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The map label for this gene is acs-1 [H]

Identifier: 162329620

GI number: 162329620

Start: 2847201

End: 2849150

Strand: Reverse

Name: acs-1 [H]

Synonym: VC0395_A2691

Alternate gene names: 162329620

Gene position: 2849150-2847201 (Counterclockwise)

Preceding gene: 147675462

Following gene: 147674602

Centisome position: 94.22

GC content: 51.54

Gene sequence:

>1950_bases
ATGAGTGAAGCCCATATTTATCCGGTCAAACAGAACATCAAAGCGCATACGCATGCCGATAACGACACCTATCTGGCGAT
GTATCAACAGTCCATCAAAGATCCGGAAGGCTTTTGGAGCGAACACGGCAAAATCGTCGACTGGATTAAACCTTTCACCA
AGGTGAAACACACCTCTTTTGACCCAGGGCACATCGATATCCGCTGGTTTGAAGATGGCACGTTAAACGTTTCTGCCAAC
TGTATTGATCGCCATTTGGCGACCCGTGGCGACCAAGTCGCGATCATTTGGGAAGGCGACGACCCGACTCAAGACAAAAC
TCTGACGTATAAGCAACTGCACCAAGAAGTGTGCCGTTTTGCCAATGCGCTGAAAGAGCAAGGCGTACGCAAGGGTGATG
TTGTCTGTATCTACATGCCTATGGTGCCAGAAGCGGCGGTTGCTATGTTGGCTTGTACCCGTATTGGCGCAGTGCACACT
ATCGTCTTTGGTGGCTTCTCGCCAGAAGCACTGGCTGGACGCATTATCGACTCGAACGCCAAATTAGTGATCACTGCCGA
CGAAGGTGTTCGCGGCGGCCGCGCCGTCCCCCTAAAGAAAAACGTCGATGAAGCACTGTGCAATCCAGAAGTCAAAAACA
TCAGTAAAGTGATGGTTCTTAAGCGTACTGGCGGCAATGTCGCTTGGCATGAACACCGTGACATTTGGTGGCATGAAGCA
ACCGCAAAAGCCTCCGATAATTGTCCACCAGAAGAGATGAAAGCCGAAGATCCGCTGTTTATCCTCTACACCTCTGGCTC
AACCGGTAAACCGAAAGGCGTATTGCACACCACTGGCGGTTATTTGGTTTATGCGACTATGACCTTCAAATATGTATTCG
ACTATCAGCCCAATGAAGTGTTCTGGTGTACCGCTGATGTGGGTTGGATAACGGGTCACTCCTATCTGGTGTATGGCCCA
TTGGCGAATGGCGCAAAAACCATTCTGTTTGAAGGCGTGCCAAACTACCCCACCACCGCACGCATGAGCGAGGTGGTAGA
CAAGCATAAGGTCAATATCCTTTACACTGCGCCAACGGCGATCCGTGCGCTGATGGCCAAAGGTGATGAAGCGATTAAAG
GCACTAGCCGTGACAGCTTGCGCATTATGGGCTCTGTGGGTGAACCGATTAACCCAGAAGCGTGGGAGTGGTACTACCGC
ACGATCGGTAACGAAGAATCGCCGATTGTCGATACTTGGTGGCAAACCGAAACCGGCGGTATCTTGATCACACCACTGCC
GGGGGCAACGGCGTTGAAACCGGGTTCGGCCACACGCCCCTTCTTTGGTGTGCAGCCAGCGTTAGTCGATAACATGGGCG
AAATCGTGGAAGGCGCAACTGAAGGCAACTTGGTGCTGCTCGATTCATGGCCGGGTCAAATGCGCACTGTGTATGGCGAT
CACGACCGCTTTGAACAAACCTACTTCTCTACCTTTAAAGGCATGTACTTTACCGGTGACGGTGCGCGTCGCGATGAAGA
CGGTTACTACTGGATCACAGGCCGTGTCGATGACGTACTCAACGTTTCGGGTCACCGTATGGGAACGGCAGAAATTGAAT
CCGCACTGGTGGCATTCAATAAGATTGCAGAAGCCGCCGTGGTCGGTGTTCCACACGATATCAAAGGCCAAGCGATTTAC
GCTTACATCACACTCAATGATGGGGTGTATCCGAGCGCTGAACTGCATAAAGAAGTGAAAGATTGGGTACGCAAAGAGAT
TGGCGCTATCGCGACACCGGATGTCCTACACTGGACCGATGCGCTACCGAAAACCCGTTCAGGTAAAATTATGCGCCGTA
TTTTGCGTAAAATTGCCACCGGCGATACCAGCAACTTGGGGGATACCTCAACGCTGGCCGATCCAAGCGTGGTTGACCGC
CTGATTGCCGAAAAAGCCCAACTTAAATAA

Upstream 100 bases:

>100_bases
CCTGCTCTGACTGAGAGTTATAAACGAAACGAATTTCCTCCTCTCGTGTTTGAAACGCGCCCTTTCAGGAAATTTGCCGA
ATTCACAAGGAGAACCCGTA

Downstream 100 bases:

>100_bases
CAAACCCTGTGGTTTGAGGTTGTAGCCTCAAGTCACAAGGGAATACACATTTGCTTGCGCTTTCAAACTCCGGTGCACCT
CATGGCCGGAGTTTTTGTTT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MSEAHIYPVKQNIKAHTHADNDTYLAMYQQSIKDPEGFWSEHGKIVDWIKPFTKVKHTSFDPGHIDIRWFEDGTLNVSAN
CIDRHLATRGDQVAIIWEGDDPTQDKTLTYKQLHQEVCRFANALKEQGVRKGDVVCIYMPMVPEAAVAMLACTRIGAVHT
IVFGGFSPEALAGRIIDSNAKLVITADEGVRGGRAVPLKKNVDEALCNPEVKNISKVMVLKRTGGNVAWHEHRDIWWHEA
TAKASDNCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATMTFKYVFDYQPNEVFWCTADVGWITGHSYLVYGP
LANGAKTILFEGVPNYPTTARMSEVVDKHKVNILYTAPTAIRALMAKGDEAIKGTSRDSLRIMGSVGEPINPEAWEWYYR
TIGNEESPIVDTWWQTETGGILITPLPGATALKPGSATRPFFGVQPALVDNMGEIVEGATEGNLVLLDSWPGQMRTVYGD
HDRFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAFNKIAEAAVVGVPHDIKGQAIY
AYITLNDGVYPSAELHKEVKDWVRKEIGAIATPDVLHWTDALPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDR
LIAEKAQLK

Sequences:

>Translated_649_residues
MSEAHIYPVKQNIKAHTHADNDTYLAMYQQSIKDPEGFWSEHGKIVDWIKPFTKVKHTSFDPGHIDIRWFEDGTLNVSAN
CIDRHLATRGDQVAIIWEGDDPTQDKTLTYKQLHQEVCRFANALKEQGVRKGDVVCIYMPMVPEAAVAMLACTRIGAVHT
IVFGGFSPEALAGRIIDSNAKLVITADEGVRGGRAVPLKKNVDEALCNPEVKNISKVMVLKRTGGNVAWHEHRDIWWHEA
TAKASDNCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATMTFKYVFDYQPNEVFWCTADVGWITGHSYLVYGP
LANGAKTILFEGVPNYPTTARMSEVVDKHKVNILYTAPTAIRALMAKGDEAIKGTSRDSLRIMGSVGEPINPEAWEWYYR
TIGNEESPIVDTWWQTETGGILITPLPGATALKPGSATRPFFGVQPALVDNMGEIVEGATEGNLVLLDSWPGQMRTVYGD
HDRFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAFNKIAEAAVVGVPHDIKGQAIY
AYITLNDGVYPSAELHKEVKDWVRKEIGAIATPDVLHWTDALPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDR
LIAEKAQLK
>Mature_648_residues
SEAHIYPVKQNIKAHTHADNDTYLAMYQQSIKDPEGFWSEHGKIVDWIKPFTKVKHTSFDPGHIDIRWFEDGTLNVSANC
IDRHLATRGDQVAIIWEGDDPTQDKTLTYKQLHQEVCRFANALKEQGVRKGDVVCIYMPMVPEAAVAMLACTRIGAVHTI
VFGGFSPEALAGRIIDSNAKLVITADEGVRGGRAVPLKKNVDEALCNPEVKNISKVMVLKRTGGNVAWHEHRDIWWHEAT
AKASDNCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATMTFKYVFDYQPNEVFWCTADVGWITGHSYLVYGPL
ANGAKTILFEGVPNYPTTARMSEVVDKHKVNILYTAPTAIRALMAKGDEAIKGTSRDSLRIMGSVGEPINPEAWEWYYRT
IGNEESPIVDTWWQTETGGILITPLPGATALKPGSATRPFFGVQPALVDNMGEIVEGATEGNLVLLDSWPGQMRTVYGDH
DRFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAFNKIAEAAVVGVPHDIKGQAIYA
YITLNDGVYPSAELHKEVKDWVRKEIGAIATPDVLHWTDALPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDRL
IAEKAQLK

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=652, Percent_Identity=53.8343558282209, Blast_Score=699, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=665, Percent_Identity=52.6315789473684, Blast_Score=696, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=632, Percent_Identity=50.3164556962025, Blast_Score=638, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=635, Percent_Identity=36.8503937007874, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI42544132, Length=541, Percent_Identity=28.0961182994455, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI31982927, Length=648, Percent_Identity=24.2283950617284, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI38505220, Length=518, Percent_Identity=29.7297297297297, Blast_Score=180, Evalue=5e-45,
Organism=Homo sapiens, GI122937307, Length=512, Percent_Identity=26.953125, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI115511026, Length=546, Percent_Identity=28.021978021978, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI58082049, Length=529, Percent_Identity=24.1965973534972, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI157311624, Length=529, Percent_Identity=23.2514177693762, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI157311622, Length=529, Percent_Identity=23.2514177693762, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI195947378, Length=438, Percent_Identity=25.7990867579909, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI187761345, Length=574, Percent_Identity=24.390243902439, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI187761343, Length=574, Percent_Identity=24.390243902439, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI42544134, Length=359, Percent_Identity=25.0696378830084, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI156151445, Length=553, Percent_Identity=23.3273056057866, Blast_Score=90, Evalue=6e-18,
Organism=Escherichia coli, GI1790505, Length=648, Percent_Identity=74.2283950617284, Blast_Score=1036, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=631, Percent_Identity=35.8161648177496, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI221142682, Length=530, Percent_Identity=22.4528301886792, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1788107, Length=598, Percent_Identity=22.5752508361204, Blast_Score=100, Evalue=6e-22,
Organism=Escherichia coli, GI145693145, Length=523, Percent_Identity=23.5181644359465, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71982997, Length=639, Percent_Identity=51.3302034428795, Blast_Score=641, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71983001, Length=639, Percent_Identity=51.3302034428795, Blast_Score=641, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=595, Percent_Identity=22.8571428571429, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17557194, Length=572, Percent_Identity=24.3006993006993, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17558820, Length=517, Percent_Identity=23.5976789168279, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17559526, Length=577, Percent_Identity=24.263431542461, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32563687, Length=525, Percent_Identity=23.6190476190476, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17538037, Length=147, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=378, Percent_Identity=24.0740740740741, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=640, Percent_Identity=48.125, Blast_Score=620, Evalue=1e-178,
Organism=Saccharomyces cerevisiae, GI6319264, Length=635, Percent_Identity=48.1889763779528, Blast_Score=594, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6319699, Length=402, Percent_Identity=22.636815920398, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24667955, Length=664, Percent_Identity=52.8614457831325, Blast_Score=690, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=57.1174377224199, Blast_Score=644, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=57.1153846153846, Blast_Score=596, Evalue=1e-170,
Organism=Drosophila melanogaster, GI21355225, Length=638, Percent_Identity=34.9529780564263, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI18859661, Length=545, Percent_Identity=25.1376146788991, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21355181, Length=522, Percent_Identity=23.3716475095785, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24656500, Length=533, Percent_Identity=25.515947467167, Blast_Score=93, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24581924, Length=538, Percent_Identity=21.7472118959108, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21358303, Length=502, Percent_Identity=19.9203187250996, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71896; Mature: 71765

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAHIYPVKQNIKAHTHADNDTYLAMYQQSIKDPEGFWSEHGKIVDWIKPFTKVKHTSF
CCCCEEEEHHCCCEEEECCCCCCEEEEEHHHCCCCCHHHHHCCCEEHHHHHHHHHCCCCC
DPGHIDIRWFEDGTLNVSANCIDRHLATRGDQVAIIWEGDDPTQDKTLTYKQLHQEVCRF
CCCEEEEEEECCCEEEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
ANALKEQGVRKGDVVCIYMPMVPEAAVAMLACTRIGAVHTIVFGGFSPEALAGRIIDSNA
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCHHHHCCEEECCCC
KLVITADEGVRGGRAVPLKKNVDEALCNPEVKNISKVMVLKRTGGNVAWHEHRDIWWHEA
EEEEECCCCCCCCEECCCCCCCHHHHCCCCHHCCEEEEEEEECCCCEEEECCCCEEEEEC
TAKASDNCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATMTFKYVFDYQPNEV
CCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEEEEEEEEECCCCEE
FWCTADVGWITGHSYLVYGPLANGAKTILFEGVPNYPTTARMSEVVDKHKVNILYTAPTA
EEEECCCCEEECCCEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAKGDEAIKGTSRDSLRIMGSVGEPINPEAWEWYYRTIGNEESPIVDTWWQTETGG
HHHHHHCCCHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEECEECCCCC
ILITPLPGATALKPGSATRPFFGVQPALVDNMGEIVEGATEGNLVLLDSWPGQMRTVYGD
EEEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECC
HDRFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAFN
HHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHH
KIAEAAVVGVPHDIKGQAIYAYITLNDGVYPSAELHKEVKDWVRKEIGAIATPDVLHWTD
HHHHHEEECCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ALPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDRLIAEKAQLK
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEAHIYPVKQNIKAHTHADNDTYLAMYQQSIKDPEGFWSEHGKIVDWIKPFTKVKHTSF
CCCEEEEHHCCCEEEECCCCCCEEEEEHHHCCCCCHHHHHCCCEEHHHHHHHHHCCCCC
DPGHIDIRWFEDGTLNVSANCIDRHLATRGDQVAIIWEGDDPTQDKTLTYKQLHQEVCRF
CCCEEEEEEECCCEEEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
ANALKEQGVRKGDVVCIYMPMVPEAAVAMLACTRIGAVHTIVFGGFSPEALAGRIIDSNA
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCHHHHCCEEECCCC
KLVITADEGVRGGRAVPLKKNVDEALCNPEVKNISKVMVLKRTGGNVAWHEHRDIWWHEA
EEEEECCCCCCCCEECCCCCCCHHHHCCCCHHCCEEEEEEEECCCCEEEECCCCEEEEEC
TAKASDNCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATMTFKYVFDYQPNEV
CCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEEEEEEEEECCCCEE
FWCTADVGWITGHSYLVYGPLANGAKTILFEGVPNYPTTARMSEVVDKHKVNILYTAPTA
EEEECCCCEEECCCEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAKGDEAIKGTSRDSLRIMGSVGEPINPEAWEWYYRTIGNEESPIVDTWWQTETGG
HHHHHHCCCHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEECEECCCCC
ILITPLPGATALKPGSATRPFFGVQPALVDNMGEIVEGATEGNLVLLDSWPGQMRTVYGD
EEEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECC
HDRFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAFN
HHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHH
KIAEAAVVGVPHDIKGQAIYAYITLNDGVYPSAELHKEVKDWVRKEIGAIATPDVLHWTD
HHHHHEEECCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ALPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDRLIAEKAQLK
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]