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The map label for this gene is glyA

Identifier: 148243427

GI number: 148243427

Start: 2023963

End: 2025234

Strand: Direct

Name: glyA

Synonym: SynRCC307_2328

Alternate gene names: 148243427

Gene position: 2023963-2025234 (Clockwise)

Preceding gene: 148243423

Following gene: 148243428

Centisome position: 90.97

GC content: 62.58

Gene sequence:

>1272_bases
ATGCGATCCCCCCAAGCACTTCTGCAGGGCGATCCAGAGATTGCCGGACTGATCAACAAAGAATTGGAACGGCAACAGAG
CCACTTGGAGCTGATTGCCAGTGAAAACTTCGCCTCACCAGCGGTGATGGCCGCCCAGGGCTCCGTACTCACCAACAAGT
ACGCCGAAGGCTTGCCGAACCGCCGCTATTACGGCGGCTGTGAGCACGTCGATGCCATTGAGGAGCTGGCGATTGAGCGC
GCCAAGCAACTCTTTGGTGCCGCCTGGGCCAACGTGCAGCCCCACAGCGGCGCTCAAGCCAACTTCGCTGTGTTTCTGGC
CCTGCTGAAACCGGGCGACACGATCCTGGGCATGGATCTCTCCCACGGCGGCCACCTCACCCACGGCTCACCGGTGAATG
TGAGCGGTAAGTGGTTCAAGGCCGTCCACTACGGCGTGGACCCTGAGACCCAACAGCTCAATTTGGAGAGCATTCGCCAG
CTAGCCCTTGAGCACAAGCCCAAACTGATCGTTTGCGGCTACTCGGCTTATCCGCGCAGCATCGATTTCGCTGGCTTCCG
CGCGATCGCTGATGAGGTGGGCGCTTACCTGCTGGCCGACATGGCCCACATCGCTGGCCTGGTGGCCGCTGGCGTGCATC
CCAGCCCCGTGCCCCATTGCCACGTGGTGACCACCACCACCCACAAAACCCTGCGGGGTCCACGCGGTGGCCTGATCCTC
TGCAACGACGCCGACTTCGCTAAGCAGTTCGACAAAGCCGTGTTTCCTGGAACCCAGGGCGGACCGCTTGAGCACGTTGT
TGCCGCCAAAGCCGTGGCCTTCGGTGAGGCGCTCCAACCCAGCTTCAAGCAGTACAGCCAACAGGTGGTGGCCAATGCTC
AGGCCCTGGCCGAGCGTTTGCAGGAGCGGGGCATTGCCGTGGTCAGCGGCGGCACCGACAACCATGTGGTGCTGCTGGAT
CTGCGCGGCATTGGCATGACCGGCAAGGTGGCTGATCTGCTGGTGAGCGAGGTGAACATCACCGCCAACAAAAACACCGT
TCCCTTTGATCCGGAGTCACCGTTTGTGACCAGCGGCCTACGCCTCGGCACCGCAGCACTCACCACCCGTGGCTTCGACG
AGGCGGCCTTCAGCGAGGTGGCTGATGTGATTGCTGACCGGCTTCTGAATCCCGAAGACGCCGCCATCGAACAGCGCTGC
CGTGATCGCGTGGCCAGCCTCTGCCAGCGGCACCCGCTTTATGGGCCTGCATCACCTGTGCTGGCGGCCTAG

Upstream 100 bases:

>100_bases
GGCGGTTTTTTTTTGGTTCCATCAACTGGAACCCCCGGTTCTTACGATTCAAGGACCGTCCACGTCCCCTTTTTCTGCAT
CGCCAGTGACTGAGCCGACC

Downstream 100 bases:

>100_bases
CTCAACTAGACTCGTGGAGAAGGCTTATTCGCCCCGTGGACTCCAGCCCGCTGATTCCTGCGCTGGCCACCTTGGGTGGG
GCCTGTTTCTTGACGGCTGC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MRSPQALLQGDPEIAGLINKELERQQSHLELIASENFASPAVMAAQGSVLTNKYAEGLPNRRYYGGCEHVDAIEELAIER
AKQLFGAAWANVQPHSGAQANFAVFLALLKPGDTILGMDLSHGGHLTHGSPVNVSGKWFKAVHYGVDPETQQLNLESIRQ
LALEHKPKLIVCGYSAYPRSIDFAGFRAIADEVGAYLLADMAHIAGLVAAGVHPSPVPHCHVVTTTTHKTLRGPRGGLIL
CNDADFAKQFDKAVFPGTQGGPLEHVVAAKAVAFGEALQPSFKQYSQQVVANAQALAERLQERGIAVVSGGTDNHVVLLD
LRGIGMTGKVADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFDEAAFSEVADVIADRLLNPEDAAIEQRC
RDRVASLCQRHPLYGPASPVLAA

Sequences:

>Translated_423_residues
MRSPQALLQGDPEIAGLINKELERQQSHLELIASENFASPAVMAAQGSVLTNKYAEGLPNRRYYGGCEHVDAIEELAIER
AKQLFGAAWANVQPHSGAQANFAVFLALLKPGDTILGMDLSHGGHLTHGSPVNVSGKWFKAVHYGVDPETQQLNLESIRQ
LALEHKPKLIVCGYSAYPRSIDFAGFRAIADEVGAYLLADMAHIAGLVAAGVHPSPVPHCHVVTTTTHKTLRGPRGGLIL
CNDADFAKQFDKAVFPGTQGGPLEHVVAAKAVAFGEALQPSFKQYSQQVVANAQALAERLQERGIAVVSGGTDNHVVLLD
LRGIGMTGKVADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFDEAAFSEVADVIADRLLNPEDAAIEQRC
RDRVASLCQRHPLYGPASPVLAA
>Mature_423_residues
MRSPQALLQGDPEIAGLINKELERQQSHLELIASENFASPAVMAAQGSVLTNKYAEGLPNRRYYGGCEHVDAIEELAIER
AKQLFGAAWANVQPHSGAQANFAVFLALLKPGDTILGMDLSHGGHLTHGSPVNVSGKWFKAVHYGVDPETQQLNLESIRQ
LALEHKPKLIVCGYSAYPRSIDFAGFRAIADEVGAYLLADMAHIAGLVAAGVHPSPVPHCHVVTTTTHKTLRGPRGGLIL
CNDADFAKQFDKAVFPGTQGGPLEHVVAAKAVAFGEALQPSFKQYSQQVVANAQALAERLQERGIAVVSGGTDNHVVLLD
LRGIGMTGKVADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFDEAAFSEVADVIADRLLNPEDAAIEQRC
RDRVASLCQRHPLYGPASPVLAA

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI261862352, Length=403, Percent_Identity=48.8833746898263, Blast_Score=355, Evalue=3e-98,
Organism=Homo sapiens, GI261862350, Length=403, Percent_Identity=48.8833746898263, Blast_Score=355, Evalue=3e-98,
Organism=Homo sapiens, GI261862348, Length=403, Percent_Identity=48.8833746898263, Blast_Score=355, Evalue=3e-98,
Organism=Homo sapiens, GI19923315, Length=403, Percent_Identity=48.8833746898263, Blast_Score=355, Evalue=3e-98,
Organism=Homo sapiens, GI261862346, Length=398, Percent_Identity=50, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI22547186, Length=403, Percent_Identity=49.1315136476427, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI22547189, Length=389, Percent_Identity=48.0719794344473, Blast_Score=311, Evalue=6e-85,
Organism=Escherichia coli, GI1788902, Length=406, Percent_Identity=59.6059113300493, Blast_Score=478, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI25144732, Length=396, Percent_Identity=47.4747474747475, Blast_Score=354, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI25144729, Length=396, Percent_Identity=47.4747474747475, Blast_Score=354, Evalue=6e-98,
Organism=Saccharomyces cerevisiae, GI6319739, Length=399, Percent_Identity=45.8646616541353, Blast_Score=352, Evalue=6e-98,
Organism=Saccharomyces cerevisiae, GI6323087, Length=401, Percent_Identity=42.643391521197, Blast_Score=327, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24640005, Length=400, Percent_Identity=48.25, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI221329721, Length=400, Percent_Identity=48.25, Blast_Score=367, Evalue=1e-101,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_SYNR3 (A5GWH2)

Other databases:

- EMBL:   CT978603
- RefSeq:   YP_001228584.1
- ProteinModelPortal:   A5GWH2
- SMR:   A5GWH2
- STRING:   A5GWH2
- GeneID:   5156328
- GenomeReviews:   CT978603_GR
- KEGG:   syr:SynRCC307_2328
- eggNOG:   COG0112
- HOGENOM:   HBG301263
- OMA:   GRAYVTC
- ProtClustDB:   PRK00011
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 45134; Mature: 45134

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSPQALLQGDPEIAGLINKELERQQSHLELIASENFASPAVMAAQGSVLTNKYAEGLPN
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCCCC
RRYYGGCEHVDAIEELAIERAKQLFGAAWANVQPHSGAQANFAVFLALLKPGDTILGMDL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHEEEEECCCCEEEEEEE
SHGGHLTHGSPVNVSGKWFKAVHYGVDPETQQLNLESIRQLALEHKPKLIVCGYSAYPRS
CCCCCCCCCCCCCCCCCEEEEEECCCCCCHHCCCHHHHHHHHHHCCCCEEEECCCCCCCC
IDFAGFRAIADEVGAYLLADMAHIAGLVAAGVHPSPVPHCHVVTTTTHKTLRGPRGGLIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHCCCCCCEEE
CNDADFAKQFDKAVFPGTQGGPLEHVVAAKAVAFGEALQPSFKQYSQQVVANAQALAERL
ECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
QERGIAVVSGGTDNHVVLLDLRGIGMTGKVADLLVSEVNITANKNTVPFDPESPFVTSGL
HHCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHEEEEECCCCCCCCCCCCCHHCCC
RLGTAALTTRGFDEAAFSEVADVIADRLLNPEDAAIEQRCRDRVASLCQRHPLYGPASPV
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LAA
CCC
>Mature Secondary Structure
MRSPQALLQGDPEIAGLINKELERQQSHLELIASENFASPAVMAAQGSVLTNKYAEGLPN
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCCCC
RRYYGGCEHVDAIEELAIERAKQLFGAAWANVQPHSGAQANFAVFLALLKPGDTILGMDL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHEEEEECCCCEEEEEEE
SHGGHLTHGSPVNVSGKWFKAVHYGVDPETQQLNLESIRQLALEHKPKLIVCGYSAYPRS
CCCCCCCCCCCCCCCCCEEEEEECCCCCCHHCCCHHHHHHHHHHCCCCEEEECCCCCCCC
IDFAGFRAIADEVGAYLLADMAHIAGLVAAGVHPSPVPHCHVVTTTTHKTLRGPRGGLIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHCCCCCCEEE
CNDADFAKQFDKAVFPGTQGGPLEHVVAAKAVAFGEALQPSFKQYSQQVVANAQALAERL
ECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
QERGIAVVSGGTDNHVVLLDLRGIGMTGKVADLLVSEVNITANKNTVPFDPESPFVTSGL
HHCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHEEEEECCCCCCCCCCCCCHHCCC
RLGTAALTTRGFDEAAFSEVADVIADRLLNPEDAAIEQRCRDRVASLCQRHPLYGPASPV
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA