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The map label for this gene is proA [H]

Identifier: 148242025

GI number: 148242025

Start: 851569

End: 852909

Strand: Direct

Name: proA [H]

Synonym: SynRCC307_0926

Alternate gene names: 148242025

Gene position: 851569-852909 (Clockwise)

Preceding gene: 148242024

Following gene: 148242026

Centisome position: 38.27

GC content: 63.24

Gene sequence:

>1341_bases
ATGATGCATGGCAGTCCCCCTGCCCAGGCGTTGAATCAGGCCGTTCCCGATCCCTCCCCTGAACTGCTGGCCCGCGCTTC
GAGCCTGAGGCGCCATGCCATTGATCTGGCCCAGTGCTCCGATCAGCAGCGCCAGGAGGCCCTGCGGGCGATGGCCGATG
CCCTCGAGCAGCAGCGTGAGGCGATTTTGCTGGCCAACCAGGATGACCTTCAGGCAGCCGAGCAGGAACAGCTAGCCCCA
GCCCTGCTGTCGCGGCTCAAGCTCGATCGCACCAAGCTCGATGGGGCCATTGCTGGCATCCGCCAGTTGGCCCAGCTACC
CGACCCATTGGCGCAACGCCAACTGCACCGGGCGCTGGATGAGGGGCTCGTGCTCGAGCGCATCAGCGTTCCCCTTGGTG
TCGTGGGGGTGATTTTTGAGGCCCGTCCTGATGCCGTGATGCAGATTGCCGCGTTGGCGATTCGCTCGGGTAATGGCGCC
ATCTTGAAAGGCGGGCGCGAGGCCAACCGCAGTTGCAGCGCAATCCTTGCGGCTCTGCAGCAAGGCCTTGCCCGCTCGGC
GGTGCACCCCGATGTGTTGACGCTGCTCACCAGCCGCGAAGAAAGCTTGGCGCTGCTCAAGCTCGATGGGCTGGTGGATC
TGATCATCCCCAGGGGGTCCAATGCCCTGGTGCAATTCATCCAGGACAACACCCGCATCCCCGTGTTGGGGCATGCCGAT
GGCATTTGCCATCTCTATGTGGATCGCCAGGTGGATCTGGATCAGGCCGTCGCGGTGGCGGTCGATAGCAAGGCGCAATA
CCCAGCGGCCTGCAATGCCATCGAAACGCTGTTGCTGCACAAGGAGATCGCCCCAGCGTTTCTGGCCGCGGCCCTGCCCG
CTTTTGCCCAGGCAGGGGTGGAATTGCGAGGCGATGGGGCTGCGATGGCGCTTGGGGTGAGTCAATCCGCTAGCGATGAC
GATTGGGCCACGGAGTATCTCGATCTGGTACTCAGCATTCGCGTGGTGGACTCAATGGATGAGGCGTTGGAGCACATCGC
CCGCTACAGCTCGCGCCACACCGAGGTGATCTGCACCACTAATACCGAGACGGCCGAGCGCTTTTTGGCTCGGGTCGATA
GCGCTGGGGTGTATCAAAACTGCTCATCGCGCTTTGCCGATGGTTTCCGTTATGGCTTTGGCGCTGAGGTGGGCATCAGC
ACCCAGACGCTGCCGCCCCGGGGGCCCGTGGGTTTGGAAGGCTTGGTCACCTACCGCTACCGCCTGCGCGGTGATGGCCA
CATCGCCGCTGATTACGCCAGTGGGGCGCGCCAGTTCACCCACCAAAATTTGCCGTTGTGA

Upstream 100 bases:

>100_bases
GCCGCCAGGATCTGGTGATTGCACCGGCCAGCTTGGGCAATGGGGCTGGCCGCTTGGGCGCGGCTCGCTTGGCGTTGGAG
CGTCTGCCAGGCCGCCAGGG

Downstream 100 bases:

>100_bases
GCGATCGCATCGTTGTTCGGGACCTGCGCCTTTGGGCCCATGTGGGCGTGCTGGAGCAAGAACGCCGATTGGGCCAATGG
TTTGCCCTTGATTTTTGGCT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MMHGSPPAQALNQAVPDPSPELLARASSLRRHAIDLAQCSDQQRQEALRAMADALEQQREAILLANQDDLQAAEQEQLAP
ALLSRLKLDRTKLDGAIAGIRQLAQLPDPLAQRQLHRALDEGLVLERISVPLGVVGVIFEARPDAVMQIAALAIRSGNGA
ILKGGREANRSCSAILAALQQGLARSAVHPDVLTLLTSREESLALLKLDGLVDLIIPRGSNALVQFIQDNTRIPVLGHAD
GICHLYVDRQVDLDQAVAVAVDSKAQYPAACNAIETLLLHKEIAPAFLAAALPAFAQAGVELRGDGAAMALGVSQSASDD
DWATEYLDLVLSIRVVDSMDEALEHIARYSSRHTEVICTTNTETAERFLARVDSAGVYQNCSSRFADGFRYGFGAEVGIS
TQTLPPRGPVGLEGLVTYRYRLRGDGHIAADYASGARQFTHQNLPL

Sequences:

>Translated_446_residues
MMHGSPPAQALNQAVPDPSPELLARASSLRRHAIDLAQCSDQQRQEALRAMADALEQQREAILLANQDDLQAAEQEQLAP
ALLSRLKLDRTKLDGAIAGIRQLAQLPDPLAQRQLHRALDEGLVLERISVPLGVVGVIFEARPDAVMQIAALAIRSGNGA
ILKGGREANRSCSAILAALQQGLARSAVHPDVLTLLTSREESLALLKLDGLVDLIIPRGSNALVQFIQDNTRIPVLGHAD
GICHLYVDRQVDLDQAVAVAVDSKAQYPAACNAIETLLLHKEIAPAFLAAALPAFAQAGVELRGDGAAMALGVSQSASDD
DWATEYLDLVLSIRVVDSMDEALEHIARYSSRHTEVICTTNTETAERFLARVDSAGVYQNCSSRFADGFRYGFGAEVGIS
TQTLPPRGPVGLEGLVTYRYRLRGDGHIAADYASGARQFTHQNLPL
>Mature_446_residues
MMHGSPPAQALNQAVPDPSPELLARASSLRRHAIDLAQCSDQQRQEALRAMADALEQQREAILLANQDDLQAAEQEQLAP
ALLSRLKLDRTKLDGAIAGIRQLAQLPDPLAQRQLHRALDEGLVLERISVPLGVVGVIFEARPDAVMQIAALAIRSGNGA
ILKGGREANRSCSAILAALQQGLARSAVHPDVLTLLTSREESLALLKLDGLVDLIIPRGSNALVQFIQDNTRIPVLGHAD
GICHLYVDRQVDLDQAVAVAVDSKAQYPAACNAIETLLLHKEIAPAFLAAALPAFAQAGVELRGDGAAMALGVSQSASDD
DWATEYLDLVLSIRVVDSMDEALEHIARYSSRHTEVICTTNTETAERFLARVDSAGVYQNCSSRFADGFRYGFGAEVGIS
TQTLPPRGPVGLEGLVTYRYRLRGDGHIAADYASGARQFTHQNLPL

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=421, Percent_Identity=45.3681710213777, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI21361368, Length=421, Percent_Identity=45.3681710213777, Blast_Score=337, Evalue=1e-92,
Organism=Escherichia coli, GI1786438, Length=412, Percent_Identity=38.3495145631068, Blast_Score=292, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17569967, Length=429, Percent_Identity=43.3566433566434, Blast_Score=340, Evalue=7e-94,
Organism=Caenorhabditis elegans, GI17569969, Length=429, Percent_Identity=43.3566433566434, Blast_Score=340, Evalue=8e-94,
Organism=Saccharomyces cerevisiae, GI6324899, Length=444, Percent_Identity=40.990990990991, Blast_Score=341, Evalue=2e-94,
Organism=Drosophila melanogaster, GI21357643, Length=411, Percent_Identity=45.0121654501217, Blast_Score=322, Evalue=4e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 47924; Mature: 47924

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMHGSPPAQALNQAVPDPSPELLARASSLRRHAIDLAQCSDQQRQEALRAMADALEQQRE
CCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
AILLANQDDLQAAEQEQLAPALLSRLKLDRTKLDGAIAGIRQLAQLPDPLAQRQLHRALD
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EGLVLERISVPLGVVGVIFEARPDAVMQIAALAIRSGNGAILKGGREANRSCSAILAALQ
CCHHHHHHHCCHHHHHHHEECCCHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHH
QGLARSAVHPDVLTLLTSREESLALLKLDGLVDLIIPRGSNALVQFIQDNTRIPVLGHAD
HHHHHHCCCHHHHHHHHCCCHHEEEEEECCEEEEEECCCCHHHHHHHHCCCCCEEEECCC
GICHLYVDRQVDLDQAVAVAVDSKAQYPAACNAIETLLLHKEIAPAFLAAALPAFAQAGV
CEEEEEECCCCCHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ELRGDGAAMALGVSQSASDDDWATEYLDLVLSIRVVDSMDEALEHIARYSSRHTEVICTT
EEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
NTETAERFLARVDSAGVYQNCSSRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTYRY
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHEEEEEE
RLRGDGHIAADYASGARQFTHQNLPL
EECCCCCEEEHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MMHGSPPAQALNQAVPDPSPELLARASSLRRHAIDLAQCSDQQRQEALRAMADALEQQRE
CCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
AILLANQDDLQAAEQEQLAPALLSRLKLDRTKLDGAIAGIRQLAQLPDPLAQRQLHRALD
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EGLVLERISVPLGVVGVIFEARPDAVMQIAALAIRSGNGAILKGGREANRSCSAILAALQ
CCHHHHHHHCCHHHHHHHEECCCHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHH
QGLARSAVHPDVLTLLTSREESLALLKLDGLVDLIIPRGSNALVQFIQDNTRIPVLGHAD
HHHHHHCCCHHHHHHHHCCCHHEEEEEECCEEEEEECCCCHHHHHHHHCCCCCEEEECCC
GICHLYVDRQVDLDQAVAVAVDSKAQYPAACNAIETLLLHKEIAPAFLAAALPAFAQAGV
CEEEEEECCCCCHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ELRGDGAAMALGVSQSASDDDWATEYLDLVLSIRVVDSMDEALEHIARYSSRHTEVICTT
EEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
NTETAERFLARVDSAGVYQNCSSRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTYRY
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHEEEEEE
RLRGDGHIAADYASGARQFTHQNLPL
EECCCCCEEEHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA