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The map label for this gene is birA [C]

Identifier: 148241755

GI number: 148241755

Start: 594626

End: 595210

Strand: Direct

Name: birA [C]

Synonym: SynRCC307_0656

Alternate gene names: 148241755

Gene position: 594626-595210 (Clockwise)

Preceding gene: 148241754

Following gene: 148241756

Centisome position: 26.73

GC content: 65.81

Gene sequence:

>585_bases
ATGCAGCCAGTCCCGTTGTTGCTGCCCTGGCGTCTGCACTATGTGCCGCTGTGCGCCAGCACCGAACGGGACTTGAGCCG
CTGCTTGCAGCAAGGGACTGAACCGCCGCTGGCGGTGGTGGCCCGCCGGCAGCGCTATGGGGTTGGTCAGCACGGCCGCC
AGTGGCAATCCCCGGCAGGCGGGCTTTGGCTGAGTGCAGCGATCCCATGGCAGCGGCCGCTTTCCCCTGCAGCTGCTGAG
CAGTTGCCCCGGCGCATGGCCGCCGCCCTCGCCGCTGAATTGGCGCCATGGACGGCAGAGGCCAGTCCCCCGCTAACGAT
CAAGTCCCCCAATGATCTGATGGTGGGTCAGCGCAAATTGGCCGGCGTCTTGAGCTCGGTGACTTGGCGCGGGGGGCAGC
CTCGCTTGCTGCGCTTTGGCATTGGCCTCAATGGCCGTCATCCCATTGCTCCTCCAGGCATCACGCTCGAGCAATGGCTC
AACGGGCGTTGTCCCCGCTTTGATCAATTGCTGCTGATTGGCCTGGGCGCTATCGAACGGCTGGCCCGCGAGGCTGGCAA
CTGGGACACTGAGCCCTGCTTGTGA

Upstream 100 bases:

>100_bases
AGCACGCCTTCCAGTTCCACACCCACGAAAAGGCCGTGGATACCGCTCGCTCAGTTGCTGCTGTGCTGCGCCGTCCTGTG
GATGTGATCAAGCTGCTTTG

Downstream 100 bases:

>100_bases
GCTGTTGTGCTGGTCCTGCTCCCCTTGCTGGCACAGCTGCCAACTCCCTCGCTGCAGCAGTTGGAGCAGCAGCAGGTGAT
CACGCCGGCTGAGCGCCGGC

Product: biotin-(acetyl-CoA carboxylase) ligase

Products: AMP; diphosphate; [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

Alternate protein names: Biotin/Acetyl-CoA-Carboxylase Ligase; Biotin-(Acetyl-CoA Carboxylase) Ligase; Biotin-[Acetyl-CoA-Carboxylase] Ligase; Biotin; Biotin Acetyl-CoA Carboxylase Ligase; Biotin-(Acetyl-CoA-Carboxylase) Ligase

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MQPVPLLLPWRLHYVPLCASTERDLSRCLQQGTEPPLAVVARRQRYGVGQHGRQWQSPAGGLWLSAAIPWQRPLSPAAAE
QLPRRMAAALAAELAPWTAEASPPLTIKSPNDLMVGQRKLAGVLSSVTWRGGQPRLLRFGIGLNGRHPIAPPGITLEQWL
NGRCPRFDQLLLIGLGAIERLAREAGNWDTEPCL

Sequences:

>Translated_194_residues
MQPVPLLLPWRLHYVPLCASTERDLSRCLQQGTEPPLAVVARRQRYGVGQHGRQWQSPAGGLWLSAAIPWQRPLSPAAAE
QLPRRMAAALAAELAPWTAEASPPLTIKSPNDLMVGQRKLAGVLSSVTWRGGQPRLLRFGIGLNGRHPIAPPGITLEQWL
NGRCPRFDQLLLIGLGAIERLAREAGNWDTEPCL
>Mature_194_residues
MQPVPLLLPWRLHYVPLCASTERDLSRCLQQGTEPPLAVVARRQRYGVGQHGRQWQSPAGGLWLSAAIPWQRPLSPAAAE
QLPRRMAAALAAELAPWTAEASPPLTIKSPNDLMVGQRKLAGVLSSVTWRGGQPRLLRFGIGLNGRHPIAPPGITLEQWL
NGRCPRFDQLLLIGLGAIERLAREAGNWDTEPCL

Specific function: Bira Acts Both As A Biotin-Operon Repressor And As The Enzyme That Synthesizes The Corepressor, Acetyl-CoA:Carbon- Dioxide Ligase. This Protein Also Activates Biotin To Form Biotinyl-5'-Adenylate And Transfers The Biotin Moiety To Biotin-Accepting Protei

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 6.3.4.15

Molecular weight: Translated: 21303; Mature: 21303

Theoretical pI: Translated: 10.79; Mature: 10.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPVPLLLPWRLHYVPLCASTERDLSRCLQQGTEPPLAVVARRQRYGVGQHGRQWQSPAG
CCCCCCEECCHHEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
GLWLSAAIPWQRPLSPAAAEQLPRRMAAALAAELAPWTAEASPPLTIKSPNDLMVGQRKL
CEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHH
AGVLSSVTWRGGQPRLLRFGIGLNGRHPIAPPGITLEQWLNGRCPRFDQLLLIGLGAIER
HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHH
LAREAGNWDTEPCL
HHHHHCCCCCCCCC
>Mature Secondary Structure
MQPVPLLLPWRLHYVPLCASTERDLSRCLQQGTEPPLAVVARRQRYGVGQHGRQWQSPAG
CCCCCCEECCHHEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
GLWLSAAIPWQRPLSPAAAEQLPRRMAAALAAELAPWTAEASPPLTIKSPNDLMVGQRKL
CEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHH
AGVLSSVTWRGGQPRLLRFGIGLNGRHPIAPPGITLEQWLNGRCPRFDQLLLIGLGAIER
HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHH
LAREAGNWDTEPCL
HHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; biotin; apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

Specific reaction: ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

General reaction: Amination; Carboxylic acid formation (carboxamide formation [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA