Click here to switch to the map view.

The map label for this gene is ppiD [H]

Identifier: 147674490

GI number: 147674490

Start: 1620001

End: 1621860

Strand: Reverse

Name: ppiD [H]

Synonym: VC0395_A1508

Alternate gene names: 147674490

Gene position: 1621860-1620001 (Counterclockwise)

Preceding gene: 147673385

Following gene: 147675214

Centisome position: 53.63

GC content: 46.02

Gene sequence:

>1860_bases
ATGATGGATCGATTACGCGAAGGCGTGAACAGCATCGCGGTTAAAATTATCCTTGGATTAATCATCCTGTCTTTCATTTT
TGCTGGTGTAGGTAACTACCTGATCAGCGGCGGTAATAACGCGGCCGCTAAAGTCGGCAATGCGGAAATCAGTCGTGGTG
ATTTTGAGCAAGCCTATCAAAACGAACGTAACCGTATGCAAGCTCAACTGGGCGATTATTTTTCAAACTTGCTGGCGGAT
CCGACCTATGTCGCCTCTTTCCGTAAGTCAGTATTAGATCGTATGGTGAACGATTTGCTCTTAGAGCAACATGCAGCGTC
ACTAGGGCTACGTGTGAGTGATGAGCAAGTTCGTCAATTGATTTTAGAAATCCCACAATTTCAATCTCAAGGCGTATTTG
ACTCTACGGCTTACCAAGCGACTCTGCGTCGCGCAGGCTTTACTCCTGAGATGTATGCTGAATACTTACGCAAAGATTTA
GTGCGTAATCAATTGATGAGTGCATTGCAGGGAAGTGAATTCAGCCTTGCTGGTGAAGTAAACTTGCAAGACCAATTGAT
TTCTCAGACGCGTGATATTCGTACGATCACCTTATCTCTAGAAGACTTCGCAAAAAAAGTGACGTTGAGCGATGAAGAGA
TCGATCAGTACTACAAAACTAACACCGAGCGTTTTACTCGCCCTGAGCAGGTAAAAGTCTCTTATGTCGAGCTCTCTGCT
GATGGACTGAAAGCGCAAGTGAGCGTTGATGATGCGGCAGCGCAGCAGTACTACCAAGAACATTTGGATAAGTACTCTAC
TGCAGAGCAGCGCAATGTGAGCCATATCCTGATTGAAGGTAATGATGAGCAAAAAGCACAAGCGATTTTGGATGAACTGA
ATGCTGGTGCTGATTTTGCGACTTTAGCGAAAGAAAAATCGCAAGATCTCGGCAGTGCAGCAGAGGGCGGCTCACTGGGT
TGGATTGAACCTGACACTATGGACCCAGCTTTCGAAGCGGCAGCATTTGCATTAACTGAAAAGGGTCAAGTTTCGGGTCT
TGTAAAGTCTGATTTCGGTTATCACATCATTCGCTTAGACGACATCAAAGCACCTGTGGTGAAGCCATACAGTGAAGTTG
AGCAGGCGATCAAACAAGAACTGATTGATCAGCAAGCCCTTGATAGTTTCTATGCTAAGCAGAGTGAACTTGAAAAGATG
GCATTTGAACATTCAGACTCTCTGGATGAAGCGGCCAAGGCTATCTCAGCTACGGTTGTGCACACCGATTTTATCTCTGC
CGAACAAGCTCCTGAGGTGTTAACCACTCCTGCGGTACTGCAAGCGCTGAAATCACCAGAAGTGAAAGAAGATGGTCTCA
ACTCTGAAGTGATTGAAGTAGCTCCAGAGCATGTCGTGGTGGTGCGTGTTGAAGAGTTTCGTCCAGAAACTGTGCTGCCA
CTTGATGAAGTCAAATCGCAAGTGGTTGAGCAGCTATCTCGTATGAAAGGTGAACAACAAGCACTTGAACTGGGTAACCA
GCTTGTGACTGCGTTGAAAGCGGGTGAAACGGATCTGCTAGCGCAAAAAGGTGTGTCTTTTGGCGAATTACAAATGATCG
ATCGCAGTTCACCTCTTGCCAACACGGTTTACGCCATGGTGAAACCACAAGAGGGCGAGAAGGTTTATGCCCAAGCGAAA
GATTTTGACGGCAATATCGTTGTGATTGAGTTGAGCAAAGTGGAAAGTAAACTGACACCGGCTTATCACGAACAGATCGC
TACACAGTTAGAACGTATCGGTTCTCAGCAAGATCTGGCGGGTGTGATCAGTGTGTTGCGTCAAAACACCGATATTGAGT
ATCACATTGCGACAGAATAA

Upstream 100 bases:

>100_bases
TTATGCGCATCCTACTGATGCGCATTTCTTTTTCTGATATTATCGCGCCATTCATTTTGGGCTTACGTGCCTGATATCAA
CCCCGGAGAGTAGTAGCACT

Downstream 100 bases:

>100_bases
GCATTCTTAGTGTAATTGATATGTTTAAAGAAACGGGCTACAGCAGTAGCCCGTTCTATTTATAAATTGTCGAAATTTCC
ATCATTTTTCCCCTCGCTAT

Product: peptidyl-prolyl cis-trans isomerase D

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MMDRLREGVNSIAVKIILGLIILSFIFAGVGNYLISGGNNAAAKVGNAEISRGDFEQAYQNERNRMQAQLGDYFSNLLAD
PTYVASFRKSVLDRMVNDLLLEQHAASLGLRVSDEQVRQLILEIPQFQSQGVFDSTAYQATLRRAGFTPEMYAEYLRKDL
VRNQLMSALQGSEFSLAGEVNLQDQLISQTRDIRTITLSLEDFAKKVTLSDEEIDQYYKTNTERFTRPEQVKVSYVELSA
DGLKAQVSVDDAAAQQYYQEHLDKYSTAEQRNVSHILIEGNDEQKAQAILDELNAGADFATLAKEKSQDLGSAAEGGSLG
WIEPDTMDPAFEAAAFALTEKGQVSGLVKSDFGYHIIRLDDIKAPVVKPYSEVEQAIKQELIDQQALDSFYAKQSELEKM
AFEHSDSLDEAAKAISATVVHTDFISAEQAPEVLTTPAVLQALKSPEVKEDGLNSEVIEVAPEHVVVVRVEEFRPETVLP
LDEVKSQVVEQLSRMKGEQQALELGNQLVTALKAGETDLLAQKGVSFGELQMIDRSSPLANTVYAMVKPQEGEKVYAQAK
DFDGNIVVIELSKVESKLTPAYHEQIATQLERIGSQQDLAGVISVLRQNTDIEYHIATE

Sequences:

>Translated_619_residues
MMDRLREGVNSIAVKIILGLIILSFIFAGVGNYLISGGNNAAAKVGNAEISRGDFEQAYQNERNRMQAQLGDYFSNLLAD
PTYVASFRKSVLDRMVNDLLLEQHAASLGLRVSDEQVRQLILEIPQFQSQGVFDSTAYQATLRRAGFTPEMYAEYLRKDL
VRNQLMSALQGSEFSLAGEVNLQDQLISQTRDIRTITLSLEDFAKKVTLSDEEIDQYYKTNTERFTRPEQVKVSYVELSA
DGLKAQVSVDDAAAQQYYQEHLDKYSTAEQRNVSHILIEGNDEQKAQAILDELNAGADFATLAKEKSQDLGSAAEGGSLG
WIEPDTMDPAFEAAAFALTEKGQVSGLVKSDFGYHIIRLDDIKAPVVKPYSEVEQAIKQELIDQQALDSFYAKQSELEKM
AFEHSDSLDEAAKAISATVVHTDFISAEQAPEVLTTPAVLQALKSPEVKEDGLNSEVIEVAPEHVVVVRVEEFRPETVLP
LDEVKSQVVEQLSRMKGEQQALELGNQLVTALKAGETDLLAQKGVSFGELQMIDRSSPLANTVYAMVKPQEGEKVYAQAK
DFDGNIVVIELSKVESKLTPAYHEQIATQLERIGSQQDLAGVISVLRQNTDIEYHIATE
>Mature_619_residues
MMDRLREGVNSIAVKIILGLIILSFIFAGVGNYLISGGNNAAAKVGNAEISRGDFEQAYQNERNRMQAQLGDYFSNLLAD
PTYVASFRKSVLDRMVNDLLLEQHAASLGLRVSDEQVRQLILEIPQFQSQGVFDSTAYQATLRRAGFTPEMYAEYLRKDL
VRNQLMSALQGSEFSLAGEVNLQDQLISQTRDIRTITLSLEDFAKKVTLSDEEIDQYYKTNTERFTRPEQVKVSYVELSA
DGLKAQVSVDDAAAQQYYQEHLDKYSTAEQRNVSHILIEGNDEQKAQAILDELNAGADFATLAKEKSQDLGSAAEGGSLG
WIEPDTMDPAFEAAAFALTEKGQVSGLVKSDFGYHIIRLDDIKAPVVKPYSEVEQAIKQELIDQQALDSFYAKQSELEKM
AFEHSDSLDEAAKAISATVVHTDFISAEQAPEVLTTPAVLQALKSPEVKEDGLNSEVIEVAPEHVVVVRVEEFRPETVLP
LDEVKSQVVEQLSRMKGEQQALELGNQLVTALKAGETDLLAQKGVSFGELQMIDRSSPLANTVYAMVKPQEGEKVYAQAK
DFDGNIVVIELSKVESKLTPAYHEQIATQLERIGSQQDLAGVISVLRQNTDIEYHIATE

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=627, Percent_Identity=38.5964912280702, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1786238, Length=328, Percent_Identity=27.4390243902439, Blast_Score=86, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 68489; Mature: 68489

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDRLREGVNSIAVKIILGLIILSFIFAGVGNYLISGGNNAAAKVGNAEISRGDFEQAYQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHCCCCCCCCCCHHHHHHH
NERNRMQAQLGDYFSNLLADPTYVASFRKSVLDRMVNDLLLEQHAASLGLRVSDEQVRQL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ILEIPQFQSQGVFDSTAYQATLRRAGFTPEMYAEYLRKDLVRNQLMSALQGSEFSLAGEV
HHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
NLQDQLISQTRDIRTITLSLEDFAKKVTLSDEEIDQYYKTNTERFTRPEQVKVSYVELSA
CHHHHHHHHHCCCEEEEEEHHHHHHHHCCCHHHHHHHHHCCHHHCCCCCCEEEEEEEEEC
DGLKAQVSVDDAAAQQYYQEHLDKYSTAEQRNVSHILIEGNDEQKAQAILDELNAGADFA
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCHH
TLAKEKSQDLGSAAEGGSLGWIEPDTMDPAFEAAAFALTEKGQVSGLVKSDFGYHIIRLD
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEC
DIKAPVVKPYSEVEQAIKQELIDQQALDSFYAKQSELEKMAFEHSDSLDEAAKAISATVV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HTDFISAEQAPEVLTTPAVLQALKSPEVKEDGLNSEVIEVAPEHVVVVRVEEFRPETVLP
HHHHHCHHCCCHHHCCHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCCCCC
LDEVKSQVVEQLSRMKGEQQALELGNQLVTALKAGETDLLAQKGVSFGELQMIDRSSPLA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEECCCCCHH
NTVYAMVKPQEGEKVYAQAKDFDGNIVVIELSKVESKLTPAYHEQIATQLERIGSQQDLA
HHHEEEECCCCCCEEEHCCCCCCCCEEEEEEHHHHHHCCHHHHHHHHHHHHHCCCHHHHH
GVISVLRQNTDIEYHIATE
HHHHHHHCCCCCEEEEECC
>Mature Secondary Structure
MMDRLREGVNSIAVKIILGLIILSFIFAGVGNYLISGGNNAAAKVGNAEISRGDFEQAYQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHCCCCCCCCCCHHHHHHH
NERNRMQAQLGDYFSNLLADPTYVASFRKSVLDRMVNDLLLEQHAASLGLRVSDEQVRQL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ILEIPQFQSQGVFDSTAYQATLRRAGFTPEMYAEYLRKDLVRNQLMSALQGSEFSLAGEV
HHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
NLQDQLISQTRDIRTITLSLEDFAKKVTLSDEEIDQYYKTNTERFTRPEQVKVSYVELSA
CHHHHHHHHHCCCEEEEEEHHHHHHHHCCCHHHHHHHHHCCHHHCCCCCCEEEEEEEEEC
DGLKAQVSVDDAAAQQYYQEHLDKYSTAEQRNVSHILIEGNDEQKAQAILDELNAGADFA
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCHH
TLAKEKSQDLGSAAEGGSLGWIEPDTMDPAFEAAAFALTEKGQVSGLVKSDFGYHIIRLD
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEC
DIKAPVVKPYSEVEQAIKQELIDQQALDSFYAKQSELEKMAFEHSDSLDEAAKAISATVV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HTDFISAEQAPEVLTTPAVLQALKSPEVKEDGLNSEVIEVAPEHVVVVRVEEFRPETVLP
HHHHHCHHCCCHHHCCHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCCCCC
LDEVKSQVVEQLSRMKGEQQALELGNQLVTALKAGETDLLAQKGVSFGELQMIDRSSPLA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEECCCCCHH
NTVYAMVKPQEGEKVYAQAKDFDGNIVVIELSKVESKLTPAYHEQIATQLERIGSQQDLA
HHHEEEECCCCCCEEEHCCCCCCCCEEEEEEHHHHHHCCHHHHHHHHHHHHHCCCHHHHH
GVISVLRQNTDIEYHIATE
HHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]