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The map label for this gene is parC [H]

Identifier: 148260212

GI number: 148260212

Start: 1344501

End: 1346735

Strand: Reverse

Name: parC [H]

Synonym: Acry_1208

Alternate gene names: 148260212

Gene position: 1346735-1344501 (Counterclockwise)

Preceding gene: 148260213

Following gene: 148260211

Centisome position: 39.74

GC content: 68.41

Gene sequence:

>2235_bases
ATGCCCGATGATCTCCTGGGCAATGTTCAGGACACGAAACTCGCCACCGCCCTTTCCGAGCGGTACCTTGCCTATGCGCT
GTCGACCATCATGGCGCGGTCGCTGCCGGATGTGCGCGACGGGCTGAAGCCGGTCCATCGCCGGCTGATCTTCGCGATGC
GCCAGCTCCGGCTCGATCCGGGCTCGGGCTTCAAGAAATGCGCCCGCGTGGTGGGCGACGTGATGGGCAAGTTCCACCCG
CATGGCGACATGTCGATCTACGAGGCGCTGGTTCGCCTCGCGCAGGATTTCGCCTCGCGCTACCCGCTGATCGAGGGCCA
GGGCAATTTCGGCAATATCGATGGCGATAACGCCGCGGCGATGCGCTACACCGAAAGCCGGCTGACCGAGGTTGCCGCCG
CGTTGCTGGAGGGGATCGACGAGGACGCCGTCGATTTCCGCCCGACCTATGACAACGAGGATACCGAGCCCGTCGTCCTG
CCCGGCGCGTTTCCCAACCTGCTGGCCAATGGCGCGGCCGGCATCGCGGTCGGCATGGCGACGTCGATCCCGCCGCACAA
CGCGGCCGAGCTGTGCGCCGCCGCGATCCACCTGATCCGCCATCCCGAGGCCGACACCGCGGCCCTGCTCGATTTCGTGC
AGGGGCCGGATTTCCCGACCGGCGGCGAGCTGGTGGAGGACCGCGCGACCCTGCTCTCCGCCTACGAGACCGGCCGCGGC
TCGCTGCGCGTGCGGGCGCGCTGGAGCCGCAGCGATCTCAAGGGCGGGGCGTGGCAGATCGTGGTCACCGAAATTCCCTA
TCAGGTGCAGAAATCCCGGCTGATCGAGCAGGTCGCGCAGCTGATGGCGGAGCGCAAGCTGCCCTTGCTGGGCGATATCC
GCGACGAAAGCACCGAGCGCGTGCGCATCGTGCTCGAGCCGAAATCGCGCACCGTCGATCCGGACATGCTGATGGCGAGC
CTGTTTCGCGCCACCGCCTTCGAGCAGCGTTTCAGCATGAACATGAACGTGCTGGACGCCGACCGCACGCCGCGGGTGAT
GGGACTGCGGGAGATGCTGCGCGCCTGGCTCGATCACCGGCACGAGGTGCTGGAGCGGCGCTCGCGCCACCGCCTCGCCG
CGATCGCCCGCCGGCTGGAAATCCTCGAAGGCTATCTCGCGGTCTTTCTCAATCTCGACGAGGTGATCCGCATCATCCGC
ACCGAGGACGAGCCGAAACCCGCGCTCATCGCCGCCTTCACCCTGACCGACACCCAGGCCGAGGCGATCCTCAACATGCG
GCTGCGCAGCCTGCGCAAGCTCGAGGAGATGGAAATCCGCAAGGAGCACAAGGCGCTGACCGCCGAGCGTAAGGCGCTGG
ATGCGATGCTGGCCGACCCGGCCAAGCGCTGGGCGCGGATCGAGACCGAAATCGAGGCGACGGCGAAGACATTCGGCGGC
GGTCCGGGCGCGCGGCGCACCACGATCAGCGGTGCTGTGCCGGTGACCGAGGTGGCGGTCGAGGCGCTGGTGGAGCGCGA
ACCGCTCACCGTGATCCTGTCGGAAAAAGGGTGGATCCGCGCGCTCAAGGGCCATGCCGTGGCCGAGGCCGAGCTGAAGT
TCAAGGAAGGCGACCGGCTGAAGGCGCTGTTGCGCTGCTCCAGCCTCGACCGCGTGACGGTTTTCGCGACCAATGGACGC
GTCTACAGCCTGCGCGCCGCCGACCTGCCGCGCGGGCGCGGCGATGGCCAGGCGATCCGGCTGATGGTCGATCTCGGCAA
CGAGGACGAGGTGGCGGCGCTTTTCATCGCCGATCCCGAGGCGCGCTATCTCGTTGCCGGCACTGACGGACGGGGCTTCA
TCATCGCCGGTGCCGAGCTTGGCGCGGAAAAACGCACCGGCAAGCAGATCCTCACCGTCCGGCCGGGGCAGGAGGCAATG
CTGTGCCGGAAGGTCGCGGGGGACCACCTCGCGGTGATCGGGCAGAACCGCAAGCTGCTGGTCTTCCCGCTCGAGCAGGT
GCCGGAGATGGCGCGCGGTGCCGGCGTGATCCTGCAGAAATACAAGGATGGCGGGCTGGCCGACGCCAAGGCCTTTACCC
TTGCGTCCGGGCTGAGCTGGCGGCTGGGCGACAAGCAGCGGACGGAAACGCGGCTCGCCGAATGGCTCGGCGCGCGCGGC
CAGGCCGGAAGGCTGCCGCCGACGGGCTTCCCGCGGTCGGGCACGTTCGGCCCGCCGGACGATGACGCCGGCTGA

Upstream 100 bases:

>100_bases
TTCCTCGCCCGCGATGCGTTCGGCGCGCGCCATGCCCCGCTTCCCACGGCCCGGCTCGACCTCTATGACCGGCTGACCCG
CAGACTGAACGGAGACGACG

Downstream 100 bases:

>100_bases
TGCGCCCTCCCGGCTGACCGATCGTGCAGGGTTGCCGCTGACGGGCGGCAGCCTCGCGCTGAACTTCCGCGCCGTCTCCC
TGCTCGAGGGAATTCGTGCC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 744; Mature: 743

Protein sequence:

>744_residues
MPDDLLGNVQDTKLATALSERYLAYALSTIMARSLPDVRDGLKPVHRRLIFAMRQLRLDPGSGFKKCARVVGDVMGKFHP
HGDMSIYEALVRLAQDFASRYPLIEGQGNFGNIDGDNAAAMRYTESRLTEVAAALLEGIDEDAVDFRPTYDNEDTEPVVL
PGAFPNLLANGAAGIAVGMATSIPPHNAAELCAAAIHLIRHPEADTAALLDFVQGPDFPTGGELVEDRATLLSAYETGRG
SLRVRARWSRSDLKGGAWQIVVTEIPYQVQKSRLIEQVAQLMAERKLPLLGDIRDESTERVRIVLEPKSRTVDPDMLMAS
LFRATAFEQRFSMNMNVLDADRTPRVMGLREMLRAWLDHRHEVLERRSRHRLAAIARRLEILEGYLAVFLNLDEVIRIIR
TEDEPKPALIAAFTLTDTQAEAILNMRLRSLRKLEEMEIRKEHKALTAERKALDAMLADPAKRWARIETEIEATAKTFGG
GPGARRTTISGAVPVTEVAVEALVEREPLTVILSEKGWIRALKGHAVAEAELKFKEGDRLKALLRCSSLDRVTVFATNGR
VYSLRAADLPRGRGDGQAIRLMVDLGNEDEVAALFIADPEARYLVAGTDGRGFIIAGAELGAEKRTGKQILTVRPGQEAM
LCRKVAGDHLAVIGQNRKLLVFPLEQVPEMARGAGVILQKYKDGGLADAKAFTLASGLSWRLGDKQRTETRLAEWLGARG
QAGRLPPTGFPRSGTFGPPDDDAG

Sequences:

>Translated_744_residues
MPDDLLGNVQDTKLATALSERYLAYALSTIMARSLPDVRDGLKPVHRRLIFAMRQLRLDPGSGFKKCARVVGDVMGKFHP
HGDMSIYEALVRLAQDFASRYPLIEGQGNFGNIDGDNAAAMRYTESRLTEVAAALLEGIDEDAVDFRPTYDNEDTEPVVL
PGAFPNLLANGAAGIAVGMATSIPPHNAAELCAAAIHLIRHPEADTAALLDFVQGPDFPTGGELVEDRATLLSAYETGRG
SLRVRARWSRSDLKGGAWQIVVTEIPYQVQKSRLIEQVAQLMAERKLPLLGDIRDESTERVRIVLEPKSRTVDPDMLMAS
LFRATAFEQRFSMNMNVLDADRTPRVMGLREMLRAWLDHRHEVLERRSRHRLAAIARRLEILEGYLAVFLNLDEVIRIIR
TEDEPKPALIAAFTLTDTQAEAILNMRLRSLRKLEEMEIRKEHKALTAERKALDAMLADPAKRWARIETEIEATAKTFGG
GPGARRTTISGAVPVTEVAVEALVEREPLTVILSEKGWIRALKGHAVAEAELKFKEGDRLKALLRCSSLDRVTVFATNGR
VYSLRAADLPRGRGDGQAIRLMVDLGNEDEVAALFIADPEARYLVAGTDGRGFIIAGAELGAEKRTGKQILTVRPGQEAM
LCRKVAGDHLAVIGQNRKLLVFPLEQVPEMARGAGVILQKYKDGGLADAKAFTLASGLSWRLGDKQRTETRLAEWLGARG
QAGRLPPTGFPRSGTFGPPDDDAG
>Mature_743_residues
PDDLLGNVQDTKLATALSERYLAYALSTIMARSLPDVRDGLKPVHRRLIFAMRQLRLDPGSGFKKCARVVGDVMGKFHPH
GDMSIYEALVRLAQDFASRYPLIEGQGNFGNIDGDNAAAMRYTESRLTEVAAALLEGIDEDAVDFRPTYDNEDTEPVVLP
GAFPNLLANGAAGIAVGMATSIPPHNAAELCAAAIHLIRHPEADTAALLDFVQGPDFPTGGELVEDRATLLSAYETGRGS
LRVRARWSRSDLKGGAWQIVVTEIPYQVQKSRLIEQVAQLMAERKLPLLGDIRDESTERVRIVLEPKSRTVDPDMLMASL
FRATAFEQRFSMNMNVLDADRTPRVMGLREMLRAWLDHRHEVLERRSRHRLAAIARRLEILEGYLAVFLNLDEVIRIIRT
EDEPKPALIAAFTLTDTQAEAILNMRLRSLRKLEEMEIRKEHKALTAERKALDAMLADPAKRWARIETEIEATAKTFGGG
PGARRTTISGAVPVTEVAVEALVEREPLTVILSEKGWIRALKGHAVAEAELKFKEGDRLKALLRCSSLDRVTVFATNGRV
YSLRAADLPRGRGDGQAIRLMVDLGNEDEVAALFIADPEARYLVAGTDGRGFIIAGAELGAEKRTGKQILTVRPGQEAML
CRKVAGDHLAVIGQNRKLLVFPLEQVPEMARGAGVILQKYKDGGLADAKAFTLASGLSWRLGDKQRTETRLAEWLGARGQ
AGRLPPTGFPRSGTFGPPDDDAG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=290, Percent_Identity=27.5862068965517, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI19913408, Length=165, Percent_Identity=32.7272727272727, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1789396, Length=715, Percent_Identity=40.5594405594406, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI1788562, Length=645, Percent_Identity=37.0542635658915, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535065, Length=462, Percent_Identity=24.2424242424242, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=330, Percent_Identity=24.5454545454545, Blast_Score=70, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=352, Percent_Identity=23.2954545454545, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136538, Length=177, Percent_Identity=31.0734463276836, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 81813; Mature: 81682

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDDLLGNVQDTKLATALSERYLAYALSTIMARSLPDVRDGLKPVHRRLIFAMRQLRLDP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
GSGFKKCARVVGDVMGKFHPHGDMSIYEALVRLAQDFASRYPLIEGQGNFGNIDGDNAAA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCHH
MRYTESRLTEVAAALLEGIDEDAVDFRPTYDNEDTEPVVLPGAFPNLLANGAAGIAVGMA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHCCCCCEEEEEE
TSIPPHNAAELCAAAIHLIRHPEADTAALLDFVQGPDFPTGGELVEDRATLLSAYETGRG
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
SLRVRARWSRSDLKGGAWQIVVTEIPYQVQKSRLIEQVAQLMAERKLPLLGDIRDESTER
CEEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
VRIVLEPKSRTVDPDMLMASLFRATAFEQRFSMNMNVLDADRTPRVMGLREMLRAWLDHR
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHH
HEVLERRSRHRLAAIARRLEILEGYLAVFLNLDEVIRIIRTEDEPKPALIAAFTLTDTQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEEEEEECCHHH
EAILNMRLRSLRKLEEMEIRKEHKALTAERKALDAMLADPAKRWARIETEIEATAKTFGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPGARRTTISGAVPVTEVAVEALVEREPLTVILSEKGWIRALKGHAVAEAELKFKEGDRL
CCCCCCEEECCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCEEEEEEEEECCCHHH
KALLRCSSLDRVTVFATNGRVYSLRAADLPRGRGDGQAIRLMVDLGNEDEVAALFIADPE
HHHHHHCCCCEEEEEEECCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCC
ARYLVAGTDGRGFIIAGAELGAEKRTGKQILTVRPGQEAMLCRKVAGDHLAVIGQNRKLL
CCEEEEECCCCEEEEECHHCCCCCCCCCEEEEECCCHHHHHHHHHCCCEEEEEECCCEEE
VFPLEQVPEMARGAGVILQKYKDGGLADAKAFTLASGLSWRLGDKQRTETRLAEWLGARG
EECHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
QAGRLPPTGFPRSGTFGPPDDDAG
CCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PDDLLGNVQDTKLATALSERYLAYALSTIMARSLPDVRDGLKPVHRRLIFAMRQLRLDP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
GSGFKKCARVVGDVMGKFHPHGDMSIYEALVRLAQDFASRYPLIEGQGNFGNIDGDNAAA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCHH
MRYTESRLTEVAAALLEGIDEDAVDFRPTYDNEDTEPVVLPGAFPNLLANGAAGIAVGMA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHCCCCCEEEEEE
TSIPPHNAAELCAAAIHLIRHPEADTAALLDFVQGPDFPTGGELVEDRATLLSAYETGRG
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
SLRVRARWSRSDLKGGAWQIVVTEIPYQVQKSRLIEQVAQLMAERKLPLLGDIRDESTER
CEEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
VRIVLEPKSRTVDPDMLMASLFRATAFEQRFSMNMNVLDADRTPRVMGLREMLRAWLDHR
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHH
HEVLERRSRHRLAAIARRLEILEGYLAVFLNLDEVIRIIRTEDEPKPALIAAFTLTDTQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEEEEEECCHHH
EAILNMRLRSLRKLEEMEIRKEHKALTAERKALDAMLADPAKRWARIETEIEATAKTFGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPGARRTTISGAVPVTEVAVEALVEREPLTVILSEKGWIRALKGHAVAEAELKFKEGDRL
CCCCCCEEECCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCEEEEEEEEECCCHHH
KALLRCSSLDRVTVFATNGRVYSLRAADLPRGRGDGQAIRLMVDLGNEDEVAALFIADPE
HHHHHHCCCCEEEEEEECCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCC
ARYLVAGTDGRGFIIAGAELGAEKRTGKQILTVRPGQEAMLCRKVAGDHLAVIGQNRKLL
CCEEEEECCCCEEEEECHHCCCCCCCCCEEEEECCCHHHHHHHHHCCCEEEEEECCCEEE
VFPLEQVPEMARGAGVILQKYKDGGLADAKAFTLASGLSWRLGDKQRTETRLAEWLGARG
EECHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
QAGRLPPTGFPRSGTFGPPDDDAG
CCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]