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The map label for this gene is rmlA1 [H]

Identifier: 148259627

GI number: 148259627

Start: 687322

End: 688203

Strand: Reverse

Name: rmlA1 [H]

Synonym: Acry_0613

Alternate gene names: 148259627

Gene position: 688203-687322 (Counterclockwise)

Preceding gene: 148259628

Following gene: 148259626

Centisome position: 20.31

GC content: 72.11

Gene sequence:

>882_bases
ATGATCCGCAAGGGCATCATCCTCGCCGGCGGCTCCGGCACCCGCCTGCACCCCTCCACCCTCGCCGCCTCGAAGCAGCT
CCTCCCCGTCTACGACAAGCCGATGGTCTACTATCCGCTGTCGACCCTGCTGCTCGCCGGCATCCGCGACCTGCTGCTGA
TCTCCACCCCGCAGGACCTGCCCCAGTTCCGCCGCCTGCTCGGCGACGGCGGCCAATACGGCATCCGCATCGGCTATGCC
GCCCAGCCCTCGCCCGACGGTCTCGCCCAGGCCTTCCTGATCGGCGCGGACTGGCTCGCCGGCGAGGCCTGCGCCCTCGC
CCTCGGCGACAACCTCATCCACGCCGATCATCTCTCGCTCGCGCTGCGCCAGGCCGCCGGCCGGGAGGCCGGCGCCACCG
TCTTCGCCTACCAGGTGCGCGATCCCGAGCGCTACGGCGTCGTCACCTTCGACAGCGCCGGCCGCGCCATCGACATCGTC
GAGAAACCCGCCGCCCCCGCCTCCAGCTGGGCGGTCACCGGCCTCTATTTCTACGACCGCCGGGTCACCGAATTCGCCCG
CCGCATCCGACCCTCCGCCCGCGGCGAGCTCGAGATCACCGATCTCAACCGCCTCTATCTCGACGACGGCTCCCTCGCCG
TCGAGCGCCTCGGCCGCGGCACCGCCTGGCTCGACGCCGGAACCCCCGACTCCCTGCTCCAGGCCGCAACCTTCGTGCAG
ACCATCCAGGCCCGCCAGGGGCAGCTCGTCGGCTGCCCCGAGGAAGTCGCCTTCCGCATGGGCTTCATCGACGCCGACAC
CCTGCGCCGCCACGCCGCCCGCCTCGGCAAGACCGAGCTCGGCCGCGTCCTGCGCGAACTCGCCGACGGAGAGGCCGCAT
GA

Upstream 100 bases:

>100_bases
CCGGACTCGCCCGCACCGTCGACTGGTATCTCGCCAACGAGCCCTGGTGGCGCGCCATCCGCGCCCGCCGCTATGCCGGC
CAGCGCCTCGGTACCGCCGC

Downstream 100 bases:

>100_bases
TCGAGCCGCTCGACCTGCCCGGCGTCATGCTCATCACCCCGCCCCGCTTCGCCGATTCCCGCGGCTGGTTCAGCGAAACC
TGGAACCAGGCAAGGCTCGC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MIRKGIILAGGSGTRLHPSTLAASKQLLPVYDKPMVYYPLSTLLLAGIRDLLLISTPQDLPQFRRLLGDGGQYGIRIGYA
AQPSPDGLAQAFLIGADWLAGEACALALGDNLIHADHLSLALRQAAGREAGATVFAYQVRDPERYGVVTFDSAGRAIDIV
EKPAAPASSWAVTGLYFYDRRVTEFARRIRPSARGELEITDLNRLYLDDGSLAVERLGRGTAWLDAGTPDSLLQAATFVQ
TIQARQGQLVGCPEEVAFRMGFIDADTLRRHAARLGKTELGRVLRELADGEAA

Sequences:

>Translated_293_residues
MIRKGIILAGGSGTRLHPSTLAASKQLLPVYDKPMVYYPLSTLLLAGIRDLLLISTPQDLPQFRRLLGDGGQYGIRIGYA
AQPSPDGLAQAFLIGADWLAGEACALALGDNLIHADHLSLALRQAAGREAGATVFAYQVRDPERYGVVTFDSAGRAIDIV
EKPAAPASSWAVTGLYFYDRRVTEFARRIRPSARGELEITDLNRLYLDDGSLAVERLGRGTAWLDAGTPDSLLQAATFVQ
TIQARQGQLVGCPEEVAFRMGFIDADTLRRHAARLGKTELGRVLRELADGEAA
>Mature_293_residues
MIRKGIILAGGSGTRLHPSTLAASKQLLPVYDKPMVYYPLSTLLLAGIRDLLLISTPQDLPQFRRLLGDGGQYGIRIGYA
AQPSPDGLAQAFLIGADWLAGEACALALGDNLIHADHLSLALRQAAGREAGATVFAYQVRDPERYGVVTFDSAGRAIDIV
EKPAAPASSWAVTGLYFYDRRVTEFARRIRPSARGELEITDLNRLYLDDGSLAVERLGRGTAWLDAGTPDSLLQAATFVQ
TIQARQGQLVGCPEEVAFRMGFIDADTLRRHAARLGKTELGRVLRELADGEAA

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=285, Percent_Identity=27.0175438596491, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI11761621, Length=285, Percent_Identity=27.0175438596491, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1788351, Length=287, Percent_Identity=60.2787456445993, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1790224, Length=284, Percent_Identity=60.5633802816901, Blast_Score=363, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI133931050, Length=238, Percent_Identity=25.6302521008403, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=249, Percent_Identity=26.1044176706827, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21355443, Length=249, Percent_Identity=25.7028112449799, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24644084, Length=249, Percent_Identity=25.7028112449799, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 31660; Mature: 31660

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRKGIILAGGSGTRLHPSTLAASKQLLPVYDKPMVYYPLSTLLLAGIRDLLLISTPQDL
CCCCCEEEECCCCCEECHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHHHHEEECCCHHH
PQFRRLLGDGGQYGIRIGYAAQPSPDGLAQAFLIGADWLAGEACALALGDNLIHADHLSL
HHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCHHCCCCEEEECCCCEEEHHHHHH
ALRQAAGREAGATVFAYQVRDPERYGVVTFDSAGRAIDIVEKPAAPASSWAVTGLYFYDR
HHHHHCCCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEECCCCCCCCCCEEEEHHHHHH
RVTEFARRIRPSARGELEITDLNRLYLDDGSLAVERLGRGTAWLDAGTPDSLLQAATFVQ
HHHHHHHHCCCCCCCCEEEEECCEEEECCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHH
TIQARQGQLVGCPEEVAFRMGFIDADTLRRHAARLGKTELGRVLRELADGEAA
HHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIRKGIILAGGSGTRLHPSTLAASKQLLPVYDKPMVYYPLSTLLLAGIRDLLLISTPQDL
CCCCCEEEECCCCCEECHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHHHHEEECCCHHH
PQFRRLLGDGGQYGIRIGYAAQPSPDGLAQAFLIGADWLAGEACALALGDNLIHADHLSL
HHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCHHCCCCEEEECCCCEEEHHHHHH
ALRQAAGREAGATVFAYQVRDPERYGVVTFDSAGRAIDIVEKPAAPASSWAVTGLYFYDR
HHHHHCCCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEECCCCCCCCCCEEEEHHHHHH
RVTEFARRIRPSARGELEITDLNRLYLDDGSLAVERLGRGTAWLDAGTPDSLLQAATFVQ
HHHHHHHHCCCCCCCCEEEEECCEEEECCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHH
TIQARQGQLVGCPEEVAFRMGFIDADTLRRHAARLGKTELGRVLRELADGEAA
HHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]