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The map label for this gene is livH [H]

Identifier: 148261194

GI number: 148261194

Start: 2433419

End: 2434300

Strand: Reverse

Name: livH [H]

Synonym: Acry_2204

Alternate gene names: 148261194

Gene position: 2434300-2433419 (Counterclockwise)

Preceding gene: 148261195

Following gene: 148261193

Centisome position: 71.82

GC content: 64.63

Gene sequence:

>882_bases
TTGGCACTTCTCGAATACGCGCTGATCGGCGGCATTCTCTACGGCATCTTCTTCAGCCTTGTCGGCATCGGGCTCAATCT
CGTCTTCGGCGTGATGCGGATGATCAATCTCGCCCACGGCCAGTTCATCATGCTGGGCGGGTTCGGCGCGTGGCTTCTGG
TGCATGACCTTCACCTCAACCCGATCTTCGGCATTCCGCTGGCGATTCTCGGCGGGATCCTGATCGGCTATCCGCTCTAT
TACGGCGTGGTGCCGCGCCTGCAGCGCAGCCAGGACCCGGAGATGCTGTCCTTCATCCTGTTCTTCGGCATCGCCCAGAT
GATCGAGGCGGTGATGCTCCTCATCTTCGGCGCGGACCAGCGCTCGCTGCCCGGTAACGCGCTGGGCTCGGGGAATATCG
GCGCGTTCGGCCAGGAATTTCCGGACAGCTGGTGGGTCGCCGCCGCGGTCAGCGTCATCTGTATCGGCGGGCTCTGGCTC
TATTTCACGCGCACGCGGCTCGGCTTCGCGACGCGCGCCATCATGGCCGACCGCGACGAGGCGCGGGCAACCGGCATCGA
TGTCGACAGGGTGTCGGCGATCGCCTTCATGATCGGCCTCTCGCTCGCCGGGATCGCCGGCGTGTTCGTGCCCTACATGG
TCGGCTCGGTGTCGCCCTCGATCGGCGACGGGCTGACCACGACATCCTTCGCCATCATCATCATCGGCTCGCTCGGCAAT
CCGCTCGGCACCGTGGTCGGCGGCCTCGTGTTCGGCGTGGGAACGATGCTGATGCAGACCTACTACGCCTCGTGGTCGAA
TCTCGTGCCCTATGCGCTGCTCCTCATCATCGTGCTGATCCGGCCCTCCGGCCTGCTCGGCAAGGCGGTGCGCAGTGCGT
AA

Upstream 100 bases:

>100_bases
CGGCGCCCCGGAACCGCAGGATCCCGGCCCGTGACGGGCCGGGATCTTTCGTCGATCCGGACCACTGGTTTCCAACTTCC
CTGCAAGAAAGGGCGCGCCG

Downstream 100 bases:

>100_bases
GCGGAACAGTACAATGCGTTATCCCGTCGCGGTGCTGGCGATCCTCGCCGCCGCCTTCCTGGTCCTGCCGCATGTCTATG
GCAACCAGTCCGTGCTGTTC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MALLEYALIGGILYGIFFSLVGIGLNLVFGVMRMINLAHGQFIMLGGFGAWLLVHDLHLNPIFGIPLAILGGILIGYPLY
YGVVPRLQRSQDPEMLSFILFFGIAQMIEAVMLLIFGADQRSLPGNALGSGNIGAFGQEFPDSWWVAAAVSVICIGGLWL
YFTRTRLGFATRAIMADRDEARATGIDVDRVSAIAFMIGLSLAGIAGVFVPYMVGSVSPSIGDGLTTTSFAIIIIGSLGN
PLGTVVGGLVFGVGTMLMQTYYASWSNLVPYALLLIIVLIRPSGLLGKAVRSA

Sequences:

>Translated_293_residues
MALLEYALIGGILYGIFFSLVGIGLNLVFGVMRMINLAHGQFIMLGGFGAWLLVHDLHLNPIFGIPLAILGGILIGYPLY
YGVVPRLQRSQDPEMLSFILFFGIAQMIEAVMLLIFGADQRSLPGNALGSGNIGAFGQEFPDSWWVAAAVSVICIGGLWL
YFTRTRLGFATRAIMADRDEARATGIDVDRVSAIAFMIGLSLAGIAGVFVPYMVGSVSPSIGDGLTTTSFAIIIIGSLGN
PLGTVVGGLVFGVGTMLMQTYYASWSNLVPYALLLIIVLIRPSGLLGKAVRSA
>Mature_292_residues
ALLEYALIGGILYGIFFSLVGIGLNLVFGVMRMINLAHGQFIMLGGFGAWLLVHDLHLNPIFGIPLAILGGILIGYPLYY
GVVPRLQRSQDPEMLSFILFFGIAQMIEAVMLLIFGADQRSLPGNALGSGNIGAFGQEFPDSWWVAAAVSVICIGGLWLY
FTRTRLGFATRAIMADRDEARATGIDVDRVSAIAFMIGLSLAGIAGVFVPYMVGSVSPSIGDGLTTTSFAIIIIGSLGNP
LGTVVGGLVFGVGTMLMQTYYASWSNLVPYALLLIIVLIRPSGLLGKAVRSA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=292, Percent_Identity=26.3698630136986, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 31129; Mature: 30997

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLEYALIGGILYGIFFSLVGIGLNLVFGVMRMINLAHGQFIMLGGFGAWLLVHDLHLN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCC
PIFGIPLAILGGILIGYPLYYGVVPRLQRSQDPEMLSFILFFGIAQMIEAVMLLIFGADQ
CHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RSLPGNALGSGNIGAFGQEFPDSWWVAAAVSVICIGGLWLYFTRTRLGFATRAIMADRDE
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ARATGIDVDRVSAIAFMIGLSLAGIAGVFVPYMVGSVSPSIGDGLTTTSFAIIIIGSLGN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHEEEEEEECCCC
PLGTVVGGLVFGVGTMLMQTYYASWSNLVPYALLLIIVLIRPSGLLGKAVRSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure 
ALLEYALIGGILYGIFFSLVGIGLNLVFGVMRMINLAHGQFIMLGGFGAWLLVHDLHLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCC
PIFGIPLAILGGILIGYPLYYGVVPRLQRSQDPEMLSFILFFGIAQMIEAVMLLIFGADQ
CHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RSLPGNALGSGNIGAFGQEFPDSWWVAAAVSVICIGGLWLYFTRTRLGFATRAIMADRDE
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ARATGIDVDRVSAIAFMIGLSLAGIAGVFVPYMVGSVSPSIGDGLTTTSFAIIIIGSLGN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHEEEEEEECCCC
PLGTVVGGLVFGVGTMLMQTYYASWSNLVPYALLLIIVLIRPSGLLGKAVRSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]