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The map label for this gene is serC [H]

Identifier: 147674623

GI number: 147674623

Start: 755035

End: 756174

Strand: Direct

Name: serC [H]

Synonym: VC0395_A0728

Alternate gene names: 147674623

Gene position: 755035-756174 (Clockwise)

Preceding gene: 147674618

Following gene: 147674215

Centisome position: 24.97

GC content: 48.77

Gene sequence:

>1140_bases
GTGGTATTAATCACAACACTTTTCGTTAGCAGGAGCAATGAACACATGGAGCACAACACCGATACGGTTTATAACTTTAG
TGCGGGTCCCGCCGCCTTGCCTAAGGCTGTGATGCTGCAAGCACAAGCGGAGTTTGTAAACTGGAATCATCTTGGCACTT
CGGTGATGGAAATTAGCCACCGTAGTCAGCCATTCATTCAAGTGGCCGAGCATGCTGAGCGCGATCTGCGCGATCTTCTG
AATATCCCAGATAATTACAAAGTACTGTTTTGCCAAGGCGGAGCGCGTGCACAGTTTGCGGCTGTACCACTTAACTTGCT
CGGGGATGCAGAGACGGCAACCTACATTGATGCCGGTTACTGGGCGATGAGCGCAGTGAAAGAAGCGAAGAAATACTGCA
CCGTCGATGTTTTTGACGCCAAAATTGAAAAAGAAGGCAAAATTGCCGTATTACCTGCGAGCGAATGGCGCATTGCGAAC
AATGCTGCCTATGTGCACTTCTGCCCGAATGAAACGATTGATGGTATTGAAATCAACGATTTGCCTGTCACAGACAAACC
GATTGTTGCCGATATGTCTTCGACCATTTTATCTCGTGAAATTGATGTATCGAAATACGGCGTGATTTACGCTGGCGCGC
AGAAGAATATTGGACCTGCGGGGATCTGTATCGCCATCGTGCGCGATGATTTGCTGGATTTGGCTAGCGATCTGTTACCG
GGAGTACTTAACTACAAAATTCTTGCTGAGCAAGAGTCGATGTTTAATACCCCGCCTACCTTTGCTTGGTATCTCTCCGG
CCTTGTTTTCCAATGGTTGAAAGCACAAGGTGGCGTCAAAGCGATTGAAGAAGTGAACCGTGCAAAAGCGGCGCTGCTTT
ATGGCTATATTGATTCATCCGATTTCTACCGTAACGAGATCCATCCAGACAACCGTTCGCTGATGAACGTCCCATTCCAA
CTGGCGAAACCCGAGTTGGACGATACCTTCTTGGAACTGGCTGAAGCGCGTGGCTTGGTGTCATTGAAAGGGCACCGTGT
TGTGGGGGGGATGCGTGCCTCTATCTATAACGCGATGCCGCTAGAGGGTGTGCAAGCGCTGGTCGATTTTATGAAAGAGT
TTGAAGCGCAATACGCTTAA

Upstream 100 bases:

>100_bases
CCGCTGATGATGTCACAAGGCTAAAAACTCGCGCGGTCGTTCGTTGCTTGGGGAAAGAGGCGTTAAGGCCTCTTTTCTCG
CTTTTTATCTGGCGTAAAAA

Downstream 100 bases:

>100_bases
TGGCATGTGGTTGATAGATCAAGAAAAAGGCTTCCATTCGGAAGCCTTTTGTCATGTTGGCGCGGTAAATAAAATCAGGA
TTACTGCGCTATCGGTGAGT

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MVLITTLFVSRSNEHMEHNTDTVYNFSAGPAALPKAVMLQAQAEFVNWNHLGTSVMEISHRSQPFIQVAEHAERDLRDLL
NIPDNYKVLFCQGGARAQFAAVPLNLLGDAETATYIDAGYWAMSAVKEAKKYCTVDVFDAKIEKEGKIAVLPASEWRIAN
NAAYVHFCPNETIDGIEINDLPVTDKPIVADMSSTILSREIDVSKYGVIYAGAQKNIGPAGICIAIVRDDLLDLASDLLP
GVLNYKILAEQESMFNTPPTFAWYLSGLVFQWLKAQGGVKAIEEVNRAKAALLYGYIDSSDFYRNEIHPDNRSLMNVPFQ
LAKPELDDTFLELAEARGLVSLKGHRVVGGMRASIYNAMPLEGVQALVDFMKEFEAQYA

Sequences:

>Translated_379_residues
MVLITTLFVSRSNEHMEHNTDTVYNFSAGPAALPKAVMLQAQAEFVNWNHLGTSVMEISHRSQPFIQVAEHAERDLRDLL
NIPDNYKVLFCQGGARAQFAAVPLNLLGDAETATYIDAGYWAMSAVKEAKKYCTVDVFDAKIEKEGKIAVLPASEWRIAN
NAAYVHFCPNETIDGIEINDLPVTDKPIVADMSSTILSREIDVSKYGVIYAGAQKNIGPAGICIAIVRDDLLDLASDLLP
GVLNYKILAEQESMFNTPPTFAWYLSGLVFQWLKAQGGVKAIEEVNRAKAALLYGYIDSSDFYRNEIHPDNRSLMNVPFQ
LAKPELDDTFLELAEARGLVSLKGHRVVGGMRASIYNAMPLEGVQALVDFMKEFEAQYA
>Mature_379_residues
MVLITTLFVSRSNEHMEHNTDTVYNFSAGPAALPKAVMLQAQAEFVNWNHLGTSVMEISHRSQPFIQVAEHAERDLRDLL
NIPDNYKVLFCQGGARAQFAAVPLNLLGDAETATYIDAGYWAMSAVKEAKKYCTVDVFDAKIEKEGKIAVLPASEWRIAN
NAAYVHFCPNETIDGIEINDLPVTDKPIVADMSSTILSREIDVSKYGVIYAGAQKNIGPAGICIAIVRDDLLDLASDLLP
GVLNYKILAEQESMFNTPPTFAWYLSGLVFQWLKAQGGVKAIEEVNRAKAALLYGYIDSSDFYRNEIHPDNRSLMNVPFQ
LAKPELDDTFLELAEARGLVSLKGHRVVGGMRASIYNAMPLEGVQALVDFMKEFEAQYA

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine [H]

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily [H]

Homologues:

Organism=Homo sapiens, GI17402893, Length=360, Percent_Identity=46.1111111111111, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI10863955, Length=356, Percent_Identity=41.2921348314607, Blast_Score=275, Evalue=5e-74,
Organism=Escherichia coli, GI1787136, Length=359, Percent_Identity=66.8523676880223, Blast_Score=502, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17506897, Length=360, Percent_Identity=43.6111111111111, Blast_Score=304, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6324758, Length=386, Percent_Identity=42.4870466321244, Blast_Score=275, Evalue=8e-75,
Organism=Drosophila melanogaster, GI21356589, Length=360, Percent_Identity=47.7777777777778, Blast_Score=334, Evalue=6e-92,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.6.1.52 [H]

Molecular weight: Translated: 41947; Mature: 41947

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLITTLFVSRSNEHMEHNTDTVYNFSAGPAALPKAVMLQAQAEFVNWNHLGTSVMEISH
CEEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCHHHCHHHHHHHC
RSQPFIQVAEHAERDLRDLLNIPDNYKVLFCQGGARAQFAAVPLNLLGDAETATYIDAGY
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEECHHHCCCCCHHEEEECHH
WAMSAVKEAKKYCTVDVFDAKIEKEGKIAVLPASEWRIANNAAYVHFCPNETIDGIEIND
HHHHHHHHHHHHEEEEEEECEECCCCCEEEEECCCEEEECCEEEEEECCCCCCCCEEECC
LPVTDKPIVADMSSTILSREIDVSKYGVIYAGAQKNIGPAGICIAIVRDDLLDLASDLLP
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHEEEHHHHHHHHHHHHHHCC
GVLNYKILAEQESMFNTPPTFAWYLSGLVFQWLKAQGGVKAIEEVNRAKAALLYGYIDSS
HHHCEEEEECHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEEEEECCC
DFYRNEIHPDNRSLMNVPFQLAKPELDDTFLELAEARGLVSLKGHRVVGGMRASIYNAMP
CHHHCCCCCCCCCEECCCHHHCCCCCHHHHHHHHHHCCEEEECCCEEECCHHHHHHCCCC
LEGVQALVDFMKEFEAQYA
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVLITTLFVSRSNEHMEHNTDTVYNFSAGPAALPKAVMLQAQAEFVNWNHLGTSVMEISH
CEEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCHHHCHHHHHHHC
RSQPFIQVAEHAERDLRDLLNIPDNYKVLFCQGGARAQFAAVPLNLLGDAETATYIDAGY
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEECHHHCCCCCHHEEEECHH
WAMSAVKEAKKYCTVDVFDAKIEKEGKIAVLPASEWRIANNAAYVHFCPNETIDGIEIND
HHHHHHHHHHHHEEEEEEECEECCCCCEEEEECCCEEEECCEEEEEECCCCCCCCEEECC
LPVTDKPIVADMSSTILSREIDVSKYGVIYAGAQKNIGPAGICIAIVRDDLLDLASDLLP
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHEEEHHHHHHHHHHHHHHCC
GVLNYKILAEQESMFNTPPTFAWYLSGLVFQWLKAQGGVKAIEEVNRAKAALLYGYIDSS
HHHCEEEEECHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEEEEECCC
DFYRNEIHPDNRSLMNVPFQLAKPELDDTFLELAEARGLVSLKGHRVVGGMRASIYNAMP
CHHHCCCCCCCCCEECCCHHHCCCCCHHHHHHHHHHCCEEEECCCEEECCHHHHHHCCCC
LEGVQALVDFMKEFEAQYA
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]