Click here to switch to the map view.

The map label for this gene is ydgK [H]

Identifier: 148259859

GI number: 148259859

Start: 936273

End: 937487

Strand: Reverse

Name: ydgK [H]

Synonym: Acry_0848

Alternate gene names: 148259859

Gene position: 937487-936273 (Counterclockwise)

Preceding gene: 148259860

Following gene: 148259858

Centisome position: 27.66

GC content: 72.02

Gene sequence:

>1215_bases
ATGTCATCCGCACAAAGCGCCGTTGCCGCCGATGCGCCGGATCTGGCGACCAGCCGGCGCCTGCCGCTGCTGCTCGGATT
CCTGATCGCGATCGGGCCGGTATCGGTCGACATGTATCTTCCCGCCTTCCCGACCATCGCGCGGCAGTTCCACGACCCGG
CCGGGCCGGGGCTGACGCTCGCGGCGTATTTCGCCGGGCTCGCCGCGGGGCAGATGACGCAGGGGCCGTTCTCGGACCGG
GCCGGGCGGCGGTTGCCGATCCTGCTCGGGCTCGCGCTCTACACCCTCGCCTCGATCGGTTGCGCGCTGGCGTGGAACAC
GGCCTCGCTCTCGGCGTTCCGGCTGGTGGCCGCCTTCGGCGGTTCGGCCGCGGTGGTGGTGCCGCGGGCGATGGTGCGCG
ACATCGCCGACGGGCCGGCGGCGGCGCTGCTGTTCTCGCGGCTGATGCTGGTGATGGGCGTGGCGCCGATCATCGCCCCC
ATTCTCGGCAGCGCGGTGATCGCGTTCGGCTCGTGGCGGTGGATTTTCGCGCTGGCGACGCTCTACGGGATCGTCGCGAT
CGGGCTGGTGTGGTTCCGGCTGCCGGACACGCTGCCGCTCGCGCGGCGCAGCACGGTGGGGTTCCGCACCATCATCATCC
GCTACGGGCAGATTTCCGCCGAGCGCGGCTTCCTGACCCATGCGCTGACCGGCACCTTCGCGATCGGCGCGCTGTTCGCC
TATCTCGCCGGCACGCCGGCCGTGTTCATCGGCGAGTTCCACTGGGACCCGATTTCCTATGCGCTGCTGTTCGGGCTGAA
CGCGGCGATCTATATCGGGTTCAACCAGTGGAACCCGCATCTCGTGGCGCGGGCGGGGCTGCGGCCGGTGATTTCCGCCG
CGGTCGCGGCGCTGGTGTGCGGCACGATCGTGCTGGTGGCGGCGGCGCTGCGCGGCGGCGGGCCGCTGCCGATCATCGCC
GGCCTGTTCATCTGCCAGGCGAGCTACGGGCTCAGCCTGCCGAGCTCGCTGGTCGCCGCCCTCTCGCGGCACCAGGCGCA
TGCGGGCTCGGCCTCGGCCCTGCTCGGCACCTGGCAGTATCTCGGCGGGGCGATCACCGGCGCGCTGGTCGGCGCCTTCG
CCGACGGCACCGCCCGGCCGATGGCCTTCGCCATGTTCGCCTGCGCGGTGCTCGCCGCACTCGCCGCCGCCTTCCGACCC
CAACGCCTGACCTGA

Upstream 100 bases:

>100_bases
TGCCCCCTGCGCGGGGCGGGCTGATCCAGATCGCCGGCGCCCGGCAGGATTGCGCCGGCGGGGCGTTTGCCGGGATTCGC
GGCCGGGTTATGGTGAGGCA

Downstream 100 bases:

>100_bases
CACGCCCCTGACGAGGACAACATGCCCAGCATCATCGGCATTCCCGCCTGCACCAAGTTCATCGGCAACCACCACCAGCA
CGCCACCCCGGCGCGCTACG

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSSAQSAVAADAPDLATSRRLPLLLGFLIAIGPVSVDMYLPAFPTIARQFHDPAGPGLTLAAYFAGLAAGQMTQGPFSDR
AGRRLPILLGLALYTLASIGCALAWNTASLSAFRLVAAFGGSAAVVVPRAMVRDIADGPAAALLFSRLMLVMGVAPIIAP
ILGSAVIAFGSWRWIFALATLYGIVAIGLVWFRLPDTLPLARRSTVGFRTIIIRYGQISAERGFLTHALTGTFAIGALFA
YLAGTPAVFIGEFHWDPISYALLFGLNAAIYIGFNQWNPHLVARAGLRPVISAAVAALVCGTIVLVAAALRGGGPLPIIA
GLFICQASYGLSLPSSLVAALSRHQAHAGSASALLGTWQYLGGAITGALVGAFADGTARPMAFAMFACAVLAALAAAFRP
QRLT

Sequences:

>Translated_404_residues
MSSAQSAVAADAPDLATSRRLPLLLGFLIAIGPVSVDMYLPAFPTIARQFHDPAGPGLTLAAYFAGLAAGQMTQGPFSDR
AGRRLPILLGLALYTLASIGCALAWNTASLSAFRLVAAFGGSAAVVVPRAMVRDIADGPAAALLFSRLMLVMGVAPIIAP
ILGSAVIAFGSWRWIFALATLYGIVAIGLVWFRLPDTLPLARRSTVGFRTIIIRYGQISAERGFLTHALTGTFAIGALFA
YLAGTPAVFIGEFHWDPISYALLFGLNAAIYIGFNQWNPHLVARAGLRPVISAAVAALVCGTIVLVAAALRGGGPLPIIA
GLFICQASYGLSLPSSLVAALSRHQAHAGSASALLGTWQYLGGAITGALVGAFADGTARPMAFAMFACAVLAALAAAFRP
QRLT
>Mature_403_residues
SSAQSAVAADAPDLATSRRLPLLLGFLIAIGPVSVDMYLPAFPTIARQFHDPAGPGLTLAAYFAGLAAGQMTQGPFSDRA
GRRLPILLGLALYTLASIGCALAWNTASLSAFRLVAAFGGSAAVVVPRAMVRDIADGPAAALLFSRLMLVMGVAPIIAPI
LGSAVIAFGSWRWIFALATLYGIVAIGLVWFRLPDTLPLARRSTVGFRTIIIRYGQISAERGFLTHALTGTFAIGALFAY
LAGTPAVFIGEFHWDPISYALLFGLNAAIYIGFNQWNPHLVARAGLRPVISAAVAALVCGTIVLVAAALRGGGPLPIIAG
LFICQASYGLSLPSSLVAALSRHQAHAGSASALLGTWQYLGGAITGALVGAFADGTARPMAFAMFACAVLAALAAAFRPQ
RLT

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=390, Percent_Identity=30.7692307692308, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI48994889, Length=241, Percent_Identity=32.3651452282158, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1790146, Length=375, Percent_Identity=24.5333333333333, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1790794, Length=238, Percent_Identity=25.2100840336134, Blast_Score=68, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319657, Length=169, Percent_Identity=27.810650887574, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41805; Mature: 41674

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAQSAVAADAPDLATSRRLPLLLGFLIAIGPVSVDMYLPAFPTIARQFHDPAGPGLTL
CCCCHHHHHCCCCCHHHCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCHHH
AAYFAGLAAGQMTQGPFSDRAGRRLPILLGLALYTLASIGCALAWNTASLSAFRLVAAFG
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHC
GSAAVVVPRAMVRDIADGPAAALLFSRLMLVMGVAPIIAPILGSAVIAFGSWRWIFALAT
CCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LYGIVAIGLVWFRLPDTLPLARRSTVGFRTIIIRYGQISAERGFLTHALTGTFAIGALFA
HHHHHHHHHHHHHCCCCCCCHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
YLAGTPAVFIGEFHWDPISYALLFGLNAAIYIGFNQWNPHLVARAGLRPVISAAVAALVC
HHHCCCEEEEEEECCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHCHHHHHHHHHHHHHH
GTIVLVAAALRGGGPLPIIAGLFICQASYGLSLPSSLVAALSRHQAHAGSASALLGTWQY
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LGGAITGALVGAFADGTARPMAFAMFACAVLAALAAAFRPQRLT
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SSAQSAVAADAPDLATSRRLPLLLGFLIAIGPVSVDMYLPAFPTIARQFHDPAGPGLTL
CCCHHHHHCCCCCHHHCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCHHH
AAYFAGLAAGQMTQGPFSDRAGRRLPILLGLALYTLASIGCALAWNTASLSAFRLVAAFG
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHC
GSAAVVVPRAMVRDIADGPAAALLFSRLMLVMGVAPIIAPILGSAVIAFGSWRWIFALAT
CCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LYGIVAIGLVWFRLPDTLPLARRSTVGFRTIIIRYGQISAERGFLTHALTGTFAIGALFA
HHHHHHHHHHHHHCCCCCCCHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
YLAGTPAVFIGEFHWDPISYALLFGLNAAIYIGFNQWNPHLVARAGLRPVISAAVAALVC
HHHCCCEEEEEEECCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHCHHHHHHHHHHHHHH
GTIVLVAAALRGGGPLPIIAGLFICQASYGLSLPSSLVAALSRHQAHAGSASALLGTWQY
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LGGAITGALVGAFADGTARPMAFAMFACAVLAALAAAFRPQRLT
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]