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The map label for this gene is cyaA [H]

Identifier: 148260102

GI number: 148260102

Start: 1218675

End: 1220744

Strand: Reverse

Name: cyaA [H]

Synonym: Acry_1095

Alternate gene names: 148260102

Gene position: 1220744-1218675 (Counterclockwise)

Preceding gene: 148260103

Following gene: 148260101

Centisome position: 36.02

GC content: 65.07

Gene sequence:

>2070_bases
GTGCTCGTTCATCTTCAAGGTCCATGGTCGCCGCTGCTCGGGCGCCTGACTCTGAGTGCCATCCCCTACACGAGCCCGAT
CGTCGACGGCGCCTTCGTCTTCGCCGCCGGCGCGGCCGTCATCGTCATCGCCGCCATCACCCTCTCCGGCCGCTGGGGCT
ATCTCTTCCGCGAATGGCTGACGACGCTCGATCACAAGAAGATCGGCGTGATGTATGTCATCGTCGGCCTCGTGATGATG
TTCCGCGGCTTCATCGACGGGCTGATGATCCGCACCCAGCAGATGATGGCGGACGGTCCGCATTCGCCCGGCCACCTGCA
GGCCCTGCACGGCTACCTCCCGCCCTTCCATTTCGACCAGATCTACAGCTCGCACGGCGTGATCATGATCCTGCTCGCCG
TCACCCCGCTGCTCACCGGCCTGTCGAACATCATCGTCCCGCTGCAGATCGGCGCGCGCGACATGGCGTTTCCCTACCTC
AACGCCGTCGGCCTCTGGCTCACCGCCGTCGCCGCGGCGCTGGTGATGCTCTCGCTCTTCGTCGGCGACTTCTCGCATGA
CGGCTGGATCGGCCTGATCCCGCTCACCGAACTGCCCTACAGTCCCGGCGTCGGCGTCGATTACTGGATGTGGGCGATCC
AGATCGGCAGCGTCGGCACCACGCTCAACGCGATCAACATGATCGCGACGATCGTGAAACTCCGCGCTCCGGGCATGACC
TGGTCGCGGTTGCCCTTCGTGGTCTGGACCTCGCTGACGACCAACATCATCGCGCTGACGGCCTTTCCCATCCTCGGCGT
CGCCCTGGCGATGCTCGGCGCCGACCGCTATCTCGGCACCCACTTCTTCACCGCCGGGCTCGGCGGCAATCTGATGCTCT
ACACCAACCTGTTCTGGATCTGGGGGCATCCGGAAGTCTATTTCGTCGTCCTGCCGGCCTTCGGCTTCATCTCCGAAATC
ATCCCCACCTTCGCCGAAAAGCCGCTCTTCGGCTACGCGACGATGGTCATCGCCACCTTCGCCATCGGCGGCATTTCCTG
GGGCGTCTGGCTGCACCATTTCTTCACCATGGGCGCCGGGCCGGGGATCAACATCTTCTTCAGCACCGCCACCATGCTCG
TCGGCATCCCGACCGGCGTGAAGGTGTTCAACTGGGCGCTGACGCTCTGGCGCGGCCGCCTGCGCTTCGAGCCGCCGATG
CTCTGGGCGCTGGGTGCCTTGTTCCTGCTCCTGGTCGGCGGCCTCACCGGCATGATGCTGGCCATCCCCGCCATCAACTA
CACGGTGCATAACAGCGTGTTTGTGGTGGCGCATTTCCACTGCATGATGCTGCTGATCGCCTACGCGATCTTCGGCGCCA
TCATCTTCTGGTTTCCCAAGCTCTTCGGCTTCCATCTCGACGCCCCCTCGGCGCGCGCGAATTTCTGGTCCTTCTCGGTG
GGCACCGTGCTGGTCTTCGGCGCCATGTTCGCCCTCGGCCTGATGGGCATGACCCGCCGGCTCGACTATCTCTCCAACCC
CGGCTACGAGCCGCTGCTGATCGTCGAGGAAATCGGCATCTTCTTCTACTGCGTCTCGGTCTACTACTTCGCGAAGATGA
TCTGGGTGAGCATCCGCGACCGCGCGCGCAACCGCGCCGGCGCCGATTGCTGGACCACCGGCCGCACGCTCGAATGGCTC
ACCCGCACCCCGGTGCCCTTCTACAACTACGCCGTCATTCCCGTCGTGAACGAGCGCGACGAGCTGGCCTGGCGGCGCGA
GCGCGGGGTCGAGTCCGTGCAGCCCGACATCACGGCGGACATCCATTTGCCGAAGAACACGGTGGCGCCGCTGCTGATCG
GCGCGCTGTCCATGGGCTTCGGCTTCGGCATGGTCTGGCGGATCTGGTGGCTCGCCGGCCTCTCCCTGCTCGGGATCATC
GCGGTCGTCATCGCCCGCTCCTTCGTGCGGCAGACCGAGTTCGTGCTCACCGCCGAGGAGTTGCGCCGGCACGAGGCCGG
GCAGCACCTGTCCGACATTTCGGCCGACCATATCAGCCCGCCGGTCGCCGAGCTGGAGCTGTTCTCATGA

Upstream 100 bases:

>100_bases
GCGATGGCGCGGGACCTGCGCGCCGGGGCCAGCTATTTCTCTCATCCGGCCGCGTCGCGCGGAACATCCGGCTGACGCCG
GCAGCGGAAAGGAAGACTGC

Downstream 100 bases:

>100_bases
GCGAAACGGATCTCACCCTCTGGGTGCGCGGCGAGCCCCCCGCGCACGATGCGATCGGCACGCAGACCTACGGTTTCTGG
CTCTACATGATGAGCGACGC

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome A1 subunit 1; Oxidase BA(3) subunit 1; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 689; Mature: 689

Protein sequence:

>689_residues
MLVHLQGPWSPLLGRLTLSAIPYTSPIVDGAFVFAAGAAVIVIAAITLSGRWGYLFREWLTTLDHKKIGVMYVIVGLVMM
FRGFIDGLMIRTQQMMADGPHSPGHLQALHGYLPPFHFDQIYSSHGVIMILLAVTPLLTGLSNIIVPLQIGARDMAFPYL
NAVGLWLTAVAAALVMLSLFVGDFSHDGWIGLIPLTELPYSPGVGVDYWMWAIQIGSVGTTLNAINMIATIVKLRAPGMT
WSRLPFVVWTSLTTNIIALTAFPILGVALAMLGADRYLGTHFFTAGLGGNLMLYTNLFWIWGHPEVYFVVLPAFGFISEI
IPTFAEKPLFGYATMVIATFAIGGISWGVWLHHFFTMGAGPGINIFFSTATMLVGIPTGVKVFNWALTLWRGRLRFEPPM
LWALGALFLLLVGGLTGMMLAIPAINYTVHNSVFVVAHFHCMMLLIAYAIFGAIIFWFPKLFGFHLDAPSARANFWSFSV
GTVLVFGAMFALGLMGMTRRLDYLSNPGYEPLLIVEEIGIFFYCVSVYYFAKMIWVSIRDRARNRAGADCWTTGRTLEWL
TRTPVPFYNYAVIPVVNERDELAWRRERGVESVQPDITADIHLPKNTVAPLLIGALSMGFGFGMVWRIWWLAGLSLLGII
AVVIARSFVRQTEFVLTAEELRRHEAGQHLSDISADHISPPVAELELFS

Sequences:

>Translated_689_residues
MLVHLQGPWSPLLGRLTLSAIPYTSPIVDGAFVFAAGAAVIVIAAITLSGRWGYLFREWLTTLDHKKIGVMYVIVGLVMM
FRGFIDGLMIRTQQMMADGPHSPGHLQALHGYLPPFHFDQIYSSHGVIMILLAVTPLLTGLSNIIVPLQIGARDMAFPYL
NAVGLWLTAVAAALVMLSLFVGDFSHDGWIGLIPLTELPYSPGVGVDYWMWAIQIGSVGTTLNAINMIATIVKLRAPGMT
WSRLPFVVWTSLTTNIIALTAFPILGVALAMLGADRYLGTHFFTAGLGGNLMLYTNLFWIWGHPEVYFVVLPAFGFISEI
IPTFAEKPLFGYATMVIATFAIGGISWGVWLHHFFTMGAGPGINIFFSTATMLVGIPTGVKVFNWALTLWRGRLRFEPPM
LWALGALFLLLVGGLTGMMLAIPAINYTVHNSVFVVAHFHCMMLLIAYAIFGAIIFWFPKLFGFHLDAPSARANFWSFSV
GTVLVFGAMFALGLMGMTRRLDYLSNPGYEPLLIVEEIGIFFYCVSVYYFAKMIWVSIRDRARNRAGADCWTTGRTLEWL
TRTPVPFYNYAVIPVVNERDELAWRRERGVESVQPDITADIHLPKNTVAPLLIGALSMGFGFGMVWRIWWLAGLSLLGII
AVVIARSFVRQTEFVLTAEELRRHEAGQHLSDISADHISPPVAELELFS
>Mature_689_residues
MLVHLQGPWSPLLGRLTLSAIPYTSPIVDGAFVFAAGAAVIVIAAITLSGRWGYLFREWLTTLDHKKIGVMYVIVGLVMM
FRGFIDGLMIRTQQMMADGPHSPGHLQALHGYLPPFHFDQIYSSHGVIMILLAVTPLLTGLSNIIVPLQIGARDMAFPYL
NAVGLWLTAVAAALVMLSLFVGDFSHDGWIGLIPLTELPYSPGVGVDYWMWAIQIGSVGTTLNAINMIATIVKLRAPGMT
WSRLPFVVWTSLTTNIIALTAFPILGVALAMLGADRYLGTHFFTAGLGGNLMLYTNLFWIWGHPEVYFVVLPAFGFISEI
IPTFAEKPLFGYATMVIATFAIGGISWGVWLHHFFTMGAGPGINIFFSTATMLVGIPTGVKVFNWALTLWRGRLRFEPPM
LWALGALFLLLVGGLTGMMLAIPAINYTVHNSVFVVAHFHCMMLLIAYAIFGAIIFWFPKLFGFHLDAPSARANFWSFSV
GTVLVFGAMFALGLMGMTRRLDYLSNPGYEPLLIVEEIGIFFYCVSVYYFAKMIWVSIRDRARNRAGADCWTTGRTLEWL
TRTPVPFYNYAVIPVVNERDELAWRRERGVESVQPDITADIHLPKNTVAPLLIGALSMGFGFGMVWRIWWLAGLSLLGII
AVVIARSFVRQTEFVLTAEELRRHEAGQHLSDISADHISPPVAELELFS

Specific function: Catalytic subunit of the enzyme. Electrons originating in a quinol are transferred to the bimetallic center formed by heme a and copper B [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=519, Percent_Identity=36.8015414258189, Blast_Score=278, Evalue=2e-74,
Organism=Escherichia coli, GI1786634, Length=666, Percent_Identity=45.4954954954955, Blast_Score=627, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=515, Percent_Identity=32.2330097087379, Blast_Score=275, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6226524, Length=335, Percent_Identity=34.9253731343284, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6226523, Length=261, Percent_Identity=29.5019157088123, Blast_Score=106, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 76282; Mature: 76282

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVHLQGPWSPLLGRLTLSAIPYTSPIVDGAFVFAAGAAVIVIAAITLSGRWGYLFREWL
CEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
TTLDHKKIGVMYVIVGLVMMFRGFIDGLMIRTQQMMADGPHSPGHLQALHGYLPPFHFDQ
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHH
IYSSHGVIMILLAVTPLLTGLSNIIVPLQIGARDMAFPYLNAVGLWLTAVAAALVMLSLF
HHCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGDFSHDGWIGLIPLTELPYSPGVGVDYWMWAIQIGSVGTTLNAINMIATIVKLRAPGMT
HHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHEEECCCCHHHHHHHHHHHHHHHCCCCCC
WSRLPFVVWTSLTTNIIALTAFPILGVALAMLGADRYLGTHFFTAGLGGNLMLYTNLFWI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCEEEEEEEEEE
WGHPEVYFVVLPAFGFISEIIPTFAEKPLFGYATMVIATFAIGGISWGVWLHHFFTMGAG
ECCCEEEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGINIFFSTATMLVGIPTGVKVFNWALTLWRGRLRFEPPMLWALGALFLLLVGGLTGMML
CCCEEEEEHHHHEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AIPAINYTVHNSVFVVAHFHCMMLLIAYAIFGAIIFWFPKLFGFHLDAPSARANFWSFSV
HHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHH
GTVLVFGAMFALGLMGMTRRLDYLSNPGYEPLLIVEEIGIFFYCVSVYYFAKMIWVSIRD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
RARNRAGADCWTTGRTLEWLTRTPVPFYNYAVIPVVNERDELAWRRERGVESVQPDITAD
HHCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCEEE
IHLPKNTVAPLLIGALSMGFGFGMVWRIWWLAGLSLLGIIAVVIARSFVRQTEFVLTAEE
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHH
LRRHEAGQHLSDISADHISPPVAELELFS
HHHHHHCCHHHHCCHHHCCCCHHHHEECC
>Mature Secondary Structure
MLVHLQGPWSPLLGRLTLSAIPYTSPIVDGAFVFAAGAAVIVIAAITLSGRWGYLFREWL
CEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
TTLDHKKIGVMYVIVGLVMMFRGFIDGLMIRTQQMMADGPHSPGHLQALHGYLPPFHFDQ
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHH
IYSSHGVIMILLAVTPLLTGLSNIIVPLQIGARDMAFPYLNAVGLWLTAVAAALVMLSLF
HHCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGDFSHDGWIGLIPLTELPYSPGVGVDYWMWAIQIGSVGTTLNAINMIATIVKLRAPGMT
HHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHEEECCCCHHHHHHHHHHHHHHHCCCCCC
WSRLPFVVWTSLTTNIIALTAFPILGVALAMLGADRYLGTHFFTAGLGGNLMLYTNLFWI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCEEEEEEEEEE
WGHPEVYFVVLPAFGFISEIIPTFAEKPLFGYATMVIATFAIGGISWGVWLHHFFTMGAG
ECCCEEEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGINIFFSTATMLVGIPTGVKVFNWALTLWRGRLRFEPPMLWALGALFLLLVGGLTGMML
CCCEEEEEHHHHEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AIPAINYTVHNSVFVVAHFHCMMLLIAYAIFGAIIFWFPKLFGFHLDAPSARANFWSFSV
HHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHH
GTVLVFGAMFALGLMGMTRRLDYLSNPGYEPLLIVEEIGIFFYCVSVYYFAKMIWVSIRD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
RARNRAGADCWTTGRTLEWLTRTPVPFYNYAVIPVVNERDELAWRRERGVESVQPDITAD
HHCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCEEE
IHLPKNTVAPLLIGALSMGFGFGMVWRIWWLAGLSLLGIIAVVIARSFVRQTEFVLTAEE
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHH
LRRHEAGQHLSDISADHISPPVAELELFS
HHHHHHCCHHHHCCHHHCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8392509 [H]