| Definition | Acidiphilium cryptum JF-5 chromosome, complete genome. |
|---|---|
| Accession | NC_009484 |
| Length | 3,389,227 |
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The map label for this gene is gno [H]
Identifier: 148259632
GI number: 148259632
Start: 696259
End: 697035
Strand: Reverse
Name: gno [H]
Synonym: Acry_0618
Alternate gene names: 148259632
Gene position: 697035-696259 (Counterclockwise)
Preceding gene: 148259642
Following gene: 148259630
Centisome position: 20.57
GC content: 68.98
Gene sequence:
>777_bases ATGACCGCGTTGAAATCCCTGTTCGACCTGACCGGCAAGCGCGCCCTGATCACCGGCGGCTCGCGCGGCCTCGGCCTGCA GATCGCCGAGGCGCTCGGCGAGTTCGGCGCCACCATCGCGATCTCCGCCCGCAAGGAGGACGAGCTGGACGAGGCGGTGA AGCACCTCGCCGGCCTCGGCATCGCCGCCACCGCCCATGTCAGCGACCTCGGCAAGGACGACGGCCCGAAGACGCTGGCC GACGCCGTGCTGGCCTCAGGCCCGGTCGACATCCTGGTGAACAATGCCGGCGCCACCTGGGGTGCCCCGGCGGTCGACGT CACGCCCGAGGCCTGGGCGCGGGTGATGAACCTCAACGTCAACAACCTGTTCTTCCTCACCCAGGCGATCGCCGCGCGCT CGATGATCCCCCGCAAGTCCGGCAAGGTGCTCAACATCGCCTCGATCGCCGGGCTGCGCGGCCATCACCCGGACATCACC GGCACCATCCCCTACAACACCTCGAAGGGCGCGGTGGTGAACATGACCCGCGCGCTCGCCGCCGAATGGGGCCCGCACAA CATCACGGTGAACGCGCTCGCCCCCGGCTTCTTCCCCTCGAAGATGACGCGCGGCATCCTCGGCCAGTTCGAGGAAAAGA TCCTGGCGAAGACGCCGATGAACAAGCTCGGCAACGACGCCGACCTGAAGGGCGCCGCCCTGCTCTTCTGCTCCGCCGCC TCCGGCCACATCACCGGCCAGATCCTCGCGGTCGATGGCGGCTCCGGCGTGATCTGA
Upstream 100 bases:
>100_bases CGCGTCCCCGTTGGCACGGGGGCTTGTGCACCATAGGATAGGCGCGTATCGCGCCCGTCAACCCCGCCCGGAACGGGCCA GCAACGATGAGGAAACCCGA
Downstream 100 bases:
>100_bases CCCGCGCTCAGCCCCCGGACGCGGCGGCCACCGCGTCGCCGATCCGGGGGCGGAAGCCGAAGAACCCGCGCCCCGCATGC GGCCACAAGGCGCGGTCCCA
Product: short-chain dehydrogenase/reductase SDR
Products: NA
Alternate protein names: 5-keto-D-gluconate 5-reductase [H]
Number of amino acids: Translated: 258; Mature: 257
Protein sequence:
>258_residues MTALKSLFDLTGKRALITGGSRGLGLQIAEALGEFGATIAISARKEDELDEAVKHLAGLGIAATAHVSDLGKDDGPKTLA DAVLASGPVDILVNNAGATWGAPAVDVTPEAWARVMNLNVNNLFFLTQAIAARSMIPRKSGKVLNIASIAGLRGHHPDIT GTIPYNTSKGAVVNMTRALAAEWGPHNITVNALAPGFFPSKMTRGILGQFEEKILAKTPMNKLGNDADLKGAALLFCSAA SGHITGQILAVDGGSGVI
Sequences:
>Translated_258_residues MTALKSLFDLTGKRALITGGSRGLGLQIAEALGEFGATIAISARKEDELDEAVKHLAGLGIAATAHVSDLGKDDGPKTLA DAVLASGPVDILVNNAGATWGAPAVDVTPEAWARVMNLNVNNLFFLTQAIAARSMIPRKSGKVLNIASIAGLRGHHPDIT GTIPYNTSKGAVVNMTRALAAEWGPHNITVNALAPGFFPSKMTRGILGQFEEKILAKTPMNKLGNDADLKGAALLFCSAA SGHITGQILAVDGGSGVI >Mature_257_residues TALKSLFDLTGKRALITGGSRGLGLQIAEALGEFGATIAISARKEDELDEAVKHLAGLGIAATAHVSDLGKDDGPKTLAD AVLASGPVDILVNNAGATWGAPAVDVTPEAWARVMNLNVNNLFFLTQAIAARSMIPRKSGKVLNIASIAGLRGHHPDITG TIPYNTSKGAVVNMTRALAAEWGPHNITVNALAPGFFPSKMTRGILGQFEEKILAKTPMNKLGNDADLKGAALLFCSAAS GHITGQILAVDGGSGVI
Specific function: Involved in the non-phosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate. Dependent on NADP, almost inactive with NAD [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=35.2, Blast_Score=138, Evalue=6e-33, Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=31.6205533596838, Blast_Score=118, Evalue=6e-27, Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=31.4516129032258, Blast_Score=107, Evalue=1e-23, Organism=Homo sapiens, GI5031737, Length=254, Percent_Identity=29.1338582677165, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=37.0967741935484, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI10190704, Length=268, Percent_Identity=31.3432835820896, Blast_Score=102, Evalue=3e-22, Organism=Homo sapiens, GI40254992, Length=247, Percent_Identity=32.3886639676113, Blast_Score=102, Evalue=4e-22, Organism=Homo sapiens, GI19923817, Length=255, Percent_Identity=29.0196078431373, Blast_Score=101, Evalue=9e-22, Organism=Homo sapiens, GI15277342, Length=250, Percent_Identity=30.4, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI4503301, Length=254, Percent_Identity=28.3464566929134, Blast_Score=91, Evalue=8e-19, Organism=Homo sapiens, GI33667109, Length=201, Percent_Identity=31.3432835820896, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI210032110, Length=197, Percent_Identity=27.9187817258883, Blast_Score=76, Evalue=4e-14, Organism=Homo sapiens, GI4503817, Length=192, Percent_Identity=29.6875, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI66933014, Length=252, Percent_Identity=26.984126984127, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI209862901, Length=254, Percent_Identity=25.1968503937008, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI19923983, Length=254, Percent_Identity=25.1968503937008, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI20149619, Length=199, Percent_Identity=29.1457286432161, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI59889578, Length=198, Percent_Identity=28.7878787878788, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI4758504, Length=256, Percent_Identity=27.34375, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI7706318, Length=227, Percent_Identity=26.8722466960352, Blast_Score=67, Evalue=2e-11, Organism=Escherichia coli, GI1790717, Length=261, Percent_Identity=35.632183908046, Blast_Score=150, Evalue=9e-38, Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=36.7588932806324, Blast_Score=140, Evalue=9e-35, Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=34.2629482071713, Blast_Score=127, Evalue=6e-31, Organism=Escherichia coli, GI1787335, Length=252, Percent_Identity=32.1428571428571, Blast_Score=121, Evalue=4e-29, Organism=Escherichia coli, GI1787905, Length=247, Percent_Identity=35.6275303643725, Blast_Score=111, Evalue=5e-26, Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=31.3953488372093, Blast_Score=103, Evalue=1e-23, Organism=Escherichia coli, GI1788459, Length=243, Percent_Identity=29.6296296296296, Blast_Score=103, Evalue=1e-23, Organism=Escherichia coli, GI1789378, Length=254, Percent_Identity=29.1338582677165, Blast_Score=83, Evalue=1e-17, Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=27.3092369477912, Blast_Score=79, Evalue=2e-16, Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=29.1497975708502, Blast_Score=73, Evalue=1e-14, Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=25.0965250965251, Blast_Score=62, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17555706, Length=249, Percent_Identity=29.718875502008, Blast_Score=110, Evalue=7e-25, Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=32.046332046332, Blast_Score=106, Evalue=1e-23, Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=30.078125, Blast_Score=100, Evalue=7e-22, Organism=Caenorhabditis elegans, GI17562906, Length=269, Percent_Identity=30.1115241635688, Blast_Score=100, Evalue=9e-22, Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=30.8, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI71994604, Length=258, Percent_Identity=30.6201550387597, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI25147288, Length=250, Percent_Identity=29.2, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17560220, Length=268, Percent_Identity=29.4776119402985, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17562908, Length=271, Percent_Identity=28.7822878228782, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI193204405, Length=268, Percent_Identity=29.1044776119403, Blast_Score=93, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17560332, Length=271, Percent_Identity=29.8892988929889, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17531453, Length=267, Percent_Identity=27.7153558052434, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17560150, Length=270, Percent_Identity=28.1481481481481, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17536025, Length=255, Percent_Identity=28.2352941176471, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=26.9662921348315, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI193203115, Length=201, Percent_Identity=31.3432835820896, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI193203117, Length=203, Percent_Identity=30.5418719211823, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17536651, Length=256, Percent_Identity=26.171875, Blast_Score=84, Evalue=7e-17, Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=29.3233082706767, Blast_Score=84, Evalue=7e-17, Organism=Caenorhabditis elegans, GI17562990, Length=269, Percent_Identity=26.7657992565056, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI71997099, Length=206, Percent_Identity=30.0970873786408, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17561272, Length=258, Percent_Identity=29.4573643410853, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17538480, Length=268, Percent_Identity=26.865671641791, Blast_Score=80, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17551412, Length=268, Percent_Identity=27.6119402985075, Blast_Score=80, Evalue=8e-16, Organism=Caenorhabditis elegans, GI17555612, Length=206, Percent_Identity=31.0679611650485, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17565030, Length=269, Percent_Identity=28.2527881040892, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17562904, Length=267, Percent_Identity=24.3445692883895, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17538486, Length=269, Percent_Identity=28.2527881040892, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17564282, Length=201, Percent_Identity=28.3582089552239, Blast_Score=76, Evalue=1e-14, Organism=Caenorhabditis elegans, GI72000259, Length=268, Percent_Identity=25, Blast_Score=74, Evalue=6e-14, Organism=Caenorhabditis elegans, GI17544670, Length=270, Percent_Identity=26.2962962962963, Blast_Score=73, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17508895, Length=179, Percent_Identity=31.2849162011173, Blast_Score=65, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17563726, Length=269, Percent_Identity=24.907063197026, Blast_Score=64, Evalue=8e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=256, Percent_Identity=24.609375, Blast_Score=78, Evalue=1e-15, Organism=Saccharomyces cerevisiae, GI6322861, Length=204, Percent_Identity=28.921568627451, Blast_Score=69, Evalue=1e-12, Organism=Drosophila melanogaster, GI21355319, Length=258, Percent_Identity=29.8449612403101, Blast_Score=110, Evalue=8e-25, Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=30.2325581395349, Blast_Score=107, Evalue=7e-24, Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=30, Blast_Score=99, Evalue=3e-21, Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=31.7460317460317, Blast_Score=98, Evalue=7e-21, Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=28.6274509803922, Blast_Score=90, Evalue=1e-18, Organism=Drosophila melanogaster, GI24644337, Length=262, Percent_Identity=28.6259541984733, Blast_Score=86, Evalue=2e-17, Organism=Drosophila melanogaster, GI24643142, Length=254, Percent_Identity=28.3464566929134, Blast_Score=85, Evalue=5e-17, Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=25.7028112449799, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI161076933, Length=200, Percent_Identity=28, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI24584748, Length=200, Percent_Identity=28, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI24640492, Length=220, Percent_Identity=28.6363636363636, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI21358495, Length=200, Percent_Identity=30.5, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI281364892, Length=178, Percent_Identity=31.4606741573034, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI18859837, Length=208, Percent_Identity=28.3653846153846, Blast_Score=70, Evalue=9e-13, Organism=Drosophila melanogaster, GI24584744, Length=202, Percent_Identity=28.2178217821782, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI28574402, Length=202, Percent_Identity=28.2178217821782, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI161076371, Length=235, Percent_Identity=28.5106382978723, Blast_Score=67, Evalue=1e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.69 [H]
Molecular weight: Translated: 26580; Mature: 26449
Theoretical pI: Translated: 8.52; Mature: 8.52
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTALKSLFDLTGKRALITGGSRGLGLQIAEALGEFGATIAISARKEDELDEAVKHLAGLG CHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCC IAATAHVSDLGKDDGPKTLADAVLASGPVDILVNNAGATWGAPAVDVTPEAWARVMNLNV CEEEHHHHHCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCC NNLFFLTQAIAARSMIPRKSGKVLNIASIAGLRGHHPDITGTIPYNTSKGAVVNMTRALA CHHHHHHHHHHHHHHCCCCCCCEEEEHHHCCCCCCCCCCEEEECCCCCCCCEEHHHHHHH AEWGPHNITVNALAPGFFPSKMTRGILGQFEEKILAKTPMNKLGNDADLKGAALLFCSAA HCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEEECC SGHITGQILAVDGGSGVI CCCEEEEEEEECCCCCCC >Mature Secondary Structure TALKSLFDLTGKRALITGGSRGLGLQIAEALGEFGATIAISARKEDELDEAVKHLAGLG HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCC IAATAHVSDLGKDDGPKTLADAVLASGPVDILVNNAGATWGAPAVDVTPEAWARVMNLNV CEEEHHHHHCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCC NNLFFLTQAIAARSMIPRKSGKVLNIASIAGLRGHHPDITGTIPYNTSKGAVVNMTRALA CHHHHHHHHHHHHHHCCCCCCCEEEEHHHCCCCCCCCCCEEEECCCCCCCCEEHHHHHHH AEWGPHNITVNALAPGFFPSKMTRGILGQFEEKILAKTPMNKLGNDADLKGAALLFCSAA HCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEEECC SGHITGQILAVDGGSGVI CCCEEEEEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7751271 [H]