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The map label for this gene is menE [H]

Identifier: 148243354

GI number: 148243354

Start: 1960990

End: 1962114

Strand: Direct

Name: menE [H]

Synonym: SynRCC307_2255

Alternate gene names: 148243354

Gene position: 1960990-1962114 (Clockwise)

Preceding gene: 148243353

Following gene: 148243357

Centisome position: 88.14

GC content: 67.82

Gene sequence:

>1125_bases
ATGAACGGCTGGGAGCTACGGGCCAGTGCGCTTGAAGAGCAAGCGGGCCGCGATGCGATGACCTGCTGCCAACGGTGGCC
AGAAGGCAGCGGCGTGGTGATCGGCAGCGGCGGCAGCAGCGGCGGGCGCAAGTGGTGCCTGCAGAGCTGGGAGAACCTCG
AGCAGTCGGCCAGCAGCTGCGCGGACTGGTTACAAGCCATTGGGGTTGATCCCAGCTGCGTGCAGCTGGTGAACCCCCTG
CCCAGCCATCACATGGGGGGACTGATGCCCCAAATCAGGGCGCGGCAGTGGCAAGCACCGCTGGTGGCCATTGCGCCTGA
ACTGATGAAATCTCCTGGCGCGCTCCTGGAGCAACACGGCAACCTCACCCGCGGCGGCCGCGATGCCGTGATCTCGCTGG
TGCCCACGCAATTGCAGCGGCTCCTGGGCGATCCCTCAGGCCGCAGCTGGCTCCGGCAATTCCGGCTGCTTTGGATCGGC
GGCGGCCCCCTCAGCACCGAGCTGGCTGATCAAGCCCGCCAGCTGCAGCTTCCGCTGAGCCCCTGTTACGGCAGCACTGA
AACAGCCGCGATGGTCTGCGCCGCAGATCCAGCCCAATTTCTGGCAGGGCACAACAGTTGCGGTGAACCGTTGAGCGATG
TGGAGCTGCAGCTCGAGCCAACCAGCGGAGCCATAGAGGTGAAAACCAGGCGGCTGAGCCCGGGCTGGCTGAAGGGAGAG
CAGGTGCAGCCCTTCGCCGATGCCGGCGGCTGGTGGCACAGCGGTGATGCAGGCCGCCTCGGGCCTGCGGGCCTGGAACT
GCTGGGGCGGCTCGATGGCGCCCTCAACAGCGGCGGGGCCACGGTGTTTCCAGAGCAAATTGAAGCGGCCTTGGCCGGCC
TGCCGGGGCTAGAGGCGGTGCTGGTGGTGGGCCTACCGGATCCGCAATGGGGCCAACGGCTCATTGGCCTGGTCAAACCG
TCACCAGGCGCCAATGGTGATGAGCTGATGGCGCTGCTGCGGCAGCGCAGCGCCGGCCTGCCGCCAGCGCAACGGCCCAA
GCATTGGCAGCTGTGCCCTGAGCTGGCGCCCAACCCCCAGGGCAAGTGGGAGCGCCAGCGCTGGCGGGCGTGGGCTCAGG
TCTGA

Upstream 100 bases:

>100_bases
GCGGCCCCACACCATGCGCCGCTGGACTGGCCCCGGGCTGGGGTGCTTCTGGCGATCTCGCCAGCACGATCCCCCAGCAG
GTGTGGGAGGCCGCCGGCTC

Downstream 100 bases:

>100_bases
ACTGAAGCCTGAAGCCAACGCTGCACTCCCTCAGGCAGGGGCGCACGGCGGCGATCAGCGGCGGCAATGCACTGATGTCG
CGTCAGCCCGCGGGCGACGG

Product: O-succinylbenzoate-CoA ligase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MNGWELRASALEEQAGRDAMTCCQRWPEGSGVVIGSGGSSGGRKWCLQSWENLEQSASSCADWLQAIGVDPSCVQLVNPL
PSHHMGGLMPQIRARQWQAPLVAIAPELMKSPGALLEQHGNLTRGGRDAVISLVPTQLQRLLGDPSGRSWLRQFRLLWIG
GGPLSTELADQARQLQLPLSPCYGSTETAAMVCAADPAQFLAGHNSCGEPLSDVELQLEPTSGAIEVKTRRLSPGWLKGE
QVQPFADAGGWWHSGDAGRLGPAGLELLGRLDGALNSGGATVFPEQIEAALAGLPGLEAVLVVGLPDPQWGQRLIGLVKP
SPGANGDELMALLRQRSAGLPPAQRPKHWQLCPELAPNPQGKWERQRWRAWAQV

Sequences:

>Translated_374_residues
MNGWELRASALEEQAGRDAMTCCQRWPEGSGVVIGSGGSSGGRKWCLQSWENLEQSASSCADWLQAIGVDPSCVQLVNPL
PSHHMGGLMPQIRARQWQAPLVAIAPELMKSPGALLEQHGNLTRGGRDAVISLVPTQLQRLLGDPSGRSWLRQFRLLWIG
GGPLSTELADQARQLQLPLSPCYGSTETAAMVCAADPAQFLAGHNSCGEPLSDVELQLEPTSGAIEVKTRRLSPGWLKGE
QVQPFADAGGWWHSGDAGRLGPAGLELLGRLDGALNSGGATVFPEQIEAALAGLPGLEAVLVVGLPDPQWGQRLIGLVKP
SPGANGDELMALLRQRSAGLPPAQRPKHWQLCPELAPNPQGKWERQRWRAWAQV
>Mature_374_residues
MNGWELRASALEEQAGRDAMTCCQRWPEGSGVVIGSGGSSGGRKWCLQSWENLEQSASSCADWLQAIGVDPSCVQLVNPL
PSHHMGGLMPQIRARQWQAPLVAIAPELMKSPGALLEQHGNLTRGGRDAVISLVPTQLQRLLGDPSGRSWLRQFRLLWIG
GGPLSTELADQARQLQLPLSPCYGSTETAAMVCAADPAQFLAGHNSCGEPLSDVELQLEPTSGAIEVKTRRLSPGWLKGE
QVQPFADAGGWWHSGDAGRLGPAGLELLGRLDGALNSGGATVFPEQIEAALAGLPGLEAVLVVGLPDPQWGQRLIGLVKP
SPGANGDELMALLRQRSAGLPPAQRPKHWQLCPELAPNPQGKWERQRWRAWAQV

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788595, Length=242, Percent_Identity=28.5123966942149, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17558820, Length=378, Percent_Identity=24.6031746031746, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI32563687, Length=255, Percent_Identity=25.4901960784314, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 40072; Mature: 40072

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGWELRASALEEQAGRDAMTCCQRWPEGSGVVIGSGGSSGGRKWCLQSWENLEQSASSC
CCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ADWLQAIGVDPSCVQLVNPLPSHHMGGLMPQIRARQWQAPLVAIAPELMKSPGALLEQHG
HHHHHHHCCCHHHHHHHCCCCCHHHCCCCHHHHHHHHCCCHHHCCHHHHHCCHHHHHHCC
NLTRGGRDAVISLVPTQLQRLLGDPSGRSWLRQFRLLWIGGGPLSTELADQARQLQLPLS
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCEEEEECCCCCCHHHHHHHHHCCCCCC
PCYGSTETAAMVCAADPAQFLAGHNSCGEPLSDVELQLEPTSGAIEVKTRRLSPGWLKGE
CCCCCCCCEEEEEECCHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCC
QVQPFADAGGWWHSGDAGRLGPAGLELLGRLDGALNSGGATVFPEQIEAALAGLPGLEAV
CCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHCCCCCCEE
LVVGLPDPQWGQRLIGLVKPSPGANGDELMALLRQRSAGLPPAQRPKHWQLCPELAPNPQ
EEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GKWERQRWRAWAQV
CCHHHHHHHHHHCC
>Mature Secondary Structure
MNGWELRASALEEQAGRDAMTCCQRWPEGSGVVIGSGGSSGGRKWCLQSWENLEQSASSC
CCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ADWLQAIGVDPSCVQLVNPLPSHHMGGLMPQIRARQWQAPLVAIAPELMKSPGALLEQHG
HHHHHHHCCCHHHHHHHCCCCCHHHCCCCHHHHHHHHCCCHHHCCHHHHHCCHHHHHHCC
NLTRGGRDAVISLVPTQLQRLLGDPSGRSWLRQFRLLWIGGGPLSTELADQARQLQLPLS
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCEEEEECCCCCCHHHHHHHHHCCCCCC
PCYGSTETAAMVCAADPAQFLAGHNSCGEPLSDVELQLEPTSGAIEVKTRRLSPGWLKGE
CCCCCCCCEEEEEECCHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCC
QVQPFADAGGWWHSGDAGRLGPAGLELLGRLDGALNSGGATVFPEQIEAALAGLPGLEAV
CCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHCCCCCCEE
LVVGLPDPQWGQRLIGLVKPSPGANGDELMALLRQRSAGLPPAQRPKHWQLCPELAPNPQ
EEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GKWERQRWRAWAQV
CCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]