BacMap

Definition	Acidiphilium cryptum JF-5 chromosome, complete genome.
Accession	NC_009484
Length	3,389,227

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The map label for this gene is bdhA [H]

Identifier: 148259510

GI number: 148259510

Start: 548900

End: 549682

Strand: Reverse

Name: bdhA [H]

Synonym: Acry_0494

Alternate gene names: 148259510

Gene position: 549682-548900 (Counterclockwise)

Preceding gene: 148259511

Following gene: 148259508

Centisome position: 16.22

GC content: 62.58

Gene sequence:

>783_bases
ATGGCCCGTTTCGACGGCAAGGTCGGCATCATCACCGGCGCCGCCAGCGGCATCGGCCGCGCCATCGCTGAACAGTTCGC
CAGAGAAGGCGGCCACGCCGTGATCGCCGATCTCGATCTCGACGCCGCACGCAAGACGGCAAGCGCTATCGCGACCTTCG
GGCCGGCGCCGCTGGCGGTTGCGATGGACGTCACCAACGAGCAACAGGTGGAGGACGGCGTTGCCGCCGCCGCTGAAAGG
TTCGGCCGGATCGATGTGCTGGTGAGCAATGCCGGCATCCAGATCGTCAGGCCGCTTGCCGAGTTTCCCTTTTCCGACTG
GAAGAAGCTGCTCTCGATACATCTCGACGGCGCATTCCTGACGACGCGCGCCTGCCTGAAATACATGTATGCGCAGAAAA
GCGGCTCGGTCGTCTATATCGGGTCGGTGCATTCAAAGGAGGCGTCGAAGCTGAAAGCGCCCTATGTCACCGCGAAGCAT
GGGCTGATCGGCCTCTGCAAGGTTCTCGCCAAGGAGGGCGCGGAACATAATGTCCGCGCCAATGTCGTCTGCCCCGGCTT
CGTGCGGACGCCGCTGGTCGAAAAGCAGATCCCGGAACAGGCAAAGGAACTCGGCATCAGCGAGGATGACGTCGTGCGCA
ATGTCATGCTGAAAGACACCGTGGACGGCGAATTCACAACCGTGGAAGACGTCGCCGCCGCGGTGCTCCATTTCGCCGGA
TTCCCGAGCAATGCCCTGACCGGCCAGTCGATGGTCGTCAGCCATGGCTGGTTCATGCAGTAG

Upstream 100 bases:

>100_bases
CACATCCTCGCGGACATGACGCTCGATCTCGGCGAGGTCGTCCACGACTATCTTGCCTGATCGACCCTCCGGATTCCCCT
CAAGAGAAAAGGATTTTCCC

Downstream 100 bases:

>100_bases
CCGCATCCGGTCAACGCGCGGGAGGCCGACCTCCCGCGCGGCTCCTTGCCAGTTGCCGATACGGGAAACAGCCGGCGTGA
CCAGTCCGGCGTGACCCGTC

Product: 3-hydroxybutyrate dehydrogenase

Products: NA

Alternate protein names: BDH; 3-hydroxybutyrate dehydrogenase; 3-HBDH [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MARFDGKVGIITGAASGIGRAIAEQFAREGGHAVIADLDLDAARKTASAIATFGPAPLAVAMDVTNEQQVEDGVAAAAER
FGRIDVLVSNAGIQIVRPLAEFPFSDWKKLLSIHLDGAFLTTRACLKYMYAQKSGSVVYIGSVHSKEASKLKAPYVTAKH
GLIGLCKVLAKEGAEHNVRANVVCPGFVRTPLVEKQIPEQAKELGISEDDVVRNVMLKDTVDGEFTTVEDVAAAVLHFAG
FPSNALTGQSMVVSHGWFMQ

Sequences:

>Translated_260_residues
MARFDGKVGIITGAASGIGRAIAEQFAREGGHAVIADLDLDAARKTASAIATFGPAPLAVAMDVTNEQQVEDGVAAAAER
FGRIDVLVSNAGIQIVRPLAEFPFSDWKKLLSIHLDGAFLTTRACLKYMYAQKSGSVVYIGSVHSKEASKLKAPYVTAKH
GLIGLCKVLAKEGAEHNVRANVVCPGFVRTPLVEKQIPEQAKELGISEDDVVRNVMLKDTVDGEFTTVEDVAAAVLHFAG
FPSNALTGQSMVVSHGWFMQ
>Mature_259_residues
ARFDGKVGIITGAASGIGRAIAEQFAREGGHAVIADLDLDAARKTASAIATFGPAPLAVAMDVTNEQQVEDGVAAAAERF
GRIDVLVSNAGIQIVRPLAEFPFSDWKKLLSIHLDGAFLTTRACLKYMYAQKSGSVVYIGSVHSKEASKLKAPYVTAKHG
LIGLCKVLAKEGAEHNVRANVVCPGFVRTPLVEKQIPEQAKELGISEDDVVRNVMLKDTVDGEFTTVEDVAAAVLHFAGF
PSNALTGQSMVVSHGWFMQ

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=195, Percent_Identity=37.9487179487179, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=31.0756972111554, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI66933014, Length=263, Percent_Identity=31.5589353612167, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI31542939, Length=219, Percent_Identity=31.0502283105023, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI15277342, Length=268, Percent_Identity=30.5970149253731, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI32483357, Length=263, Percent_Identity=30.7984790874525, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI19923817, Length=192, Percent_Identity=30.7291666666667, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI10190704, Length=184, Percent_Identity=33.695652173913, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4758504, Length=210, Percent_Identity=30, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI224922801, Length=168, Percent_Identity=31.547619047619, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI5031737, Length=243, Percent_Identity=28.8065843621399, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI33667109, Length=188, Percent_Identity=30.8510638297872, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI210032110, Length=214, Percent_Identity=24.7663551401869, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI126723191, Length=207, Percent_Identity=31.4009661835749, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI59889578, Length=233, Percent_Identity=28.755364806867, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI157739938, Length=202, Percent_Identity=26.7326732673267, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI7706318, Length=205, Percent_Identity=26.8292682926829, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI209862901, Length=207, Percent_Identity=28.9855072463768, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI19923983, Length=207, Percent_Identity=28.9855072463768, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI142976729, Length=214, Percent_Identity=24.7663551401869, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4503817, Length=268, Percent_Identity=25.3731343283582, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI20149619, Length=215, Percent_Identity=24.6511627906977, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4503301, Length=189, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI83715985, Length=210, Percent_Identity=29.0476190476191, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI126723750, Length=266, Percent_Identity=26.6917293233083, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI40254986, Length=169, Percent_Identity=29.585798816568, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI40807363, Length=193, Percent_Identity=25.9067357512953, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI310128830, Length=267, Percent_Identity=24.3445692883895, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI310115468, Length=267, Percent_Identity=24.3445692883895, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI7705925, Length=259, Percent_Identity=24.7104247104247, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=29.296875, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI87082100, Length=195, Percent_Identity=35.3846153846154, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1788459, Length=255, Percent_Identity=29.8039215686275, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790717, Length=196, Percent_Identity=29.5918367346939, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=28.0155642023346, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=29.5019157088123, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789208, Length=260, Percent_Identity=24.6153846153846, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=27.843137254902, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787526, Length=214, Percent_Identity=26.1682242990654, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789378, Length=193, Percent_Identity=26.9430051813472, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI2367175, Length=195, Percent_Identity=30.7692307692308, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=260, Percent_Identity=29.2307692307692, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17568967, Length=204, Percent_Identity=34.8039215686275, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17555706, Length=260, Percent_Identity=30, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17564282, Length=189, Percent_Identity=30.1587301587302, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193203117, Length=259, Percent_Identity=25.8687258687259, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193203115, Length=256, Percent_Identity=26.171875, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=26.171875, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=253, Percent_Identity=27.2727272727273, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=210, Percent_Identity=31.9047619047619, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=202, Percent_Identity=30.1980198019802, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=188, Percent_Identity=31.3829787234043, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=274, Percent_Identity=27.3722627737226, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=210, Percent_Identity=29.0476190476191, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=201, Percent_Identity=26.865671641791, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=210, Percent_Identity=30.4761904761905, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=198, Percent_Identity=29.7979797979798, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17560332, Length=277, Percent_Identity=26.7148014440433, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=202, Percent_Identity=29.2079207920792, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=270, Percent_Identity=27.4074074074074, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=198, Percent_Identity=29.2929292929293, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=212, Percent_Identity=27.8301886792453, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=215, Percent_Identity=30.2325581395349, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=212, Percent_Identity=30.188679245283, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=202, Percent_Identity=28.7128712871287, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=202, Percent_Identity=29.2079207920792, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=200, Percent_Identity=29, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17551412, Length=216, Percent_Identity=28.7037037037037, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17567345, Length=191, Percent_Identity=25.130890052356, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=249, Percent_Identity=27.3092369477912, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=188, Percent_Identity=23.936170212766, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115534660, Length=190, Percent_Identity=28.9473684210526, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=202, Percent_Identity=27.7227722772277, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17536025, Length=190, Percent_Identity=28.9473684210526, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=190, Percent_Identity=27.8947368421053, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32563809, Length=195, Percent_Identity=28.7179487179487, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17507613, Length=195, Percent_Identity=28.7179487179487, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561272, Length=190, Percent_Identity=29.4736842105263, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=196, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=213, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324126, Length=262, Percent_Identity=27.4809160305344, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323882, Length=194, Percent_Identity=26.8041237113402, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=31.7647058823529, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18859837, Length=190, Percent_Identity=36.3157894736842, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI21355319, Length=260, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI23397609, Length=249, Percent_Identity=32.9317269076305, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357041, Length=257, Percent_Identity=29.9610894941634, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21358495, Length=195, Percent_Identity=28.7179487179487, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17737361, Length=207, Percent_Identity=27.0531400966184, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571526, Length=257, Percent_Identity=29.1828793774319, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24649181, Length=189, Percent_Identity=27.5132275132275, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24581726, Length=189, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648944, Length=240, Percent_Identity=28.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641232, Length=227, Percent_Identity=28.1938325991189, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356301, Length=261, Percent_Identity=23.7547892720307, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221331218, Length=212, Percent_Identity=31.1320754716981, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24643142, Length=201, Percent_Identity=29.3532338308458, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357673, Length=196, Percent_Identity=29.0816326530612, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24665243, Length=212, Percent_Identity=31.1320754716981, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24644339, Length=191, Percent_Identity=27.7486910994764, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24640492, Length=195, Percent_Identity=25.1282051282051, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221331216, Length=213, Percent_Identity=31.4553990610329, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24665247, Length=213, Percent_Identity=31.4553990610329, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28571387, Length=232, Percent_Identity=25.4310344827586, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011294
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.30 [H]

Molecular weight: Translated: 27651; Mature: 27520

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARFDGKVGIITGAASGIGRAIAEQFAREGGHAVIADLDLDAARKTASAIATFGPAPLAV
CCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEE
AMDVTNEQQVEDGVAAAAERFGRIDVLVSNAGIQIVRPLAEFPFSDWKKLLSIHLDGAFL
EEECCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCHHH
TTRACLKYMYAQKSGSVVYIGSVHSKEASKLKAPYVTAKHGLIGLCKVLAKEGAEHNVRA
HHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCEEEHHCCHHHHHHHHHHCCCCCCCEE
NVVCPGFVRTPLVEKQIPEQAKELGISEDDVVRNVMLKDTVDGEFTTVEDVAAAVLHFAG
EEECCCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
FPSNALTGQSMVVSHGWFMQ
CCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
ARFDGKVGIITGAASGIGRAIAEQFAREGGHAVIADLDLDAARKTASAIATFGPAPLAV
CCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEE
AMDVTNEQQVEDGVAAAAERFGRIDVLVSNAGIQIVRPLAEFPFSDWKKLLSIHLDGAFL
EEECCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCHHH
TTRACLKYMYAQKSGSVVYIGSVHSKEASKLKAPYVTAKHGLIGLCKVLAKEGAEHNVRA
HHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCEEEHHCCHHHHHHHHHHCCCCCCCEE
NVVCPGFVRTPLVEKQIPEQAKELGISEDDVVRNVMLKDTVDGEFTTVEDVAAAVLHFAG
EEECCCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
FPSNALTGQSMVVSHGWFMQ
CCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9922248; 11481431 [H]