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The map label for this gene is aprE [H]

Identifier: 148284165

GI number: 148284165

Start: 301250

End: 302806

Strand: Direct

Name: aprE [H]

Synonym: OTBS_0306

Alternate gene names: 148284165

Gene position: 301250-302806 (Clockwise)

Preceding gene: 148284164

Following gene: 148284166

Centisome position: 14.16

GC content: 31.6

Gene sequence:

>1557_bases
TTGGGTAAAAAAATGTCTCAGCTTTGGAATGATAATAATAATAATAATGGCATAAAGGGAATAATACCTAAAATGTCGCC
TCAAGACCGAAAAAATATAATGGATGTGTTATTGCAAAATCAGCAAAAACAACAAAAACTAGAAAAGAGTAAATGGCTAA
AATCATTGCTTAAAGCAATATTGTTGCAGTTAACACGATTAATTTATGGTATAGGTAATGCTGTAGATAGCTTTATTAGT
TTTATTATTAACTCAAAAGGTACAGCCAAAAATATTGTAGTTCAGACTGCAAGAGGGCCAATATTGTTTGGAGTTTGGGT
CATGATTATTTTTATTGTAGTAGGTGGTTTATGGAGTGCATTAGCTCCACTTGACAGTGCTGCAGTAGCTGTTGGAACTG
TGATATCAAGTACTGAAAATAAAATTATACAGCATCAGGAAGGTGGTATTGTTAAAGAAATCTTTGTTAAACAAGGAGAT
TACGTTAAGACAGGTAATCCTATAATAGCATTGGATGATACTAAAATTAGAGCTAGTGTAGAAATTAAGCTAGGTCAATA
TAGAACATTATTAGCTAATCAGGCTAGGTTAACTGCTGAACTAGAGCAACAAGAAGAAATAATATTTTCTGAAATTCTGG
TTAATAATAATCATATACCAGAAGTAGCAAAAATAATGTCAATTCAGCAGCATCTATTTCAAGCAAGAAAGAAAGGCTTA
AATGCAAGAATCATGCAATTTGAAAAAAGAATTGATTCTTTAGAAGCTAAAGTAGTAGCATCTAAAAAGCAGCTTGAGTA
TGTTAGAAAGCTTATTAAAAACGCTGAAAGCCTAATTGCTCAAGGCTTTGGACAAAAAACAGAGCTGGATAAATTGTTGG
TTGAAGAATCAAGCTTGGTAGGTAATATCATAATTACTGAACTTGAGATAAACAGTACTCAGCAAGATATCGAAAGAACA
AAGTCTGAAGCAATAGATCGTACATTATCTGAACTTAAAGAAGTTGAACATGCTGTCATTGAAGCTCAAGAAAGCTATAA
CTCTTTGATTGATATATTAAGCAGAACCTTAGTAAAATCTCCAGTTGATGGTATAATTAAGGTTTTGGATGTTAATACTA
AAGGTGGAGTTATTGGATCTGGACAAAGGATTGCAGAAATTACACCTAGTAATGATTCTCTAATAATTAAAGCTAAAATT
CCTCAAAAGAATATTGATTCAGTTAAGGTAGGATTGAAGGCTAAAATAAGATTTGGTGCTTTCAAATATAGAACTACACC
AGTGTTTACTGGTAGGATAGTGCTAGTGTCGCCTGATACAGTTCAAGATCAACAATCAGCAATGCAGTTTAATAATGCAA
TGATAGGTGATACCTTTTATATTGCTAAAATAGAAATAGATATGGATGAATTTAATAAAGTAGCAAAAGTTCAAAAATTA
AAACTTTTTCCAGGAATGCAAGCTGATATTCAAATTATTACTGGAACTAGAACTTTATTAAGATACTTGCTTGATCCAAT
AACTGATAACATGTTTAGAGCATTTACGGAGAAATAA

Upstream 100 bases:

>100_bases
ACAGTAGCTGTCTTTGGAGATAGAGAAGAAGTTATGAATCAGCTTAATAAGCATAAACTAAGTATTCATAAATAGGATAG
TAATATAATTAATTAAAGAT

Downstream 100 bases:

>100_bases
AAAATGCCTTGGTGTACCTTTTGTTTTATAAGATGAATTACTTTTCTTTCATGTTAGAGCTGATTTTTAAAATTGGCTCT
AACCCTTGGTTAGCAAGTAA

Product: alkaline protease secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MGKKMSQLWNDNNNNNGIKGIIPKMSPQDRKNIMDVLLQNQQKQQKLEKSKWLKSLLKAILLQLTRLIYGIGNAVDSFIS
FIINSKGTAKNIVVQTARGPILFGVWVMIIFIVVGGLWSALAPLDSAAVAVGTVISSTENKIIQHQEGGIVKEIFVKQGD
YVKTGNPIIALDDTKIRASVEIKLGQYRTLLANQARLTAELEQQEEIIFSEILVNNNHIPEVAKIMSIQQHLFQARKKGL
NARIMQFEKRIDSLEAKVVASKKQLEYVRKLIKNAESLIAQGFGQKTELDKLLVEESSLVGNIIITELEINSTQQDIERT
KSEAIDRTLSELKEVEHAVIEAQESYNSLIDILSRTLVKSPVDGIIKVLDVNTKGGVIGSGQRIAEITPSNDSLIIKAKI
PQKNIDSVKVGLKAKIRFGAFKYRTTPVFTGRIVLVSPDTVQDQQSAMQFNNAMIGDTFYIAKIEIDMDEFNKVAKVQKL
KLFPGMQADIQIITGTRTLLRYLLDPITDNMFRAFTEK

Sequences:

>Translated_518_residues
MGKKMSQLWNDNNNNNGIKGIIPKMSPQDRKNIMDVLLQNQQKQQKLEKSKWLKSLLKAILLQLTRLIYGIGNAVDSFIS
FIINSKGTAKNIVVQTARGPILFGVWVMIIFIVVGGLWSALAPLDSAAVAVGTVISSTENKIIQHQEGGIVKEIFVKQGD
YVKTGNPIIALDDTKIRASVEIKLGQYRTLLANQARLTAELEQQEEIIFSEILVNNNHIPEVAKIMSIQQHLFQARKKGL
NARIMQFEKRIDSLEAKVVASKKQLEYVRKLIKNAESLIAQGFGQKTELDKLLVEESSLVGNIIITELEINSTQQDIERT
KSEAIDRTLSELKEVEHAVIEAQESYNSLIDILSRTLVKSPVDGIIKVLDVNTKGGVIGSGQRIAEITPSNDSLIIKAKI
PQKNIDSVKVGLKAKIRFGAFKYRTTPVFTGRIVLVSPDTVQDQQSAMQFNNAMIGDTFYIAKIEIDMDEFNKVAKVQKL
KLFPGMQADIQIITGTRTLLRYLLDPITDNMFRAFTEK
>Mature_517_residues
GKKMSQLWNDNNNNNGIKGIIPKMSPQDRKNIMDVLLQNQQKQQKLEKSKWLKSLLKAILLQLTRLIYGIGNAVDSFISF
IINSKGTAKNIVVQTARGPILFGVWVMIIFIVVGGLWSALAPLDSAAVAVGTVISSTENKIIQHQEGGIVKEIFVKQGDY
VKTGNPIIALDDTKIRASVEIKLGQYRTLLANQARLTAELEQQEEIIFSEILVNNNHIPEVAKIMSIQQHLFQARKKGLN
ARIMQFEKRIDSLEAKVVASKKQLEYVRKLIKNAESLIAQGFGQKTELDKLLVEESSLVGNIIITELEINSTQQDIERTK
SEAIDRTLSELKEVEHAVIEAQESYNSLIDILSRTLVKSPVDGIIKVLDVNTKGGVIGSGQRIAEITPSNDSLIIKAKIP
QKNIDSVKVGLKAKIRFGAFKYRTTPVFTGRIVLVSPDTVQDQQSAMQFNNAMIGDTFYIAKIEIDMDEFNKVAKVQKLK
LFPGMQADIQIITGTRTLLRYLLDPITDNMFRAFTEK

Specific function: Involved in the secretion of proteases A, B, C and G [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003997
- InterPro:   IPR006143
- InterPro:   IPR006144
- InterPro:   IPR010129 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 57870; Mature: 57739

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKKMSQLWNDNNNNNGIKGIIPKMSPQDRKNIMDVLLQNQQKQQKLEKSKWLKSLLKAI
CCCHHHHHHCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLQLTRLIYGIGNAVDSFISFIINSKGTAKNIVVQTARGPILFGVWVMIIFIVVGGLWSA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
LAPLDSAAVAVGTVISSTENKIIQHQEGGIVKEIFVKQGDYVKTGNPIIALDDTKIRASV
HCCCCHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHCCCCEEECCCCEEEECCCEEEEEE
EIKLGQYRTLLANQARLTAELEQQEEIIFSEILVNNNHIPEVAKIMSIQQHLFQARKKGL
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
NARIMQFEKRIDSLEAKVVASKKQLEYVRKLIKNAESLIAQGFGQKTELDKLLVEESSLV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GNIIITELEINSTQQDIERTKSEAIDRTLSELKEVEHAVIEAQESYNSLIDILSRTLVKS
CEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PVDGIIKVLDVNTKGGVIGSGQRIAEITPSNDSLIIKAKIPQKNIDSVKVGLKAKIRFGA
CHHHHEEEEEECCCCCEEECCCEEEEECCCCCCEEEEEECCCCCCCCEEECEEEEEEECE
FKYRTTPVFTGRIVLVSPDTVQDQQSAMQFNNAMIGDTFYIAKIEIDMDEFNKVAKVQKL
EEEECCEEEEEEEEEECCCCCHHHHHHHHHCCCEECCEEEEEEEEECHHHHHHHHHHHHH
KLFPGMQADIQIITGTRTLLRYLLDPITDNMFRAFTEK
HCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GKKMSQLWNDNNNNNGIKGIIPKMSPQDRKNIMDVLLQNQQKQQKLEKSKWLKSLLKAI
CCHHHHHHCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLQLTRLIYGIGNAVDSFISFIINSKGTAKNIVVQTARGPILFGVWVMIIFIVVGGLWSA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
LAPLDSAAVAVGTVISSTENKIIQHQEGGIVKEIFVKQGDYVKTGNPIIALDDTKIRASV
HCCCCHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHCCCCEEECCCCEEEECCCEEEEEE
EIKLGQYRTLLANQARLTAELEQQEEIIFSEILVNNNHIPEVAKIMSIQQHLFQARKKGL
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
NARIMQFEKRIDSLEAKVVASKKQLEYVRKLIKNAESLIAQGFGQKTELDKLLVEESSLV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GNIIITELEINSTQQDIERTKSEAIDRTLSELKEVEHAVIEAQESYNSLIDILSRTLVKS
CEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PVDGIIKVLDVNTKGGVIGSGQRIAEITPSNDSLIIKAKIPQKNIDSVKVGLKAKIRFGA
CHHHHEEEEEECCCCCEEECCCEEEEECCCCCCEEEEEECCCCCCCCEEECEEEEEEECE
FKYRTTPVFTGRIVLVSPDTVQDQQSAMQFNNAMIGDTFYIAKIEIDMDEFNKVAKVQKL
EEEECCEEEEEEEEEECCCCCHHHHHHHHHCCCEECCEEEEEEEEECHHHHHHHHHHHHH
KLFPGMQADIQIITGTRTLLRYLLDPITDNMFRAFTEK
HCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2184029 [H]