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The map label for this gene is wcaG [H]

Identifier: 148241317

GI number: 148241317

Start: 217026

End: 218024

Strand: Direct

Name: wcaG [H]

Synonym: SynRCC307_0218

Alternate gene names: 148241317

Gene position: 217026-218024 (Clockwise)

Preceding gene: 148241316

Following gene: 148241318

Centisome position: 9.75

GC content: 54.55

Gene sequence:

>999_bases
GTGACGTTGATTCAACCCACAGATCGCTTTGCGATTTTTGGTGCCCGCGGAATGGCCGGTAGTGCCATCAGCAGAGCTTT
AGGGCGGCAGGGTTACCAAGACCAACTCCTGCCCTCACGCCAACAGCTTGATCTCCTCGATGGAGGCTCTGTTGATCAAT
GGATGGCAACCAACAAACCCGATGTGGTTGTTTTGGCGGCGGCTAAAGTTGGGGGAATTCTTGCGAATAACACCTACCCA
GCCGACTTCTTGCTGGAGAACCTCAAAATTCAGACCCACGTGATTGAGAGTGCCTGGAGGCATGGTGTGCGGCGGCTTTT
GTTTCTCGGCAGTAGCTGCATTTATCCCAAACTTGCAAAACAGCCCATTCGTGAAGAGTCTCTCTTAAAAGGAGATTTAG
AGCCCACCAATGAGTGGTATGCCATCGCCAAAATTGCGGGTATCAAGCTGTGTGAATCACTGCGCAAGCAATATGGATTT
GATGCCATCAGCTTGATGCCAACCAACCTCTATGGCCCTGGGGATAACTACCACCCGCAGAACAGCCATGTGTTGCCGGC
GCTGATACGCCGCTTTCATGAGGCAGTCCAGGCGGATGCCACGAGCGTGACCTGTTGGGGGTCGGGCTCACCCTTGCGGG
AGTTTCTGCATGTGGATGATTTGGGTGATGCCTGTGTGTTCGCGTTGGAGCGCTGGAGTGCCTTGGCAGCCAATGCCCCC
AAAGATCAGTCCGGTGACGCGCTGGCCTTTTTGAATGTGGGTACCGGCGTGGATTGCACGATCAAACAGCTGGCTGAACA
AGTAGCTGCGGCAACCGGTTTTGTTGGGGAGATCCAATGGGACACCAGTAAGCCGGATGGCACACCCAAAAAGCAGCTTG
ATGTGTCCAGGCTGCAAGCGATGGGGTGGTCAGCGCGCATCCCGCTGAATCAAGGCATCCCGATGGCGTTTCAGGATTTC
AAACAGGCTGAGGCCGCTCAGTTGGTGCGCTCTAAGTAA

Upstream 100 bases:

>100_bases
TGGAAGAACTGGTGGCTGAGATGGTGGCAACAGACAAAGAAGAAGCTCAGAAAGAGGCTTACCTCAAGCGCAAGGGCTTC
AACGTCGTTGGAGCGCGCGA

Downstream 100 bases:

>100_bases
CGATTGCGCCTTGATGGGATACGAGGGGATTGCAATTTTGCACACCCAGAACGCTGACGGGCGGCGCTTTTCCAGGCAGC
ATCAGTTCGGCTCGAGCCAG

Product: GDP-L fucose synthetase

Products: NA

Alternate protein names: GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTLIQPTDRFAIFGARGMAGSAISRALGRQGYQDQLLPSRQQLDLLDGGSVDQWMATNKPDVVVLAAAKVGGILANNTYP
ADFLLENLKIQTHVIESAWRHGVRRLLFLGSSCIYPKLAKQPIREESLLKGDLEPTNEWYAIAKIAGIKLCESLRKQYGF
DAISLMPTNLYGPGDNYHPQNSHVLPALIRRFHEAVQADATSVTCWGSGSPLREFLHVDDLGDACVFALERWSALAANAP
KDQSGDALAFLNVGTGVDCTIKQLAEQVAAATGFVGEIQWDTSKPDGTPKKQLDVSRLQAMGWSARIPLNQGIPMAFQDF
KQAEAAQLVRSK

Sequences:

>Translated_332_residues
MTLIQPTDRFAIFGARGMAGSAISRALGRQGYQDQLLPSRQQLDLLDGGSVDQWMATNKPDVVVLAAAKVGGILANNTYP
ADFLLENLKIQTHVIESAWRHGVRRLLFLGSSCIYPKLAKQPIREESLLKGDLEPTNEWYAIAKIAGIKLCESLRKQYGF
DAISLMPTNLYGPGDNYHPQNSHVLPALIRRFHEAVQADATSVTCWGSGSPLREFLHVDDLGDACVFALERWSALAANAP
KDQSGDALAFLNVGTGVDCTIKQLAEQVAAATGFVGEIQWDTSKPDGTPKKQLDVSRLQAMGWSARIPLNQGIPMAFQDF
KQAEAAQLVRSK
>Mature_331_residues
TLIQPTDRFAIFGARGMAGSAISRALGRQGYQDQLLPSRQQLDLLDGGSVDQWMATNKPDVVVLAAAKVGGILANNTYPA
DFLLENLKIQTHVIESAWRHGVRRLLFLGSSCIYPKLAKQPIREESLLKGDLEPTNEWYAIAKIAGIKLCESLRKQYGFD
AISLMPTNLYGPGDNYHPQNSHVLPALIRRFHEAVQADATSVTCWGSGSPLREFLHVDDLGDACVFALERWSALAANAPK
DQSGDALAFLNVGTGVDCTIKQLAEQVAAATGFVGEIQWDTSKPDGTPKKQLDVSRLQAMGWSARIPLNQGIPMAFQDFK
QAEAAQLVRSK

Specific function: Two step NADP-dependent conversion of GDP-4-dehydro-6- deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=314, Percent_Identity=30.2547770700637, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1788365, Length=312, Percent_Identity=55.4487179487179, Blast_Score=359, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17554428, Length=313, Percent_Identity=27.7955271565495, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19922778, Length=302, Percent_Identity=30.4635761589404, Blast_Score=144, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.271 [H]

Molecular weight: Translated: 36247; Mature: 36116

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLIQPTDRFAIFGARGMAGSAISRALGRQGYQDQLLPSRQQLDLLDGGSVDQWMATNKP
CCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCHHHCCCCHHHCCCCCCCCCHHHHCCCCC
DVVVLAAAKVGGILANNTYPADFLLENLKIQTHVIESAWRHGVRRLLFLGSSCIYPKLAK
CEEEEECHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
QPIREESLLKGDLEPTNEWYAIAKIAGIKLCESLRKQYGFDAISLMPTNLYGPGDNYHPQ
CCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
NSHVLPALIRRFHEAVQADATSVTCWGSGSPLREFLHVDDLGDACVFALERWSALAANAP
CCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
KDQSGDALAFLNVGTGVDCTIKQLAEQVAAATGFVGEIQWDTSKPDGTPKKQLDVSRLQA
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHH
MGWSARIPLNQGIPMAFQDFKQAEAAQLVRSK
CCCCEECCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLIQPTDRFAIFGARGMAGSAISRALGRQGYQDQLLPSRQQLDLLDGGSVDQWMATNKP
CCCCCCCCEEEEECCCCCHHHHHHHHCCCCCHHHCCCCHHHCCCCCCCCCHHHHCCCCC
DVVVLAAAKVGGILANNTYPADFLLENLKIQTHVIESAWRHGVRRLLFLGSSCIYPKLAK
CEEEEECHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
QPIREESLLKGDLEPTNEWYAIAKIAGIKLCESLRKQYGFDAISLMPTNLYGPGDNYHPQ
CCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
NSHVLPALIRRFHEAVQADATSVTCWGSGSPLREFLHVDDLGDACVFALERWSALAANAP
CCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
KDQSGDALAFLNVGTGVDCTIKQLAEQVAAATGFVGEIQWDTSKPDGTPKKQLDVSRLQA
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHH
MGWSARIPLNQGIPMAFQDFKQAEAAQLVRSK
CCCCEECCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7815923; 8759852; 9097040; 9278503; 9473059; 9862812 [H]