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The map label for this gene is lig [H]

Identifier: 148260609

GI number: 148260609

Start: 1776671

End: 1778239

Strand: Reverse

Name: lig [H]

Synonym: Acry_1611

Alternate gene names: 148260609

Gene position: 1778239-1776671 (Counterclockwise)

Preceding gene: 148260610

Following gene: 148260605

Centisome position: 52.47

GC content: 71.57

Gene sequence:

>1569_bases
ATGAAACCCTTCGCCGATCTGCTGGAACGCCTGCTCTACACCACCGGGCGCAACGCCAAGATCGCGCTCCTCGCCGATTA
CTTCGCCCACCGCCCCGATCCCGAGCGCGGCTACGCGCTCGCCGCCATCGCCGGCGCGCTCGACTTTCCCGGCGCGAAAC
CCGCCGTGCTGCGCGAGCTGGCCGCCGCCCGCACCGATCCCGAGCTGTTCGCGCTCTCCTACGATTTCGTCGGCGACCTC
GCCGAGACCATCGCCCTGCTCTGGCCGCCGGCCGCGCGCCCGGCGCCGCCCGGCCTGCCCGATCTCGTCGCCGCCCTGCG
CGCGGCGCCGCGCGCCGAAATCCCGGCGCTGATCGAAGGCTGGCTCGATGCGAGCGACGTCTCGACGCGGATCGCCCTGA
TCAAGCTGATCACCGGAGGCCTGCGCGTCGGCGCCTCGCTGCGGCTGGCGAAACTCGCCCTGGCCCGGCAATTCGCCGTC
GAGGCCGACGAGATCGAGGAAGTCTGGCACGGGCTGGAGGCGCCCTACACCGCGCTGTTCGACTGGCTGGAAGGCCGCGC
CCCGCGCCCCGCGCCCGGTGCGGCCCCCGTCTTCCGCCCGCCGATGCTGGCCCACCCGATCGAGGCGGCCGACCTCGCGA
CACTCGACTGGTCCGCCCATCGCGCCGAATGGAAATGGGACGGCATCCGCGTCCAGCTCGTGTCCACCCCCGGCGGCAGC
CGGCTCTATTCGCGCGGCGCGGAAGACATCTCCGCCGCCTTCCCCGAAATCGTCGCGGCGATGGATTTCCACGCCGTGCT
CGATGGCGAGCTGCTGGTCATCCGCGATGGCGCGGTCGCCCCCTTCGCCGATCTCCAGCAGCGCCTCAACCGCAAGAGCG
TCCCGGCGAAACTCCGCGCCGCCAACCCGGTCGGCGTGCGGCTGTATGACATGCTGTTCGAGGGCGAAACCGACCTCCGG
GGCCTGCCCTTCGATGCCCGCCGCGCCCGGCTCGAAGCCTGGTTCGCCCGCACCGCCCCGGCGCGGATGGACCTTTCGGA
GCTGATCCCTTTCGCCGCGGCCGAGGATCTCGCCGCCCTGCGCGCCGGCGCCCGCGATGCCGCGATCGAGGGGCTGATGC
TCAAGCGCGCCGACAGCCCCTATCTCGCCGGCCGCCCCAAGGGCCATTGGTGGAAATGGAAGCGCGACCCGCTCAGCCTC
GACTGCGTGCTGATGTATGCCCAGCGCGGCCACGGCAAGCGCTCCTCCTATTATTCCGACTACACGTTCGGCGTCTGGAC
GGCGGAGGGCGCGCTGGTGCCGGTCGGCAAGGCCTATTCCGGCTATACCGATGCCGAGCTGCAACGGCTCGACCGCTGGA
TCCGCGCCCACACGGTCGCGAGCTACGGCCCGGTGCGCGAGGTGGAGAAGGCGATCGTGCTGGAAGTGGGGTTCGACGCG
GCGCAGCGCTCGACCCGCCACAAATCCGGCATCGCGCTGCGCTTTCCGCGCATCCTGCGCATCCGCGAGGACAAGCCGGC
CGCTGAGGCGGACACGCTGGAGACCGCGCGTTTGCTCCTGCCCGGCTAG

Upstream 100 bases:

>100_bases
CCCACGGCGCCGAGGCGGCCCTGCTGCGCCAGCTCTCGCTGATGGGCCGGCGCGGCCGCGCGCTCAGCCTGATCGGCTAT
GGCGACGAGGCGGAGCAGGA

Downstream 100 bases:

>100_bases
TCCGGGCCGCTTGAGAGCGGCAGCTTCACTGATCCGTGCCGCCTGCGAGCGGCCCGAGCGCCGCCTGGATGCCGAATTCG
CCGGGCAGCGCCCCATGCGG

Product: ATP dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MKPFADLLERLLYTTGRNAKIALLADYFAHRPDPERGYALAAIAGALDFPGAKPAVLRELAAARTDPELFALSYDFVGDL
AETIALLWPPAARPAPPGLPDLVAALRAAPRAEIPALIEGWLDASDVSTRIALIKLITGGLRVGASLRLAKLALARQFAV
EADEIEEVWHGLEAPYTALFDWLEGRAPRPAPGAAPVFRPPMLAHPIEAADLATLDWSAHRAEWKWDGIRVQLVSTPGGS
RLYSRGAEDISAAFPEIVAAMDFHAVLDGELLVIRDGAVAPFADLQQRLNRKSVPAKLRAANPVGVRLYDMLFEGETDLR
GLPFDARRARLEAWFARTAPARMDLSELIPFAAAEDLAALRAGARDAAIEGLMLKRADSPYLAGRPKGHWWKWKRDPLSL
DCVLMYAQRGHGKRSSYYSDYTFGVWTAEGALVPVGKAYSGYTDAELQRLDRWIRAHTVASYGPVREVEKAIVLEVGFDA
AQRSTRHKSGIALRFPRILRIREDKPAAEADTLETARLLLPG

Sequences:

>Translated_522_residues
MKPFADLLERLLYTTGRNAKIALLADYFAHRPDPERGYALAAIAGALDFPGAKPAVLRELAAARTDPELFALSYDFVGDL
AETIALLWPPAARPAPPGLPDLVAALRAAPRAEIPALIEGWLDASDVSTRIALIKLITGGLRVGASLRLAKLALARQFAV
EADEIEEVWHGLEAPYTALFDWLEGRAPRPAPGAAPVFRPPMLAHPIEAADLATLDWSAHRAEWKWDGIRVQLVSTPGGS
RLYSRGAEDISAAFPEIVAAMDFHAVLDGELLVIRDGAVAPFADLQQRLNRKSVPAKLRAANPVGVRLYDMLFEGETDLR
GLPFDARRARLEAWFARTAPARMDLSELIPFAAAEDLAALRAGARDAAIEGLMLKRADSPYLAGRPKGHWWKWKRDPLSL
DCVLMYAQRGHGKRSSYYSDYTFGVWTAEGALVPVGKAYSGYTDAELQRLDRWIRAHTVASYGPVREVEKAIVLEVGFDA
AQRSTRHKSGIALRFPRILRIREDKPAAEADTLETARLLLPG
>Mature_522_residues
MKPFADLLERLLYTTGRNAKIALLADYFAHRPDPERGYALAAIAGALDFPGAKPAVLRELAAARTDPELFALSYDFVGDL
AETIALLWPPAARPAPPGLPDLVAALRAAPRAEIPALIEGWLDASDVSTRIALIKLITGGLRVGASLRLAKLALARQFAV
EADEIEEVWHGLEAPYTALFDWLEGRAPRPAPGAAPVFRPPMLAHPIEAADLATLDWSAHRAEWKWDGIRVQLVSTPGGS
RLYSRGAEDISAAFPEIVAAMDFHAVLDGELLVIRDGAVAPFADLQQRLNRKSVPAKLRAANPVGVRLYDMLFEGETDLR
GLPFDARRARLEAWFARTAPARMDLSELIPFAAAEDLAALRAGARDAAIEGLMLKRADSPYLAGRPKGHWWKWKRDPLSL
DCVLMYAQRGHGKRSSYYSDYTFGVWTAEGALVPVGKAYSGYTDAELQRLDRWIRAHTVASYGPVREVEKAIVLEVGFDA
AQRSTRHKSGIALRFPRILRIREDKPAAEADTLETARLLLPG

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=354, Percent_Identity=27.4011299435028, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI73747829, Length=354, Percent_Identity=27.9661016949153, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI73747844, Length=354, Percent_Identity=27.9661016949153, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71985269, Length=363, Percent_Identity=28.3746556473829, Blast_Score=105, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6320038, Length=521, Percent_Identity=26.4875239923225, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24762424, Length=357, Percent_Identity=26.3305322128852, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI85815841, Length=373, Percent_Identity=30.0268096514745, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 57219; Mature: 57219

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPFADLLERLLYTTGRNAKIALLADYFAHRPDPERGYALAAIAGALDFPGAKPAVLREL
CCCHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCEEHHHHHHHHCCCCCCHHHHHHH
AAARTDPELFALSYDFVGDLAETIALLWPPAARPAPPGLPDLVAALRAAPRAEIPALIEG
HHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
WLDASDVSTRIALIKLITGGLRVGASLRLAKLALARQFAVEADEIEEVWHGLEAPYTALF
CCCHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHH
DWLEGRAPRPAPGAAPVFRPPMLAHPIEAADLATLDWSAHRAEWKWDGIRVQLVSTPGGS
HHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCEEEECCCCCCCCEEECCEEEEEEECCCCH
RLYSRGAEDISAAFPEIVAAMDFHAVLDGELLVIRDGAVAPFADLQQRLNRKSVPAKLRA
HHHHCCCHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCCCHHHHHHHHCCCCCCCCEEC
ANPVGVRLYDMLFEGETDLRGLPFDARRARLEAWFARTAPARMDLSELIPFAAAEDLAAL
CCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHH
RAGARDAAIEGLMLKRADSPYLAGRPKGHWWKWKRDPLSLDCVLMYAQRGHGKRSSYYSD
HCCCHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEHHCCCCCCCCCCCC
YTFGVWTAEGALVPVGKAYSGYTDAELQRLDRWIRAHTVASYGPVREVEKAIVLEVGFDA
CEEEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEEECCCH
AQRSTRHKSGIALRFPRILRIREDKPAAEADTLETARLLLPG
HHHHHHHHCCEEEECCHHEEEECCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKPFADLLERLLYTTGRNAKIALLADYFAHRPDPERGYALAAIAGALDFPGAKPAVLREL
CCCHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCEEHHHHHHHHCCCCCCHHHHHHH
AAARTDPELFALSYDFVGDLAETIALLWPPAARPAPPGLPDLVAALRAAPRAEIPALIEG
HHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
WLDASDVSTRIALIKLITGGLRVGASLRLAKLALARQFAVEADEIEEVWHGLEAPYTALF
CCCHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHH
DWLEGRAPRPAPGAAPVFRPPMLAHPIEAADLATLDWSAHRAEWKWDGIRVQLVSTPGGS
HHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCEEEECCCCCCCCEEECCEEEEEEECCCCH
RLYSRGAEDISAAFPEIVAAMDFHAVLDGELLVIRDGAVAPFADLQQRLNRKSVPAKLRA
HHHHCCCHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCCCHHHHHHHHCCCCCCCCEEC
ANPVGVRLYDMLFEGETDLRGLPFDARRARLEAWFARTAPARMDLSELIPFAAAEDLAAL
CCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHH
RAGARDAAIEGLMLKRADSPYLAGRPKGHWWKWKRDPLSLDCVLMYAQRGHGKRSSYYSD
HCCCHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEHHCCCCCCCCCCCC
YTFGVWTAEGALVPVGKAYSGYTDAELQRLDRWIRAHTVASYGPVREVEKAIVLEVGFDA
CEEEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEEECCCH
AQRSTRHKSGIALRFPRILRIREDKPAAEADTLETARLLLPG
HHHHHHHHCCEEEECCHHEEEECCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA