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The map label for this gene is hemN [H]

Identifier: 148260690

GI number: 148260690

Start: 1873101

End: 1874249

Strand: Reverse

Name: hemN [H]

Synonym: Acry_1693

Alternate gene names: 148260690

Gene position: 1874249-1873101 (Counterclockwise)

Preceding gene: 148260693

Following gene: 148260684

Centisome position: 55.3

GC content: 71.45

Gene sequence:

>1149_bases
ATGACGCCGCTCGCCCTTTATATCCACTGGCCGTTCTGCAAGGCCAAATGCCCCTATTGCGACTTCAACTCCCATGTCCG
CGAGCGGATCCCGGAGCGGCGGATCGTCGCCGCACTCCTCGCCGAACTCGACTTCGAGGCCGCCCGCCTCGGTCCGCGCC
GGCTGACCTCGATCTTCTTCGGCGGCGGCACGCCGAGCCTGATGGCGCCCGAAGGCGTCTCGGCACTGATCGCGCGGGCC
TGCCGCCTGTTCGCGCCGGCGCCCGATCTCGAGATCACGCTCGAAGCCAACCCCACCAGCATCGAGGCCGGGCGGTTCCG
CGCCTATCGCGAGGCCGGGGTCAACCGCGTCTCGATCGGCGTGCAGAGCCTGAACGACGACGCGCTGCGCTTTCTCGGCC
GCGAGCATGGCGCGGCCGAGGCGATGGCCGCGGTGGAACTCGGCCGGGCCATCTTCCCGCGCCTGTCCTTCGACCTGATC
TATGCCCGGCCGGGCCAGACGCTCGCCGCCTGGCGCGCCGAACTCGGCGCCGCCCTCGCCGTCGGGCTCGATCATCTCTC
GCTCTACCAGCTCACCATCGAGCCCGGCACGCGATTCGCCACCGCCCATGCCCGCGGCGATTTCGCGCTCCCCGAGGATG
ACGATGCCGCGGCACTTTACGACGCCACCGCCGAGGAGGCGGCGCGCTTTGGCCTCGGCCCCTACGAGATTTCGAACTAC
GCGAAGCCGGGCGAGGAGTCGCGCCACAACCTCGCCTACTGGCGCTACCGCGACTATGCTGGCATCGGCGCCGGCGCGCA
TGGGCGGATCAGCCTGGGCGGCACCCTGCTCGCGACCCGGCGGCACCGCGCGCCGGAGGAATGGGCCGCCCGGGTCGAGG
CGGCGGGGCATGGCAGCACCGAGGAAATCGAGATCGGCGCGGACGAGCGCGCCCGCGAGGCGCTGCTGATGGGGCTGCGG
CTGGCCGAGGGGATCGACAGGGACGCCTACGCGGCGCGGACCGGGCGCGATCTCATGGACATGCTCGACCCCGATGTGAC
GGCGCAGGCGATCGAGGCGGGCTATCTCGACGTCACGCCGGCGCGGGTGAGCGCGACCTATGAAGGCCGCAAGCGGCTCG
ACTCGCTACTGGCGGCGCTGCTCGGCTAG

Upstream 100 bases:

>100_bases
GCTTCGTGTGCGAATTATCGGCAACTTCGCCCGAAGGCGTGCCGATCGGGGCGATATGGCCCAGATCGGCCTCCGGCGCA
AGACGTGCTAGACGCCGGGC

Downstream 100 bases:

>100_bases
AGCATCATCCGATCAGATGGAGTCATCTGATCGAATAAAGATGCTTTAATTATCAATATTATAGAGCACTACATCCGATC
CGGATGGATCGGAAAGTGCT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MTPLALYIHWPFCKAKCPYCDFNSHVRERIPERRIVAALLAELDFEAARLGPRRLTSIFFGGGTPSLMAPEGVSALIARA
CRLFAPAPDLEITLEANPTSIEAGRFRAYREAGVNRVSIGVQSLNDDALRFLGREHGAAEAMAAVELGRAIFPRLSFDLI
YARPGQTLAAWRAELGAALAVGLDHLSLYQLTIEPGTRFATAHARGDFALPEDDDAAALYDATAEEAARFGLGPYEISNY
AKPGEESRHNLAYWRYRDYAGIGAGAHGRISLGGTLLATRRHRAPEEWAARVEAAGHGSTEEIEIGADERAREALLMGLR
LAEGIDRDAYAARTGRDLMDMLDPDVTAQAIEAGYLDVTPARVSATYEGRKRLDSLLAALLG

Sequences:

>Translated_382_residues
MTPLALYIHWPFCKAKCPYCDFNSHVRERIPERRIVAALLAELDFEAARLGPRRLTSIFFGGGTPSLMAPEGVSALIARA
CRLFAPAPDLEITLEANPTSIEAGRFRAYREAGVNRVSIGVQSLNDDALRFLGREHGAAEAMAAVELGRAIFPRLSFDLI
YARPGQTLAAWRAELGAALAVGLDHLSLYQLTIEPGTRFATAHARGDFALPEDDDAAALYDATAEEAARFGLGPYEISNY
AKPGEESRHNLAYWRYRDYAGIGAGAHGRISLGGTLLATRRHRAPEEWAARVEAAGHGSTEEIEIGADERAREALLMGLR
LAEGIDRDAYAARTGRDLMDMLDPDVTAQAIEAGYLDVTPARVSATYEGRKRLDSLLAALLG
>Mature_381_residues
TPLALYIHWPFCKAKCPYCDFNSHVRERIPERRIVAALLAELDFEAARLGPRRLTSIFFGGGTPSLMAPEGVSALIARAC
RLFAPAPDLEITLEANPTSIEAGRFRAYREAGVNRVSIGVQSLNDDALRFLGREHGAAEAMAAVELGRAIFPRLSFDLIY
ARPGQTLAAWRAELGAALAVGLDHLSLYQLTIEPGTRFATAHARGDFALPEDDDAAALYDATAEEAARFGLGPYEISNYA
KPGEESRHNLAYWRYRDYAGIGAGAHGRISLGGTLLATRRHRAPEEWAARVEAAGHGSTEEIEIGADERAREALLMGLRL
AEGIDRDAYAARTGRDLMDMLDPDVTAQAIEAGYLDVTPARVSATYEGRKRLDSLLAALLG

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=375, Percent_Identity=38.1333333333333, Blast_Score=224, Evalue=9e-59,
Organism=Escherichia coli, GI1789325, Length=384, Percent_Identity=38.8020833333333, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI87082341, Length=384, Percent_Identity=25.2604166666667, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 41508; Mature: 41377

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLALYIHWPFCKAKCPYCDFNSHVRERIPERRIVAALLAELDFEAARLGPRRLTSIFF
CCCEEEEEECCHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCHHHHHCCHHHHHEEEE
GGGTPSLMAPEGVSALIARACRLFAPAPDLEITLEANPTSIEAGRFRAYREAGVNRVSIG
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEE
VQSLNDDALRFLGREHGAAEAMAAVELGRAIFPRLSFDLIYARPGQTLAAWRAELGAALA
HHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHH
VGLDHLSLYQLTIEPGTRFATAHARGDFALPEDDDAAALYDATAEEAARFGLGPYEISNY
HCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCCCHHHHHCCHHHHHHHCCCCHHHCCC
AKPGEESRHNLAYWRYRDYAGIGAGAHGRISLGGTLLATRRHRAPEEWAARVEAAGHGST
CCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCEEEEHHHCCCCHHHHHHHHHCCCCCC
EEIEIGADERAREALLMGLRLAEGIDRDAYAARTGRDLMDMLDPDVTAQAIEAGYLDVTP
CEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHCCCCHHHHHHHCCCEECCH
ARVSATYEGRKRLDSLLAALLG
HHEEECHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TPLALYIHWPFCKAKCPYCDFNSHVRERIPERRIVAALLAELDFEAARLGPRRLTSIFF
CCEEEEEECCHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCHHHHHCCHHHHHEEEE
GGGTPSLMAPEGVSALIARACRLFAPAPDLEITLEANPTSIEAGRFRAYREAGVNRVSIG
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEE
VQSLNDDALRFLGREHGAAEAMAAVELGRAIFPRLSFDLIYARPGQTLAAWRAELGAALA
HHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHH
VGLDHLSLYQLTIEPGTRFATAHARGDFALPEDDDAAALYDATAEEAARFGLGPYEISNY
HCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCCCHHHHHCCHHHHHHHCCCCHHHCCC
AKPGEESRHNLAYWRYRDYAGIGAGAHGRISLGGTLLATRRHRAPEEWAARVEAAGHGST
CCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCEEEEHHHCCCCHHHHHHHHHCCCCCC
EEIEIGADERAREALLMGLRLAEGIDRDAYAARTGRDLMDMLDPDVTAQAIEAGYLDVTP
CEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHCCCCHHHHHHHCCCEECCH
ARVSATYEGRKRLDSLLAALLG
HHEEECHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]