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The map label for this gene is ctaD [H]

Identifier: 148261157

GI number: 148261157

Start: 2389946

End: 2391544

Strand: Reverse

Name: ctaD [H]

Synonym: Acry_2166

Alternate gene names: 148261157

Gene position: 2391544-2389946 (Counterclockwise)

Preceding gene: 148261158

Following gene: 148261156

Centisome position: 70.56

GC content: 63.04

Gene sequence:

>1599_bases
ATGTCCGCGACCGCACTGCACGATGCCCATGGCGAACATGCCCACCACCAGCCGGGATTCTTCCGGCGCTGGGTGATGAG
CACGAACCACAAGGATATCGGCACGCTCTACATCACCTGGGCGATCATCGCCGCGATCGAGGGCGGCGTGCTCTCGATGA
TCATGCGCGCGCAGCTGGCCCATCCGAACAACACGATCATCACCTCGGGCCAGACCTGGAACGCGATCGTGACCGCGCAC
GGCCTGCTGATGATCTTCTTCTTCGTCATGCCCGCGCTGATCGGCGGTTTCGGCAACTGGATGGTGCCGATGATGATCGG
CGCGCCGGACATGGCGTTCCCGCGCCTGAACAATATGAGCTTCTGGTTCCTGTTCATGGCGTTCATCTTCGTCAACCTGG
GCCTGCTGGTCGGCGCCGGCTCCGGCGTGGGCTGGACGCTGTATCCGCCGCTGTCGGACATCACCTACCAGCCCGGGGTG
GCCGTCGACTTCACGCTGTTCTCGCTGCATCTGGCCGGCATTTCCTCGCTGCTCGGCGCGATCAACTTCATCGCGACGAT
CCTGAACATGCGCGCGCCCGGCATGACGATGCACAAGATGCCGCTGTTCGTGTGGTCGATCCTGGTGACGGCGTTCCTGC
TGCTGCTGGCCATTCCGGTGCTGGCCGGCGCGATCACCATGCTCATCATGGACCGCAATTTCGGCACCTCGTTCTTCGAG
CCGGCGGGCGGCGGCGATCCGGTGCTGTTCCAGCACCTGTTCTGGTTCTTCGGCCATCCCGAAGTGTACATCATGATCCT
GCCGGCCTTCGGCGTGATCAGCCACGTGGTCTCGACCTTCTCGAAGAAGCCGATCTTCGGCTATCTCGGCATGGTCTACG
CGATGGTGGCGATCGGGTTCGTCGGCTTCGTGGTCTGGGCGCACCACATGTTCGTCTCGGGCATCTCGGTGGACAGCAAG
GTCTATTTCGAGGCCGCGACCCTGGTGATCGCGGTGCCGACCGGCGTGAAGGTGTTCTCGTGGATCGCCACGATGTGGGG
CGGGTCGATCGAGCTGAAGACGCCGATGCTGTGGGCGATCGGGTTCATCTTCATGTTCGTGCTCGGCGGCGCCACGGGCG
TGGTGCTGGCGAATGCCGGCCTCGATACCGAGCTGCACAACACTTATTTCGTGATCGCCCACTTCCATTACGTGCTGTCG
ATGGGCTCGGTGTTCGCGATCTTTGCCGGCTTCTACTACTGGATCGGCAAGATGTATGGCCAGCCCTATCCCGAGGGCGC
GGCGAAGCTGCATTTCTGGCTGTTCTTCATCGGGGTGAACCTGACCTTCTTCCCGCAGCACTTCCTCGGCCTCGCCGGCA
TGCCGCGCCGCTACCCGGACTATCCGGTGGCGTTCGCGGGGTGGAACTACGTCTCCTCCGTGGGGGCGCTGATCTCCGGC
ATCAGCACGCTGGTGTTCTTCTACATCCTCTTCAAGATCTTCACCGGGCGGCAGCAGCTGGCCGCCAACTACTGGGGTGA
GGGCGCGACGACCCTCGAGTGGACGGTTCCCTCGCCGGCGCCGCACCACACCTTCGAGGATGTTCCGGTAATCCGCTGA

Upstream 100 bases:

>100_bases
GGCCGCATCGCGCGCGCAGGGGCACATCGCCCTGGCCAGCGCAACCACCGATGAAACGACGCGTTAATCTGTAGTCGGCG
ATCATCAGGAGCATATGACA

Downstream 100 bases:

>100_bases
CGCGCGGGTTGCCACTGACGAAAGCGGGCGGGTGATGGTTCTCTCCGGCGGGGAGAACCATCCTCGTTCCCGCAAGGCAA
AATCCGGATGCGAATATTCG

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MSATALHDAHGEHAHHQPGFFRRWVMSTNHKDIGTLYITWAIIAAIEGGVLSMIMRAQLAHPNNTIITSGQTWNAIVTAH
GLLMIFFFVMPALIGGFGNWMVPMMIGAPDMAFPRLNNMSFWFLFMAFIFVNLGLLVGAGSGVGWTLYPPLSDITYQPGV
AVDFTLFSLHLAGISSLLGAINFIATILNMRAPGMTMHKMPLFVWSILVTAFLLLLAIPVLAGAITMLIMDRNFGTSFFE
PAGGGDPVLFQHLFWFFGHPEVYIMILPAFGVISHVVSTFSKKPIFGYLGMVYAMVAIGFVGFVVWAHHMFVSGISVDSK
VYFEAATLVIAVPTGVKVFSWIATMWGGSIELKTPMLWAIGFIFMFVLGGATGVVLANAGLDTELHNTYFVIAHFHYVLS
MGSVFAIFAGFYYWIGKMYGQPYPEGAAKLHFWLFFIGVNLTFFPQHFLGLAGMPRRYPDYPVAFAGWNYVSSVGALISG
ISTLVFFYILFKIFTGRQQLAANYWGEGATTLEWTVPSPAPHHTFEDVPVIR

Sequences:

>Translated_532_residues
MSATALHDAHGEHAHHQPGFFRRWVMSTNHKDIGTLYITWAIIAAIEGGVLSMIMRAQLAHPNNTIITSGQTWNAIVTAH
GLLMIFFFVMPALIGGFGNWMVPMMIGAPDMAFPRLNNMSFWFLFMAFIFVNLGLLVGAGSGVGWTLYPPLSDITYQPGV
AVDFTLFSLHLAGISSLLGAINFIATILNMRAPGMTMHKMPLFVWSILVTAFLLLLAIPVLAGAITMLIMDRNFGTSFFE
PAGGGDPVLFQHLFWFFGHPEVYIMILPAFGVISHVVSTFSKKPIFGYLGMVYAMVAIGFVGFVVWAHHMFVSGISVDSK
VYFEAATLVIAVPTGVKVFSWIATMWGGSIELKTPMLWAIGFIFMFVLGGATGVVLANAGLDTELHNTYFVIAHFHYVLS
MGSVFAIFAGFYYWIGKMYGQPYPEGAAKLHFWLFFIGVNLTFFPQHFLGLAGMPRRYPDYPVAFAGWNYVSSVGALISG
ISTLVFFYILFKIFTGRQQLAANYWGEGATTLEWTVPSPAPHHTFEDVPVIR
>Mature_531_residues
SATALHDAHGEHAHHQPGFFRRWVMSTNHKDIGTLYITWAIIAAIEGGVLSMIMRAQLAHPNNTIITSGQTWNAIVTAHG
LLMIFFFVMPALIGGFGNWMVPMMIGAPDMAFPRLNNMSFWFLFMAFIFVNLGLLVGAGSGVGWTLYPPLSDITYQPGVA
VDFTLFSLHLAGISSLLGAINFIATILNMRAPGMTMHKMPLFVWSILVTAFLLLLAIPVLAGAITMLIMDRNFGTSFFEP
AGGGDPVLFQHLFWFFGHPEVYIMILPAFGVISHVVSTFSKKPIFGYLGMVYAMVAIGFVGFVVWAHHMFVSGISVDSKV
YFEAATLVIAVPTGVKVFSWIATMWGGSIELKTPMLWAIGFIFMFVLGGATGVVLANAGLDTELHNTYFVIAHFHYVLSM
GSVFAIFAGFYYWIGKMYGQPYPEGAAKLHFWLFFIGVNLTFFPQHFLGLAGMPRRYPDYPVAFAGWNYVSSVGALISGI
STLVFFYILFKIFTGRQQLAANYWGEGATTLEWTVPSPAPHHTFEDVPVIR

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=509, Percent_Identity=57.7603143418468, Blast_Score=585, Evalue=1e-167,
Organism=Escherichia coli, GI1786634, Length=514, Percent_Identity=43.1906614785992, Blast_Score=396, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6226519, Length=472, Percent_Identity=59.7457627118644, Blast_Score=589, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6226524, Length=322, Percent_Identity=59.6273291925466, Blast_Score=401, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6226523, Length=247, Percent_Identity=55.0607287449393, Blast_Score=258, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 58754; Mature: 58623

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATALHDAHGEHAHHQPGFFRRWVMSTNHKDIGTLYITWAIIAAIEGGVLSMIMRAQLA
CCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHC
HPNNTIITSGQTWNAIVTAHGLLMIFFFVMPALIGGFGNWMVPMMIGAPDMAFPRLNNMS
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCH
FWFLFMAFIFVNLGLLVGAGSGVGWTLYPPLSDITYQPGVAVDFTLFSLHLAGISSLLGA
HHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHH
INFIATILNMRAPGMTMHKMPLFVWSILVTAFLLLLAIPVLAGAITMLIMDRNFGTSFFE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCC
PAGGGDPVLFQHLFWFFGHPEVYIMILPAFGVISHVVSTFSKKPIFGYLGMVYAMVAIGF
CCCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VGFVVWAHHMFVSGISVDSKVYFEAATLVIAVPTGVKVFSWIATMWGGSIELKTPMLWAI
HHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHCCCEEECCHHHHHH
GFIFMFVLGGATGVVLANAGLDTELHNTYFVIAHFHYVLSMGSVFAIFAGFYYWIGKMYG
HHHHHHHHCCCCEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QPYPEGAAKLHFWLFFIGVNLTFFPQHFLGLAGMPRRYPDYPVAFAGWNYVSSVGALISG
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHH
ISTLVFFYILFKIFTGRQQLAANYWGEGATTLEWTVPSPAPHHTFEDVPVIR
HHHHHHHHHHHHHHHCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SATALHDAHGEHAHHQPGFFRRWVMSTNHKDIGTLYITWAIIAAIEGGVLSMIMRAQLA
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHC
HPNNTIITSGQTWNAIVTAHGLLMIFFFVMPALIGGFGNWMVPMMIGAPDMAFPRLNNMS
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCH
FWFLFMAFIFVNLGLLVGAGSGVGWTLYPPLSDITYQPGVAVDFTLFSLHLAGISSLLGA
HHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHH
INFIATILNMRAPGMTMHKMPLFVWSILVTAFLLLLAIPVLAGAITMLIMDRNFGTSFFE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCC
PAGGGDPVLFQHLFWFFGHPEVYIMILPAFGVISHVVSTFSKKPIFGYLGMVYAMVAIGF
CCCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VGFVVWAHHMFVSGISVDSKVYFEAATLVIAVPTGVKVFSWIATMWGGSIELKTPMLWAI
HHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHCCCEEECCHHHHHH
GFIFMFVLGGATGVVLANAGLDTELHNTYFVIAHFHYVLSMGSVFAIFAGFYYWIGKMYG
HHHHHHHHCCCCEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QPYPEGAAKLHFWLFFIGVNLTFFPQHFLGLAGMPRRYPDYPVAFAGWNYVSSVGALISG
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHH
ISTLVFFYILFKIFTGRQQLAANYWGEGATTLEWTVPSPAPHHTFEDVPVIR
HHHHHHHHHHHHHHHCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]