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The map label for this gene is wecC [H]

Identifier: 147674871

GI number: 147674871

Start: 471337

End: 472578

Strand: Direct

Name: wecC [H]

Synonym: VC0395_A0442

Alternate gene names: 147674871

Gene position: 471337-472578 (Clockwise)

Preceding gene: 147674876

Following gene: 147674228

Centisome position: 15.59

GC content: 47.83

Gene sequence:

>1242_bases
ATGTTTAATAAAGTTTCAGTGATTGGCCTAGGTTATATTGGTCTGCCAACAGCAGCCGTTTTGGCCTCTCGTGGTTTGGA
TGTGGTCGGTGTTGATGTCAACGCCCATGCAGTGGATACCATCAACAAAGGCGAGATTCACATTGTGGAGCCGGATCTTG
ATATCGTGGTACGCAGTGCTGTCATGACCGGGAAACTCAAAGCGACATTAACAGCTGAGCCTGCCGATGCGTTTTTGGTG
GCCGTTCCTACACCTTTTAAAGGGGATAACCACGAACCTGATCTTAGCTACATTGAAGCGGCGGCAAAAACCATCGCTCC
CGTTCTTGCTAAAGGGAACTTGGTGGTTCTAGAGAGTACTTCCCCAGTAGGCACAACCGAAAAATTGGCGCAATGGCTTG
CAGAAGCGCGTCCGGATCTGACGTTTCCTCAGCAAAAAGGCATCGCTGCGGATGTGAAGATTGCGTACTGCCCAGAGCGT
GTGTTGCCGGGTTATGTCCTACAAGAGCTTGTGAGTAATGACCGCGTGATTGGTGGCGTGAGTAAGGCTTGTAGCGAAAA
GGCTGTTGCCCTGTACAAAACCTTTGTAAAAGGTGAGTGCATTGTCACCAATGCGCGTACGGCGGAAATGGCTAAATTAA
CCGAAAACTCATTCCGTGATGTCAACATTGCCTTTGCCAATGAACTCTCTTTGGTGTGCAACAAATTGAAAATCAATGTA
TGGGAATTGATCCGCTTAGCCAACCGCCATCCTCGTGTGAGTATTCTTAACCCAGGTCCTGGTGTCGGTGGCCACTGTAT
TGCGGTTGATCCGTGGTTTATCGTTAATAGTTGTCCAGATGAAGCGCAATTGATCCGTACTGCACGTGAAGTCAATGATG
GCAAACCTCATTGGGTTGTGGATCAAGTTAAACAAGCGGCTGACCAATTCAAAAAGCCAATCATTGCTTGCCTAGGCTTA
GCGTTTAAAGCGGATATTGATGATCTGCGTGAAAGTCCAGCCTTGGATATCACTAAACATCTGGCTGAAAGCAAAGTGGG
TCAGTTGTTGGCGGTTGAACCAAATATTACTGAACTACCTAGCAAACTTGCGAAGCAAGGTATCGAGTTGGTTTCTCTAG
AGCGCGCGCTTGAGCTCGCCAATATCGTTGTCGTGCTGGTCGATCACAAAGAATTTAAAGCGGCGGATAAAACCGAGTTT
GCTAAGAAAGTGGTGATTGATACTCGCGGAGTGGTGGCATGA

Upstream 100 bases:

>100_bases
TATCAAGCCATGAGTCAGGCACACAACCCTTATGGGGATGGTAAAGCCTGTCAACGTATTGCGGACATTTTAGCGAAATA
GACTCATCAGGGGATGACAG

Downstream 100 bases:

>100_bases
GTTCACCTTGGGAGCTGATTAAAGCTGATCTTTATCGGCATACTGGGCAGGTAAGTATTGGGTTAGTCGTAAAGCACCTA
CTACTCAATGCGGGTTTCGC

Product: UDP-N-acetyl-D-mannosamine dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MFNKVSVIGLGYIGLPTAAVLASRGLDVVGVDVNAHAVDTINKGEIHIVEPDLDIVVRSAVMTGKLKATLTAEPADAFLV
AVPTPFKGDNHEPDLSYIEAAAKTIAPVLAKGNLVVLESTSPVGTTEKLAQWLAEARPDLTFPQQKGIAADVKIAYCPER
VLPGYVLQELVSNDRVIGGVSKACSEKAVALYKTFVKGECIVTNARTAEMAKLTENSFRDVNIAFANELSLVCNKLKINV
WELIRLANRHPRVSILNPGPGVGGHCIAVDPWFIVNSCPDEAQLIRTAREVNDGKPHWVVDQVKQAADQFKKPIIACLGL
AFKADIDDLRESPALDITKHLAESKVGQLLAVEPNITELPSKLAKQGIELVSLERALELANIVVVLVDHKEFKAADKTEF
AKKVVIDTRGVVA

Sequences:

>Translated_413_residues
MFNKVSVIGLGYIGLPTAAVLASRGLDVVGVDVNAHAVDTINKGEIHIVEPDLDIVVRSAVMTGKLKATLTAEPADAFLV
AVPTPFKGDNHEPDLSYIEAAAKTIAPVLAKGNLVVLESTSPVGTTEKLAQWLAEARPDLTFPQQKGIAADVKIAYCPER
VLPGYVLQELVSNDRVIGGVSKACSEKAVALYKTFVKGECIVTNARTAEMAKLTENSFRDVNIAFANELSLVCNKLKINV
WELIRLANRHPRVSILNPGPGVGGHCIAVDPWFIVNSCPDEAQLIRTAREVNDGKPHWVVDQVKQAADQFKKPIIACLGL
AFKADIDDLRESPALDITKHLAESKVGQLLAVEPNITELPSKLAKQGIELVSLERALELANIVVVLVDHKEFKAADKTEF
AKKVVIDTRGVVA
>Mature_413_residues
MFNKVSVIGLGYIGLPTAAVLASRGLDVVGVDVNAHAVDTINKGEIHIVEPDLDIVVRSAVMTGKLKATLTAEPADAFLV
AVPTPFKGDNHEPDLSYIEAAAKTIAPVLAKGNLVVLESTSPVGTTEKLAQWLAEARPDLTFPQQKGIAADVKIAYCPER
VLPGYVLQELVSNDRVIGGVSKACSEKAVALYKTFVKGECIVTNARTAEMAKLTENSFRDVNIAFANELSLVCNKLKINV
WELIRLANRHPRVSILNPGPGVGGHCIAVDPWFIVNSCPDEAQLIRTAREVNDGKPHWVVDQVKQAADQFKKPIIACLGL
AFKADIDDLRESPALDITKHLAESKVGQLLAVEPNITELPSKLAKQGIELVSLERALELANIVVVLVDHKEFKAADKTEF
AKKVVIDTRGVVA

Specific function: Probably involved in the synthesis of sugar components of EPS I, by converting NDP-N-acetyl-D-galactosamine into NDP-N- acetyl-D-galactosaminuronic acid [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=444, Percent_Identity=27.7027027027027, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI296040438, Length=346, Percent_Identity=26.3005780346821, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI296040443, Length=275, Percent_Identity=26.5454545454545, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI48994968, Length=421, Percent_Identity=64.6080760095012, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1788340, Length=369, Percent_Identity=22.2222222222222, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560350, Length=426, Percent_Identity=28.4037558685446, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI17136908, Length=398, Percent_Identity=28.894472361809, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 44501; Mature: 44501

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKVSVIGLGYIGLPTAAVLASRGLDVVGVDVNAHAVDTINKGEIHIVEPDLDIVVRSA
CCCCEEEEEECCHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCEEEEECCCHHHHHHHH
VMTGKLKATLTAEPADAFLVAVPTPFKGDNHEPDLSYIEAAAKTIAPVLAKGNLVVLEST
HHHCCEEEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
SPVGTTEKLAQWLAEARPDLTFPQQKGIAADVKIAYCPERVLPGYVLQELVSNDRVIGGV
CCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCHHHCCHHHHHHHHCCCCEEECH
SKACSEKAVALYKTFVKGECIVTNARTAEMAKLTENSFRDVNIAFANELSLVCNKLKINV
HHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCH
WELIRLANRHPRVSILNPGPGVGGHCIAVDPWFIVNSCPDEAQLIRTAREVNDGKPHWVV
HHHHHHHCCCCEEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHCCCCCCCHHH
DQVKQAADQFKKPIIACLGLAFKADIDDLRESPALDITKHLAESKVGQLLAVEPNITELP
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCEEEECCCHHHHH
SKLAKQGIELVSLERALELANIVVVLVDHKEFKAADKTEFAKKVVIDTRGVVA
HHHHHCCCHHHHHHHHHHHHCEEEEEECCHHHCCCCHHHHHHHHHEECCCCCC
>Mature Secondary Structure
MFNKVSVIGLGYIGLPTAAVLASRGLDVVGVDVNAHAVDTINKGEIHIVEPDLDIVVRSA
CCCCEEEEEECCHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCEEEEECCCHHHHHHHH
VMTGKLKATLTAEPADAFLVAVPTPFKGDNHEPDLSYIEAAAKTIAPVLAKGNLVVLEST
HHHCCEEEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
SPVGTTEKLAQWLAEARPDLTFPQQKGIAADVKIAYCPERVLPGYVLQELVSNDRVIGGV
CCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCHHHCCHHHHHHHHCCCCEEECH
SKACSEKAVALYKTFVKGECIVTNARTAEMAKLTENSFRDVNIAFANELSLVCNKLKINV
HHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCH
WELIRLANRHPRVSILNPGPGVGGHCIAVDPWFIVNSCPDEAQLIRTAREVNDGKPHWVV
HHHHHHHCCCCEEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHCCCCCCCHHH
DQVKQAADQFKKPIIACLGLAFKADIDDLRESPALDITKHLAESKVGQLLAVEPNITELP
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCEEEECCCHHHHH
SKLAKQGIELVSLERALELANIVVVLVDHKEFKAADKTEFAKKVVIDTRGVVA
HHHHHCCCHHHHHHHHHHHHCEEEEEECCHHHCCCCHHHHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]