| Definition | Acidiphilium cryptum JF-5 chromosome, complete genome. |
|---|---|
| Accession | NC_009484 |
| Length | 3,389,227 |
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The map label for this gene is mrcA [H]
Identifier: 148260684
GI number: 148260684
Start: 1864451
End: 1867078
Strand: Reverse
Name: mrcA [H]
Synonym: Acry_1687
Alternate gene names: 148260684
Gene position: 1867078-1864451 (Counterclockwise)
Preceding gene: 148260690
Following gene: 148260683
Centisome position: 55.09
GC content: 68.53
Gene sequence:
>2628_bases ATGTCTCGACCTCTGAAAGCCGGCGAGCGGCTGGCCAAATCCGATTCGCGGCGCCGTGCCGGCCCCACTCCTCCCAAGCG TGGCGGCAAGCCTGCCCCCAGGAAGCGCCCCGGCCTTGCCGGCGTTGCGGGCGGGATGTTCGTGCGCGGCCTCTATCGCC TGGCGCTGGTCGGGATGGTGGGCGGCGTTCTCGTGGGCGGCGGGCTGTTCTTCTATTTCAGCAGCGGCCTGCCCGGCGTG GACCGGCTGCGCCATTACGAGCCGCCGCTCGAAACCCGGATCTACGCCGAGAATTTCCGCCTGATCGGCGCGCTGGGCAC GCAGCACCGGATCTATGTGCCCTACGACCGGATTCCGCCGCTGGTCGCCGATGCGTTCATCGCGGCCGAGGACAAGAATT TCTGGACCGAGCCGGGAATCGACCCGCTGGCCATCGTCCGCGCCGGCGTGGTCGACCTGACCCGGATCGGCAGCCATGAG CGCCCGCTCGGCGCCTCGACCATCACGATGCAGGTGGTCAAGAACATGCTGCTCGACAACCGGATCGACTTCACCCGGAA GATCAAGGAGGCGATCCTCGCCGTCCGGGTCAACCGGGCGATGTCGAAGAAGCAGATCCTGACCCTGTATCTGAACGAGA TCTTCCTCGGCCAGGACAGCTGGGGCGTGGCCGCGGCGGCGCAGGCCTATTTCGACAAGCCGCTGTCGCAGCTGACCGTT GCCGAGGCGGCGATGCTCGGCGGCCTGCCGAAGGCGCCGACCAATTACAACCCCTTCCTTCACCCCAAGCGCGCCCGCGA CCGGCGGGACTGGGTGATCGGGCAGATGCAGGCGGACGGGTTCATCACCGCGGCGCAGGCGCGCGAGGCACTCGCCGCGC CGCTGGTGCCAAAGGCGGCTGCCGGGCCGGCGTCGATTCCCGGCGCGGGCTATTTCGTCGGCGCGGTGGAGACGCAGCTG GTCCGCATGTTCGGCCGCAAGACGGCGATGGAGGGCGGGCTCATCGTCCGCACCAGCCTCGATCCGAAGCTGCAGGCGGC GGCGACGCGGGCGATGCGCGACCGGCTCGTGTCGTACGACCACGAATTCGGCGTCTATCACGGCCCGGTCGGGCATATCG GCGCCGGGGAACTGGCCGCCGGCTGGGCGCGGGCGCTGGCGCGGCAGGACACGCCGAAGGGGCTCATCGCCTCCTGGCGT CTCGGCGTGGTGATCAGCGAGACCGCGCAGCGCGCGCGAATCGGCTGGCTCGACGGCGACTCGCCGTCGGAGGCGCATAC CGGCACGCTCACCCTGGCGGCGATCCAGTGGGGGCGGCCGATGATCCACGGCCGTCCCGGGCCGCTGCTGCGCAACATGG CGCAGATGCTCAAGCCGGGCGATGTGATCATGATCGAGCCCAAGCCGGACAAGGGCGGGACGGTCTCGCTCGAGCAGGTG CCGAAGGTCGAGGGGGCGATGCTCAGCCTCGACCCGCAGACCGGGCGGGTACTTGCCATGGTCGGCGGCTGGAGCAACCG GCTCAGCCCCTATAACCGCGCGATCCAGGCGCATCGGCAGCCCGGCTCCAGCGTCAAGCCGTTCGACTATCTGACCGCGA TGCAGGCGGGCGTTCAGCCGGATGCGACGATTCTCGACGCGCCGTTCATCCAGCGCCTGTCGGACGGGCAGATCTACCGG CCGGGCAATTACGAGAATTCCTTCCAGGGCCCGGTGCCGGTGTTCTACGCGATCCAGGAGTCGCTCAACCTGGCCACGCT GCATCTGGTGCGGCGGGTCGGGCTGCCCAACGTGATCGCCAATTTCAAGAAATTCGGCGTGGTGAAGCACGCGCCGCTGA TCTATCCGGCGGCGATCGGCGCGCTCGACACCACGCTGTGGCGCATGGTCCGCGGCTATGCCGCGCTCGACGAATACGGG CGCAAGGTGCAGCCCTCGCTCATCGACAGCGTGACCGCGCCGGACGGGCACATCCTGTACCAGGCGCCCGACCAGTCCTG CGCCAACTGCATGGACGGTTCGGCGCAGCAACCGCCGATCCTGAACCGGCCGGGCGCGCGGCTCGCTAATCCGGACAGCG TCTATCAGGTCATCATGATGATGCGGAACGTGGCCGAATACGGCACCGGCGTGCCGGCGGTGAAGGGGCTGAAGCGGCCG ATCGCCGGCAAGACCGGCACGACCAACAATTTCAACGACGCCTGGTTCATCGGCTTCGTGCCGCAGATGGTGACGGGATG CTGGATCGGCTTCGACAAGCCGAGGGATCTCGGCGTCAACCAGACCGGCGGCAATGTCTGCGGCCCGGCCTGGAACCAGT ACATGAAGGTCGCGCTCAAGAACCAGCCGGTGATTCCGTTCAAGCCGCCGCCGGGCATCACGCTGCACAAGGTGACGTTC CGCGACGAGACGGTGGAAGAGGCATTCAAGCCGGGCCAGACGCCGGGCGCGCAGTCCAACCCCGGGCTCGTCGCCGACGA TCCGCTGAATCTCGGCGGTGCCTTCGCGAACACGACGCCGTCGACCGGGTCGCACGATTTCAGCCCGGCGCCGGATGGCC AGACCCCTTCGGGCGGGGCGCCGGCGCCGTCCGGCAATGTCGACAAATCGCTGGGCGGGCTGTATTGA
Upstream 100 bases:
>100_bases CGGAAAGTGACGCAGGGCCACCATTGCGTTGACGAGATTTAACCACAGCATCCCGCCCCGATTATTCGCGATCTTGCAGA TTGGGTGCTATGGAGCCGCC
Downstream 100 bases:
>100_bases CCGGCTTTGGAAATCATCCCGACAGAATCTGAAGAGAAGAGAGAATGTCTGCCGAAACCCAATCGCTCGCCGAGCAGATC ACGCAAAGCGTGGCCCTGCT
Product: 1A family penicillin-binding protein
Products: NA
Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 875; Mature: 874
Protein sequence:
>875_residues MSRPLKAGERLAKSDSRRRAGPTPPKRGGKPAPRKRPGLAGVAGGMFVRGLYRLALVGMVGGVLVGGGLFFYFSSGLPGV DRLRHYEPPLETRIYAENFRLIGALGTQHRIYVPYDRIPPLVADAFIAAEDKNFWTEPGIDPLAIVRAGVVDLTRIGSHE RPLGASTITMQVVKNMLLDNRIDFTRKIKEAILAVRVNRAMSKKQILTLYLNEIFLGQDSWGVAAAAQAYFDKPLSQLTV AEAAMLGGLPKAPTNYNPFLHPKRARDRRDWVIGQMQADGFITAAQAREALAAPLVPKAAAGPASIPGAGYFVGAVETQL VRMFGRKTAMEGGLIVRTSLDPKLQAAATRAMRDRLVSYDHEFGVYHGPVGHIGAGELAAGWARALARQDTPKGLIASWR LGVVISETAQRARIGWLDGDSPSEAHTGTLTLAAIQWGRPMIHGRPGPLLRNMAQMLKPGDVIMIEPKPDKGGTVSLEQV PKVEGAMLSLDPQTGRVLAMVGGWSNRLSPYNRAIQAHRQPGSSVKPFDYLTAMQAGVQPDATILDAPFIQRLSDGQIYR PGNYENSFQGPVPVFYAIQESLNLATLHLVRRVGLPNVIANFKKFGVVKHAPLIYPAAIGALDTTLWRMVRGYAALDEYG RKVQPSLIDSVTAPDGHILYQAPDQSCANCMDGSAQQPPILNRPGARLANPDSVYQVIMMMRNVAEYGTGVPAVKGLKRP IAGKTGTTNNFNDAWFIGFVPQMVTGCWIGFDKPRDLGVNQTGGNVCGPAWNQYMKVALKNQPVIPFKPPPGITLHKVTF RDETVEEAFKPGQTPGAQSNPGLVADDPLNLGGAFANTTPSTGSHDFSPAPDGQTPSGGAPAPSGNVDKSLGGLY
Sequences:
>Translated_875_residues MSRPLKAGERLAKSDSRRRAGPTPPKRGGKPAPRKRPGLAGVAGGMFVRGLYRLALVGMVGGVLVGGGLFFYFSSGLPGV DRLRHYEPPLETRIYAENFRLIGALGTQHRIYVPYDRIPPLVADAFIAAEDKNFWTEPGIDPLAIVRAGVVDLTRIGSHE RPLGASTITMQVVKNMLLDNRIDFTRKIKEAILAVRVNRAMSKKQILTLYLNEIFLGQDSWGVAAAAQAYFDKPLSQLTV AEAAMLGGLPKAPTNYNPFLHPKRARDRRDWVIGQMQADGFITAAQAREALAAPLVPKAAAGPASIPGAGYFVGAVETQL VRMFGRKTAMEGGLIVRTSLDPKLQAAATRAMRDRLVSYDHEFGVYHGPVGHIGAGELAAGWARALARQDTPKGLIASWR LGVVISETAQRARIGWLDGDSPSEAHTGTLTLAAIQWGRPMIHGRPGPLLRNMAQMLKPGDVIMIEPKPDKGGTVSLEQV PKVEGAMLSLDPQTGRVLAMVGGWSNRLSPYNRAIQAHRQPGSSVKPFDYLTAMQAGVQPDATILDAPFIQRLSDGQIYR PGNYENSFQGPVPVFYAIQESLNLATLHLVRRVGLPNVIANFKKFGVVKHAPLIYPAAIGALDTTLWRMVRGYAALDEYG RKVQPSLIDSVTAPDGHILYQAPDQSCANCMDGSAQQPPILNRPGARLANPDSVYQVIMMMRNVAEYGTGVPAVKGLKRP IAGKTGTTNNFNDAWFIGFVPQMVTGCWIGFDKPRDLGVNQTGGNVCGPAWNQYMKVALKNQPVIPFKPPPGITLHKVTF RDETVEEAFKPGQTPGAQSNPGLVADDPLNLGGAFANTTPSTGSHDFSPAPDGQTPSGGAPAPSGNVDKSLGGLY >Mature_874_residues SRPLKAGERLAKSDSRRRAGPTPPKRGGKPAPRKRPGLAGVAGGMFVRGLYRLALVGMVGGVLVGGGLFFYFSSGLPGVD RLRHYEPPLETRIYAENFRLIGALGTQHRIYVPYDRIPPLVADAFIAAEDKNFWTEPGIDPLAIVRAGVVDLTRIGSHER PLGASTITMQVVKNMLLDNRIDFTRKIKEAILAVRVNRAMSKKQILTLYLNEIFLGQDSWGVAAAAQAYFDKPLSQLTVA EAAMLGGLPKAPTNYNPFLHPKRARDRRDWVIGQMQADGFITAAQAREALAAPLVPKAAAGPASIPGAGYFVGAVETQLV RMFGRKTAMEGGLIVRTSLDPKLQAAATRAMRDRLVSYDHEFGVYHGPVGHIGAGELAAGWARALARQDTPKGLIASWRL GVVISETAQRARIGWLDGDSPSEAHTGTLTLAAIQWGRPMIHGRPGPLLRNMAQMLKPGDVIMIEPKPDKGGTVSLEQVP KVEGAMLSLDPQTGRVLAMVGGWSNRLSPYNRAIQAHRQPGSSVKPFDYLTAMQAGVQPDATILDAPFIQRLSDGQIYRP GNYENSFQGPVPVFYAIQESLNLATLHLVRRVGLPNVIANFKKFGVVKHAPLIYPAAIGALDTTLWRMVRGYAALDEYGR KVQPSLIDSVTAPDGHILYQAPDQSCANCMDGSAQQPPILNRPGARLANPDSVYQVIMMMRNVAEYGTGVPAVKGLKRPI AGKTGTTNNFNDAWFIGFVPQMVTGCWIGFDKPRDLGVNQTGGNVCGPAWNQYMKVALKNQPVIPFKPPPGITLHKVTFR DETVEEAFKPGQTPGAQSNPGLVADDPLNLGGAFANTTPSTGSHDFSPAPDGQTPSGGAPAPSGNVDKSLGGLY
Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal
COG id: COG5009
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI87082258, Length=849, Percent_Identity=31.9199057714959, Blast_Score=348, Evalue=1e-96, Organism=Escherichia coli, GI1786343, Length=286, Percent_Identity=33.5664335664336, Blast_Score=120, Evalue=5e-28, Organism=Escherichia coli, GI1788867, Length=189, Percent_Identity=37.037037037037, Blast_Score=108, Evalue=2e-24, Organism=Escherichia coli, GI1789601, Length=183, Percent_Identity=37.1584699453552, Blast_Score=98, Evalue=2e-21,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-; 3.4.-.-
Molecular weight: Translated: 94164; Mature: 94032
Theoretical pI: Translated: 10.18; Mature: 10.18
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSRPLKAGERLAKSDSRRRAGPTPPKRGGKPAPRKRPGLAGVAGGMFVRGLYRLALVGMV CCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH GGVLVGGGLFFYFSSGLPGVDRLRHYEPPLETRIYAENFRLIGALGTQHRIYVPYDRIPP HHHHHHCHHEEHCCCCCCHHHHHHCCCCCHHHEEECCCEEEEEECCCCCEEEECHHHCCH LVADAFIAAEDKNFWTEPGIDPLAIVRAGVVDLTRIGSHERPLGASTITMQVVKNMLLDN HHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCC RIDFTRKIKEAILAVRVNRAMSKKQILTLYLNEIFLGQDSWGVAAAAQAYFDKPLSQLTV CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHH AEAAMLGGLPKAPTNYNPFLHPKRARDRRDWVIGQMQADGFITAAQAREALAAPLVPKAA HHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCEEEEEECCCEEEHHHHHHHHHCCCCCCCC AGPASIPGAGYFVGAVETQLVRMFGRKTAMEGGLIVRTSLDPKLQAAATRAMRDRLVSYD CCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCC HEFGVYHGPVGHIGAGELAAGWARALARQDTPKGLIASWRLGVVISETAQRARIGWLDGD CCCCCEECCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHEECEEECCCHHHHEEECCCCC SPSEAHTGTLTLAAIQWGRPMIHGRPGPLLRNMAQMLKPGDVIMIEPKPDKGGTVSLEQV CCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCEEEHHHC PKVEGAMLSLDPQTGRVLAMVGGWSNRLSPYNRAIQAHRQPGSSVKPFDYLTAMQAGVQP CCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC DATILDAPFIQRLSDGQIYRPGNYENSFQGPVPVFYAIQESLNLATLHLVRRVGLPNVIA CCEEECCHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHH NFKKFGVVKHAPLIYPAAIGALDTTLWRMVRGYAALDEYGRKVQPSLIDSVTAPDGHILY HHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEE QAPDQSCANCMDGSAQQPPILNRPGARLANPDSVYQVIMMMRNVAEYGTGVPAVKGLKRP ECCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC IAGKTGTTNNFNDAWFIGFVPQMVTGCWIGFDKPRDLGVNQTGGNVCGPAWNQYMKVALK CCCCCCCCCCCCCEEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC NQPVIPFKPPPGITLHKVTFRDETVEEAFKPGQTPGAQSNPGLVADDPLNLGGAFANTTP CCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC STGSHDFSPAPDGQTPSGGAPAPSGNVDKSLGGLY CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCC >Mature Secondary Structure SRPLKAGERLAKSDSRRRAGPTPPKRGGKPAPRKRPGLAGVAGGMFVRGLYRLALVGMV CCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH GGVLVGGGLFFYFSSGLPGVDRLRHYEPPLETRIYAENFRLIGALGTQHRIYVPYDRIPP HHHHHHCHHEEHCCCCCCHHHHHHCCCCCHHHEEECCCEEEEEECCCCCEEEECHHHCCH LVADAFIAAEDKNFWTEPGIDPLAIVRAGVVDLTRIGSHERPLGASTITMQVVKNMLLDN HHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCC RIDFTRKIKEAILAVRVNRAMSKKQILTLYLNEIFLGQDSWGVAAAAQAYFDKPLSQLTV CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHH AEAAMLGGLPKAPTNYNPFLHPKRARDRRDWVIGQMQADGFITAAQAREALAAPLVPKAA HHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCEEEEEECCCEEEHHHHHHHHHCCCCCCCC AGPASIPGAGYFVGAVETQLVRMFGRKTAMEGGLIVRTSLDPKLQAAATRAMRDRLVSYD CCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCC HEFGVYHGPVGHIGAGELAAGWARALARQDTPKGLIASWRLGVVISETAQRARIGWLDGD CCCCCEECCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHEECEEECCCHHHHEEECCCCC SPSEAHTGTLTLAAIQWGRPMIHGRPGPLLRNMAQMLKPGDVIMIEPKPDKGGTVSLEQV CCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCEEEHHHC PKVEGAMLSLDPQTGRVLAMVGGWSNRLSPYNRAIQAHRQPGSSVKPFDYLTAMQAGVQP CCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC DATILDAPFIQRLSDGQIYRPGNYENSFQGPVPVFYAIQESLNLATLHLVRRVGLPNVIA CCEEECCHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHH NFKKFGVVKHAPLIYPAAIGALDTTLWRMVRGYAALDEYGRKVQPSLIDSVTAPDGHILY HHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEE QAPDQSCANCMDGSAQQPPILNRPGARLANPDSVYQVIMMMRNVAEYGTGVPAVKGLKRP ECCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC IAGKTGTTNNFNDAWFIGFVPQMVTGCWIGFDKPRDLGVNQTGGNVCGPAWNQYMKVALK CCCCCCCCCCCCCEEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC NQPVIPFKPPPGITLHKVTFRDETVEEAFKPGQTPGAQSNPGLVADDPLNLGGAFANTTP CCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC STGSHDFSPAPDGQTPSGGAPAPSGNVDKSLGGLY CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 9823893 [H]