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The map label for this gene is ilvD

Identifier: 148242347

GI number: 148242347

Start: 1103520

End: 1105196

Strand: Direct

Name: ilvD

Synonym: SynRCC307_1248

Alternate gene names: 148242347

Gene position: 1103520-1105196 (Clockwise)

Preceding gene: 148242346

Following gene: 148242355

Centisome position: 49.6

GC content: 60.41

Gene sequence:

>1677_bases
ATGGCCCCCCTCCGATCCAGCGCCATCACGCAAGGTGTTCAGCGCAGTCCCAACCGCGCCATGTTGCGCGCTGTTGGTTT
CGGAGATGGTGACTTCAGCAAACCGATCATCGGGATTGCCAACGGTTACAGCACCATCACGCCCTGCAATGTGGGGCTCA
ACGATCTAGCCCTGCGCGCCGAAGCAGCCACACAAGCAGCCGGGGGGATGCCGCAACTCTTCGGCACCATCACCGTGAGT
GATGGCATCTCCATGGGCACCGAGGGGATGAAGTACTCCCTGGTGAGCCGCGAAGTGATTGCCGATGCCATCGAGACCGC
CTGCAACGGTCAAAGCATGGATGGCGTATTGGCCATCGGCGGCTGCGACAAAAACATGCCCGCCGCCATGTTGGCGATGG
CGCGGATGAACATCCCAGGTGTCTTCGTCTATGGCGGCACCATCAAGCCCGGCAAATTGGGCGGCTGCGACCTCACCGTG
GTCAGCGCCTTTGAAGCGGTTGGTCAGTTGAGCAGCGGCAAGATCGATGAAGCCCAGCTCACCGCTGTTGAAAAGAACGC
TTGCCCAGGAGCTGGCAGCTGTGGTGGCATGTTCACGGCCAACACGATGAGTGCGGCCATCGAAACGATGGGGTTGAGCT
TGCCGTTCAGCTCCACCATGGCGGCGGAAGATCCCGAGAAAGCCGAGAGCGCTGCTCGCTCGGCTGAGGTGTTGGTGGAG
GCCATTGCTGCCAACATTCGTCCGTTGGATCTGCTGACCCGCGAAGCGTTTGAAAACGCCATCAGCGTGATCATGGCCGT
GGGTGGCTCCACCAATGCGGTGTTGCACTTGCTCGCGATTGCACGCACCGCCGGCGTACCACTGTCAATCGACGACTTCG
AAACGATTCGGCAACGGGTGCCTGTGATCTGCGATCTCAAACCAAGCGGACGCTTTGTAACGGTCGACCTGCACAACGCT
GGTGGCATTCCGCAAGTCATGAAACTTCTGCTCGATGGTGGGTTGCTCCATGGCGATTGCCGCACCGTGGAGGGCAAAAC
CTTGCGAGAGGTTCTGGCTGATGTTCCCTCAGAACCGCCGGCTGATCAGGAGGTGATCCGGCCCCTGAGCAATCCCCTCT
ATGCCAAAGGGCACCTGGCTGTGTTGAAAGGCAACCTCGCCAGTGAAGGGGCTGTCGCCAAGATCAGTGGTGTCAAAACA
CCAGTGCTCACAGGCCCAGCCAGGGTGTTTGAAAGCGAAGAGCAGTGCCTGCAGGCGATCTTGGCGAACCAGGTTCACGC
AGGTGATGTGGTGGTGGTGCGCAATGAAGGCCCCGTTGGTGGCCCGGGAATGCGGGAGATGTTGGCGCCCACCGCCGCCA
TCGTTGGTGAAGGGCTCGGCGACAAGGTGGCGTTGATCACCGACGGTCGCTTCAGCGGCGGCACCTACGGCCTGGTGGTT
GGGCATGTGGCCCCAGAAGCAGCCGTAGGCGGCATGATCGGCCTGGTGCAAGAGGGCGATTCCATCACCGTGGATGCCCA
ACAACAATTGCTGCAGCTCAATGTGGATGCCGCTGAATTGGAGCGGCGCAAGCAAGCGTGGGTCAAACCAGAACCGCGTT
ACCGCACCGGTGTTTTGGGTAAATACGCCCGTTTGGTGAGCAGCAGCAGCAAGGGCGCTGTGACTGATCAACCCTGA

Upstream 100 bases:

>100_bases
TGAACCGCCTCAACCTGGCGATCGAGGATGTGCGCCGTCAGCTGGAGAGCATGGCTCCCGAGAGCAGCAACTGAGAGGAT
CGTGCAAACCGCACGGACCC

Downstream 100 bases:

>100_bases
ACCAGTTCGGCGCGCAAGCGACGCGCCAAGGTTTCCAATGGAATGCCGTCGTCAGGCCTGGGGCAGGCTTGTCCGGAGGT
GCCGTCCATCCACACCGGAT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MAPLRSSAITQGVQRSPNRAMLRAVGFGDGDFSKPIIGIANGYSTITPCNVGLNDLALRAEAATQAAGGMPQLFGTITVS
DGISMGTEGMKYSLVSREVIADAIETACNGQSMDGVLAIGGCDKNMPAAMLAMARMNIPGVFVYGGTIKPGKLGGCDLTV
VSAFEAVGQLSSGKIDEAQLTAVEKNACPGAGSCGGMFTANTMSAAIETMGLSLPFSSTMAAEDPEKAESAARSAEVLVE
AIAANIRPLDLLTREAFENAISVIMAVGGSTNAVLHLLAIARTAGVPLSIDDFETIRQRVPVICDLKPSGRFVTVDLHNA
GGIPQVMKLLLDGGLLHGDCRTVEGKTLREVLADVPSEPPADQEVIRPLSNPLYAKGHLAVLKGNLASEGAVAKISGVKT
PVLTGPARVFESEEQCLQAILANQVHAGDVVVVRNEGPVGGPGMREMLAPTAAIVGEGLGDKVALITDGRFSGGTYGLVV
GHVAPEAAVGGMIGLVQEGDSITVDAQQQLLQLNVDAAELERRKQAWVKPEPRYRTGVLGKYARLVSSSSKGAVTDQP

Sequences:

>Translated_558_residues
MAPLRSSAITQGVQRSPNRAMLRAVGFGDGDFSKPIIGIANGYSTITPCNVGLNDLALRAEAATQAAGGMPQLFGTITVS
DGISMGTEGMKYSLVSREVIADAIETACNGQSMDGVLAIGGCDKNMPAAMLAMARMNIPGVFVYGGTIKPGKLGGCDLTV
VSAFEAVGQLSSGKIDEAQLTAVEKNACPGAGSCGGMFTANTMSAAIETMGLSLPFSSTMAAEDPEKAESAARSAEVLVE
AIAANIRPLDLLTREAFENAISVIMAVGGSTNAVLHLLAIARTAGVPLSIDDFETIRQRVPVICDLKPSGRFVTVDLHNA
GGIPQVMKLLLDGGLLHGDCRTVEGKTLREVLADVPSEPPADQEVIRPLSNPLYAKGHLAVLKGNLASEGAVAKISGVKT
PVLTGPARVFESEEQCLQAILANQVHAGDVVVVRNEGPVGGPGMREMLAPTAAIVGEGLGDKVALITDGRFSGGTYGLVV
GHVAPEAAVGGMIGLVQEGDSITVDAQQQLLQLNVDAAELERRKQAWVKPEPRYRTGVLGKYARLVSSSSKGAVTDQP
>Mature_557_residues
APLRSSAITQGVQRSPNRAMLRAVGFGDGDFSKPIIGIANGYSTITPCNVGLNDLALRAEAATQAAGGMPQLFGTITVSD
GISMGTEGMKYSLVSREVIADAIETACNGQSMDGVLAIGGCDKNMPAAMLAMARMNIPGVFVYGGTIKPGKLGGCDLTVV
SAFEAVGQLSSGKIDEAQLTAVEKNACPGAGSCGGMFTANTMSAAIETMGLSLPFSSTMAAEDPEKAESAARSAEVLVEA
IAANIRPLDLLTREAFENAISVIMAVGGSTNAVLHLLAIARTAGVPLSIDDFETIRQRVPVICDLKPSGRFVTVDLHNAG
GIPQVMKLLLDGGLLHGDCRTVEGKTLREVLADVPSEPPADQEVIRPLSNPLYAKGHLAVLKGNLASEGAVAKISGVKTP
VLTGPARVFESEEQCLQAILANQVHAGDVVVVRNEGPVGGPGMREMLAPTAAIVGEGLGDKVALITDGRFSGGTYGLVVG
HVAPEAAVGGMIGLVQEGDSITVDAQQQLLQLNVDAAELERRKQAWVKPEPRYRTGVLGKYARLVSSSSKGAVTDQP

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=611, Percent_Identity=38.9525368248772, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1788157, Length=486, Percent_Identity=34.5679012345679, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI2367371, Length=519, Percent_Identity=32.7552986512524, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI1786464, Length=515, Percent_Identity=33.3980582524272, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6322476, Length=559, Percent_Identity=48.6583184257603, Blast_Score=520, Evalue=1e-148,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_SYNR3 (A5GTE2)

Other databases:

- EMBL:   CT978603
- RefSeq:   YP_001227504.1
- ProteinModelPortal:   A5GTE2
- SMR:   A5GTE2
- STRING:   A5GTE2
- GeneID:   5157843
- GenomeReviews:   CT978603_GR
- KEGG:   syr:SynRCC307_1248
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   NMPGAMI
- ProtClustDB:   PRK00911
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 57650; Mature: 57519

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPLRSSAITQGVQRSPNRAMLRAVGFGDGDFSKPIIGIANGYSTITPCNVGLNDLALRA
CCCCCHHHHHHHHHCCCCHHEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHH
EAATQAAGGMPQLFGTITVSDGISMGTEGMKYSLVSREVIADAIETACNGQSMDGVLAIG
HHHHHHCCCCCHHEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCEEEEC
GCDKNMPAAMLAMARMNIPGVFVYGGTIKPGKLGGCDLTVVSAFEAVGQLSSGKIDEAQL
CCCCCCCHHHHHHHHCCCCEEEEECCEECCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHE
TAVEKNACPGAGSCGGMFTANTMSAAIETMGLSLPFSSTMAAEDPEKAESAARSAEVLVE
EEECCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AIAANIRPLDLLTREAFENAISVIMAVGGSTNAVLHLLAIARTAGVPLSIDDFETIRQRV
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
PVICDLKPSGRFVTVDLHNAGGIPQVMKLLLDGGLLHGDCRTVEGKTLREVLADVPSEPP
CEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHCCCCCC
ADQEVIRPLSNPLYAKGHLAVLKGNLASEGAVAKISGVKTPVLTGPARVFESEEQCLQAI
CCHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHCCHHHHHHHH
LANQVHAGDVVVVRNEGPVGGPGMREMLAPTAAIVGEGLGDKVALITDGRFSGGTYGLVV
HHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEE
GHVAPEAAVGGMIGLVQEGDSITVDAQQQLLQLNVDAAELERRKQAWVKPEPRYRTGVLG
ECCCCHHHHCCCEEEEECCCEEEEHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHH
KYARLVSSSSKGAVTDQP
HHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
APLRSSAITQGVQRSPNRAMLRAVGFGDGDFSKPIIGIANGYSTITPCNVGLNDLALRA
CCCCHHHHHHHHHCCCCHHEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHH
EAATQAAGGMPQLFGTITVSDGISMGTEGMKYSLVSREVIADAIETACNGQSMDGVLAIG
HHHHHHCCCCCHHEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCEEEEC
GCDKNMPAAMLAMARMNIPGVFVYGGTIKPGKLGGCDLTVVSAFEAVGQLSSGKIDEAQL
CCCCCCCHHHHHHHHCCCCEEEEECCEECCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHE
TAVEKNACPGAGSCGGMFTANTMSAAIETMGLSLPFSSTMAAEDPEKAESAARSAEVLVE
EEECCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AIAANIRPLDLLTREAFENAISVIMAVGGSTNAVLHLLAIARTAGVPLSIDDFETIRQRV
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
PVICDLKPSGRFVTVDLHNAGGIPQVMKLLLDGGLLHGDCRTVEGKTLREVLADVPSEPP
CEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHCCCCCC
ADQEVIRPLSNPLYAKGHLAVLKGNLASEGAVAKISGVKTPVLTGPARVFESEEQCLQAI
CCHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHCCHHHHHHHH
LANQVHAGDVVVVRNEGPVGGPGMREMLAPTAAIVGEGLGDKVALITDGRFSGGTYGLVV
HHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEE
GHVAPEAAVGGMIGLVQEGDSITVDAQQQLLQLNVDAAELERRKQAWVKPEPRYRTGVLG
ECCCCHHHHCCCEEEEECCCEEEEHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHH
KYARLVSSSSKGAVTDQP
HHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA