Click here to switch to the map view.

The map label for this gene is mutM

Identifier: 148260719

GI number: 148260719

Start: 1904125

End: 1904952

Strand: Reverse

Name: mutM

Synonym: Acry_1723

Alternate gene names: 148260719

Gene position: 1904952-1904125 (Counterclockwise)

Preceding gene: 148260723

Following gene: 148260711

Centisome position: 56.21

GC content: 71.5

Gene sequence:

>828_bases
ATGCCGGAACTCCCCGAAGTCGAAACCGTGATGCGCGGCCTCGCCGCCAAGCTCGAAGGCCGCCGCCTCGCCCGGGTCGT
CCTCGCCCGGCCCGACCTGCGCTGGCCGATCCCCGAGGGCTTCGTGCAGTTCCTCTCCGGCGCCCGCGTCGAGGGTTTCC
GCCGCCGCGGCAAATACATGTTCATGCGGCTCGACCGCGCGCTGTCGGTGCTGATCCATCTCGGCATGTCCGGCCGGATG
ACGATCGATTCCGCCCCGCTGCCGCACCAGCACCTGACCCTCGAAACCGACGACGGCGCCGTGATCGGCTTCGTCGATCC
CCGCCGCTTCGGCGCGCTCGACCTCGTCGCGACCGCGGCGGAGGACTCCCACCGCCTGATCGCCGGCCTCGGCCCCGAAC
CGCTCGACGATGCCTTTTCGCCCGCCACTCTTGCGTCCGCCCTCGAAGGCAAGAAAACCCCGATCAAGGCGGCGCTGCTC
GACCAGTCGGTCGTCGCCGGCCTCGGCAACATCTATGTCAGCGAGGCCCTGTTCCGCGCCGGCATCCTCCCGCACCGCCT
CGCCGGCACGATCGGGCGGGGCAGGGCAGGGCGCCTGGTGCCGGCGATCAAGGCCACGCTCACGGACGCCATCGCCGCCG
GCGGCTCCTCGCTGCGCGACTACGTCCAGCCCTCCGGCGAACTCGGCTATTTCCAGCACGCCTGGAAAGTCTACGACCGC
GCCGGCCAGCCCTGCGAACGCTGCCCCGGCCCGGCCGCCTGCGCCGGCATCAGCCGCACCGTCCAGTCCGGCCGCGCCAC
CTATTTCTGCGCCCGCACCCAGAAATAG

Upstream 100 bases:

>100_bases
CTTGTGCCGCTTCTCGCCGCGCGGCACGGTGGAAAACCCGAAATCGACGGTCTCGCTGCTGGTATCGGCCATGGGCTCAG
GCTATAGCCGCAAACGCACC

Downstream 100 bases:

>100_bases
CCCGCGCCGGGCAACCGCCGGCCCGGCCTCAGGCCGCGTGCGCCGCCGCGACGAAGTCCCGGATCAGCGGAACCGATTTC
TCCCCCGGCGCGCTCTCCAC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MPELPEVETVMRGLAAKLEGRRLARVVLARPDLRWPIPEGFVQFLSGARVEGFRRRGKYMFMRLDRALSVLIHLGMSGRM
TIDSAPLPHQHLTLETDDGAVIGFVDPRRFGALDLVATAAEDSHRLIAGLGPEPLDDAFSPATLASALEGKKTPIKAALL
DQSVVAGLGNIYVSEALFRAGILPHRLAGTIGRGRAGRLVPAIKATLTDAIAAGGSSLRDYVQPSGELGYFQHAWKVYDR
AGQPCERCPGPAACAGISRTVQSGRATYFCARTQK

Sequences:

>Translated_275_residues
MPELPEVETVMRGLAAKLEGRRLARVVLARPDLRWPIPEGFVQFLSGARVEGFRRRGKYMFMRLDRALSVLIHLGMSGRM
TIDSAPLPHQHLTLETDDGAVIGFVDPRRFGALDLVATAAEDSHRLIAGLGPEPLDDAFSPATLASALEGKKTPIKAALL
DQSVVAGLGNIYVSEALFRAGILPHRLAGTIGRGRAGRLVPAIKATLTDAIAAGGSSLRDYVQPSGELGYFQHAWKVYDR
AGQPCERCPGPAACAGISRTVQSGRATYFCARTQK
>Mature_274_residues
PELPEVETVMRGLAAKLEGRRLARVVLARPDLRWPIPEGFVQFLSGARVEGFRRRGKYMFMRLDRALSVLIHLGMSGRMT
IDSAPLPHQHLTLETDDGAVIGFVDPRRFGALDLVATAAEDSHRLIAGLGPEPLDDAFSPATLASALEGKKTPIKAALLD
QSVVAGLGNIYVSEALFRAGILPHRLAGTIGRGRAGRLVPAIKATLTDAIAAGGSSLRDYVQPSGELGYFQHAWKVYDRA
GQPCERCPGPAACAGISRTVQSGRATYFCARTQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=278, Percent_Identity=41.3669064748201, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1786932, Length=280, Percent_Identity=26.0714285714286, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_ACICJ (A5FZ95)

Other databases:

- EMBL:   CP000697
- RefSeq:   YP_001234846.1
- ProteinModelPortal:   A5FZ95
- SMR:   A5FZ95
- STRING:   A5FZ95
- GeneID:   5159646
- GenomeReviews:   CP000697_GR
- KEGG:   acr:Acry_1723
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   FQHAWKV
- ProtClustDB:   PRK01103
- BioCyc:   ACRY349163:ACRY_1723-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 29582; Mature: 29450

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 265-265 BINDING 89-89 BINDING 108-108 BINDING 151-151

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVMRGLAAKLEGRRLARVVLARPDLRWPIPEGFVQFLSGARVEGFRRRGKYM
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHCCHHH
FMRLDRALSVLIHLGMSGRMTIDSAPLPHQHLTLETDDGAVIGFVDPRRFGALDLVATAA
HHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEECCCCEEEEEECCCHHCHHHHHHHCC
EDSHRLIAGLGPEPLDDAFSPATLASALEGKKTPIKAALLDQSVVAGLGNIYVSEALFRA
CCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GILPHRLAGTIGRGRAGRLVPAIKATLTDAIAAGGSSLRDYVQPSGELGYFQHAWKVYDR
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHH
AGQPCERCPGPAACAGISRTVQSGRATYFCARTQK
CCCCHHHCCCHHHHHHHHHHHHCCCEEEEEECCCC
>Mature Secondary Structure 
PELPEVETVMRGLAAKLEGRRLARVVLARPDLRWPIPEGFVQFLSGARVEGFRRRGKYM
CCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHCCHHH
FMRLDRALSVLIHLGMSGRMTIDSAPLPHQHLTLETDDGAVIGFVDPRRFGALDLVATAA
HHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEECCCCEEEEEECCCHHCHHHHHHHCC
EDSHRLIAGLGPEPLDDAFSPATLASALEGKKTPIKAALLDQSVVAGLGNIYVSEALFRA
CCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GILPHRLAGTIGRGRAGRLVPAIKATLTDAIAAGGSSLRDYVQPSGELGYFQHAWKVYDR
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHH
AGQPCERCPGPAACAGISRTVQSGRATYFCARTQK
CCCCHHHCCCHHHHHHHHHHHHCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA