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The map label for this gene is mdtA [H]

Identifier: 148259155

GI number: 148259155

Start: 153913

End: 155073

Strand: Reverse

Name: mdtA [H]

Synonym: Acry_0135

Alternate gene names: 148259155

Gene position: 155073-153913 (Counterclockwise)

Preceding gene: 148259156

Following gene: 148259154

Centisome position: 4.58

GC content: 65.98

Gene sequence:

>1161_bases
ATGGCGAAACGGCGCGGACGGATCATTTTCGGGCTGGTGGCGCTCGCCCTTGTCGGCGCGGTGGCGTACCGGCTGGCGCA
CCGGACGAAACCCGCGCACGGCGGCGGGGCAACGGCGATTCCTGTGGAGGTGGCGAAGGCGACGCGGCAGAACGTGCCCG
TCTACCTCGATGCGCTCGGCACCGTCGTCGCCTACCACACGGTGACGGTGCAGCCGATGATCACCGGGCCGCTCACCAGA
ATCCTGTTCACGCCCGGCCAGTTCGTGAAGAAGGGCGATCTTCTCGCGGAGATCGATCCCGCGCCCTATCGCGCGACACT
CGACCAGGCGGAGGCGAAGCTTGCGCAGGACAAGGCGAGTCTCGCCAACGCGGAAATGCAGGCGCGACAATACGCCTCGC
TGGTCAAGCAGAACTACACCTCGAAACTGCAGGCGGCGACGGCGCTCGCCACCGCCGCCGAGGATCGGGCGCTGGTGAAG
CAGGACGAGGCCAGCATCGAGACCGACCGGATCAATCTCGGCTATACGCGGATCACCGCGCCGATTTCCGGACGCACCGG
CATCCTGCAGGTGAATGCCGGCAATATCGTCAGCCCAAGCACTACCAGCGGCATCGTGGTGATCAACACGCTGCAGCCGA
TCTCGGTGCAGTTCAGCCTGCCGCAGCAGGATCTGCCGGCGATCATCGCCGCGATGAAGCGTGGCAAGGTTGACCTGCTC
GCCACCGAGGAGGGCGATCCGCAGACCGCGAAGGTGCTCGACCACGGCACGCTCGCCGTTCTCGACAACACGGTGAATGC
GAACACGGGAACGCTGACGCTGAAGGGCACGTTTGCAAATCCGGACCTCACGCTGTGGCCCGGCGCCTATGTGAACGTCC
GCACGCTGGTCCGGACGATCGACAATGCGGTGACCGTGCCACCGGTCGCGGTGCAGCAGGGACCTTCCGGTAGCTTCGTC
TTTCTCGTGAAGCCGCCGGCCAAGAAGGGGGGATCGTTCACCGTGATTGACCAGAAAGTGACGCTCGGCGTGCAGACGGC
GCGCGTCGTGGTCGTCACCAGCGGACTTGTCCCTGGCGACGAGGTGGTGACCGAGGGCAATTCGCGCCTGAAGGGCGGAT
CGGCGATCCACATCGTCACGGGTTCCGCCGGCGCGCCGTGA

Upstream 100 bases:

>100_bases
CGCTGGTGACGACGCGGCTCACCCGGCTCGATGCCGCGGTCAATCTCTACAAGGCGATGGGCGGTGGCTGGACGGCCGGC
GCCGGCAAGGATCACTGACG

Downstream 100 bases:

>100_bases
ACATTTCCGCCCCGTTCATCGCCCGGCCGGTCGCGACATCGCTGCTCGCGATCGCGCTGCTGCTGATCGGCGCGATGGGC
TATCGGGCACTGCCGGTCTC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MAKRRGRIIFGLVALALVGAVAYRLAHRTKPAHGGGATAIPVEVAKATRQNVPVYLDALGTVVAYHTVTVQPMITGPLTR
ILFTPGQFVKKGDLLAEIDPAPYRATLDQAEAKLAQDKASLANAEMQARQYASLVKQNYTSKLQAATALATAAEDRALVK
QDEASIETDRINLGYTRITAPISGRTGILQVNAGNIVSPSTTSGIVVINTLQPISVQFSLPQQDLPAIIAAMKRGKVDLL
ATEEGDPQTAKVLDHGTLAVLDNTVNANTGTLTLKGTFANPDLTLWPGAYVNVRTLVRTIDNAVTVPPVAVQQGPSGSFV
FLVKPPAKKGGSFTVIDQKVTLGVQTARVVVVTSGLVPGDEVVTEGNSRLKGGSAIHIVTGSAGAP

Sequences:

>Translated_386_residues
MAKRRGRIIFGLVALALVGAVAYRLAHRTKPAHGGGATAIPVEVAKATRQNVPVYLDALGTVVAYHTVTVQPMITGPLTR
ILFTPGQFVKKGDLLAEIDPAPYRATLDQAEAKLAQDKASLANAEMQARQYASLVKQNYTSKLQAATALATAAEDRALVK
QDEASIETDRINLGYTRITAPISGRTGILQVNAGNIVSPSTTSGIVVINTLQPISVQFSLPQQDLPAIIAAMKRGKVDLL
ATEEGDPQTAKVLDHGTLAVLDNTVNANTGTLTLKGTFANPDLTLWPGAYVNVRTLVRTIDNAVTVPPVAVQQGPSGSFV
FLVKPPAKKGGSFTVIDQKVTLGVQTARVVVVTSGLVPGDEVVTEGNSRLKGGSAIHIVTGSAGAP
>Mature_385_residues
AKRRGRIIFGLVALALVGAVAYRLAHRTKPAHGGGATAIPVEVAKATRQNVPVYLDALGTVVAYHTVTVQPMITGPLTRI
LFTPGQFVKKGDLLAEIDPAPYRATLDQAEAKLAQDKASLANAEMQARQYASLVKQNYTSKLQAATALATAAEDRALVKQ
DEASIETDRINLGYTRITAPISGRTGILQVNAGNIVSPSTTSGIVVINTLQPISVQFSLPQQDLPAIIAAMKRGKVDLLA
TEEGDPQTAKVLDHGTLAVLDNTVNANTGTLTLKGTFANPDLTLWPGAYVNVRTLVRTIDNAVTVPPVAVQQGPSGSFVF
LVKPPAKKGGSFTVIDQKVTLGVQTARVVVVTSGLVPGDEVVTEGNSRLKGGSAIHIVTGSAGAP

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=339, Percent_Identity=42.1828908554572, Blast_Score=257, Evalue=8e-70,
Organism=Escherichia coli, GI1786668, Length=380, Percent_Identity=31.3157894736842, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789665, Length=329, Percent_Identity=30.3951367781155, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1789929, Length=390, Percent_Identity=29.4871794871795, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40387; Mature: 40256

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRRGRIIFGLVALALVGAVAYRLAHRTKPAHGGGATAIPVEVAKATRQNVPVYLDALG
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHCCCCEEEECHH
TVVAYHTVTVQPMITGPLTRILFTPGQFVKKGDLLAEIDPAPYRATLDQAEAKLAQDKAS
HEEEEEEEEEEEEECCCCCEEEECCCHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
LANAEMQARQYASLVKQNYTSKLQAATALATAAEDRALVKQDEASIETDRINLGYTRITA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEECEEECCEEEEEE
PISGRTGILQVNAGNIVSPSTTSGIVVINTLQPISVQFSLPQQDLPAIIAAMKRGKVDLL
ECCCCCEEEEECCCCEECCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHCCCEEEE
ATEEGDPQTAKVLDHGTLAVLDNTVNANTGTLTLKGTFANPDLTLWPGAYVNVRTLVRTI
EECCCCCCHHHHCCCCEEEEEECCCCCCCCEEEEEEEECCCCEEECCCCEEHHHHHHHHH
DNAVTVPPVAVQQGPSGSFVFLVKPPAKKGGSFTVIDQKVTLGVQTARVVVVTSGLVPGD
HCCCCCCCEEEECCCCCCEEEEECCCCCCCCCEEEEECEEEEEEEEEEEEEEECCCCCCH
EVVTEGNSRLKGGSAIHIVTGSAGAP
HHEECCCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
AKRRGRIIFGLVALALVGAVAYRLAHRTKPAHGGGATAIPVEVAKATRQNVPVYLDALG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHCCCCEEEECHH
TVVAYHTVTVQPMITGPLTRILFTPGQFVKKGDLLAEIDPAPYRATLDQAEAKLAQDKAS
HEEEEEEEEEEEEECCCCCEEEECCCHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
LANAEMQARQYASLVKQNYTSKLQAATALATAAEDRALVKQDEASIETDRINLGYTRITA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEECEEECCEEEEEE
PISGRTGILQVNAGNIVSPSTTSGIVVINTLQPISVQFSLPQQDLPAIIAAMKRGKVDLL
ECCCCCEEEEECCCCEECCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHCCCEEEE
ATEEGDPQTAKVLDHGTLAVLDNTVNANTGTLTLKGTFANPDLTLWPGAYVNVRTLVRTI
EECCCCCCHHHHCCCCEEEEEECCCCCCCCEEEEEEEECCCCEEECCCCEEHHHHHHHHH
DNAVTVPPVAVQQGPSGSFVFLVKPPAKKGGSFTVIDQKVTLGVQTARVVVVTSGLVPGD
HCCCCCCCEEEECCCCCCEEEEECCCCCCCCCEEEEECEEEEEEEEEEEEEEECCCCCCH
EVVTEGNSRLKGGSAIHIVTGSAGAP
HHEECCCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA