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The map label for this gene is uvrD [H]

Identifier: 148259238

GI number: 148259238

Start: 251668

End: 253854

Strand: Reverse

Name: uvrD [H]

Synonym: Acry_0218

Alternate gene names: 148259238

Gene position: 253854-251668 (Counterclockwise)

Preceding gene: 148259239

Following gene: 148259237

Centisome position: 7.49

GC content: 68.54

Gene sequence:

>2187_bases
GTGAGCGACTATCTCGACAGGCTGAACCCCGCCCAGCGCGAAGCCGTCGAGGCGGTGGACGGGCCGGTGCTGGTGCTTGC
CGGTGCCGGCACCGGCAAGACCCGCGTGCTGACCACCCGCTTCGCCCATATCCTGCTCACGCGCCGCGCCTTTCCGAACC
AGGTGCTCGCCGTCACCTTCACGAACAAGGCGGCGCGGGAGATGCGCGAGCGCGTCTCCGCCCTGCTCGGCGAGCCGGCG
GAGGGGCTCTGGCTCGGCACCTTCCACGCCCTCGCGGCACGGATGCTCCGCCGCCATGCCGAACTCGTCGGCCGCACGTC
GAATTTCTCGATCCTCGACCCGGACGACCAGCTCCGCCTGCTCAAGCAGGTGATGGAAGCGCGACGGATGGACGTGAAGC
GCTTCACCCCGCAGGGGCTGATGGGCACGATCCAGCGCTGGAAGGATCGCGGCCTGCTGCCGGACCAGGTGCCGCGCGAG
CTCGATATCGACTGGGGGGCCGAATCCGCGCGCGACCTCTATGCTGCCTACCAGGAACGGCTGCAGGCGCTAAACGCGAT
GGATTTCGGCGACCTGTTGATGCTCGCGACCGACCTGCTCAAGCGCGAGCCCGAGATCCTCGCGCAGTATCACCGCCGCT
TCCGCTACATCCTGGTCGACGAATACCAGGACACCAACCTCGTCCAGTATTACTGGCTGCGCCTGCTCGCCCAGGCCTCG
AAGAACATCTGCTGCGTGGGCGACGACGACCAGAGCATCTATTCCTGGCGCGGTGCGGAGATCGAGAACATCCTGCGCTT
CGAGCAGGATTTCCCGGGTGCGAAAATCGTCAGGCTGGAGGCGAATTACCGCTCGACCGCGCCGATCCTGCGCGCCGCCT
CGGCGCTGATCGCGCATAATGAAGGCCGGCTCGGCAAGACGCTGCATGCCGGGCGGAACGATGCCGAGGGCGAGAAGGTC
GAGGTTCTCGCCTTCTGGGATTCGGACGAGGAAAGCCGCGCCGTCGCCAGCCGGATCGAAGGGCTGCGCGCCGACGGCCA
CAAGCTCGCCGAATGCGCGGTGCTGGTCCGCGCCGGCTTCCAGACCCGCGGCTTCGAGGAGCGCTTCATCACCATCGGCC
TGCCCTATCGCATTGTCGGCGGCCTGCGCTTCTACGAGCGGGCGGAAATCCGCGACGCCATCGCCTATCTGCGGCTGCTG
GCCCAGCCGGCGGACGACCTCGCTTTCGAGCGCATCGTCAACACGCCGAAACGCGGCCTGGGCGACACCGCGCTGCGCAC
CCTGCACGAGCGCGCCCGCGCCGATGGCGTCCCGCTCGCCGAGGCCGCGAGCCGCGTGGTCGCCGAAGGCGGGCTGCGCG
GCAAGGCGCGGGACGGGCTGCGCACCCTGCTCGCCCAGTTCGCCGAATGGCGCGAGACCCTGCGGCTCGATGGCCATGTC
GTCGCCCTTTCCACCCTGCTCGATGCCAGCGGCTACATCGCGATGTGGCAGGAGCAGAAAACCCCCGAGGCGGCCGGCCG
GATCGAGAACCTGAAGGAGTTGGTCCGCGCCGTCGCCGAGTTCGAGACGCTCGGCGGCTTTCTCGAACATGTCGCCCTCG
TGATGGACAACGACAATGAACCGGACGACGACAAGGTCGTGCTGATGACGCTGCACGCGGCGAAGGGGCTGGAGTTCGAC
ACCGTGTTCCTCCCCGGCTGGGAAGAGGGCGTGTTCCCCAACCAGCGCGCGCTCGACGAGGGCGGCGGCCGCGCGCTGGA
GGAGGAACGCCGCCTCGCCTATGTCGGCATCACCAGGGCGAAGCAGCGCGCCATCATCTCACACTGCGCCAACCGCCGGA
TCTACGCCAACTGGCAAAGCAGCGTGCCGTCCCGCTTCATCGAGGAACTGCCGGAGGATGCGATCCGTACCGGCGGCTCC
GCGGCGCTTGAGCAGCGCAACGCACCGCCCGTCTTCGCCACCGCGCGCCCGCTGGTCGCCGCCCGGCGGGCGAGCGGCGA
ACACGCCGATGCCTGGGCCGCCACCCCGCGCCCGCCCCGCACCGACAGGATCACCGAAGGAACCCGCGTGTTTCACCAGA
AATTCGGCTACGGCGTCGTGATCGACGCGGAAGACGACCGGCTCGACATCCGTTTCGACAATGCCGGCGAAAAACGCGTG
CTCGACCGTTTCGTGGAGCGGGCGTGA

Upstream 100 bases:

>100_bases
CGCTGCAGGCCAACGGCATCGACGAGTTCCATTTCTACACCCTCAACCGCGCCGACCTCACCTACGCCATCGCGCGCATC
CTGGGCGTGAAGCCGGCCAG

Downstream 100 bases:

>100_bases
TGGCGCGGGGCGGCGTGGAAATGCTCGAGCGCGTCACCGTGACGGTGCCGGAGGAAGCGCTCGAAACCTTCGAGGCGGCG
CTGGAGACGTGCTGCCGCAG

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 728; Mature: 727

Protein sequence:

>728_residues
MSDYLDRLNPAQREAVEAVDGPVLVLAGAGTGKTRVLTTRFAHILLTRRAFPNQVLAVTFTNKAAREMRERVSALLGEPA
EGLWLGTFHALAARMLRRHAELVGRTSNFSILDPDDQLRLLKQVMEARRMDVKRFTPQGLMGTIQRWKDRGLLPDQVPRE
LDIDWGAESARDLYAAYQERLQALNAMDFGDLLMLATDLLKREPEILAQYHRRFRYILVDEYQDTNLVQYYWLRLLAQAS
KNICCVGDDDQSIYSWRGAEIENILRFEQDFPGAKIVRLEANYRSTAPILRAASALIAHNEGRLGKTLHAGRNDAEGEKV
EVLAFWDSDEESRAVASRIEGLRADGHKLAECAVLVRAGFQTRGFEERFITIGLPYRIVGGLRFYERAEIRDAIAYLRLL
AQPADDLAFERIVNTPKRGLGDTALRTLHERARADGVPLAEAASRVVAEGGLRGKARDGLRTLLAQFAEWRETLRLDGHV
VALSTLLDASGYIAMWQEQKTPEAAGRIENLKELVRAVAEFETLGGFLEHVALVMDNDNEPDDDKVVLMTLHAAKGLEFD
TVFLPGWEEGVFPNQRALDEGGGRALEEERRLAYVGITRAKQRAIISHCANRRIYANWQSSVPSRFIEELPEDAIRTGGS
AALEQRNAPPVFATARPLVAARRASGEHADAWAATPRPPRTDRITEGTRVFHQKFGYGVVIDAEDDRLDIRFDNAGEKRV
LDRFVERA

Sequences:

>Translated_728_residues
MSDYLDRLNPAQREAVEAVDGPVLVLAGAGTGKTRVLTTRFAHILLTRRAFPNQVLAVTFTNKAAREMRERVSALLGEPA
EGLWLGTFHALAARMLRRHAELVGRTSNFSILDPDDQLRLLKQVMEARRMDVKRFTPQGLMGTIQRWKDRGLLPDQVPRE
LDIDWGAESARDLYAAYQERLQALNAMDFGDLLMLATDLLKREPEILAQYHRRFRYILVDEYQDTNLVQYYWLRLLAQAS
KNICCVGDDDQSIYSWRGAEIENILRFEQDFPGAKIVRLEANYRSTAPILRAASALIAHNEGRLGKTLHAGRNDAEGEKV
EVLAFWDSDEESRAVASRIEGLRADGHKLAECAVLVRAGFQTRGFEERFITIGLPYRIVGGLRFYERAEIRDAIAYLRLL
AQPADDLAFERIVNTPKRGLGDTALRTLHERARADGVPLAEAASRVVAEGGLRGKARDGLRTLLAQFAEWRETLRLDGHV
VALSTLLDASGYIAMWQEQKTPEAAGRIENLKELVRAVAEFETLGGFLEHVALVMDNDNEPDDDKVVLMTLHAAKGLEFD
TVFLPGWEEGVFPNQRALDEGGGRALEEERRLAYVGITRAKQRAIISHCANRRIYANWQSSVPSRFIEELPEDAIRTGGS
AALEQRNAPPVFATARPLVAARRASGEHADAWAATPRPPRTDRITEGTRVFHQKFGYGVVIDAEDDRLDIRFDNAGEKRV
LDRFVERA
>Mature_727_residues
SDYLDRLNPAQREAVEAVDGPVLVLAGAGTGKTRVLTTRFAHILLTRRAFPNQVLAVTFTNKAAREMRERVSALLGEPAE
GLWLGTFHALAARMLRRHAELVGRTSNFSILDPDDQLRLLKQVMEARRMDVKRFTPQGLMGTIQRWKDRGLLPDQVPREL
DIDWGAESARDLYAAYQERLQALNAMDFGDLLMLATDLLKREPEILAQYHRRFRYILVDEYQDTNLVQYYWLRLLAQASK
NICCVGDDDQSIYSWRGAEIENILRFEQDFPGAKIVRLEANYRSTAPILRAASALIAHNEGRLGKTLHAGRNDAEGEKVE
VLAFWDSDEESRAVASRIEGLRADGHKLAECAVLVRAGFQTRGFEERFITIGLPYRIVGGLRFYERAEIRDAIAYLRLLA
QPADDLAFERIVNTPKRGLGDTALRTLHERARADGVPLAEAASRVVAEGGLRGKARDGLRTLLAQFAEWRETLRLDGHVV
ALSTLLDASGYIAMWQEQKTPEAAGRIENLKELVRAVAEFETLGGFLEHVALVMDNDNEPDDDKVVLMTLHAAKGLEFDT
VFLPGWEEGVFPNQRALDEGGGRALEEERRLAYVGITRAKQRAIISHCANRRIYANWQSSVPSRFIEELPEDAIRTGGSA
ALEQRNAPPVFATARPLVAARRASGEHADAWAATPRPPRTDRITEGTRVFHQKFGYGVVIDAEDDRLDIRFDNAGEKRVL
DRFVERA

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=736, Percent_Identity=43.3423913043478, Blast_Score=537, Evalue=1e-153,
Organism=Escherichia coli, GI48994965, Length=687, Percent_Identity=38.7190684133916, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1787196, Length=347, Percent_Identity=29.1066282420749, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322369, Length=432, Percent_Identity=31.0185185185185, Blast_Score=173, Evalue=9e-44,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81795; Mature: 81664

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDYLDRLNPAQREAVEAVDGPVLVLAGAGTGKTRVLTTRFAHILLTRRAFPNQVLAVTF
CCCHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEE
TNKAAREMRERVSALLGEPAEGLWLGTFHALAARMLRRHAELVGRTSNFSILDPDDQLRL
CCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHH
LKQVMEARRMDVKRFTPQGLMGTIQRWKDRGLLPDQVPRELDIDWGAESARDLYAAYQER
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LQALNAMDFGDLLMLATDLLKREPEILAQYHRRFRYILVDEYQDTNLVQYYWLRLLAQAS
HHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHC
KNICCVGDDDQSIYSWRGAEIENILRFEQDFPGAKIVRLEANYRSTAPILRAASALIAHN
CCEEEECCCCCHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHCC
EGRLGKTLHAGRNDAEGEKVEVLAFWDSDEESRAVASRIEGLRADGHKLAECAVLVRAGF
CCCCCHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
QTRGFEERFITIGLPYRIVGGLRFYERAEIRDAIAYLRLLAQPADDLAFERIVNTPKRGL
CCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
GDTALRTLHERARADGVPLAEAASRVVAEGGLRGKARDGLRTLLAQFAEWRETLRLDGHV
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCE
VALSTLLDASGYIAMWQEQKTPEAAGRIENLKELVRAVAEFETLGGFLEHVALVMDNDNE
EEHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
PDDDKVVLMTLHAAKGLEFDTVFLPGWEEGVFPNQRALDEGGGRALEEERRLAYVGITRA
CCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHCCCCCCHHHHCCEEEEEHHHH
KQRAIISHCANRRIYANWQSSVPSRFIEELPEDAIRTGGSAALEQRNAPPVFATARPLVA
HHHHHHHHHHCCCEEECHHHCCHHHHHHHCCHHHHHCCCHHHHHCCCCCCCEECCCHHHH
ARRASGEHADAWAATPRPPRTDRITEGTRVFHQKFGYGVVIDAEDDRLDIRFDNAGEKRV
HHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCEEEEEECCCCHHHH
LDRFVERA
HHHHHHCC
>Mature Secondary Structure 
SDYLDRLNPAQREAVEAVDGPVLVLAGAGTGKTRVLTTRFAHILLTRRAFPNQVLAVTF
CCHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEE
TNKAAREMRERVSALLGEPAEGLWLGTFHALAARMLRRHAELVGRTSNFSILDPDDQLRL
CCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHH
LKQVMEARRMDVKRFTPQGLMGTIQRWKDRGLLPDQVPRELDIDWGAESARDLYAAYQER
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LQALNAMDFGDLLMLATDLLKREPEILAQYHRRFRYILVDEYQDTNLVQYYWLRLLAQAS
HHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHC
KNICCVGDDDQSIYSWRGAEIENILRFEQDFPGAKIVRLEANYRSTAPILRAASALIAHN
CCEEEECCCCCHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHCC
EGRLGKTLHAGRNDAEGEKVEVLAFWDSDEESRAVASRIEGLRADGHKLAECAVLVRAGF
CCCCCHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
QTRGFEERFITIGLPYRIVGGLRFYERAEIRDAIAYLRLLAQPADDLAFERIVNTPKRGL
CCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
GDTALRTLHERARADGVPLAEAASRVVAEGGLRGKARDGLRTLLAQFAEWRETLRLDGHV
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCE
VALSTLLDASGYIAMWQEQKTPEAAGRIENLKELVRAVAEFETLGGFLEHVALVMDNDNE
EEHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
PDDDKVVLMTLHAAKGLEFDTVFLPGWEEGVFPNQRALDEGGGRALEEERRLAYVGITRA
CCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHCCCCCCHHHHCCEEEEEHHHH
KQRAIISHCANRRIYANWQSSVPSRFIEELPEDAIRTGGSAALEQRNAPPVFATARPLVA
HHHHHHHHHHCCCEEECHHHCCHHHHHHHCCHHHHHCCCHHHHHCCCCCCCEECCCHHHH
ARRASGEHADAWAATPRPPRTDRITEGTRVFHQKFGYGVVIDAEDDRLDIRFDNAGEKRV
HHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCEEEEEECCCCHHHH
LDRFVERA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA