALILQNAIQEAYGARLIGLNACGTDFNFN
LYLHRGAGAYICGEETALLESLEGKKGMPRLKPPFPANTGLYGCPTTINNVESIAVVPTILRRGAKWFASIGKPNNTGTK
IFSISGHVNNPCNIEEAMGVPLKYLIEKYAGGVRGGWDNLKAIIPGGSSVPLIPKNICDTVEMDFDSLKAVGSGLGTGGI
IVMDNNTDIIYAIARLSKFYMHESCGQCTPCREGTGWMWRIMMRLVEGNASVSDIDMILDVTKQIEGNTICALGDAAAWP
IQGLIKHFRHEIEDRIKNFNIQ

Sequences:

>Translated_422_residues
MLNIEDKIFTNLSGAMAVDLASAKKRGDWYTTKNLILNSREWIIEEIKSSGLRGRGGAGFPTGLKWSFMPKNSEKATYLV
VNADESEPGTCKDRDIIRYEPHKLIEGCLLAAYAIGAQTCYIYIRGEYYNEALILQNAIQEAYGARLIGLNACGTDFNFN
LYLHRGAGAYICGEETALLESLEGKKGMPRLKPPFPANTGLYGCPTTINNVESIAVVPTILRRGAKWFASIGKPNNTGTK
IFSISGHVNNPCNIEEAMGVPLKYLIEKYAGGVRGGWDNLKAIIPGGSSVPLIPKNICDTVEMDFDSLKAVGSGLGTGGI
IVMDNNTDIIYAIARLSKFYMHESCGQCTPCREGTGWMWRIMMRLVEGNASVSDIDMILDVTKQIEGNTICALGDAAAWP
IQGLIKHFRHEIEDRIKNFNIQ
>Mature_422_residues
MLNIEDKIFTNLSGAMAVDLASAKKRGDWYTTKNLILNSREWIIEEIKSSGLRGRGGAGFPTGLKWSFMPKNSEKATYLV
VNADESEPGTCKDRDIIRYEPHKLIEGCLLAAYAIGAQTCYIYIRGEYYNEALILQNAIQEAYGARLIGLNACGTDFNFN
LYLHRGAGAYICGEETALLESLEGKKGMPRLKPPFPANTGLYGCPTTINNVESIAVVPTILRRGAKWFASIGKPNNTGTK
IFSISGHVNNPCNIEEAMGVPLKYLIEKYAGGVRGGWDNLKAIIPGGSSVPLIPKNICDTVEMDFDSLKAVGSGLGTGGI
IVMDNNTDIIYAIARLSKFYMHESCGQCTPCREGTGWMWRIMMRLVEGNASVSDIDMILDVTKQIEGNTICALGDAAAWP
IQGLIKHFRHEIEDRIKNFNIQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=64.9164677804296, Blast_Score=590, Evalue=1e-169,
Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=64.9164677804296, Blast_Score=590, Evalue=1e-168,
Organism=Escherichia coli, GI1788620, Length=378, Percent_Identity=44.973544973545, Blast_Score=328, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI17531727, Length=422, Percent_Identity=65.1658767772512, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI19920794, Length=417, Percent_Identity=66.1870503597122, Blast_Score=599, Evalue=1e-171,
Organism=Drosophila melanogaster, GI45550452, Length=414, Percent_Identity=63.768115942029, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24653819, Length=417, Percent_Identity=47.0023980815348, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24653817, Length=417, Percent_Identity=43.6450839328537, Blast_Score=355, Evalue=4e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 46312; Mature: 46312

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNIEDKIFTNLSGAMAVDLASAKKRGDWYTTKNLILNSREWIIEEIKSSGLRGRGGAGF
CCCCCHHHHHCCCCHHEEEHHHHHHCCCCEEEHHHEECCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKNSEKATYLVVNADESEPGTCKDRDIIRYEPHKLIEGCLLAAYAIGAQTC
CCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCEEE
YIYIRGEYYNEALILQNAIQEAYGARLIGLNACGTDFNFNLYLHRGAGAYICGEETALLE
EEEEEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCCEEEECCHHHHHH
SLEGKKGMPRLKPPFPANTGLYGCPTTINNVESIAVVPTILRRGAKWFASIGKPNNTGTK
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCE
IFSISGHVNNPCNIEEAMGVPLKYLIEKYAGGVRGGWDNLKAIIPGGSSVPLIPKNICDT
EEEEECCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHH
VEMDFDSLKAVGSGLGTGGIIVMDNNTDIIYAIARLSKFYMHESCGQCTPCREGTGWMWR
HHCCHHHHHHHHCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
IMMRLVEGNASVSDIDMILDVTKQIEGNTICALGDAAAWPIQGLIKHFRHEIEDRIKNFN
HHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCC
IQ
CC
>Mature Secondary Structure
MLNIEDKIFTNLSGAMAVDLASAKKRGDWYTTKNLILNSREWIIEEIKSSGLRGRGGAGF
CCCCCHHHHHCCCCHHEEEHHHHHHCCCCEEEHHHEECCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKNSEKATYLVVNADESEPGTCKDRDIIRYEPHKLIEGCLLAAYAIGAQTC
CCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCEEE
YIYIRGEYYNEALILQNAIQEAYGARLIGLNACGTDFNFNLYLHRGAGAYICGEETALLE
EEEEEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCCEEEECCHHHHHH
SLEGKKGMPRLKPPFPANTGLYGCPTTINNVESIAVVPTILRRGAKWFASIGKPNNTGTK
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCE
IFSISGHVNNPCNIEEAMGVPLKYLIEKYAGGVRGGWDNLKAIIPGGSSVPLIPKNICDT
EEEEECCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHH
VEMDFDSLKAVGSGLGTGGIIVMDNNTDIIYAIARLSKFYMHESCGQCTPCREGTGWMWR
HHCCHHHHHHHHCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
IMMRLVEGNASVSDIDMILDVTKQIEGNTICALGDAAAWPIQGLIKHFRHEIEDRIKNFN
HHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCC
IQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA