Click here to switch to the map view.

The map label for this gene is ctaB

Identifier: 148261156

GI number: 148261156

Start: 2388873

End: 2389826

Strand: Reverse

Name: ctaB

Synonym: Acry_2165

Alternate gene names: 148261156

Gene position: 2389826-2388873 (Counterclockwise)

Preceding gene: 148261157

Following gene: 148261155

Centisome position: 70.51

GC content: 67.92

Gene sequence:

>954_bases
ATGAGCGATACGATCCTGCGCACCTCTGCCACCGCTGTCCCCGATACGGCGCTGCTCGACCAGTCGCTGCTCGGCGCGAC
GGCCGGCGACTGGCTCGCCCTGCTCAAGCCGCGGGTGCTCTACCTCGTGGTCTATACGGGCGCGGCCGGATTGCTCGTGG
CGCCGGGCGGGATCAATCCCATCCTCGGCTTTACCGCGATTCTCTGCATCGCCATGGCCGCCGGCGCGGCGGGGGCGATC
AACATGTGGTATGATCGCGACATCGATGCCGTGATGCGGCGGACCGCCGGCCGGCCGATCCCGACCGGGCGGATTTCGCC
GGATGGCGCGCTGGCCTACGGCGTTGCGCTTTCCGCATTGTCGGTGCTGTTGATGTGGCTCGCCACGAACCTGCTGGCCG
CCGGGCTGCTGGCCGCCTCGATCGGGTTCTACGTGTTCATCTACACGATGTGGCTGAAGCGGCGGACGCCGCAGAATATC
GTGATCGGGGGCGCGGCGGGGGCGTTTCCGCCGGTCATCGGCTGGGCCGCCGCGACCGGGCATGTCGGATTGCTGCCGGT
GCTGCTGTTCGCGATCATCTTCTTCTGGACGCCGCCGCATTTCTGGGCCCTGTCGCTCTTCGCGTCGGCCGATTACCAGA
AGGCGGGCGTGCCGATGCTGCCGGTGGTGGCCGGCCAGAAGGCCACGCGCCTCGCGGTGATGCGCTACACGCTGTGGCTG
GTGCCGCTCTCGCTGCTGCCCTACGTGCTGCACCTCGCGGGCCCGGTCTACGGCGCGAGCGCCATGGTGCTGGGCCTCGC
GTTCGTGTGGTATTCCTGGCGGGTGCTGCGCGACCGGCAGGATGGAAATGGCGTCAGCCTGACGCGGGACGCGCCGGCGA
AGGCGGCGTTCAAGTTCTCGATTCTGTACCTTTTCCTGATCTTCGGCGCGCTCGTTCTGGACCATCTGGTATGA

Upstream 100 bases:

>100_bases
GAAAGCGGGCGGGTGATGGTTCTCTCCGGCGGGGAGAACCATCCTCGTTCCCGCAAGGCAAAATCCGGATGCGAATATTC
GCGCCGGCTGGATTGATGGA

Downstream 100 bases:

>100_bases
CCGGGGTGGAACGGGCCAGCAGCAAGGACTGGAGCCGGGAGGAGCGGGCGGAATTCATCCGCCGGCGGCGGGGGCGGAAC
TGGGCGCTGCTCGCGGCGCT

Product: protoheme IX farnesyltransferase

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSDTILRTSATAVPDTALLDQSLLGATAGDWLALLKPRVLYLVVYTGAAGLLVAPGGINPILGFTAILCIAMAAGAAGAI
NMWYDRDIDAVMRRTAGRPIPTGRISPDGALAYGVALSALSVLLMWLATNLLAAGLLAASIGFYVFIYTMWLKRRTPQNI
VIGGAAGAFPPVIGWAAATGHVGLLPVLLFAIIFFWTPPHFWALSLFASADYQKAGVPMLPVVAGQKATRLAVMRYTLWL
VPLSLLPYVLHLAGPVYGASAMVLGLAFVWYSWRVLRDRQDGNGVSLTRDAPAKAAFKFSILYLFLIFGALVLDHLV

Sequences:

>Translated_317_residues
MSDTILRTSATAVPDTALLDQSLLGATAGDWLALLKPRVLYLVVYTGAAGLLVAPGGINPILGFTAILCIAMAAGAAGAI
NMWYDRDIDAVMRRTAGRPIPTGRISPDGALAYGVALSALSVLLMWLATNLLAAGLLAASIGFYVFIYTMWLKRRTPQNI
VIGGAAGAFPPVIGWAAATGHVGLLPVLLFAIIFFWTPPHFWALSLFASADYQKAGVPMLPVVAGQKATRLAVMRYTLWL
VPLSLLPYVLHLAGPVYGASAMVLGLAFVWYSWRVLRDRQDGNGVSLTRDAPAKAAFKFSILYLFLIFGALVLDHLV
>Mature_316_residues
SDTILRTSATAVPDTALLDQSLLGATAGDWLALLKPRVLYLVVYTGAAGLLVAPGGINPILGFTAILCIAMAAGAAGAIN
MWYDRDIDAVMRRTAGRPIPTGRISPDGALAYGVALSALSVLLMWLATNLLAAGLLAASIGFYVFIYTMWLKRRTPQNIV
IGGAAGAFPPVIGWAAATGHVGLLPVLLFAIIFFWTPPHFWALSLFASADYQKAGVPMLPVVAGQKATRLAVMRYTLWLV
PLSLLPYVLHLAGPVYGASAMVLGLAFVWYSWRVLRDRQDGNGVSLTRDAPAKAAFKFSILYLFLIFGALVLDHLV

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=230, Percent_Identity=33.9130434782609, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI1786631, Length=226, Percent_Identity=31.858407079646, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71998235, Length=216, Percent_Identity=32.4074074074074, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6325085, Length=290, Percent_Identity=27.5862068965517, Blast_Score=93, Evalue=5e-20,
Organism=Drosophila melanogaster, GI19921064, Length=280, Percent_Identity=28.2142857142857, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_ACICJ (A5G0I2)

Other databases:

- EMBL:   CP000697
- RefSeq:   YP_001235283.1
- STRING:   A5G0I2
- GeneID:   5162027
- GenomeReviews:   CP000697_GR
- KEGG:   acr:Acry_2165
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- ProtClustDB:   PRK04375
- BioCyc:   ACRY349163:ACRY_2165-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 33815; Mature: 33683

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1538c38c)-; HASH(0x1561bb18)-; HASH(0x1691147c)-; HASH(0x1645e03c)-; HASH(0x169113ec)-; HASH(0x169214ac)-; HASH(0x15e26ff4)-; HASH(0x152fe9a4)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTILRTSATAVPDTALLDQSLLGATAGDWLALLKPRVLYLVVYTGAAGLLVAPGGINP
CCCCEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHCCHHEEEEEEECCCCEEECCCCCCH
ILGFTAILCIAMAAGAAGAINMWYDRDIDAVMRRTAGRPIPTGRISPDGALAYGVALSAL
HHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
SVLLMWLATNLLAAGLLAASIGFYVFIYTMWLKRRTPQNIVIGGAAGAFPPVIGWAAATG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHCC
HVGLLPVLLFAIIFFWTPPHFWALSLFASADYQKAGVPMLPVVAGQKATRLAVMRYTLWL
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCEEECCCHHHHHHHHHHHHHH
VPLSLLPYVLHLAGPVYGASAMVLGLAFVWYSWRVLRDRQDGNGVSLTRDAPAKAAFKFS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHH
ILYLFLIFGALVLDHLV
HHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
SDTILRTSATAVPDTALLDQSLLGATAGDWLALLKPRVLYLVVYTGAAGLLVAPGGINP
CCCEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHCCHHEEEEEEECCCCEEECCCCCCH
ILGFTAILCIAMAAGAAGAINMWYDRDIDAVMRRTAGRPIPTGRISPDGALAYGVALSAL
HHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
SVLLMWLATNLLAAGLLAASIGFYVFIYTMWLKRRTPQNIVIGGAAGAFPPVIGWAAATG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHCC
HVGLLPVLLFAIIFFWTPPHFWALSLFASADYQKAGVPMLPVVAGQKATRLAVMRYTLWL
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCEEECCCHHHHHHHHHHHHHH
VPLSLLPYVLHLAGPVYGASAMVLGLAFVWYSWRVLRDRQDGNGVSLTRDAPAKAAFKFS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHH
ILYLFLIFGALVLDHLV
HHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA