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The map label for this gene is ygcM [C]

Identifier: 148241391

GI number: 148241391

Start: 289136

End: 290041

Strand: Direct

Name: ygcM [C]

Synonym: SynRCC307_0292

Alternate gene names: 148241391

Gene position: 289136-290041 (Clockwise)

Preceding gene: 148241389

Following gene: 148241392

Centisome position: 13.0

GC content: 61.81

Gene sequence:

>906_bases
GTGACAATTTTGGCGCCACAGGTGATTGGGCATGCTGCCACGGCCCCCCACGGCCAGGGCAGGTCCTGCGTGATCACGCG
CCGGGCCACCTTCAGTTCGAGCCATCTCTATTCCCTGCCGGAGCTGAGCGCCGCTGAAAATCAGCAGCGTTTTGGCCCCT
GCAGCCAGGCGCCAGGCCATGGCCACAACTACGAGTTGATCGTGGCCATGGAAGGCGGGCTCGATGCCAACGGCATGGTG
CTCAACCTGTCCGATGTGAAGCATGCGATCCGCTCCCAGGTGACCGAGCAGCTGGATTTCCGCTGCCTCAACACCACCTG
GCCGGAGTTCGATGTGGAAGGCAGCCAGCAGGCCGCTTTGCCTACCACCGAGTGGTTGCTGTATGCCATTTGGCAGCGCC
TATCAACGCATCTGCCCCTGCGCAGCCTGCGCCTGTTTGAACAATCCACCCTCTGGGCCGATTACTTCGGCAATGACATG
GAAGCCTTCCTCACCATCCGCGGACACTTTGCGGCGGCCCACCGCTTGGCCCGTGAGGAGCTGAGCCAGAGCGAAAACGA
AACCATCTATGGCAAGTGCGCCCGGCCCCATGGCCATGGCCACAACTACCTGCTCGATGTGACGGTGCGCGGCCAGATCG
ATCCCCGTAGCGGCATGGTCTGTGACCTGGCTGCCCTGCAGAAGCTGCTCGATGACGAAGTGCTTGAGCCCTTCGATCAC
ACGTTCCTCAACAAGGACGTGCCGTTTTTCGCCAGCTGCGTGCCCACGGCTGAAAACATCGCTCTGCACATCGCTGATCG
GCTCAAGGCGCCGATCGCTGATCTCGGTGCCTCACTGCACAAGATTCGTCTGCAGGAGAGCCCCAACAACGCCGCTGAGA
TCTACGCCGAACCCGCCCAGGTGTGA

Upstream 100 bases:

>100_bases
TTGCCGCTGCCCATCATTCCCACCAAATACAGGTTCGTGCCCTGGAGCCGTTCACCAAGGGGCTGGGATGGATCCGTAGG
ATGCATGCGCTTTACAAGCT

Downstream 100 bases:

>100_bases
CGCTTCGCCTGGTTCTGGCGGTCAGCCTCGATGGCCGGCTGGCACCCCCTGCAGGCGGAGCTGCCCAATTGGGTGGCGCC
GGTGATCGCTGCGTGCTTGA

Product: 6-pyruvoyl-tetrahydropterin synthase

Products: 6-pyruvoyl-5,6,7,8-tetrahydropterin; triphosphate

Alternate protein names: 6-Pyruvoyl-Tetrahydropterin Synthase; 6-Pyruvoyltetrahydropterin Synthase; 6-Pyruvoyl-Tetrahydropterin Synthase-Like Protein; 6-Pyruvoyl Tetrahydrobiopterin Synthase; 6-Pyruvoyl Tetrahydropterin Synthase Family; 6-Pyruvoyl Tetrahydropterin Synthase Family Protein; Tetrahydrobiopterin Biosynthesis-Like Protein; 6-Pyruvoyltetrahydrobiopterin Synthase; Preq(0) Biosynthesis Protein Qued; 6-Pyruvoyltetrahydropterin Synthase Synthase

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTILAPQVIGHAATAPHGQGRSCVITRRATFSSSHLYSLPELSAAENQQRFGPCSQAPGHGHNYELIVAMEGGLDANGMV
LNLSDVKHAIRSQVTEQLDFRCLNTTWPEFDVEGSQQAALPTTEWLLYAIWQRLSTHLPLRSLRLFEQSTLWADYFGNDM
EAFLTIRGHFAAAHRLAREELSQSENETIYGKCARPHGHGHNYLLDVTVRGQIDPRSGMVCDLAALQKLLDDEVLEPFDH
TFLNKDVPFFASCVPTAENIALHIADRLKAPIADLGASLHKIRLQESPNNAAEIYAEPAQV

Sequences:

>Translated_301_residues
MTILAPQVIGHAATAPHGQGRSCVITRRATFSSSHLYSLPELSAAENQQRFGPCSQAPGHGHNYELIVAMEGGLDANGMV
LNLSDVKHAIRSQVTEQLDFRCLNTTWPEFDVEGSQQAALPTTEWLLYAIWQRLSTHLPLRSLRLFEQSTLWADYFGNDM
EAFLTIRGHFAAAHRLAREELSQSENETIYGKCARPHGHGHNYLLDVTVRGQIDPRSGMVCDLAALQKLLDDEVLEPFDH
TFLNKDVPFFASCVPTAENIALHIADRLKAPIADLGASLHKIRLQESPNNAAEIYAEPAQV
>Mature_300_residues
TILAPQVIGHAATAPHGQGRSCVITRRATFSSSHLYSLPELSAAENQQRFGPCSQAPGHGHNYELIVAMEGGLDANGMVL
NLSDVKHAIRSQVTEQLDFRCLNTTWPEFDVEGSQQAALPTTEWLLYAIWQRLSTHLPLRSLRLFEQSTLWADYFGNDME
AFLTIRGHFAAAHRLAREELSQSENETIYGKCARPHGHGHNYLLDVTVRGQIDPRSGMVCDLAALQKLLDDEVLEPFDHT
FLNKDVPFFASCVPTAENIALHIADRLKAPIADLGASLHKIRLQESPNNAAEIYAEPAQV

Specific function: Tetrahydrobiopterin biosynthesis; second step. [C]

COG id: COG0720

COG function: function code H; 6-pyruvoyl-tetrahydropterin synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506331, Length=134, Percent_Identity=44.0298507462687, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI115532224, Length=121, Percent_Identity=46.2809917355372, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI115532226, Length=121, Percent_Identity=46.2809917355372, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI19550074, Length=129, Percent_Identity=41.0852713178295, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24585378, Length=129, Percent_Identity=41.0852713178295, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.3.12

Molecular weight: Translated: 33358; Mature: 33227

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILAPQVIGHAATAPHGQGRSCVITRRATFSSSHLYSLPELSAAENQQRFGPCSQAPGH
CCEECCHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHCCHHHCCCCCCCCCC
GHNYELIVAMEGGLDANGMVLNLSDVKHAIRSQVTEQLDFRCLNTTWPEFDVEGSQQAAL
CCCEEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCC
PTTEWLLYAIWQRLSTHLPLRSLRLFEQSTLWADYFGNDMEAFLTIRGHFAAAHRLAREE
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHH
LSQSENETIYGKCARPHGHGHNYLLDVTVRGQIDPRSGMVCDLAALQKLLDDEVLEPFDH
HHCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCEECHHHHHHHHHHHHHCHHHH
TFLNKDVPFFASCVPTAENIALHIADRLKAPIADLGASLHKIRLQESPNNAAEIYAEPAQ
HHCCCCCCHHHHHCCCHHHHEEEEHHHHCCCHHHHCCHHEEEEECCCCCCCCEEEECCCC
V
C
>Mature Secondary Structure 
TILAPQVIGHAATAPHGQGRSCVITRRATFSSSHLYSLPELSAAENQQRFGPCSQAPGH
CEECCHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHCCHHHCCCCCCCCCC
GHNYELIVAMEGGLDANGMVLNLSDVKHAIRSQVTEQLDFRCLNTTWPEFDVEGSQQAAL
CCCEEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCC
PTTEWLLYAIWQRLSTHLPLRSLRLFEQSTLWADYFGNDMEAFLTIRGHFAAAHRLAREE
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHH
LSQSENETIYGKCARPHGHGHNYLLDVTVRGQIDPRSGMVCDLAALQKLLDDEVLEPFDH
HHCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCEECHHHHHHHHHHHHHCHHHH
TFLNKDVPFFASCVPTAENIALHIADRLKAPIADLGASLHKIRLQESPNNAAEIYAEPAQ
HHCCCCCCHHHHHCCCHHHHEEEEHHHHCCCHHHHCCHHEEEEECCCCCCCCEEEECCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Mg2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 17.7 {6-(L-erythro-1,2-dihydroxypropyl} 5 {6-(L-erythro-1,2-dihydroxypropyl} 0.0091 {6-(L-erythro-1,2-dihydroxypropyl} 0.008 {6-(L-erythro-1,2-dihydroxypropyl} [C]

Substrates: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin

Specific reaction: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate

General reaction: Intramolecular redox reaction; P-O bond cleavage; Triphosphate elimination [C]

Inhibitor: (NH4)2SO4 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA