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The map label for this gene is livM [H]

Identifier: 148261193

GI number: 148261193

Start: 2432497

End: 2433405

Strand: Reverse

Name: livM [H]

Synonym: Acry_2203

Alternate gene names: 148261193

Gene position: 2433405-2432497 (Counterclockwise)

Preceding gene: 148261194

Following gene: 148261192

Centisome position: 71.8

GC content: 66.12

Gene sequence:

>909_bases
ATGCGTTATCCCGTCGCGGTGCTGGCGATCCTCGCCGCCGCCTTCCTGGTCCTGCCGCATGTCTATGGCAACCAGTCCGT
GCTGTTCACCATGATGACGTTCATGGCGCTCGCCCAGGGGCTGAACCTGCTCTACGGCTTCACCGGATATCTGCCGTTCG
GCTATGTCGGCTTCTTCGGCACCGGCGCCTATGCCACCTCGCTGCTGGTCACCTTCACCGGCCTGCCGGTGCTGGTCTGC
GTGCTTGGCGGCGGGTTGGCGGCGGTCGTGGTCGGGCTCATCCTCGGGCCGCTGCTGCGCCTGTCCGGCGCGTATTTCTC
GATCGCCAATCTCGCCGCCTCGCAGATCATCTACTACGTGGTGGCGAACGAGGCGCTCAAGCATGTGACCGGCGGGCCCT
ATGGCGTGAAGATCGAGCAGGTCTACGCGCCCACGGCGAGCTACGCGACGATGCTGGCGATCCTGTTGCTCGCCACCGGG
CTTGCCGCGTATTTCCGCCGCTCGCGATTCGGGCTCGGGCTGCGGGCGATGCACCAGGACCCGATCAGCGCGGGGCTCGC
GGGTGTCAACATCGTGCGCGAGCGCCTCATCGTCTGGCTGGCCTCGGCCGGCATCGCCGGGCTGGTCGGCGGCGCCTATG
CGTGGAACCTGTCGGTGTTCTACCCCGACGCGGTGTTCACCCTGCAGATTTCGGTCTTCGCCATCGTCTTCGCCCTGTTC
GGCGGGGTGGGCACGGTGATCGGCCCGCTGCTCGGCGCGGCCCTGCTCTATGCGTTCTACGCGGTGATCGGCGTCTCCGC
GCCGCAATATTTCGAACTGCTCTACGGGCTGCTGATCGTGCTGCTGGTGCTGTTCCTGCCCAACGGCCTGATGTCGCTGC
TGATCCGGAGAAATGTCGATGTCCTCTGA

Upstream 100 bases:

>100_bases
TCGAATCTCGTGCCCTATGCGCTGCTCCTCATCATCGTGCTGATCCGGCCCTCCGGCCTGCTCGGCAAGGCGGTGCGCAG
TGCGTAAGCGGAACAGTACA

Downstream 100 bases:

>100_bases
ACCGCTGCTCCGGCTGGACGGGGTGAGCAAGCGCTTCGGCGGGCTCACCGTGCTCGACCGGCAGAGTTTCTCGATATCCG
AAGGCGAGATTCTCGGCCTG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MRYPVAVLAILAAAFLVLPHVYGNQSVLFTMMTFMALAQGLNLLYGFTGYLPFGYVGFFGTGAYATSLLVTFTGLPVLVC
VLGGGLAAVVVGLILGPLLRLSGAYFSIANLAASQIIYYVVANEALKHVTGGPYGVKIEQVYAPTASYATMLAILLLATG
LAAYFRRSRFGLGLRAMHQDPISAGLAGVNIVRERLIVWLASAGIAGLVGGAYAWNLSVFYPDAVFTLQISVFAIVFALF
GGVGTVIGPLLGAALLYAFYAVIGVSAPQYFELLYGLLIVLLVLFLPNGLMSLLIRRNVDVL

Sequences:

>Translated_302_residues
MRYPVAVLAILAAAFLVLPHVYGNQSVLFTMMTFMALAQGLNLLYGFTGYLPFGYVGFFGTGAYATSLLVTFTGLPVLVC
VLGGGLAAVVVGLILGPLLRLSGAYFSIANLAASQIIYYVVANEALKHVTGGPYGVKIEQVYAPTASYATMLAILLLATG
LAAYFRRSRFGLGLRAMHQDPISAGLAGVNIVRERLIVWLASAGIAGLVGGAYAWNLSVFYPDAVFTLQISVFAIVFALF
GGVGTVIGPLLGAALLYAFYAVIGVSAPQYFELLYGLLIVLLVLFLPNGLMSLLIRRNVDVL
>Mature_302_residues
MRYPVAVLAILAAAFLVLPHVYGNQSVLFTMMTFMALAQGLNLLYGFTGYLPFGYVGFFGTGAYATSLLVTFTGLPVLVC
VLGGGLAAVVVGLILGPLLRLSGAYFSIANLAASQIIYYVVANEALKHVTGGPYGVKIEQVYAPTASYATMLAILLLATG
LAAYFRRSRFGLGLRAMHQDPISAGLAGVNIVRERLIVWLASAGIAGLVGGAYAWNLSVFYPDAVFTLQISVFAIVFALF
GGVGTVIGPLLGAALLYAFYAVIGVSAPQYFELLYGLLIVLLVLFLPNGLMSLLIRRNVDVL

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=296, Percent_Identity=27.027027027027, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 31954; Mature: 31954

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYPVAVLAILAAAFLVLPHVYGNQSVLFTMMTFMALAQGLNLLYGFTGYLPFGYVGFFG
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGAYATSLLVTFTGLPVLVCVLGGGLAAVVVGLILGPLLRLSGAYFSIANLAASQIIYYV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VANEALKHVTGGPYGVKIEQVYAPTASYATMLAILLLATGLAAYFRRSRFGLGLRAMHQD
HHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
PISAGLAGVNIVRERLIVWLASAGIAGLVGGAYAWNLSVFYPDAVFTLQISVFAIVFALF
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHEEEEEEEECCHHHHHHHHHHHHHHHHH
GGVGTVIGPLLGAALLYAFYAVIGVSAPQYFELLYGLLIVLLVLFLPNGLMSLLIRRNVD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCC
VL
CC
>Mature Secondary Structure
MRYPVAVLAILAAAFLVLPHVYGNQSVLFTMMTFMALAQGLNLLYGFTGYLPFGYVGFFG
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGAYATSLLVTFTGLPVLVCVLGGGLAAVVVGLILGPLLRLSGAYFSIANLAASQIIYYV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VANEALKHVTGGPYGVKIEQVYAPTASYATMLAILLLATGLAAYFRRSRFGLGLRAMHQD
HHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
PISAGLAGVNIVRERLIVWLASAGIAGLVGGAYAWNLSVFYPDAVFTLQISVFAIVFALF
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHEEEEEEEECCHHHHHHHHHHHHHHHHH
GGVGTVIGPLLGAALLYAFYAVIGVSAPQYFELLYGLLIVLLVLFLPNGLMSLLIRRNVD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCC
VL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]