Click here to switch to the map view.

The map label for this gene is dapA

Identifier: 148260901

GI number: 148260901

Start: 2105418

End: 2106296

Strand: Reverse

Name: dapA

Synonym: Acry_1908

Alternate gene names: 148260901

Gene position: 2106296-2105418 (Counterclockwise)

Preceding gene: 148260906

Following gene: 148260900

Centisome position: 62.15

GC content: 69.74

Gene sequence:

>879_bases
ATGTTTCACGGCTCACTGGTCGCGCTGGTCACCCCGATGCACGAAGACGGTCGCATCGACGAGGCGGCGCTCGAACGTTT
CATCGAATGGCAGATCGCCGAGGGCACCAACGGCCTCGTCCCGGTCGGCACCACCGGCGAATCCCCCACGCTCAGCCATG
ACGAGCACAAGCGTGTGGTCGAGATCACCGTCGAGGTGGCGAGGAAACGCGTCCCGGTGATCGCCGGCGCCGGCTCGAAC
GCCACGCGCGAGGCCATCGGCCTCGCGAAGCACGCCGAATCCGTCGGCGCCGACGGCGTTCTCGTCGTCACCCCCTACTA
CAACAAGCCGACGCAGGACGGCCTGCTCCGCCACTTCACCGCGGTCGCCGACGCGATCGGTATTCCGCTCATCATCTACA
ACATCCCGCCCCGCTCGGTGATCGACATGAGCGTGGCGACGATGGCCCGCCTCGCGCAGCACCCCAACATCGTCGGCGTG
AAGGACGCGACGGCGAACCTCACCCGCCCGCTGCACACCACCGCCGCCTGCGGCGCGTCGTTCTGCCAGCTCTCGGGCGA
GGATCACACCGCGCTCGCCTTCCTCGCCGCCGGCGGCGTCGGCTGCATCTCGGTGACCGCCAACATCGCTCCGCGCCTCT
GCGCCGAGATGCAGGCGGCCTGGCGCGCCGGCGACCTGAAGACCGCGATGGCGATCCAGTCCCGCCTGCTGCCCCTGCAC
GATGCGATGTTCGCCGAGAGCAATCCCGCCCCGGCGAAATACGCCGCCTCCCTGCTCGGATTCGGCTCGGAATTCTGCCG
CCTGCCGCTCGCCCCGCTCGCCGAGGCGACGAAGGCGCAGATGCGCGCCGCGATGACCGGGCTCGGGCTGCTCGCCTGA

Upstream 100 bases:

>100_bases
CCGGACCATGCGCGAACCAATAGCAGGACTGCTCCCGCGCTCCCATACCTTGCCGCCGCCGAATGCTGCGAATAGGTTAC
GCGCACTCACGGAGAACACA

Downstream 100 bases:

>100_bases
TGGCCGAGCCCCGGAAATCCGGGCTGATCTCCCACGGGATCGCGGCGCAGAACCGCAAGGCCCGGTTCAACTACACGATC
AAGGACACGGTCGAGGCGGG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MFHGSLVALVTPMHEDGRIDEAALERFIEWQIAEGTNGLVPVGTTGESPTLSHDEHKRVVEITVEVARKRVPVIAGAGSN
ATREAIGLAKHAESVGADGVLVVTPYYNKPTQDGLLRHFTAVADAIGIPLIIYNIPPRSVIDMSVATMARLAQHPNIVGV
KDATANLTRPLHTTAACGASFCQLSGEDHTALAFLAAGGVGCISVTANIAPRLCAEMQAAWRAGDLKTAMAIQSRLLPLH
DAMFAESNPAPAKYAASLLGFGSEFCRLPLAPLAEATKAQMRAAMTGLGLLA

Sequences:

>Translated_292_residues
MFHGSLVALVTPMHEDGRIDEAALERFIEWQIAEGTNGLVPVGTTGESPTLSHDEHKRVVEITVEVARKRVPVIAGAGSN
ATREAIGLAKHAESVGADGVLVVTPYYNKPTQDGLLRHFTAVADAIGIPLIIYNIPPRSVIDMSVATMARLAQHPNIVGV
KDATANLTRPLHTTAACGASFCQLSGEDHTALAFLAAGGVGCISVTANIAPRLCAEMQAAWRAGDLKTAMAIQSRLLPLH
DAMFAESNPAPAKYAASLLGFGSEFCRLPLAPLAEATKAQMRAAMTGLGLLA
>Mature_292_residues
MFHGSLVALVTPMHEDGRIDEAALERFIEWQIAEGTNGLVPVGTTGESPTLSHDEHKRVVEITVEVARKRVPVIAGAGSN
ATREAIGLAKHAESVGADGVLVVTPYYNKPTQDGLLRHFTAVADAIGIPLIIYNIPPRSVIDMSVATMARLAQHPNIVGV
KDATANLTRPLHTTAACGASFCQLSGEDHTALAFLAAGGVGCISVTANIAPRLCAEMQAAWRAGDLKTAMAIQSRLLPLH
DAMFAESNPAPAKYAASLLGFGSEFCRLPLAPLAEATKAQMRAAMTGLGLLA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=288, Percent_Identity=28.8194444444444, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI13540533, Length=242, Percent_Identity=28.099173553719, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=46.5753424657534, Blast_Score=269, Evalue=1e-73,
Organism=Escherichia coli, GI87082415, Length=297, Percent_Identity=33.3333333333333, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1786463, Length=243, Percent_Identity=33.7448559670782, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1789620, Length=284, Percent_Identity=27.8169014084507, Blast_Score=115, Evalue=2e-27,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_ACICJ (A5FZS7)

Other databases:

- EMBL:   CP000697
- RefSeq:   YP_001235028.1
- ProteinModelPortal:   A5FZS7
- SMR:   A5FZS7
- STRING:   A5FZS7
- GeneID:   5160691
- GenomeReviews:   CP000697_GR
- KEGG:   acr:Acry_1908
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   SGEDMTA
- ProtClustDB:   PRK03170
- BioCyc:   ACRY349163:ACRY_1908-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 30646; Mature: 30646

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 161-161 BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHGSLVALVTPMHEDGRIDEAALERFIEWQIAEGTNGLVPVGTTGESPTLSHDEHKRVV
CCCCCEEEEEECCCCCCCCCHHHHHHHHHEEEECCCCCEEEECCCCCCCCCCCHHHHHHH
EITVEVARKRVPVIAGAGSNATREAIGLAKHAESVGADGVLVVTPYYNKPTQDGLLRHFT
HHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
AVADAIGIPLIIYNIPPRSVIDMSVATMARLAQHPNIVGVKDATANLTRPLHTTAACGAS
HHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHCCCHHHHHHHHHH
FCQLSGEDHTALAFLAAGGVGCISVTANIAPRLCAEMQAAWRAGDLKTAMAIQSRLLPLH
HHHCCCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHH
DAMFAESNPAPAKYAASLLGFGSEFCRLPLAPLAEATKAQMRAAMTGLGLLA
HHHHCCCCCCCHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFHGSLVALVTPMHEDGRIDEAALERFIEWQIAEGTNGLVPVGTTGESPTLSHDEHKRVV
CCCCCEEEEEECCCCCCCCCHHHHHHHHHEEEECCCCCEEEECCCCCCCCCCCHHHHHHH
EITVEVARKRVPVIAGAGSNATREAIGLAKHAESVGADGVLVVTPYYNKPTQDGLLRHFT
HHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
AVADAIGIPLIIYNIPPRSVIDMSVATMARLAQHPNIVGVKDATANLTRPLHTTAACGAS
HHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHCCCHHHHHHHHHH
FCQLSGEDHTALAFLAAGGVGCISVTANIAPRLCAEMQAAWRAGDLKTAMAIQSRLLPLH
HHHCCCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHH
DAMFAESNPAPAKYAASLLGFGSEFCRLPLAPLAEATKAQMRAAMTGLGLLA
HHHHCCCCCCCHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA