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The map label for this gene is gyaR [H]

Identifier: 148261047

GI number: 148261047

Start: 2258386

End: 2259366

Strand: Reverse

Name: gyaR [H]

Synonym: Acry_2055

Alternate gene names: 148261047

Gene position: 2259366-2258386 (Counterclockwise)

Preceding gene: 148261048

Following gene: 148261045

Centisome position: 66.66

GC content: 72.88

Gene sequence:

>981_bases
ATGCACATCCACATCCAGGAATTCGCCGACAGCCCCTATCTCAAGCTGACGGCGGCCGAATTTCACGAGGCCGCCGCGCT
GGCCGGCGGGATCGGGGAGGGGCATACGCTGACCGTGGGCGAGAGCGAGGCGGAGTTCGCCGCCGCGGCACCCGGGATCG
AGGCGCTGATCGCCACCCCCGCCGCGATCCGCCGGCTCGACCTCTCGATCGCGCCGAAGCTGCGGCTGATCCAGTCCACC
TCCGCCGGCGTCGACCCGCTCGCCCCGTTCGACATGATCCCCGACGGGGTGATGCTGCTGAACAATCGCGGCGTGCATGC
CGACCGCGCCGGCGAGTTCGCGATCATGGCGATGCTGATGCTGGCCACCCACATGCCCGCCTTCGCGACCGACCAGCGGG
CGCATCGCTGGCAGCGCCGGTCCTCCGGCACGGTGGCCGGCATGCGGGCGACGATCGTCGGCGTCGGCGGGCTCGGCGGC
GGCGCGGCGCGGCGGGCGCGGCAGTTCGGCATCCATGTCACCGGCGTGCGCAACGGCGCCGCGCCGCACCCCGATTGCGA
CGCGACGCGGCCGGTCGGCGATCTCGACCTGATCCTGCCGCACACCGATTTCCTGCTGCTGACCTGCCCGCTCACCGCGG
CGACGCGCAACCTGCTCGATGCGCGGCGGCTGGCGCTGCTGCCGCCGCATGCCGGGGTGATCAACATGGGCCGCGGCGCG
CTGGTCGATCAGCCGGCACTCTGCGCCGCGCTGCGCGCGGGCAGCATCGCCGGCGCGGTGCTCGACGTGTTCACGACCGA
GCCGGTGCCGCCGGACGATCCGGTGTGGGACACGCCGAACCTGGTCATGACGCCGCATATCTCGTCGGACGATCCGGCGC
GCTACAACGCGGCGACGCTGGCCAGCTTCTTCGCCGCGCTGCGGGCGCTCGCCGCCGGGCGCGTCCCGGCCACGCTGGTC
GATTTCGCGAGAGGCTACTGA

Upstream 100 bases:

>100_bases
ACCTGCAATATATCCGCGTCAACGGCACGCTGGTCGGCTTCCTGATCGGCGGGCTGATCTTCCTTGTCCTGCATTTCGGA
TTTCACCAGCCGGGGTAAGC

Downstream 100 bases:

>100_bases
GGCGCGTGGCGGGCGCCGAACAGCGCCGAGCCGACGCGCACCTCGGTCGCCCCGCAGGCGATCGCGGTCTCGAAATCGTC
GGACATGCCGATCGAGCGCA

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MHIHIQEFADSPYLKLTAAEFHEAAALAGGIGEGHTLTVGESEAEFAAAAPGIEALIATPAAIRRLDLSIAPKLRLIQST
SAGVDPLAPFDMIPDGVMLLNNRGVHADRAGEFAIMAMLMLATHMPAFATDQRAHRWQRRSSGTVAGMRATIVGVGGLGG
GAARRARQFGIHVTGVRNGAAPHPDCDATRPVGDLDLILPHTDFLLLTCPLTAATRNLLDARRLALLPPHAGVINMGRGA
LVDQPALCAALRAGSIAGAVLDVFTTEPVPPDDPVWDTPNLVMTPHISSDDPARYNAATLASFFAALRALAAGRVPATLV
DFARGY

Sequences:

>Translated_326_residues
MHIHIQEFADSPYLKLTAAEFHEAAALAGGIGEGHTLTVGESEAEFAAAAPGIEALIATPAAIRRLDLSIAPKLRLIQST
SAGVDPLAPFDMIPDGVMLLNNRGVHADRAGEFAIMAMLMLATHMPAFATDQRAHRWQRRSSGTVAGMRATIVGVGGLGG
GAARRARQFGIHVTGVRNGAAPHPDCDATRPVGDLDLILPHTDFLLLTCPLTAATRNLLDARRLALLPPHAGVINMGRGA
LVDQPALCAALRAGSIAGAVLDVFTTEPVPPDDPVWDTPNLVMTPHISSDDPARYNAATLASFFAALRALAAGRVPATLV
DFARGY
>Mature_326_residues
MHIHIQEFADSPYLKLTAAEFHEAAALAGGIGEGHTLTVGESEAEFAAAAPGIEALIATPAAIRRLDLSIAPKLRLIQST
SAGVDPLAPFDMIPDGVMLLNNRGVHADRAGEFAIMAMLMLATHMPAFATDQRAHRWQRRSSGTVAGMRATIVGVGGLGG
GAARRARQFGIHVTGVRNGAAPHPDCDATRPVGDLDLILPHTDFLLLTCPLTAATRNLLDARRLALLPPHAGVINMGRGA
LVDQPALCAALRAGSIAGAVLDVFTTEPVPPDDPVWDTPNLVMTPHISSDDPARYNAATLASFFAALRALAAGRVPATLV
DFARGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=251, Percent_Identity=30.6772908366534, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI6912396, Length=274, Percent_Identity=29.1970802919708, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI61743967, Length=249, Percent_Identity=27.710843373494, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4557497, Length=249, Percent_Identity=27.710843373494, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI145580578, Length=185, Percent_Identity=31.8918918918919, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4557499, Length=185, Percent_Identity=31.8918918918919, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI145580575, Length=187, Percent_Identity=31.5508021390374, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI87082289, Length=272, Percent_Identity=31.6176470588235, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1789279, Length=171, Percent_Identity=31.5789473684211, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081824, Length=223, Percent_Identity=26.457399103139, Blast_Score=85, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=293, Percent_Identity=25.5972696245734, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25147481, Length=190, Percent_Identity=29.4736842105263, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320925, Length=206, Percent_Identity=29.126213592233, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322116, Length=206, Percent_Identity=29.126213592233, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24585516, Length=262, Percent_Identity=26.7175572519084, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19921140, Length=264, Percent_Identity=28.4090909090909, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28574286, Length=239, Percent_Identity=25.9414225941423, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28571528, Length=176, Percent_Identity=31.25, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45552429, Length=163, Percent_Identity=32.5153374233129, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585514, Length=250, Percent_Identity=26.8, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574282, Length=250, Percent_Identity=26.8, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574284, Length=163, Percent_Identity=32.5153374233129, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45551003, Length=163, Percent_Identity=32.5153374233129, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34151; Mature: 34151

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIHIQEFADSPYLKLTAAEFHEAAALAGGIGEGHTLTVGESEAEFAAAAPGIEALIATP
CEEEEHHHCCCCEEEEEHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHCCCCHHHHHHCH
AAIRRLDLSIAPKLRLIQSTSAGVDPLAPFDMIPDGVMLLNNRGVHADRAGEFAIMAMLM
HHHHHHCCCCCCCEEEEECCCCCCCCCCCHHCCCCCEEEEECCCCCCCCCCHHHHHHHHH
LATHMPAFATDQRAHRWQRRSSGTVAGMRATIVGVGGLGGGAARRARQFGIHVTGVRNGA
HHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEEECCCCCHHHHHHHHCCEEEEEECCCC
APHPDCDATRPVGDLDLILPHTDFLLLTCPLTAATRNLLDARRLALLPPHAGVINMGRGA
CCCCCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHEECCCCCCEEECCCCC
LVDQPALCAALRAGSIAGAVLDVFTTEPVPPDDPVWDTPNLVMTPHISSDDPARYNAATL
CCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHH
ASFFAALRALAAGRVPATLVDFARGY
HHHHHHHHHHHCCCCCHHHHHHHCCC
>Mature Secondary Structure
MHIHIQEFADSPYLKLTAAEFHEAAALAGGIGEGHTLTVGESEAEFAAAAPGIEALIATP
CEEEEHHHCCCCEEEEEHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHCCCCHHHHHHCH
AAIRRLDLSIAPKLRLIQSTSAGVDPLAPFDMIPDGVMLLNNRGVHADRAGEFAIMAMLM
HHHHHHCCCCCCCEEEEECCCCCCCCCCCHHCCCCCEEEEECCCCCCCCCCHHHHHHHHH
LATHMPAFATDQRAHRWQRRSSGTVAGMRATIVGVGGLGGGAARRARQFGIHVTGVRNGA
HHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEEECCCCCHHHHHHHHCCEEEEEECCCC
APHPDCDATRPVGDLDLILPHTDFLLLTCPLTAATRNLLDARRLALLPPHAGVINMGRGA
CCCCCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHEECCCCCCEEECCCCC
LVDQPALCAALRAGSIAGAVLDVFTTEPVPPDDPVWDTPNLVMTPHISSDDPARYNAATL
CCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHH
ASFFAALRALAAGRVPATLVDFARGY
HHHHHHHHHHHCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA