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The map label for this gene is yngE [H]

Identifier: 148260516

GI number: 148260516

Start: 1676827

End: 1678434

Strand: Reverse

Name: yngE [H]

Synonym: Acry_1516

Alternate gene names: 148260516

Gene position: 1678434-1676827 (Counterclockwise)

Preceding gene: 148260517

Following gene: 148260515

Centisome position: 49.52

GC content: 68.84

Gene sequence:

>1608_bases
ATGACGGCGTTCCGCTCGTCGCTCGATCCGCGCAGCGCCGCGTTTCGGGCGAATCAGGAGGCGATGCGCAGCCTGGTCGA
GGATCTGCGCGCCAGGGTGGATGACATCCGCGCCGGCGGCGGTGAAGCGGCGCGGGAGCGGCATGTCGCGCGGGGGAAGC
TGCTGCCGCGTGACCGGATCCGCACGCTGATCGACCCGGCATCGCCCTTCCTCGAATTCTCCCAGCTCGCCGGGTACGGC
ATGTATGACGAGCCGGTGCCGGCCGGCGGCATCATCACCGGGATCGGCCGGGTGTCGGGGCGGGAATGCGTGATCGTCGC
CAACGACGCCACGGTGAAGGGCGGCACCTATTTCCCGATCACGGTCAAGAAGCACCTGCGCGCCCAGGCGATCGCGGCGC
AGAACCGGCTGCCCTGCCTCTATCTCGTCGATTCCGGCGGCGCCAACCTGCCCAACCAGGACGAGGTCTTCCCCGACCGC
GAGCATTTCGGCCGCATCTTCTACAATCAGGCGCAGATGTCTGCGGCGGGGATTCCGCAGATCGCGGTGGTGATGGGCTC
CTGCACGGCGGGCGGCGCCTATGTGCCGGCGATGGCCGATGAGAGCATCATCGTCCGCGAGCAGGGGACGATTTTTCTCG
GCGGCCCGCCGCTGGTGAAGGCGGCGACCGGCGAGGTGGTCACCGCCGAGGCGCTGGGCGGGGCCGACGTGCATACGAGG
GTCTCCGGTGTGGCCGATCATTTCGCAGAGTCGGACGCGCATGCCCTCGGCATTGCCCGGCGGATCGTCGGCGGGCTGAA
CACCCGCAAGCCGGCGCAGATGGACTTGCTCCCGCCACGCCCGCCGGTGGGGGCGCCGGATGCGATCTATGGCGCCGTGC
CGGCCGATCCGCGCACGCCCTATGACGTGCGCGAGGTGATCCGGCTTATCGTCGATGCCGGCGAATTCGACGAGTTCAAG
GCGCGCTACGGCACGACGCTGGTGACCGCCTTCGCCCGCATCTGGGGCTATCCGGTCGGCATCGTCGCGAATAACGGCGT
GCTGTTCTCCGAATCGGCGCTCAAGGGCGCGCATTTCATCGAGCTCTGCGCGCAGCGGGGGATTCCGCTGGTGTTCCTGC
AGAACATCACCGGCTTCATGGTCGGGCGGAAATACGAATCCGGCGGCATCGCCAGGGACGGCGCAAAGCTGGTGACGGCG
GTGGCCACCGCGAACGTGCCGAAATTCACCGTGATCATCGGCGGCTCGTTCGGGGCCGGGAATTACGGCATGTGCGGCCG
GGCCTACGATCCGCGCTTCCTGTGGATGTGGCCGAACGCGCGGATCTCGGTGATGGGCGGGACGCAGGCGGCGTCGGTGC
TGGCGACGCTCCGGCGCGACAATATCGAGGCGCGGGGCGGCGCATGGTCGGCGGCGGAGGAGCAGGCGTTCCGGGCGCCG
ATCGAGGCGCAGTACGAGCATCAGGGGCATCCTTATTACGCCAGCGCCCGGCTGTGGGACGATGGGGTGATCGACCCGGC
GGATACGCGGATGGTGCTGGCGCTCGGGCTCTCGGCGAGCCTGAACGCGCCGATCGAGCCGACGCGGTTCGGCCTGTTCA
GGATGTGA

Upstream 100 bases:

>100_bases
CGGGAGTTTCGCCGCCCCGCCTTGCCGGGGGCAGGCAGTTGCGCGATAGACAGGAGCATAATCAACGGGATGGAGGCGCA
ATGTTCAGGCAGACTGACGC

Downstream 100 bases:

>100_bases
GGCGATGAGCGAACCGGTTGAATTTTCCCTGGCCGAAGACGGCACCGCGACGATCTCGATGAACCGCCCCGCGCTGCACA
ACGCGTTCGACGAGGGGATG

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTAFRSSLDPRSAAFRANQEAMRSLVEDLRARVDDIRAGGGEAARERHVARGKLLPRDRIRTLIDPASPFLEFSQLAGYG
MYDEPVPAGGIITGIGRVSGRECVIVANDATVKGGTYFPITVKKHLRAQAIAAQNRLPCLYLVDSGGANLPNQDEVFPDR
EHFGRIFYNQAQMSAAGIPQIAVVMGSCTAGGAYVPAMADESIIVREQGTIFLGGPPLVKAATGEVVTAEALGGADVHTR
VSGVADHFAESDAHALGIARRIVGGLNTRKPAQMDLLPPRPPVGAPDAIYGAVPADPRTPYDVREVIRLIVDAGEFDEFK
ARYGTTLVTAFARIWGYPVGIVANNGVLFSESALKGAHFIELCAQRGIPLVFLQNITGFMVGRKYESGGIARDGAKLVTA
VATANVPKFTVIIGGSFGAGNYGMCGRAYDPRFLWMWPNARISVMGGTQAASVLATLRRDNIEARGGAWSAAEEQAFRAP
IEAQYEHQGHPYYASARLWDDGVIDPADTRMVLALGLSASLNAPIEPTRFGLFRM

Sequences:

>Translated_535_residues
MTAFRSSLDPRSAAFRANQEAMRSLVEDLRARVDDIRAGGGEAARERHVARGKLLPRDRIRTLIDPASPFLEFSQLAGYG
MYDEPVPAGGIITGIGRVSGRECVIVANDATVKGGTYFPITVKKHLRAQAIAAQNRLPCLYLVDSGGANLPNQDEVFPDR
EHFGRIFYNQAQMSAAGIPQIAVVMGSCTAGGAYVPAMADESIIVREQGTIFLGGPPLVKAATGEVVTAEALGGADVHTR
VSGVADHFAESDAHALGIARRIVGGLNTRKPAQMDLLPPRPPVGAPDAIYGAVPADPRTPYDVREVIRLIVDAGEFDEFK
ARYGTTLVTAFARIWGYPVGIVANNGVLFSESALKGAHFIELCAQRGIPLVFLQNITGFMVGRKYESGGIARDGAKLVTA
VATANVPKFTVIIGGSFGAGNYGMCGRAYDPRFLWMWPNARISVMGGTQAASVLATLRRDNIEARGGAWSAAEEQAFRAP
IEAQYEHQGHPYYASARLWDDGVIDPADTRMVLALGLSASLNAPIEPTRFGLFRM
>Mature_534_residues
TAFRSSLDPRSAAFRANQEAMRSLVEDLRARVDDIRAGGGEAARERHVARGKLLPRDRIRTLIDPASPFLEFSQLAGYGM
YDEPVPAGGIITGIGRVSGRECVIVANDATVKGGTYFPITVKKHLRAQAIAAQNRLPCLYLVDSGGANLPNQDEVFPDRE
HFGRIFYNQAQMSAAGIPQIAVVMGSCTAGGAYVPAMADESIIVREQGTIFLGGPPLVKAATGEVVTAEALGGADVHTRV
SGVADHFAESDAHALGIARRIVGGLNTRKPAQMDLLPPRPPVGAPDAIYGAVPADPRTPYDVREVIRLIVDAGEFDEFKA
RYGTTLVTAFARIWGYPVGIVANNGVLFSESALKGAHFIELCAQRGIPLVFLQNITGFMVGRKYESGGIARDGAKLVTAV
ATANVPKFTVIIGGSFGAGNYGMCGRAYDPRFLWMWPNARISVMGGTQAASVLATLRRDNIEARGGAWSAAEEQAFRAPI
EAQYEHQGHPYYASARLWDDGVIDPADTRMVLALGLSASLNAPIEPTRFGLFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=528, Percent_Identity=67.4242424242424, Blast_Score=716, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=527, Percent_Identity=32.258064516129, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI295821216, Length=551, Percent_Identity=31.2159709618875, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI310133460, Length=135, Percent_Identity=66.6666666666667, Blast_Score=168, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17552936, Length=537, Percent_Identity=62.1973929236499, Blast_Score=696, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=498, Percent_Identity=34.3373493975904, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI25147362, Length=506, Percent_Identity=33.9920948616601, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=63.1578947368421, Blast_Score=709, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57284; Mature: 57153

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFRSSLDPRSAAFRANQEAMRSLVEDLRARVDDIRAGGGEAARERHVARGKLLPRDRI
CCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHH
RTLIDPASPFLEFSQLAGYGMYDEPVPAGGIITGIGRVSGRECVIVANDATVKGGTYFPI
HHHHCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCEECCCEEEEE
TVKKHLRAQAIAAQNRLPCLYLVDSGGANLPNQDEVFPDREHFGRIFYNQAQMSAAGIPQ
EHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHCCCCE
IAVVMGSCTAGGAYVPAMADESIIVREQGTIFLGGPPLVKAATGEVVTAEALGGADVHTR
EEEEEECCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCEEEECCCCCCCHHHH
VSGVADHFAESDAHALGIARRIVGGLNTRKPAQMDLLPPRPPVGAPDAIYGAVPADPRTP
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCC
YDVREVIRLIVDAGEFDEFKARYGTTLVTAFARIWGYPVGIVANNGVLFSESALKGAHFI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEECHHHCCHHHH
ELCAQRGIPLVFLQNITGFMVGRKYESGGIARDGAKLVTAVATANVPKFTVIIGGSFGAG
HHHHHCCCCEEEECCCCHHHEECEECCCCCCCCCHHHEEHHHHCCCCEEEEEEECCCCCC
NYGMCGRAYDPRFLWMWPNARISVMGGTQAASVLATLRRDNIEARGGAWSAAEEQAFRAP
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
IEAQYEHQGHPYYASARLWDDGVIDPADTRMVLALGLSASLNAPIEPTRFGLFRM
CCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAFRSSLDPRSAAFRANQEAMRSLVEDLRARVDDIRAGGGEAARERHVARGKLLPRDRI
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHH
RTLIDPASPFLEFSQLAGYGMYDEPVPAGGIITGIGRVSGRECVIVANDATVKGGTYFPI
HHHHCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCEECCCEEEEE
TVKKHLRAQAIAAQNRLPCLYLVDSGGANLPNQDEVFPDREHFGRIFYNQAQMSAAGIPQ
EHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHCCCCE
IAVVMGSCTAGGAYVPAMADESIIVREQGTIFLGGPPLVKAATGEVVTAEALGGADVHTR
EEEEEECCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCEEEECCCCCCCHHHH
VSGVADHFAESDAHALGIARRIVGGLNTRKPAQMDLLPPRPPVGAPDAIYGAVPADPRTP
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCC
YDVREVIRLIVDAGEFDEFKARYGTTLVTAFARIWGYPVGIVANNGVLFSESALKGAHFI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEECHHHCCHHHH
ELCAQRGIPLVFLQNITGFMVGRKYESGGIARDGAKLVTAVATANVPKFTVIIGGSFGAG
HHHHHCCCCEEEECCCCHHHEECEECCCCCCCCCHHHEEHHHHCCCCEEEEEEECCCCCC
NYGMCGRAYDPRFLWMWPNARISVMGGTQAASVLATLRRDNIEARGGAWSAAEEQAFRAP
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
IEAQYEHQGHPYYASARLWDDGVIDPADTRMVLALGLSASLNAPIEPTRFGLFRM
CCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]