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The map label for this gene is ahcY [H]

Identifier: 148241205

GI number: 148241205

Start: 103547

End: 104983

Strand: Direct

Name: ahcY [H]

Synonym: SynRCC307_0106

Alternate gene names: 148241205

Gene position: 103547-104983 (Clockwise)

Preceding gene: 148241203

Following gene: 148241206

Centisome position: 4.65

GC content: 59.92

Gene sequence:

>1437_bases
ATGGTCGCTGCACCTGAAGCTCTGTCGTTTGCTGGCCTGCAAGCCACAGACACCTACGTCATTGCCGATATCGCTCAGGC
CGCGTTTGGCCGCAAGGAAATTGCCATTGCCGAGACCGAGATGCCCGGTCTGGTGGAGCTGCGCAACAAGTACGGCGCCC
AGCAGCCCCTCAAGGGTGCTCGCATCTGCGGCAGCCTCCACATGACGATTCAGACGGCTGTTCTGATCGAGACCCTGGTG
GCCCTGGGCGCTGATGTGCGCTGGGCCTCCTGCAACATCTTCTCCACCCAGGATCACGCCGCGGCAGCCATTGCTGAGCG
GGGCATCCCCGTGTTTGCTTACAAGGGCGAGACCCTTGATGAGTACTGGGCTTTCACCCACCGGATCATGGAGTGGTCTG
ATGGCGGCACCCCCAACATGATCCTGGATGACGGTGGTGATGCCACCGGCCTGATCATGCTGGGCTCCAAGGCCGAGCAA
GACATCTCGGTGCTGGATAACCCCTCCAATGAGGAGGAGATTGCTCTCTTTAAGAGCATCAAGGCCCGTCTGGCCGTTGA
TCCAACCTTCTATTCCCGCATCAAGGCCAACATCCTTGGCGTGACGGAAGAAACCACCACCGGTGTGGCCCGTCTCTATC
AAATGGTGGAAACCGGTGAGCTGCCCTTCCCGGCCATCAACGTCAACGACTCGGTCACCAAGAGCAAGTTCGACAACCTC
TACGGCTGCCGTGAGTCCCTGGTCGACAGCATCAAGCGCGCCACCGATGTGATGGTGGCTGGCAAGCAAGCCTTGGTCAT
GGGCTACGGCGATGTGGGCAAGGGCTCTGCCCAGTCCCTGCGCGGCCTCGGGGCCACCGTTTGCATCGCTGAAGTGGATC
CGATCTGCGCTCTGCAGGCCGCCATGGAAGGCTTCCGCGTTGTTCGCCTCGACGACGTGGTCGATCAGATGGACATCTTT
GTGACGGCGACTGGCAACTTCCAGGTGATTCGCCATGAGCACCTGGTGCGCATGAAGGATGAGGCCATCGTTTGCAACAT
CGGCCACTTCGACAACGAGATCGATGTGGCCTCCCTCAAGCAGTACGAGTGGGACAACATCAAGCCGCAGGTGGACCACA
TCACCCTGCCTAGCGGCAACAAGATCATCCTTCTGGCCGAGGGCCGTCTGGTGAATCTGGGCTGCGCCACCGGCCACCCC
AGCTTCGTGATGAGCAACTCGTTCACCAACCAGACCCTGGCTCAAATCGAGCTGTTCACCAAGCGCGATCAGTACGAGAA
CAAGGTGTATGTGCTCCCCAAGCACCTCGATGAGATGGTGGCTCGCCTCCATCTCGACAAGATCGGCGCCAAGCTCACCG
AACTGACCAGCGAGCAGGCCGCCTACATCAACGTGCCGGTGGAAGGCCCTTACAAGGTGGATCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
TGACCGGCGTCAGCGAGAAAAAGATCCATCTCTGTAGATTCCTCCGACGCGAGCCCGAAGCCTCGGCGACTCCGCAGAGA
ATCCCTTACCCATTCTTTCC

Downstream 100 bases:

>100_bases
TTGGGCTGAACCCATGGAAGACTTGCGCGGTTTCACATCGCGCAGGCTCCATGGGGCTCACTGAGCTGGTCACCCAACTA
CCGGAGCTCATCGGTCAGGC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MVAAPEALSFAGLQATDTYVIADIAQAAFGRKEIAIAETEMPGLVELRNKYGAQQPLKGARICGSLHMTIQTAVLIETLV
ALGADVRWASCNIFSTQDHAAAAIAERGIPVFAYKGETLDEYWAFTHRIMEWSDGGTPNMILDDGGDATGLIMLGSKAEQ
DISVLDNPSNEEEIALFKSIKARLAVDPTFYSRIKANILGVTEETTTGVARLYQMVETGELPFPAINVNDSVTKSKFDNL
YGCRESLVDSIKRATDVMVAGKQALVMGYGDVGKGSAQSLRGLGATVCIAEVDPICALQAAMEGFRVVRLDDVVDQMDIF
VTATGNFQVIRHEHLVRMKDEAIVCNIGHFDNEIDVASLKQYEWDNIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHP
SFVMSNSFTNQTLAQIELFTKRDQYENKVYVLPKHLDEMVARLHLDKIGAKLTELTSEQAAYINVPVEGPYKVDHYRY

Sequences:

>Translated_478_residues
MVAAPEALSFAGLQATDTYVIADIAQAAFGRKEIAIAETEMPGLVELRNKYGAQQPLKGARICGSLHMTIQTAVLIETLV
ALGADVRWASCNIFSTQDHAAAAIAERGIPVFAYKGETLDEYWAFTHRIMEWSDGGTPNMILDDGGDATGLIMLGSKAEQ
DISVLDNPSNEEEIALFKSIKARLAVDPTFYSRIKANILGVTEETTTGVARLYQMVETGELPFPAINVNDSVTKSKFDNL
YGCRESLVDSIKRATDVMVAGKQALVMGYGDVGKGSAQSLRGLGATVCIAEVDPICALQAAMEGFRVVRLDDVVDQMDIF
VTATGNFQVIRHEHLVRMKDEAIVCNIGHFDNEIDVASLKQYEWDNIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHP
SFVMSNSFTNQTLAQIELFTKRDQYENKVYVLPKHLDEMVARLHLDKIGAKLTELTSEQAAYINVPVEGPYKVDHYRY
>Mature_478_residues
MVAAPEALSFAGLQATDTYVIADIAQAAFGRKEIAIAETEMPGLVELRNKYGAQQPLKGARICGSLHMTIQTAVLIETLV
ALGADVRWASCNIFSTQDHAAAAIAERGIPVFAYKGETLDEYWAFTHRIMEWSDGGTPNMILDDGGDATGLIMLGSKAEQ
DISVLDNPSNEEEIALFKSIKARLAVDPTFYSRIKANILGVTEETTTGVARLYQMVETGELPFPAINVNDSVTKSKFDNL
YGCRESLVDSIKRATDVMVAGKQALVMGYGDVGKGSAQSLRGLGATVCIAEVDPICALQAAMEGFRVVRLDDVVDQMDIF
VTATGNFQVIRHEHLVRMKDEAIVCNIGHFDNEIDVASLKQYEWDNIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHP
SFVMSNSFTNQTLAQIELFTKRDQYENKVYVLPKHLDEMVARLHLDKIGAKLTELTSEQAAYINVPVEGPYKVDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=59.0909090909091, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=59.0909090909091, Blast_Score=492, Evalue=1e-139,
Organism=Homo sapiens, GI298286489, Length=468, Percent_Identity=49.7863247863248, Blast_Score=465, Evalue=1e-131,
Organism=Homo sapiens, GI24308043, Length=468, Percent_Identity=49.7863247863248, Blast_Score=465, Evalue=1e-131,
Organism=Homo sapiens, GI195539337, Length=468, Percent_Identity=49.7863247863248, Blast_Score=465, Evalue=1e-131,
Organism=Homo sapiens, GI195539349, Length=468, Percent_Identity=49.7863247863248, Blast_Score=464, Evalue=1e-131,
Organism=Homo sapiens, GI21361647, Length=478, Percent_Identity=48.326359832636, Blast_Score=444, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17506425, Length=471, Percent_Identity=58.1740976645435, Blast_Score=524, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6320882, Length=478, Percent_Identity=57.3221757322176, Blast_Score=510, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24642172, Length=463, Percent_Identity=59.6112311015119, Blast_Score=515, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24656245, Length=457, Percent_Identity=51.8599562363239, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45553387, Length=462, Percent_Identity=51.7316017316017, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI45553385, Length=461, Percent_Identity=51.6268980477223, Blast_Score=450, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52383; Mature: 52383

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAAPEALSFAGLQATDTYVIADIAQAAFGRKEIAIAETEMPGLVELRNKYGAQQPLKGA
CCCCCCCHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCCCCCHH
RICGSLHMTIQTAVLIETLVALGADVRWASCNIFSTQDHAAAAIAERGIPVFAYKGETLD
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCHH
EYWAFTHRIMEWSDGGTPNMILDDGGDATGLIMLGSKAEQDISVLDNPSNEEEIALFKSI
HHHHHHHHHHEECCCCCCCEEEECCCCEEEEEEECCCCCCCHHHCCCCCCHHHHHHHHHH
KARLAVDPTFYSRIKANILGVTEETTTGVARLYQMVETGELPFPAINVNDSVTKSKFDNL
HHHEEECHHHHHHHHHHEEECCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHH
YGCRESLVDSIKRATDVMVAGKQALVMGYGDVGKGSAQSLRGLGATVCIAEVDPICALQA
HHHHHHHHHHHHHHHHHEEECCEEEEEECCCCCCCCHHHHHCCCCEEEEECCCHHHHHHH
AMEGFRVVRLDDVVDQMDIFVTATGNFQVIRHEHLVRMKDEAIVCNIGHFDNEIDVASLK
HHCCCEEEEHHHHHCCEEEEEEECCCEEEEEHHHHEEECCCEEEEECCCCCCCCCHHHHH
QYEWDNIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFT
CCCCCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCCCCCHHHHHHEEC
KRDQYENKVYVLPKHLDEMVARLHLDKIGAKLTELTSEQAAYINVPVEGPYKVDHYRY
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MVAAPEALSFAGLQATDTYVIADIAQAAFGRKEIAIAETEMPGLVELRNKYGAQQPLKGA
CCCCCCCHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCCCCCHH
RICGSLHMTIQTAVLIETLVALGADVRWASCNIFSTQDHAAAAIAERGIPVFAYKGETLD
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCHH
EYWAFTHRIMEWSDGGTPNMILDDGGDATGLIMLGSKAEQDISVLDNPSNEEEIALFKSI
HHHHHHHHHHEECCCCCCCEEEECCCCEEEEEEECCCCCCCHHHCCCCCCHHHHHHHHHH
KARLAVDPTFYSRIKANILGVTEETTTGVARLYQMVETGELPFPAINVNDSVTKSKFDNL
HHHEEECHHHHHHHHHHEEECCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHH
YGCRESLVDSIKRATDVMVAGKQALVMGYGDVGKGSAQSLRGLGATVCIAEVDPICALQA
HHHHHHHHHHHHHHHHHEEECCEEEEEECCCCCCCCHHHHHCCCCEEEEECCCHHHHHHH
AMEGFRVVRLDDVVDQMDIFVTATGNFQVIRHEHLVRMKDEAIVCNIGHFDNEIDVASLK
HHCCCEEEEHHHHHCCEEEEEEECCCEEEEEHHHHEEECCCEEEEECCCCCCCCCHHHHH
QYEWDNIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFT
CCCCCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCCCCCHHHHHHEEC
KRDQYENKVYVLPKHLDEMVARLHLDKIGAKLTELTSEQAAYINVPVEGPYKVDHYRY
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA