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The map label for this gene is zwf [H]

Identifier: 148260278

GI number: 148260278

Start: 1422711

End: 1424315

Strand: Reverse

Name: zwf [H]

Synonym: Acry_1275

Alternate gene names: 148260278

Gene position: 1424315-1422711 (Counterclockwise)

Preceding gene: 148260279

Following gene: 148260277

Centisome position: 42.02

GC content: 64.3

Gene sequence:

>1605_bases
ATGAACCCGCTGGCAAAACACCCGCTCCGGTCAGAGGCCGGATCCTCCGGCGCCGCCTCGGCCTCCCCCGCGGGCCCCTG
CAGCGTCGTGATTTTCGGTGCCGCGGGGGATCTGACCAAGCGGCTGCTGGTGCCGGCGCTCTACAATCTTGCGAATACCG
GCCTGGTGCCCGAGAAGTTCGGCCTGCTTGGCGCCGATATCGCCGACCTCGACGCAAAGCACTGGACCGGCTCGCTGCGC
GAGATGCTGGAGAGCTTCGTCGGCGATCCGGAAGCCGAAGACCAGATCAAGCAAGTTGACGACGCCGCATGGGATCGCCT
GAGGGCGCATGCCGATTACGTCCAGGGTGATTTCACCAGGGACGAATTCTACGAAACCCTGAAGTCCCGCCTCGAAGCGA
TCGAAAATTCGCAAGGCACGGGCGGCAACCGGCTGTTCTACCTTGCGGTGGCCGACCGGTTCTTCGCACCGATCGTCGAG
CATCTGGGCAAGGCCGGCCTCGTGACCGAGGATGAGTCGGGCGGGGGGACGTGGCGGCGGATCATCATCGAAAAGCCGTT
CGGCCACGACCTTGCATCGGCTCAGGACCTGAACCGACGGCTTCTGAGCGTGGTCGACGAGCGGCAGATCTACCGGATCG
ACCATTTTCTTGGCAAGGAAACCGTTCAGAACATCATGGCGTTGCGGTTCGGCAACGGAATCTTCGATCCGCTCTGGAAT
CGCGATCGAATCGACCATGTGCAGATCACCGTCGCCGAGACGGTCGGCGTCGAGGGACGGGCGAAATTCTACGAGCAGGC
CGGCGCGTTGCGCGACATGGTGCCGAACCACGTCTTCCAGCTCGTCGCCATGGTGGCGATGGAACCGCCGGTTGGTGTGC
GGGCCGAGGCGATCCGCGACAAGAAGCTGGAACTCTTCTCCGCCATCCGCACCTTGCGTCCGGAGGATGCCGTGCGTGGC
CAGTATGGCGCGGGCGAGGTGTCCGGCCAGTCAGCGCGCGGCTATCGCGAGGAGCCAGGTGTTGCTGCGGACTCGAATAC
CGAAACATATGTCGCGTTGCGGCTTGCCATCGACAACTGGCGCTGGGCCGGCGTGCCGTTCTACATTCGCACCGGCAAGC
ATCTTTCCGAGCGGATGACCGAAATCGCCATCCGCTTCCGCAAGCAGCCGCTGGCGCCGTTCCAGGGCGCATCGCTCGAT
GGCCTGCCGCCGAACTGGCTGGTTCTGCGCATCCAGCCCGATGAAGGCATCGCCATCGAGTTCGAGGTGAAGCAACCCGG
CCAGACCATGCGGCTGGCGCCCGCCCGGATGCAGTTCAGATATCGTGACCGTTTCGAACCGGAACCGAACGTCGGCTACG
AAACCCTTCTGTATGATTGCATGATCGGCGATCAGACCCTATTCCAGCGGGCAGACATGGTCGAGGAGACGTGGCGTGTG
GTCGGCCGTGTTCTGGACGCCTGGGGCAGAGACCGAGCCGCCGATTTCCCGAACTACCGCAGCGGCAGCGCGGGACCGGA
TGCGGCGGACAAGCTGCTTGCGGATGATGAGCCGACGCGGCGCTGGCGACCGGTCGCGCTCGATCCGGCGGAGAGCGGGC
AATGA

Upstream 100 bases:

>100_bases
TCGATCATACGTTCGGCGAGAAGATCCTGTCTGCCATGCGACAGGGCTTCGGCGGTCATGTCGAGCAGGGACCGGCTGCT
GCCAAGCAGGGAGGTGGCGC

Downstream 100 bases:

>100_bases
GCCGCGCGGTCGATCTCGTGATTGCCGATGTCGATGGCACCCTGGTCACCAATGACAAGCGCCTGACGGCGGCGACGAAG
CTGGCGGTCGATGCGCTTCG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MNPLAKHPLRSEAGSSGAASASPAGPCSVVIFGAAGDLTKRLLVPALYNLANTGLVPEKFGLLGADIADLDAKHWTGSLR
EMLESFVGDPEAEDQIKQVDDAAWDRLRAHADYVQGDFTRDEFYETLKSRLEAIENSQGTGGNRLFYLAVADRFFAPIVE
HLGKAGLVTEDESGGGTWRRIIIEKPFGHDLASAQDLNRRLLSVVDERQIYRIDHFLGKETVQNIMALRFGNGIFDPLWN
RDRIDHVQITVAETVGVEGRAKFYEQAGALRDMVPNHVFQLVAMVAMEPPVGVRAEAIRDKKLELFSAIRTLRPEDAVRG
QYGAGEVSGQSARGYREEPGVAADSNTETYVALRLAIDNWRWAGVPFYIRTGKHLSERMTEIAIRFRKQPLAPFQGASLD
GLPPNWLVLRIQPDEGIAIEFEVKQPGQTMRLAPARMQFRYRDRFEPEPNVGYETLLYDCMIGDQTLFQRADMVEETWRV
VGRVLDAWGRDRAADFPNYRSGSAGPDAADKLLADDEPTRRWRPVALDPAESGQ

Sequences:

>Translated_534_residues
MNPLAKHPLRSEAGSSGAASASPAGPCSVVIFGAAGDLTKRLLVPALYNLANTGLVPEKFGLLGADIADLDAKHWTGSLR
EMLESFVGDPEAEDQIKQVDDAAWDRLRAHADYVQGDFTRDEFYETLKSRLEAIENSQGTGGNRLFYLAVADRFFAPIVE
HLGKAGLVTEDESGGGTWRRIIIEKPFGHDLASAQDLNRRLLSVVDERQIYRIDHFLGKETVQNIMALRFGNGIFDPLWN
RDRIDHVQITVAETVGVEGRAKFYEQAGALRDMVPNHVFQLVAMVAMEPPVGVRAEAIRDKKLELFSAIRTLRPEDAVRG
QYGAGEVSGQSARGYREEPGVAADSNTETYVALRLAIDNWRWAGVPFYIRTGKHLSERMTEIAIRFRKQPLAPFQGASLD
GLPPNWLVLRIQPDEGIAIEFEVKQPGQTMRLAPARMQFRYRDRFEPEPNVGYETLLYDCMIGDQTLFQRADMVEETWRV
VGRVLDAWGRDRAADFPNYRSGSAGPDAADKLLADDEPTRRWRPVALDPAESGQ
>Mature_534_residues
MNPLAKHPLRSEAGSSGAASASPAGPCSVVIFGAAGDLTKRLLVPALYNLANTGLVPEKFGLLGADIADLDAKHWTGSLR
EMLESFVGDPEAEDQIKQVDDAAWDRLRAHADYVQGDFTRDEFYETLKSRLEAIENSQGTGGNRLFYLAVADRFFAPIVE
HLGKAGLVTEDESGGGTWRRIIIEKPFGHDLASAQDLNRRLLSVVDERQIYRIDHFLGKETVQNIMALRFGNGIFDPLWN
RDRIDHVQITVAETVGVEGRAKFYEQAGALRDMVPNHVFQLVAMVAMEPPVGVRAEAIRDKKLELFSAIRTLRPEDAVRG
QYGAGEVSGQSARGYREEPGVAADSNTETYVALRLAIDNWRWAGVPFYIRTGKHLSERMTEIAIRFRKQPLAPFQGASLD
GLPPNWLVLRIQPDEGIAIEFEVKQPGQTMRLAPARMQFRYRDRFEPEPNVGYETLLYDCMIGDQTLFQRADMVEETWRV
VGRVLDAWGRDRAADFPNYRSGSAGPDAADKLLADDEPTRRWRPVALDPAESGQ

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=502, Percent_Identity=34.2629482071713, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI108773793, Length=502, Percent_Identity=34.4621513944223, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI52145310, Length=380, Percent_Identity=33.6842105263158, Blast_Score=182, Evalue=7e-46,
Organism=Escherichia coli, GI1788158, Length=507, Percent_Identity=39.4477317554241, Blast_Score=352, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI17538218, Length=492, Percent_Identity=35.5691056910569, Blast_Score=312, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6324088, Length=483, Percent_Identity=33.7474120082816, Blast_Score=277, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24643350, Length=492, Percent_Identity=35.3658536585366, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24643352, Length=492, Percent_Identity=35.3658536585366, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI221513548, Length=482, Percent_Identity=30.0829875518672, Blast_Score=213, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 59510; Mature: 59510

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLAKHPLRSEAGSSGAASASPAGPCSVVIFGAAGDLTKRLLVPALYNLANTGLVPEKF
CCCCCCCCCHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHH
GLLGADIADLDAKHWTGSLREMLESFVGDPEAEDQIKQVDDAAWDRLRAHADYVQGDFTR
CCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DEFYETLKSRLEAIENSQGTGGNRLFYLAVADRFFAPIVEHLGKAGLVTEDESGGGTWRR
HHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCEECCCCCCCEEEE
IIIEKPFGHDLASAQDLNRRLLSVVDERQIYRIDHFLGKETVQNIMALRFGNGIFDPLWN
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RDRIDHVQITVAETVGVEGRAKFYEQAGALRDMVPNHVFQLVAMVAMEPPVGVRAEAIRD
CCCCCEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
KKLELFSAIRTLRPEDAVRGQYGAGEVSGQSARGYREEPGVAADSNTETYVALRLAIDNW
HHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCC
RWAGVPFYIRTGKHLSERMTEIAIRFRKQPLAPFQGASLDGLPPNWLVLRIQPDEGIAIE
EECCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEE
FEVKQPGQTMRLAPARMQFRYRDRFEPEPNVGYETLLYDCMIGDQTLFQRADMVEETWRV
EEECCCCCCEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VGRVLDAWGRDRAADFPNYRSGSAGPDAADKLLADDEPTRRWRPVALDPAESGQ
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure
MNPLAKHPLRSEAGSSGAASASPAGPCSVVIFGAAGDLTKRLLVPALYNLANTGLVPEKF
CCCCCCCCCHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHH
GLLGADIADLDAKHWTGSLREMLESFVGDPEAEDQIKQVDDAAWDRLRAHADYVQGDFTR
CCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DEFYETLKSRLEAIENSQGTGGNRLFYLAVADRFFAPIVEHLGKAGLVTEDESGGGTWRR
HHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCEECCCCCCCEEEE
IIIEKPFGHDLASAQDLNRRLLSVVDERQIYRIDHFLGKETVQNIMALRFGNGIFDPLWN
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RDRIDHVQITVAETVGVEGRAKFYEQAGALRDMVPNHVFQLVAMVAMEPPVGVRAEAIRD
CCCCCEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
KKLELFSAIRTLRPEDAVRGQYGAGEVSGQSARGYREEPGVAADSNTETYVALRLAIDNW
HHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCC
RWAGVPFYIRTGKHLSERMTEIAIRFRKQPLAPFQGASLDGLPPNWLVLRIQPDEGIAIE
EECCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEE
FEVKQPGQTMRLAPARMQFRYRDRFEPEPNVGYETLLYDCMIGDQTLFQRADMVEETWRV
EEECCCCCCEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VGRVLDAWGRDRAADFPNYRSGSAGPDAADKLLADDEPTRRWRPVALDPAESGQ
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1643289 [H]