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The map label for this gene is mutL

Identifier: 148259642

GI number: 148259642

Start: 708635

End: 710383

Strand: Reverse

Name: mutL

Synonym: Acry_0628

Alternate gene names: 148259642

Gene position: 710383-708635 (Counterclockwise)

Preceding gene: 148259644

Following gene: 148259632

Centisome position: 20.96

GC content: 74.16

Gene sequence:

>1749_bases
ATGCCGATCCGCCGCCTAGACCCGACCACGATCAACCGGATTGCCGCCGGCGAGGTCATCGAACGGCCGGCCGCCGCGGT
CAAGGAACTGGTCGAGAACGCGCTCGATGCCGGGGCGCGGCGGATCGGGGTGACGATCGAGGGCGGCGGGATCGGCCGGA
TCGAGGTGACCGATGACGGTCACGGGATTCCCGAGGCCGAACTGCCGCTGGCGATCGAACGGCACGCCACGTCGAAACTG
ACCGACGAGGCGCTGGTCCGGATCGCCACGCTGGGGTTCCGGGGCGAGGCGTTGCCGTCGATCGGGGCGGCCGGACGGCT
GACCGTAACGTCCCGCCCGGCGGGGCAGGATTCGGCGGCCAGGATCGTGGTCGATGGCGGGGCCGTCCGCGAGGTCGAGC
CGGTGGCCGGGCCGGTCGGGACCTGCGTGACCGTCGAGGACCTGTTCCACGCGACGCCGGCGCGGCGCAAATTCCTGCGC
AGTGCCGGTTCGGAGGCGGGGTCCTGCGCCGATGCGGTCCGGCACCTGGCGCTGGCGGCGCCTGCGGTGGGGTTTTCGCT
GACGATCGACGGGGCGGCGAGTTTCGACCTGCCGCCGCAGGACCGGCGGGAGCGGGTGGCGGCGATCTATGGGCGGGCGG
ATGCGGAGAAGCTGCTGGAGATCGAGGCGGTTCGCGAAGAGGTGGCGCTGCGGGGGTTCATCTCGCCGGCGAGCCTGACG
CGGGCGGCGGCGCGGCACCAGCACATGGTGGTGAACGGGCGGCCGGTGCGGGACCCGCTGCTGCGGATGGCGCTGCGGCT
CGCGTATCGGGAGCGGATTCCGGCGGGGCGGCATCCGCTGGCGGCGCTGTGGCTGGAGATTCCGGCGGAGATGCTGGATG
TGAACGTGCATCCGGCGAAGGCGGAGCTGCGGTTCGCGACGCCGGACGCGGTGCGGTCGCTGATGATCGGGGCGGTGCAG
CGGGCGCTGGCGACGCCGGCAGACCTGGCGGCGGCCCCCTCGGTGTCGATGCCGCGGACGAGCTGGGCGGCTTCCTCGCC
GATGCCGCGGTATCCGCAGGCGGAGAGCCGGGCGGCGCGGGGGTTCGCGGAGGCGGAGTTGCGCGGGCTGGATTTGCCGC
CGGCGCGGGTGGCGCCGGAGGTTCTGCCCGAATCGCGGCCGGACTATCCGCTGGGGACGCCGATCGCGCAGGTGTTCGAC
ACGTATATTCTCGCGCAGAGCGGGGACGGGACGCTGGTGCTGGTGGACCAGCACGCGGCGCATGAGCGGCTGACCGAGAT
CAGGCTGCGGGCGGAGCGGGATTCGGGGGCGATTCCGGCGCAGGCGCTGCTGGCGCCTTCGGTGGTGGAGCTGCCGGCGG
AGGATATCGCGCGGCTGCTGGGGGCGGCGGAGCGGCTGGCGGGGCTGGGGCTGGAGATCGAGGCGTTCGGGCCGGGGGCG
GTGCTGGTGCGGGCGGTGCCGGCCGCGCTGGCCAAGGCCGACCCGGCCGCGCTGGCGCGGGATGTGGCGGACACGCTGGC
GGAGAGCGGGACGGCGATGGCGCTGGAAGCGAAGCTGGACGCGGTGCTGATCCGCATGGCGTGCCACCGTTCGGTGCGGG
CGGGGCGGCGGCTGGCGTTCGCCGAGATGGAGGCGCTGTTGCGGGCGATGGAGACGACCCCCCTCGCCCAGACCTGCCCG
CACGGGCGGCCCACGGTGCTGCGGCTGAGCCGGGGCGATCTGGAACGGATGTTCGGCCGGGCCGGCTGA

Upstream 100 bases:

>100_bases
CGCAGGACCGGATTGATCAGGTGGGCTGCGAGGCTGGCCATGGGTCTGTGTCGGGCTCCGGGTGCATGGCGGAAGAGGCT
TGTTGCTGTAAGATGGGGCC

Downstream 100 bases:

>100_bases
GACCATCCAGATCGTTCTTCCCGAACGGCCCGCACCCGCTGAAAACGTGGCTTTGTCCGGTAGCTGTCTGGTTGCTACGA
GGCCCAAGCCCACGGTTCAT

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 582; Mature: 581

Protein sequence:

>582_residues
MPIRRLDPTTINRIAAGEVIERPAAAVKELVENALDAGARRIGVTIEGGGIGRIEVTDDGHGIPEAELPLAIERHATSKL
TDEALVRIATLGFRGEALPSIGAAGRLTVTSRPAGQDSAARIVVDGGAVREVEPVAGPVGTCVTVEDLFHATPARRKFLR
SAGSEAGSCADAVRHLALAAPAVGFSLTIDGAASFDLPPQDRRERVAAIYGRADAEKLLEIEAVREEVALRGFISPASLT
RAAARHQHMVVNGRPVRDPLLRMALRLAYRERIPAGRHPLAALWLEIPAEMLDVNVHPAKAELRFATPDAVRSLMIGAVQ
RALATPADLAAAPSVSMPRTSWAASSPMPRYPQAESRAARGFAEAELRGLDLPPARVAPEVLPESRPDYPLGTPIAQVFD
TYILAQSGDGTLVLVDQHAAHERLTEIRLRAERDSGAIPAQALLAPSVVELPAEDIARLLGAAERLAGLGLEIEAFGPGA
VLVRAVPAALAKADPAALARDVADTLAESGTAMALEAKLDAVLIRMACHRSVRAGRRLAFAEMEALLRAMETTPLAQTCP
HGRPTVLRLSRGDLERMFGRAG

Sequences:

>Translated_582_residues
MPIRRLDPTTINRIAAGEVIERPAAAVKELVENALDAGARRIGVTIEGGGIGRIEVTDDGHGIPEAELPLAIERHATSKL
TDEALVRIATLGFRGEALPSIGAAGRLTVTSRPAGQDSAARIVVDGGAVREVEPVAGPVGTCVTVEDLFHATPARRKFLR
SAGSEAGSCADAVRHLALAAPAVGFSLTIDGAASFDLPPQDRRERVAAIYGRADAEKLLEIEAVREEVALRGFISPASLT
RAAARHQHMVVNGRPVRDPLLRMALRLAYRERIPAGRHPLAALWLEIPAEMLDVNVHPAKAELRFATPDAVRSLMIGAVQ
RALATPADLAAAPSVSMPRTSWAASSPMPRYPQAESRAARGFAEAELRGLDLPPARVAPEVLPESRPDYPLGTPIAQVFD
TYILAQSGDGTLVLVDQHAAHERLTEIRLRAERDSGAIPAQALLAPSVVELPAEDIARLLGAAERLAGLGLEIEAFGPGA
VLVRAVPAALAKADPAALARDVADTLAESGTAMALEAKLDAVLIRMACHRSVRAGRRLAFAEMEALLRAMETTPLAQTCP
HGRPTVLRLSRGDLERMFGRAG
>Mature_581_residues
PIRRLDPTTINRIAAGEVIERPAAAVKELVENALDAGARRIGVTIEGGGIGRIEVTDDGHGIPEAELPLAIERHATSKLT
DEALVRIATLGFRGEALPSIGAAGRLTVTSRPAGQDSAARIVVDGGAVREVEPVAGPVGTCVTVEDLFHATPARRKFLRS
AGSEAGSCADAVRHLALAAPAVGFSLTIDGAASFDLPPQDRRERVAAIYGRADAEKLLEIEAVREEVALRGFISPASLTR
AAARHQHMVVNGRPVRDPLLRMALRLAYRERIPAGRHPLAALWLEIPAEMLDVNVHPAKAELRFATPDAVRSLMIGAVQR
ALATPADLAAAPSVSMPRTSWAASSPMPRYPQAESRAARGFAEAELRGLDLPPARVAPEVLPESRPDYPLGTPIAQVFDT
YILAQSGDGTLVLVDQHAAHERLTEIRLRAERDSGAIPAQALLAPSVVELPAEDIARLLGAAERLAGLGLEIEAFGPGAV
LVRAVPAALAKADPAALARDVADTLAESGTAMALEAKLDAVLIRMACHRSVRAGRRLAFAEMEALLRAMETTPLAQTCPH
GRPTVLRLSRGDLERMFGRAG

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=316, Percent_Identity=37.6582278481013, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI4505913, Length=330, Percent_Identity=27.8787878787879, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI310128478, Length=332, Percent_Identity=28.6144578313253, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI4505911, Length=329, Percent_Identity=26.7477203647416, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI189458898, Length=329, Percent_Identity=26.7477203647416, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI189458896, Length=319, Percent_Identity=27.5862068965517, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI263191589, Length=222, Percent_Identity=31.0810810810811, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI310128480, Length=283, Percent_Identity=25.7950530035336, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI91992162, Length=329, Percent_Identity=27.0516717325228, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI91992160, Length=329, Percent_Identity=27.0516717325228, Blast_Score=87, Evalue=6e-17,
Organism=Escherichia coli, GI1790612, Length=553, Percent_Identity=37.0705244122966, Blast_Score=247, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=35.9375, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=395, Percent_Identity=26.8354430379747, Blast_Score=119, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=324, Percent_Identity=37.037037037037, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6324247, Length=333, Percent_Identity=27.9279279279279, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6325093, Length=173, Percent_Identity=30.0578034682081, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323063, Length=349, Percent_Identity=24.9283667621776, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136968, Length=315, Percent_Identity=37.1428571428571, Blast_Score=202, Evalue=7e-52,
Organism=Drosophila melanogaster, GI17136970, Length=350, Percent_Identity=26.8571428571429, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_ACICJ (A5FW68)

Other databases:

- EMBL:   CP000697
- RefSeq:   YP_001233769.1
- ProteinModelPortal:   A5FW68
- STRING:   A5FW68
- GeneID:   5161536
- GenomeReviews:   CP000697_GR
- KEGG:   acr:Acry_0628
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- BioCyc:   ACRY349163:ACRY_0628-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 61603; Mature: 61471

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRRLDPTTINRIAAGEVIERPAAAVKELVENALDAGARRIGVTIEGGGIGRIEVTDDG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEECCCC
HGIPEAELPLAIERHATSKLTDEALVRIATLGFRGEALPSIGAAGRLTVTSRPAGQDSAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCC
RIVVDGGAVREVEPVAGPVGTCVTVEDLFHATPARRKFLRSAGSEAGSCADAVRHLALAA
EEEECCCCCEECCCCCCCCCCEEEHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHC
PAVGFSLTIDGAASFDLPPQDRRERVAAIYGRADAEKLLEIEAVREEVALRGFISPASLT
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
RAAARHQHMVVNGRPVRDPLLRMALRLAYRERIPAGRHPLAALWLEIPAEMLDVNVHPAK
HHHHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHCCCCCCCC
AELRFATPDAVRSLMIGAVQRALATPADLAAAPSVSMPRTSWAASSPMPRYPQAESRAAR
CEEEECCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHC
GFAEAELRGLDLPPARVAPEVLPESRPDYPLGTPIAQVFDTYILAQSGDGTLVLVDQHAA
CCHHHHHCCCCCCHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHEEECCCCEEEEECCHHH
HERLTEIRLRAERDSGAIPAQALLAPSVVELPAEDIARLLGAAERLAGLGLEIEAFGPGA
HHHHHHHHHHCCCCCCCCCHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCHH
VLVRAVPAALAKADPAALARDVADTLAESGTAMALEAKLDAVLIRMACHRSVRAGRRLAF
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
AEMEALLRAMETTPLAQTCPHGRPTVLRLSRGDLERMFGRAG
HHHHHHHHHHHCCCCHHHCCCCCCEEEEECCCHHHHHHCCCC
>Mature Secondary Structure 
PIRRLDPTTINRIAAGEVIERPAAAVKELVENALDAGARRIGVTIEGGGIGRIEVTDDG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEECCCC
HGIPEAELPLAIERHATSKLTDEALVRIATLGFRGEALPSIGAAGRLTVTSRPAGQDSAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCC
RIVVDGGAVREVEPVAGPVGTCVTVEDLFHATPARRKFLRSAGSEAGSCADAVRHLALAA
EEEECCCCCEECCCCCCCCCCEEEHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHC
PAVGFSLTIDGAASFDLPPQDRRERVAAIYGRADAEKLLEIEAVREEVALRGFISPASLT
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
RAAARHQHMVVNGRPVRDPLLRMALRLAYRERIPAGRHPLAALWLEIPAEMLDVNVHPAK
HHHHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHCCCCCCCC
AELRFATPDAVRSLMIGAVQRALATPADLAAAPSVSMPRTSWAASSPMPRYPQAESRAAR
CEEEECCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHC
GFAEAELRGLDLPPARVAPEVLPESRPDYPLGTPIAQVFDTYILAQSGDGTLVLVDQHAA
CCHHHHHCCCCCCHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHEEECCCCEEEEECCHHH
HERLTEIRLRAERDSGAIPAQALLAPSVVELPAEDIARLLGAAERLAGLGLEIEAFGPGA
HHHHHHHHHHCCCCCCCCCHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCHH
VLVRAVPAALAKADPAALARDVADTLAESGTAMALEAKLDAVLIRMACHRSVRAGRRLAF
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
AEMEALLRAMETTPLAQTCPHGRPTVLRLSRGDLERMFGRAG
HHHHHHHHHHHCCCCHHHCCCCCCEEEEECCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA