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The map label for this gene is gyrA [H]

Identifier: 148284134

GI number: 148284134

Start: 244244

End: 246961

Strand: Direct

Name: gyrA [H]

Synonym: OTBS_0252

Alternate gene names: 148284134

Gene position: 244244-246961 (Clockwise)

Preceding gene: 148284133

Following gene: 148284135

Centisome position: 11.48

GC content: 32.12

Gene sequence:

>2718_bases
TTGTCTGAACAAGAGTATAAAGAATCAAATATAAATATTATTAGTATAAAAGAAGAAATGCAACGCTCATATCTGGATTA
TGCTATGAGCGTAATAGTAAGTCGTGCATTACCTGATGTTAGGGATGGATTAAAACCTGTACATAGGCGCGTACTTTATG
CAATGTATGAATCTGGCTATCACTATAATAAACAATATCGTAAGTCTGCAAGGGTTGTTGGAGATGTGATAGGTAAATAT
CACCCTCATGGTGAATTAGCTGTTTACGATTCATTAGTTAGAATGGCACAGGATTTTTCTCTAAGATTACCACTAGTAGA
TGGTCAAGGTAATTTTGGTTCTATGGATGGAGATGCTGCTGCTGCAATGCGTTATACTGAAGTACGTTTAAAAAAAGTTG
CGCATAGCTTGTTAGAGGATATTAATAAGGATACTGTTGATTTTCAGGCTAATTATGATGGCTTAGAACAAGAACCAAAA
GTTTTGCCAGCTGGATTCCCTAATTTATTAGTAAATGGGACTGGAGGAATTGCAGTAGGAATGGCAACTAATATTCCACC
TCATAATTTATGTGAGGTAGTTGATGCCTGCTGCGCTTATATCGATAATAATAATATAACAATTATCGAACTAATGGAAT
TAGTTAAAGGGCCAGACTTTCCTACTGGTGGGCAAATTATTGGCACATTTGGAATTAAGTCAGCATATAACACAGGCAGA
GGTAAAATTATTGTTCGTGGTAAAACCGATATTGAAAGCGATAGTTTAAAACATGCTATTATTATTACAGAAATACCTTT
TATGGTTAATAAAGCTAGTTTAGTTGAAAAAATCGCTGAACTTGTGAATGATAAAAGGATTGAAGGTATTAGTGCTATTA
GAGATGAATCTAATAAATCTGGTATAAGGGTAGTAATAGAGCTTAAAAAACATGCTAATACTGATCTTATTCTAAATCAA
TTATATTCCTATACTAGTCTGCAAACTACATTTAATGTTATGATGCTAGCCTTAGATCAAGGCATACCAAAAACAATGAC
ATTAAAAGATATTATTGTTGCTTTTACTAATTTTCGTGAAGAAGTTATTACTAAGAGAACTATATTTTTGCTCAATAAAG
CTCGAGATAAAGCTCATATTTTAGTAGGCATAATTATTGCTGTTAGTAATATTGATGAAGTAATCAAAATTATAAGATCA
TCTGCTAACTCGGAGGAAGCAAAAAGTAGATTAATGGCTAGAATGTGGAATGTTAGTGATGTATATGATCTTGTGAAGTT
AGTTGATGATAGAGCTATTTTAAAAGAAGATGGACAATGTTTTTTAACTGAGCAGCAAACAAAATCGATATTAGAATTAA
GGTTACAACGCTTAACAAATACTGAGAGAGGTAAAGTTGAAGATGAGTTAAACAACTTAGTAAAGGAAATTAAAGCATAT
CTTGAAATTTTGGGCTCAAGGGATAAATTACTTGAAACAATGAAGTTTGAGCTAAATCAAATTAAGGAACAATTTTCTAC
AGCTCGCCTTACTACAATTGAAAACCAAGAATTTGAGCAAGATATTGAGGATTTAATTCCTGAAGAAGAAGTAGTAGTTA
CTGTTACATTGGCTGGTTATATTAAAAGAGTTCCTTTATCAACTTATCGTGCTCAAAAAAGAGGCGGAAAAGGAAGAGTT
GGTTCATCAGTACAGAATGAAGATGTGATTACTCATCTGTTTATAGAAAATACTCACACTTCTATTTTGTTTTTTTCAAA
TATTGGGCAAGTATATAATTTAAAAGTGTATAAATTGCCATTAGGCACTCCGCAGTCTAAAGGTAGACCAATTATTAATC
TGATTTCTATTAAAGAAAATGAAACTATCACTAATATTATGCCAATGCCTGCAGAAAGCGAGAATGATTCAGAGAAAAAA
TATATCATCTTTGCAACTAAGCATGGTAATATAAGAAGAAATGATTTATCTGATTTTAAACATATAGCTTCTAATGGCAA
AATTGCTATTCGCCTTGATGAAGGCGATAGCCTAATTTCTGTAAAATCTTGCGATGAAGAAAATCATGTGTTGCTAGCAA
CACAGAATGGTAAAGCTATAAGGTTTCCAGTAAAAGATCTAAGAGTTTTCAAAAGCCGTACTTCCGATGGAGTTAAAGCT
ATTAAATTAGCTGGAAATGATGCGGTTATATCAATGACTATTTTAAAAGGAATTAATTGTAGTCTTGAGGTTCGAGAAAA
CTACTTGAATTTACCAGTAAGCAATCGTCTGTTAATTGCTAAAAATAAATTACTACATCCGAGCATCGATCTTTCTAAAT
ATAACTTAACTGAAGATGAAATGTTAACTATGGCTAGTAATGAAGAATTCATCTTGACTGTATCAGAAAATGGTTATGGT
AAGTTTAGTTCAGCTTATGAATATCGAGTTACTAAGAGAGGTGGAAAAGGAGTAGCAAATATGAATGTATCATCTAAAAC
TGGAAAGGTTGTTAGTGTATTGCCAGCCTGTCAAGATAATGAGTTGATGCTAATTACTAGCAGCGGAAAACTAATAAGAT
GTCAATTAAATAGTGTCAGAATTATCGGCCGTAGCACTAGTGGAGTTATATTATTCAAAACTTCTAAAGATGAAAAAGTA
GTATCAATTGATACTATTAAAGATACTGATTATAGTGATGATTGTAGCGATGATGAAAGTAATAACAATAACATCTAA

Upstream 100 bases:

>100_bases
AATGTTTTATTATGAAATAATAGAGTATGCTTTATAACAAAAATAATTTATAGTAGTTTAAGTTACTATCAATATTTTTT
AATAAATAAATGTAATTGCT

Downstream 100 bases:

>100_bases
AACTTGGTTATAAGATAAAATTAGAGTTGGTAAATGTGTAAAGAAATATATGATTTAATTGCTAAAGAATTATATAGACA
GCAATCAACAATAGAATTAA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 905; Mature: 904

Protein sequence:

>905_residues
MSEQEYKESNINIISIKEEMQRSYLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMYESGYHYNKQYRKSARVVGDVIGKY
HPHGELAVYDSLVRMAQDFSLRLPLVDGQGNFGSMDGDAAAAMRYTEVRLKKVAHSLLEDINKDTVDFQANYDGLEQEPK
VLPAGFPNLLVNGTGGIAVGMATNIPPHNLCEVVDACCAYIDNNNITIIELMELVKGPDFPTGGQIIGTFGIKSAYNTGR
GKIIVRGKTDIESDSLKHAIIITEIPFMVNKASLVEKIAELVNDKRIEGISAIRDESNKSGIRVVIELKKHANTDLILNQ
LYSYTSLQTTFNVMMLALDQGIPKTMTLKDIIVAFTNFREEVITKRTIFLLNKARDKAHILVGIIIAVSNIDEVIKIIRS
SANSEEAKSRLMARMWNVSDVYDLVKLVDDRAILKEDGQCFLTEQQTKSILELRLQRLTNTERGKVEDELNNLVKEIKAY
LEILGSRDKLLETMKFELNQIKEQFSTARLTTIENQEFEQDIEDLIPEEEVVVTVTLAGYIKRVPLSTYRAQKRGGKGRV
GSSVQNEDVITHLFIENTHTSILFFSNIGQVYNLKVYKLPLGTPQSKGRPIINLISIKENETITNIMPMPAESENDSEKK
YIIFATKHGNIRRNDLSDFKHIASNGKIAIRLDEGDSLISVKSCDEENHVLLATQNGKAIRFPVKDLRVFKSRTSDGVKA
IKLAGNDAVISMTILKGINCSLEVRENYLNLPVSNRLLIAKNKLLHPSIDLSKYNLTEDEMLTMASNEEFILTVSENGYG
KFSSAYEYRVTKRGGKGVANMNVSSKTGKVVSVLPACQDNELMLITSSGKLIRCQLNSVRIIGRSTSGVILFKTSKDEKV
VSIDTIKDTDYSDDCSDDESNNNNI

Sequences:

>Translated_905_residues
MSEQEYKESNINIISIKEEMQRSYLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMYESGYHYNKQYRKSARVVGDVIGKY
HPHGELAVYDSLVRMAQDFSLRLPLVDGQGNFGSMDGDAAAAMRYTEVRLKKVAHSLLEDINKDTVDFQANYDGLEQEPK
VLPAGFPNLLVNGTGGIAVGMATNIPPHNLCEVVDACCAYIDNNNITIIELMELVKGPDFPTGGQIIGTFGIKSAYNTGR
GKIIVRGKTDIESDSLKHAIIITEIPFMVNKASLVEKIAELVNDKRIEGISAIRDESNKSGIRVVIELKKHANTDLILNQ
LYSYTSLQTTFNVMMLALDQGIPKTMTLKDIIVAFTNFREEVITKRTIFLLNKARDKAHILVGIIIAVSNIDEVIKIIRS
SANSEEAKSRLMARMWNVSDVYDLVKLVDDRAILKEDGQCFLTEQQTKSILELRLQRLTNTERGKVEDELNNLVKEIKAY
LEILGSRDKLLETMKFELNQIKEQFSTARLTTIENQEFEQDIEDLIPEEEVVVTVTLAGYIKRVPLSTYRAQKRGGKGRV
GSSVQNEDVITHLFIENTHTSILFFSNIGQVYNLKVYKLPLGTPQSKGRPIINLISIKENETITNIMPMPAESENDSEKK
YIIFATKHGNIRRNDLSDFKHIASNGKIAIRLDEGDSLISVKSCDEENHVLLATQNGKAIRFPVKDLRVFKSRTSDGVKA
IKLAGNDAVISMTILKGINCSLEVRENYLNLPVSNRLLIAKNKLLHPSIDLSKYNLTEDEMLTMASNEEFILTVSENGYG
KFSSAYEYRVTKRGGKGVANMNVSSKTGKVVSVLPACQDNELMLITSSGKLIRCQLNSVRIIGRSTSGVILFKTSKDEKV
VSIDTIKDTDYSDDCSDDESNNNNI
>Mature_904_residues
SEQEYKESNINIISIKEEMQRSYLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMYESGYHYNKQYRKSARVVGDVIGKYH
PHGELAVYDSLVRMAQDFSLRLPLVDGQGNFGSMDGDAAAAMRYTEVRLKKVAHSLLEDINKDTVDFQANYDGLEQEPKV
LPAGFPNLLVNGTGGIAVGMATNIPPHNLCEVVDACCAYIDNNNITIIELMELVKGPDFPTGGQIIGTFGIKSAYNTGRG
KIIVRGKTDIESDSLKHAIIITEIPFMVNKASLVEKIAELVNDKRIEGISAIRDESNKSGIRVVIELKKHANTDLILNQL
YSYTSLQTTFNVMMLALDQGIPKTMTLKDIIVAFTNFREEVITKRTIFLLNKARDKAHILVGIIIAVSNIDEVIKIIRSS
ANSEEAKSRLMARMWNVSDVYDLVKLVDDRAILKEDGQCFLTEQQTKSILELRLQRLTNTERGKVEDELNNLVKEIKAYL
EILGSRDKLLETMKFELNQIKEQFSTARLTTIENQEFEQDIEDLIPEEEVVVTVTLAGYIKRVPLSTYRAQKRGGKGRVG
SSVQNEDVITHLFIENTHTSILFFSNIGQVYNLKVYKLPLGTPQSKGRPIINLISIKENETITNIMPMPAESENDSEKKY
IIFATKHGNIRRNDLSDFKHIASNGKIAIRLDEGDSLISVKSCDEENHVLLATQNGKAIRFPVKDLRVFKSRTSDGVKAI
KLAGNDAVISMTILKGINCSLEVRENYLNLPVSNRLLIAKNKLLHPSIDLSKYNLTEDEMLTMASNEEFILTVSENGYGK
FSSAYEYRVTKRGGKGVANMNVSSKTGKVVSVLPACQDNELMLITSSGKLIRCQLNSVRIIGRSTSGVILFKTSKDEKVV
SIDTIKDTDYSDDCSDDESNNNNI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=337, Percent_Identity=25.8160237388724, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI19913406, Length=349, Percent_Identity=24.9283667621776, Blast_Score=75, Evalue=4e-13,
Organism=Escherichia coli, GI1788562, Length=889, Percent_Identity=47.3565804274466, Blast_Score=822, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=710, Percent_Identity=34.5070422535211, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645845, Length=378, Percent_Identity=26.1904761904762, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17535065, Length=366, Percent_Identity=27.0491803278689, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=361, Percent_Identity=27.4238227146814, Blast_Score=81, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=164, Percent_Identity=31.7073170731707, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136538, Length=365, Percent_Identity=24.9315068493151, Blast_Score=81, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 101257; Mature: 101125

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQEYKESNINIISIKEEMQRSYLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMYESGY
CCCCHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
HYNKQYRKSARVVGDVIGKYHPHGELAVYDSLVRMAQDFSLRLPLVDGQGNFGSMDGDAA
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHH
AAMRYTEVRLKKVAHSLLEDINKDTVDFQANYDGLEQEPKVLPAGFPNLLVNGTGGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEEEE
MATNIPPHNLCEVVDACCAYIDNNNITIIELMELVKGPDFPTGGQIIGTFGIKSAYNTGR
EECCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCC
GKIIVRGKTDIESDSLKHAIIITEIPFMVNKASLVEKIAELVNDKRIEGISAIRDESNKS
CEEEEECCCCCCCCCCCEEEEEEECCHHHCHHHHHHHHHHHHCCCCCCCHHHHHCCCCCC
GIRVVIELKKHANTDLILNQLYSYTSLQTTFNVMMLALDQGIPKTMTLKDIIVAFTNFRE
CEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
EVITKRTIFLLNKARDKAHILVGIIIAVSNIDEVIKIIRSSANSEEAKSRLMARMWNVSD
HHHHHHHEEEEECCCCCHHEEEEEEHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHH
VYDLVKLVDDRAILKEDGQCFLTEQQTKSILELRLQRLTNTERGKVEDELNNLVKEIKAY
HHHHHHHHCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
LEILGSRDKLLETMKFELNQIKEQFSTARLTTIENQEFEQDIEDLIPEEEVVVTVTLAGY
HHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHCCCCCEEEEEEEHHH
IKRVPLSTYRAQKRGGKGRVGSSVQNEDVITHLFIENTHTSILFFSNIGQVYNLKVYKLP
HHHCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEEEEEEEEE
LGTPQSKGRPIINLISIKENETITNIMPMPAESENDSEKKYIIFATKHGNIRRNDLSDFK
CCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHH
HIASNGKIAIRLDEGDSLISVKSCDEENHVLLATQNGKAIRFPVKDLRVFKSRTSDGVKA
HHHCCCEEEEEECCCCCEEEEECCCCCCCEEEEECCCCEEECCHHHHHHHHHCCCCCCEE
IKLAGNDAVISMTILKGINCSLEVRENYLNLPVSNRLLIAKNKLLHPSIDLSKYNLTEDE
EEEECCCEEEEEEEHHCCCCEEEEECCEECCCCCCCEEEEECCCCCCCCCCCCCCCCHHH
MLTMASNEEFILTVSENGYGKFSSAYEYRVTKRGGKGVANMNVSSKTGKVVSVLPACQDN
EEEEECCCEEEEEECCCCCCCCCCCEEEEEECCCCCCEEECCCCCCCCCEEEEECCCCCC
ELMLITSSGKLIRCQLNSVRIIGRSTSGVILFKTSKDEKVVSIDTIKDTDYSDDCSDDES
CEEEEECCCCEEEEEECCEEEEEECCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCCC
NNNNI
CCCCC
>Mature Secondary Structure 
SEQEYKESNINIISIKEEMQRSYLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMYESGY
CCCHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
HYNKQYRKSARVVGDVIGKYHPHGELAVYDSLVRMAQDFSLRLPLVDGQGNFGSMDGDAA
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHH
AAMRYTEVRLKKVAHSLLEDINKDTVDFQANYDGLEQEPKVLPAGFPNLLVNGTGGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEEEE
MATNIPPHNLCEVVDACCAYIDNNNITIIELMELVKGPDFPTGGQIIGTFGIKSAYNTGR
EECCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCC
GKIIVRGKTDIESDSLKHAIIITEIPFMVNKASLVEKIAELVNDKRIEGISAIRDESNKS
CEEEEECCCCCCCCCCCEEEEEEECCHHHCHHHHHHHHHHHHCCCCCCCHHHHHCCCCCC
GIRVVIELKKHANTDLILNQLYSYTSLQTTFNVMMLALDQGIPKTMTLKDIIVAFTNFRE
CEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
EVITKRTIFLLNKARDKAHILVGIIIAVSNIDEVIKIIRSSANSEEAKSRLMARMWNVSD
HHHHHHHEEEEECCCCCHHEEEEEEHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHH
VYDLVKLVDDRAILKEDGQCFLTEQQTKSILELRLQRLTNTERGKVEDELNNLVKEIKAY
HHHHHHHHCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
LEILGSRDKLLETMKFELNQIKEQFSTARLTTIENQEFEQDIEDLIPEEEVVVTVTLAGY
HHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHCCCCCEEEEEEEHHH
IKRVPLSTYRAQKRGGKGRVGSSVQNEDVITHLFIENTHTSILFFSNIGQVYNLKVYKLP
HHHCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEEEEEEEEE
LGTPQSKGRPIINLISIKENETITNIMPMPAESENDSEKKYIIFATKHGNIRRNDLSDFK
CCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHH
HIASNGKIAIRLDEGDSLISVKSCDEENHVLLATQNGKAIRFPVKDLRVFKSRTSDGVKA
HHHCCCEEEEEECCCCCEEEEECCCCCCCEEEEECCCCEEECCHHHHHHHHHCCCCCCEE
IKLAGNDAVISMTILKGINCSLEVRENYLNLPVSNRLLIAKNKLLHPSIDLSKYNLTEDE
EEEECCCEEEEEEEHHCCCCEEEEECCEECCCCCCCEEEEECCCCCCCCCCCCCCCCHHH
MLTMASNEEFILTVSENGYGKFSSAYEYRVTKRGGKGVANMNVSSKTGKVVSVLPACQDN
EEEEECCCEEEEEECCCCCCCCCCCEEEEEECCCCCCEEECCCCCCCCCEEEEECCCCCC
ELMLITSSGKLIRCQLNSVRIIGRSTSGVILFKTSKDEKVVSIDTIKDTDYSDDCSDDES
CEEEEECCCCEEEEEECCEEEEEECCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCCC
NNNNI
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA