Click here to switch to the map view.

The map label for this gene is wecB [H]

Identifier: 147674876

GI number: 147674876

Start: 470199

End: 471317

Strand: Direct

Name: wecB [H]

Synonym: VC0395_A0441

Alternate gene names: 147674876

Gene position: 470199-471317 (Clockwise)

Preceding gene: 147675486

Following gene: 147674871

Centisome position: 15.55

GC content: 48.44

Gene sequence:

>1119_bases
GTGAAAAAAGTTCTCATCGTATTTGGTACGCGCCCAGAGGCAATCAAAATGGCACCTCTGGTGCAGCAACTCTGTCAAGA
CAATCGTTTTGTCGCCAAGGTATGTGTAACGGGCCAACACCGTGAGATGTTAGATCAGGTATTAGAGCTGTTTTCGATTA
CGCCTGATTTTGATCTCAACATCATGGAGCCTGGGCAAACACTCAATGGCGTGACCAGCAAAATTTTGCTCGGTATGCAG
CAAGTGTTGAGTAGTGAACAGCCAGATGTGGTTTTAGTGCATGGTGATACCGCTACCACGTTTGCTGCCTCTTTAGCCGC
GTATTATCAACAAATTCCGGTAGGTCATGTTGAAGCGGGTTTGAGAACGGGCAATATCTATTCCCCTTGGCCTGAAGAGG
GCAACCGCAAACTCACGGCCGCACTCACGCAGTACCACTTTGCACCTACAGATACTTCGCGTGCCAATCTGCTGCAAGAA
AACTACAACGCAGAGAATATTTTCGTCACTGGTAATACGGTGATTGATGCGTTGTTGGCTGTGCGTGAAAAGATCCATAC
CGATATGGATCTGCAAGCCACTCTAGAGAGTCAGTTTCCAATGCTTGATGCGAGCAAAAAGCTGATTCTGGTAACAGGAC
ACCGCCGTGAAAGTTTTGGTGGTGGCTTTGAGCGTATTTGCCAAGCGCTGATCACTACCGCAGAGCAGCATCCCGAATGC
CAAATTTTGTATCCCGTGCATCTCAATCCGAATGTGCGTGAACCGGTCAATAAGCTCCTAAAAGGTGTCAGCAATATTGT
CTTGATTGAACCGCAGCAGTATTTGCCTTTCGTTTACTTGATGGATCGCGCACACATTATTTTGACTGACTCTGGCGGCA
TTCAAGAAGAGGCGCCCTCGCTGGGTAAGCCAGTGCTGGTGATGCGTGAAACGACTGAGCGCCCTGAAGCGGTGGCTGCG
GGCACGGTGAAATTAGTCGGTACCAACCAACAACAAATTTGTGATGCGTTAAGCTTACTACTGACTGACCCACAGGCTTA
TCAAGCCATGAGTCAGGCACACAACCCTTATGGGGATGGTAAAGCCTGTCAACGTATTGCGGACATTTTAGCGAAATAG

Upstream 100 bases:

>100_bases
AATTCAGTGTTCGCTTATGTATATGTTCCTCATTTAAGGAGCAGTGGGACTTTATTGCTTGAATTTTGTGAAATTTCTTT
TTTAAAGAGGATGTGGGGAA

Downstream 100 bases:

>100_bases
ACTCATCAGGGGATGACAGATGTTTAATAAAGTTTCAGTGATTGGCCTAGGTTATATTGGTCTGCCAACAGCAGCCGTTT
TGGCCTCTCGTGGTTTGGAT

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKKVLIVFGTRPEAIKMAPLVQQLCQDNRFVAKVCVTGQHREMLDQVLELFSITPDFDLNIMEPGQTLNGVTSKILLGMQ
QVLSSEQPDVVLVHGDTATTFAASLAAYYQQIPVGHVEAGLRTGNIYSPWPEEGNRKLTAALTQYHFAPTDTSRANLLQE
NYNAENIFVTGNTVIDALLAVREKIHTDMDLQATLESQFPMLDASKKLILVTGHRRESFGGGFERICQALITTAEQHPEC
QILYPVHLNPNVREPVNKLLKGVSNIVLIEPQQYLPFVYLMDRAHIILTDSGGIQEEAPSLGKPVLVMRETTERPEAVAA
GTVKLVGTNQQQICDALSLLLTDPQAYQAMSQAHNPYGDGKACQRIADILAK

Sequences:

>Translated_372_residues
MKKVLIVFGTRPEAIKMAPLVQQLCQDNRFVAKVCVTGQHREMLDQVLELFSITPDFDLNIMEPGQTLNGVTSKILLGMQ
QVLSSEQPDVVLVHGDTATTFAASLAAYYQQIPVGHVEAGLRTGNIYSPWPEEGNRKLTAALTQYHFAPTDTSRANLLQE
NYNAENIFVTGNTVIDALLAVREKIHTDMDLQATLESQFPMLDASKKLILVTGHRRESFGGGFERICQALITTAEQHPEC
QILYPVHLNPNVREPVNKLLKGVSNIVLIEPQQYLPFVYLMDRAHIILTDSGGIQEEAPSLGKPVLVMRETTERPEAVAA
GTVKLVGTNQQQICDALSLLLTDPQAYQAMSQAHNPYGDGKACQRIADILAK
>Mature_372_residues
MKKVLIVFGTRPEAIKMAPLVQQLCQDNRFVAKVCVTGQHREMLDQVLELFSITPDFDLNIMEPGQTLNGVTSKILLGMQ
QVLSSEQPDVVLVHGDTATTFAASLAAYYQQIPVGHVEAGLRTGNIYSPWPEEGNRKLTAALTQYHFAPTDTSRANLLQE
NYNAENIFVTGNTVIDALLAVREKIHTDMDLQATLESQFPMLDASKKLILVTGHRRESFGGGFERICQALITTAEQHPEC
QILYPVHLNPNVREPVNKLLKGVSNIVLIEPQQYLPFVYLMDRAHIILTDSGGIQEEAPSLGKPVLVMRETTERPEAVAA
GTVKLVGTNQQQICDALSLLLTDPQAYQAMSQAHNPYGDGKACQRIADILAK

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=368, Percent_Identity=67.3913043478261, Blast_Score=512, Evalue=1e-146,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 41041; Mature: 41041

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLIVFGTRPEAIKMAPLVQQLCQDNRFVAKVCVTGQHREMLDQVLELFSITPDFDLN
CCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCE
IMEPGQTLNGVTSKILLGMQQVLSSEQPDVVLVHGDTATTFAASLAAYYQQIPVGHVEAG
EECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHCC
LRTGNIYSPWPEEGNRKLTAALTQYHFAPTDTSRANLLQENYNAENIFVTGNTVIDALLA
CEECCCCCCCCCCCCCEEEEHHHHHCCCCCCCHHHHHHHHCCCCCEEEEECHHHHHHHHH
VREKIHTDMDLQATLESQFPMLDASKKLILVTGHRRESFGGGFERICQALITTAEQHPEC
HHHHHCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCE
QILYPVHLNPNVREPVNKLLKGVSNIVLIEPQQYLPFVYLMDRAHIILTDSGGIQEEAPS
EEEEEEECCCCHHHHHHHHHHCCCCEEEECCHHHCCEEEEECCCEEEEECCCCCCCCCCC
LGKPVLVMRETTERPEAVAAGTVKLVGTNQQQICDALSLLLTDPQAYQAMSQAHNPYGDG
CCCCEEEEECCCCCCCCEECCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
KACQRIADILAK
HHHHHHHHHHCC
>Mature Secondary Structure
MKKVLIVFGTRPEAIKMAPLVQQLCQDNRFVAKVCVTGQHREMLDQVLELFSITPDFDLN
CCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCE
IMEPGQTLNGVTSKILLGMQQVLSSEQPDVVLVHGDTATTFAASLAAYYQQIPVGHVEAG
EECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHCC
LRTGNIYSPWPEEGNRKLTAALTQYHFAPTDTSRANLLQENYNAENIFVTGNTVIDALLA
CEECCCCCCCCCCCCCEEEEHHHHHCCCCCCCHHHHHHHHCCCCCEEEEECHHHHHHHHH
VREKIHTDMDLQATLESQFPMLDASKKLILVTGHRRESFGGGFERICQALITTAEQHPEC
HHHHHCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCE
QILYPVHLNPNVREPVNKLLKGVSNIVLIEPQQYLPFVYLMDRAHIILTDSGGIQEEAPS
EEEEEEECCCCHHHHHHHHHHCCCCEEEECCHHHCCEEEEECCCEEEEECCCCCCCCCCC
LGKPVLVMRETTERPEAVAAGTVKLVGTNQQQICDALSLLLTDPQAYQAMSQAHNPYGDG
CCCCEEEEECCCCCCCCEECCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
KACQRIADILAK
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]