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The map label for this gene is trpE [H]

Identifier: 148243187

GI number: 148243187

Start: 1804394

End: 1805896

Strand: Direct

Name: trpE [H]

Synonym: SynRCC307_2088

Alternate gene names: 148243187

Gene position: 1804394-1805896 (Clockwise)

Preceding gene: 148243186

Following gene: 148243188

Centisome position: 81.1

GC content: 64.2

Gene sequence:

>1503_bases
ATGGCCAGTCCCGATCCGACTACCAACTTCGAGCCGCTGTGGCGGCGTTGGCCGGCGGACCTGGACACGCCGCTGAGCAC
CTGGCTCAAGGTGGGCCAGGGCCGCCCCTATGGCGTTTTGCTGGAGTCGGTCGAGGGCGGAGAGCATCTAGGCCGCTGGA
GTTTTGTCGCCAGCGACCCTCTTTGGGTGCTGAGTGTGCGCGGCGATCAAGCCTGGCTGGAACACCGCGATGGGCGCCGG
GAATCGCTCCAAGGCGACCCCTTTGAACTGCTGCGCCAACGCCTCGCCCCCTACAAAAGCGCCCCAATCCCTGGGCTTCC
ACCAGTGGGTCAGTTGTTTGGCTTCTGGGGTTACGAACTCATCCACTGGGTCGAGCCCAGTGTTCCGGTGCATCCCCGCA
GCGATGACGACCAGCCCGATGGCTGCTGGATGTTCTGCGACACCTTGCTGGTGTTTGACCAGGTGCGGCGCCAAGTGACG
GCTGTCGCTTACGCCGATCACAGCCAAAACGACGATCAAGCAGCCGCCAGAGCGGCGGCTGAACAGCGGCTGGATGCCCT
GGAAACCCAATTGCAGCAGCCCCTACCGGCGGGCCTGACGCCACTGGCCTGGAAAGAGCAAGACGCCCAATCGCTCAAGG
TGGTCAGCAACACCTCCCAGAGCGCCTTTGAAGACGCTGTCCGCCAAGCTCGCGACCACATCGGCGCCGGTGATGTCTTC
CAACTGGTGCTGTCGCAACGCTTGGAGGCGGAGGTCAGCCACGACCCCTTCGATCTGTACCGCAGTCTGCGGATGGTGAA
CCCATCGCCCTACATGGGGTTCTTCAGCTTCAACGGCTGGCATCTGATTGGCTCCAGCCCCGAGGTGATGGTGAAAGCCG
ACCCCCAAGACGATGGACGGGTGGTGGCCTCCCTGCGGCCGATCGCTGGAACCCGTCGCCGCGGCAGCACAGCCGCCGAA
GATCAAGCCCTCGAAGCGGAGCTGCTCGCCGATCCCAAAGAACGGGCCGAGCACGTGATGTTGGTGGATCTCGGCCGCAA
TGACCTGGGCCGGGTCTGCCAGCCCGGCAGCGTTGCGGTCAAGGAGCTGATGCTGATTGAGCGCTATTCCCACGTGATGC
ACATCGTCTCCCAGGTGGAAGGCGATCTGCAGCCGCAGCACGATGTTTGGGATCTCCTGCGGGCGTCCTTCCCCGCAGGC
ACCGTCAGCGGAGCACCCAAGATTCGGGCCATGCAGCTGATCCATGAATTGGAACCCGATGCCCGCGGCCCCTACTCAGG
GGTCTATGGCTCGATGGACCTCTGTGGTGCCCTCAACACCGCCATCACCATCCGCACGATGGTGGTGCAACCCGGAGACA
ACGGGAGTTGGCGGGTGCAGGTGCAAGCCGGAGCCGGCGTTGTGGCCGACTCTCAGCCGACCGCCGAGCACGAGGAAACC
CTCAACAAAGCCCGCGGCATGCTCAAGGCCCTGGCTTGCCTCGAGCCAGGCCAACAGCCATGA

Upstream 100 bases:

>100_bases
CGGCCGCAACACCTTCGACAGCTGAATCAACGGCGCTTGGCGCCACATCCTTTAGAAAGGCGGGTCGAACGACCCGCCTT
TTTTTCTGCCAAGCCCTGTG

Downstream 100 bases:

>100_bases
GCCAAAGCTTGCTCAAGGGCTTTGAAGTGGAGATGTACACCGGCCGCCCCGACGGCACGGTGGTGGGCTGCTCCAGCGAA
GCTGCCGCGGCCATCGACGG

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MASPDPTTNFEPLWRRWPADLDTPLSTWLKVGQGRPYGVLLESVEGGEHLGRWSFVASDPLWVLSVRGDQAWLEHRDGRR
ESLQGDPFELLRQRLAPYKSAPIPGLPPVGQLFGFWGYELIHWVEPSVPVHPRSDDDQPDGCWMFCDTLLVFDQVRRQVT
AVAYADHSQNDDQAAARAAAEQRLDALETQLQQPLPAGLTPLAWKEQDAQSLKVVSNTSQSAFEDAVRQARDHIGAGDVF
QLVLSQRLEAEVSHDPFDLYRSLRMVNPSPYMGFFSFNGWHLIGSSPEVMVKADPQDDGRVVASLRPIAGTRRRGSTAAE
DQALEAELLADPKERAEHVMLVDLGRNDLGRVCQPGSVAVKELMLIERYSHVMHIVSQVEGDLQPQHDVWDLLRASFPAG
TVSGAPKIRAMQLIHELEPDARGPYSGVYGSMDLCGALNTAITIRTMVVQPGDNGSWRVQVQAGAGVVADSQPTAEHEET
LNKARGMLKALACLEPGQQP

Sequences:

>Translated_500_residues
MASPDPTTNFEPLWRRWPADLDTPLSTWLKVGQGRPYGVLLESVEGGEHLGRWSFVASDPLWVLSVRGDQAWLEHRDGRR
ESLQGDPFELLRQRLAPYKSAPIPGLPPVGQLFGFWGYELIHWVEPSVPVHPRSDDDQPDGCWMFCDTLLVFDQVRRQVT
AVAYADHSQNDDQAAARAAAEQRLDALETQLQQPLPAGLTPLAWKEQDAQSLKVVSNTSQSAFEDAVRQARDHIGAGDVF
QLVLSQRLEAEVSHDPFDLYRSLRMVNPSPYMGFFSFNGWHLIGSSPEVMVKADPQDDGRVVASLRPIAGTRRRGSTAAE
DQALEAELLADPKERAEHVMLVDLGRNDLGRVCQPGSVAVKELMLIERYSHVMHIVSQVEGDLQPQHDVWDLLRASFPAG
TVSGAPKIRAMQLIHELEPDARGPYSGVYGSMDLCGALNTAITIRTMVVQPGDNGSWRVQVQAGAGVVADSQPTAEHEET
LNKARGMLKALACLEPGQQP
>Mature_499_residues
ASPDPTTNFEPLWRRWPADLDTPLSTWLKVGQGRPYGVLLESVEGGEHLGRWSFVASDPLWVLSVRGDQAWLEHRDGRRE
SLQGDPFELLRQRLAPYKSAPIPGLPPVGQLFGFWGYELIHWVEPSVPVHPRSDDDQPDGCWMFCDTLLVFDQVRRQVTA
VAYADHSQNDDQAAARAAAEQRLDALETQLQQPLPAGLTPLAWKEQDAQSLKVVSNTSQSAFEDAVRQARDHIGAGDVFQ
LVLSQRLEAEVSHDPFDLYRSLRMVNPSPYMGFFSFNGWHLIGSSPEVMVKADPQDDGRVVASLRPIAGTRRRGSTAAED
QALEAELLADPKERAEHVMLVDLGRNDLGRVCQPGSVAVKELMLIERYSHVMHIVSQVEGDLQPQHDVWDLLRASFPAGT
VSGAPKIRAMQLIHELEPDARGPYSGVYGSMDLCGALNTAITIRTMVVQPGDNGSWRVQVQAGAGVVADSQPTAEHEETL
NKARGMLKALACLEPGQQP

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=392, Percent_Identity=38.7755102040816, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1788114, Length=458, Percent_Identity=32.3144104803493, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1786809, Length=289, Percent_Identity=28.3737024221453, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320935, Length=488, Percent_Identity=36.2704918032787, Blast_Score=303, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6324361, Length=421, Percent_Identity=24.4655581947743, Blast_Score=114, Evalue=5e-26,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 55229; Mature: 55098

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPDPTTNFEPLWRRWPADLDTPLSTWLKVGQGRPYGVLLESVEGGEHLGRWSFVASDP
CCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCC
LWVLSVRGDQAWLEHRDGRRESLQGDPFELLRQRLAPYKSAPIPGLPPVGQLFGFWGYEL
EEEEEECCCHHHHHHCCCCHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
IHWVEPSVPVHPRSDDDQPDGCWMFCDTLLVFDQVRRQVTAVAYADHSQNDDQAAARAAA
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
EQRLDALETQLQQPLPAGLTPLAWKEQDAQSLKVVSNTSQSAFEDAVRQARDHIGAGDVF
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHH
QLVLSQRLEAEVSHDPFDLYRSLRMVNPSPYMGFFSFNGWHLIGSSPEVMVKADPQDDGR
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCEEEECCCCCCCE
VVASLRPIAGTRRRGSTAAEDQALEAELLADPKERAEHVMLVDLGRNDLGRVCQPGSVAV
EEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCHHHCCEEEEEECCCCCHHHCCCCCHHHH
KELMLIERYSHVMHIVSQVEGDLQPQHDVWDLLRASFPAGTVSGAPKIRAMQLIHELEPD
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
ARGPYSGVYGSMDLCGALNTAITIRTMVVQPGDNGSWRVQVQAGAGVVADSQPTAEHEET
CCCCCCCCCCCHHHHHHHHHEEEEEEEEEECCCCCCEEEEEEECCCEEECCCCCHHHHHH
LNKARGMLKALACLEPGQQP
HHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ASPDPTTNFEPLWRRWPADLDTPLSTWLKVGQGRPYGVLLESVEGGEHLGRWSFVASDP
CCCCCCCCCCHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCC
LWVLSVRGDQAWLEHRDGRRESLQGDPFELLRQRLAPYKSAPIPGLPPVGQLFGFWGYEL
EEEEEECCCHHHHHHCCCCHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
IHWVEPSVPVHPRSDDDQPDGCWMFCDTLLVFDQVRRQVTAVAYADHSQNDDQAAARAAA
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
EQRLDALETQLQQPLPAGLTPLAWKEQDAQSLKVVSNTSQSAFEDAVRQARDHIGAGDVF
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHH
QLVLSQRLEAEVSHDPFDLYRSLRMVNPSPYMGFFSFNGWHLIGSSPEVMVKADPQDDGR
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCEEEECCCCCCCE
VVASLRPIAGTRRRGSTAAEDQALEAELLADPKERAEHVMLVDLGRNDLGRVCQPGSVAV
EEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCHHHCCEEEEEECCCCCHHHCCCCCHHHH
KELMLIERYSHVMHIVSQVEGDLQPQHDVWDLLRASFPAGTVSGAPKIRAMQLIHELEPD
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
ARGPYSGVYGSMDLCGALNTAITIRTMVVQPGDNGSWRVQVQAGAGVVADSQPTAEHEET
CCCCCCCCCCCHHHHHHHHHEEEEEEEEEECCCCCCEEEEEEECCCEEECCCCCHHHHHH
LNKARGMLKALACLEPGQQP
HHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 3141423 [H]