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The map label for this gene is pyrC

Identifier: 148241508

GI number: 148241508

Start: 391043

End: 392083

Strand: Direct

Name: pyrC

Synonym: SynRCC307_0409

Alternate gene names: 148241508

Gene position: 391043-392083 (Clockwise)

Preceding gene: 148241504

Following gene: 148241518

Centisome position: 17.58

GC content: 60.61

Gene sequence:

>1041_bases
ATGACTCCGGCTCCCGATCAGCTGGTGCTGCGCAGGCCTGATGACTGGCATGTGCATTTGCGTGATGACGTGATGCTCGA
GCAGGTGCTGCCGGCCACGGCGCGTCAATTTGCGCGCGCGATTGTGATGCCCAACCTGCGGCCGCCGGTGACCACCGTGG
ATGCGGCGATCGCTTACCGCCAGCGCATTGAGGCGGCATTGCCTGATGGGATGGCCTTCACCCCATTGATGACGGCCTAT
CTCACCGATGACATCAGCCCTGATGAGCTGGAGCGCGGTCATCGGGAGGGTGTGTTCACAGCCGCCAAGCTCTATCCAGC
CAATGCCACCACCAATTCAGCGGCGGGGGTGAGTGATCTGGCCTGCATCACAGCGGTTTTGGAGCGGATGCAGGCCATTG
ATATGCCCCTGTTGATTCACGGTGAGGTCACCGATCCCGACATCGACATCTTTGATCGGGAGGCGGTCTTTATTGAGCGG
CATCTGATCCCGCTGCGCCGTCAGTTCCCGCAGCTGCGCGTGGTGTTTGAGCACATCACCACCGAGCAGGCCGCCCAATT
TGTGGTTGATGGCGACCCATTGATGGCGGCAACCATCACGCCCCACCATTTGCATATCAACCGCAACGCCATGTTCCAAG
GCGGTTTGCGTAGCGATTTCTATTGCTTGCCAGTGGCCAAGCGGGAGCGCCATCGCTTGGCGTTGCGCCAAGCGGCTACC
AGCGGTGATCCCTCGTTTTTCTTGGGCACGGACTCAGCGCCCCATCCGCGCGCCGGGAAGGAAAGCAGCTGTGGGTGCGC
TGGCATCTACAACGCGCCCTATGCGCTGGAGAGCTATCTGGCGGTGTTTGAAGCCGAAGGCGCGCTGCAGCATTTCGAGG
CCTTTGCCAGTGAAAACGGCCCGCGCTTCTACAAGTTGCCTCTCAATGAGGACACCATCACGCTTAAGCGCACAGCACAA
CTGGTGCCGGCTCAACTGGAGGGGCAGGGCCTGGTGCCCTTCCATGCCAGTGAGGTGTTGGATTGGCGTTTGGCCGATTA
A

Upstream 100 bases:

>100_bases
ATCAGCCAGGCTGCTGGGCGTTTTGCTCACAGGCATCGGTGAAGAGCGGCTGCGACCGTAGGGCACAGCTGCTTTAAATA
AAGGCAGTGCACTGCAGCTC

Downstream 100 bases:

>100_bases
TCAGCGATTTGACTCTGGCCGCAGAGCCGTTGGCTGCGCTCCAGCTTGCGTTGCAGTCGCGGGGTGATGCCGAGCTCAGC
GCTCTGCCAGAGCCGGTCCA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTPAPDQLVLRRPDDWHVHLRDDVMLEQVLPATARQFARAIVMPNLRPPVTTVDAAIAYRQRIEAALPDGMAFTPLMTAY
LTDDISPDELERGHREGVFTAAKLYPANATTNSAAGVSDLACITAVLERMQAIDMPLLIHGEVTDPDIDIFDREAVFIER
HLIPLRRQFPQLRVVFEHITTEQAAQFVVDGDPLMAATITPHHLHINRNAMFQGGLRSDFYCLPVAKRERHRLALRQAAT
SGDPSFFLGTDSAPHPRAGKESSCGCAGIYNAPYALESYLAVFEAEGALQHFEAFASENGPRFYKLPLNEDTITLKRTAQ
LVPAQLEGQGLVPFHASEVLDWRLAD

Sequences:

>Translated_346_residues
MTPAPDQLVLRRPDDWHVHLRDDVMLEQVLPATARQFARAIVMPNLRPPVTTVDAAIAYRQRIEAALPDGMAFTPLMTAY
LTDDISPDELERGHREGVFTAAKLYPANATTNSAAGVSDLACITAVLERMQAIDMPLLIHGEVTDPDIDIFDREAVFIER
HLIPLRRQFPQLRVVFEHITTEQAAQFVVDGDPLMAATITPHHLHINRNAMFQGGLRSDFYCLPVAKRERHRLALRQAAT
SGDPSFFLGTDSAPHPRAGKESSCGCAGIYNAPYALESYLAVFEAEGALQHFEAFASENGPRFYKLPLNEDTITLKRTAQ
LVPAQLEGQGLVPFHASEVLDWRLAD
>Mature_345_residues
TPAPDQLVLRRPDDWHVHLRDDVMLEQVLPATARQFARAIVMPNLRPPVTTVDAAIAYRQRIEAALPDGMAFTPLMTAYL
TDDISPDELERGHREGVFTAAKLYPANATTNSAAGVSDLACITAVLERMQAIDMPLLIHGEVTDPDIDIFDREAVFIERH
LIPLRRQFPQLRVVFEHITTEQAAQFVVDGDPLMAATITPHHLHINRNAMFQGGLRSDFYCLPVAKRERHRLALRQAATS
GDPSFFLGTDSAPHPRAGKESSCGCAGIYNAPYALESYLAVFEAEGALQHFEAFASENGPRFYKLPLNEDTITLKRTAQL
VPAQLEGQGLVPFHASEVLDWRLAD

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1787301, Length=344, Percent_Identity=61.6279069767442, Blast_Score=414, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6323452, Length=356, Percent_Identity=33.9887640449438, Blast_Score=192, Evalue=8e-50,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRC_SYNR3 (A5GR03)

Other databases:

- EMBL:   CT978603
- RefSeq:   YP_001226665.1
- ProteinModelPortal:   A5GR03
- SMR:   A5GR03
- STRING:   A5GR03
- GeneID:   5157973
- GenomeReviews:   CT978603_GR
- KEGG:   syr:SynRCC307_0409
- eggNOG:   COG0418
- HOGENOM:   HBG628648
- OMA:   KESACGC
- ProtClustDB:   PRK05451
- HAMAP:   MF_00219
- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195
- PIRSF:   PIRSF001237
- TIGRFAMs:   TIGR00856

Pfam domain/function: PF01979 Amidohydro_1

EC number: =3.5.2.3

Molecular weight: Translated: 38412; Mature: 38281

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPAPDQLVLRRPDDWHVHLRDDVMLEQVLPATARQFARAIVMPNLRPPVTTVDAAIAYR
CCCCCCCEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
QRIEAALPDGMAFTPLMTAYLTDDISPDELERGHREGVFTAAKLYPANATTNSAAGVSDL
HHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHH
ACITAVLERMQAIDMPLLIHGEVTDPDIDIFDREAVFIERHLIPLRRQFPQLRVVFEHIT
HHHHHHHHHHHHCCCCEEEECCCCCCCCCEECCCEEEHHHHHHHHHHHCHHHHHHHHHHH
TEQAAQFVVDGDPLMAATITPHHLHINRNAMFQGGLRSDFYCLPVAKRERHRLALRQAAT
HHHHHEEEECCCCEEEEEECCEEEEECCCCEECCCCCCCEEEEECCHHHHHHHHHHHHHC
SGDPSFFLGTDSAPHPRAGKESSCGCAGIYNAPYALESYLAVFEAEGALQHFEAFASENG
CCCCCEEEECCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCC
PRFYKLPLNEDTITLKRTAQLVPAQLEGQGLVPFHASEVLDWRLAD
CEEEEECCCCCEEEEEHHHHHCCCEECCCCCCCCCHHHHCEEEECC
>Mature Secondary Structure 
TPAPDQLVLRRPDDWHVHLRDDVMLEQVLPATARQFARAIVMPNLRPPVTTVDAAIAYR
CCCCCCEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
QRIEAALPDGMAFTPLMTAYLTDDISPDELERGHREGVFTAAKLYPANATTNSAAGVSDL
HHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHH
ACITAVLERMQAIDMPLLIHGEVTDPDIDIFDREAVFIERHLIPLRRQFPQLRVVFEHIT
HHHHHHHHHHHHCCCCEEEECCCCCCCCCEECCCEEEHHHHHHHHHHHCHHHHHHHHHHH
TEQAAQFVVDGDPLMAATITPHHLHINRNAMFQGGLRSDFYCLPVAKRERHRLALRQAAT
HHHHHEEEECCCCEEEEEECCEEEEECCCCEECCCCCCCEEEEECCHHHHHHHHHHHHHC
SGDPSFFLGTDSAPHPRAGKESSCGCAGIYNAPYALESYLAVFEAEGALQHFEAFASENG
CCCCCEEEECCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCC
PRFYKLPLNEDTITLKRTAQLVPAQLEGQGLVPFHASEVLDWRLAD
CEEEEECCCCCEEEEEHHHHHCCCEECCCCCCCCCHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA