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The map label for this gene is uvrC

Identifier: 147674383

GI number: 147674383

Start: 849689

End: 851521

Strand: Direct

Name: uvrC

Synonym: VC0395_A0834

Alternate gene names: 147674383

Gene position: 849689-851521 (Clockwise)

Preceding gene: 147673828

Following gene: 147673568

Centisome position: 28.1

GC content: 49.15

Gene sequence:

>1833_bases
GTGTCGACACAGTTTGATTCTGCCCCTTTTCTTAAGACAGTCACCAACCAGCCCGGCGTATACCGAATGTATAACGCTGA
GGCTGAAGTGATTTATGTCGGCAAAGCCAAAGACCTCAAAAAGCGTCTAACCAGCTATTTTCGCAAGAATCTCGACAGCG
AAAAAACCAAAGCTCTCGTCAGCAACATCGCCAAGATTGACGTGACGGTCACCCACACCGAAACGGAAGCATTGATCCTT
GAGCACAATTACATCAAGCAGTATCTGCCTAAGTACAACGTGCTGCTGCGTGATGATAAGTCTTATCCCTATATTTTCTT
AAGCGCGCACAAACACCCGCGACTGTCCTCACATCGTGGTGCCAAAAAACGCCGTGGTGAATATTTCGGGCCTTATCCGG
ATTCGGGGGCAGTGCGTGAAACTCTGCATTTGATCCAGAAAATCTTTCCCGTCCGTCAGTGTGAAGATACGGTGTACAGC
AACCGTACTCGACCTTGCTTGATGTATCAGATTGGGCGCTGTGCCGGACCTTGTGTGAAAGGACTGATTTCTGACCAAGG
CTATCAAGAGATCGTCCATTACCTACGTCTTTTCCTGCAAGGCAAAGACAACCAAGTACTGTCGATTCTGGTTGAGAAAA
TGGAGCAGGCGAGCCGTGAACTGCGTTTTGAAGATGCCGCTAAAGCGCGTGACCAAATTCAAGCCATTCGCCGCGTACAA
GAGCAGCAGTTTGTGTCGGACGACAGTTTGGAAGACTTGGATGTGCTCGGTTTTGCACAAGAAAATGGCATTGCTTGCAT
CCATATTTTGATGATCCGCCAAGGCAAAGTGCTCGGCAGTCGTAGCCATTTTCCGAAAATTCCAAGTGACACCTCGCAGG
TCGAAGTGTTTGAGAGCTTTTTAAGCCAATATTATTTAAGTCACAGTGAAGCTCGCAGTATTCCGGCACGGATCATTTTA
AATCGAGGATTGACCGAAGAAACCGAGGCGCTACAAATCGCGATCAGTGAACTTGCAGGGCGCAAAGTCACTTTCCATGT
CAATCCTACCGGCACGCGAGGTCGTTATCTGAAACTCGCCAATACCAACGCGCTGACGGCGATCACGACTAAGATGAATC
ACAAGATGACCATCAGTCAGCGCTTCAAAGCCCTGCAAGAAGAGCTCGGAATGGATGCGATTACCCGCATGGAGTGTTTT
GATATCTCGCATACCATGGGCGAAAGCACGATGGCCTCTTGTGTGGTGTTTAACCAAGAAGGGCCGCTAAAGCAAGAGTA
TCGGCGTTACAACATCACGGGCATCACTGGTGGGGATGATTACGCGGCGATGGCGCAAGTGTTGGAGCGCCGTTACAGTA
AGCAGCTTGATAGCAGCAAAATTCCCGACATTATTTTTATTGATGGTGGGAAAGGGCAGCTTAATCGTGCGTACGAAATT
ATCTCCTCATGTTGGCAGGATTGGCCGAAGTACCCGAAGATCATCGGCATCGCCAAAGGGGTGACACGTAAACCTGGTTT
AGAAACGCTGATCACTATTGATGGTGATGAGTTTCATCTGCCGAGTGATGCGCCTGCGTTGCACTTAATTCAACACATTC
GGGATGAAAGCCATAACCACGCGATTGCAGGACACCGCGCGCAGCGCGGAAAAACTCGCCGTACCAGTACACTTGAGGGT
ATCGAAGGCGTCGGGCCGAAACGGCGTCAAGCCTTGCTGAAATATCTGGGTGGTATGCAGGAGTTAAAACGCGCTTCTGT
TGAAGAAATCGCCAAAGTGCCGGGCATCAGCCACGCATTGGCAGAAAACATTTATCAAGCATTGAAACAATAA

Upstream 100 bases:

>100_bases
GCTACCGCTACCGTTTGTTCGCCAAGCTGAATATCAACGGTGATGTGGAATTAACCCACTTAGCTATCCGACACGGGATC
TTAGATACTGAGAAGTTATA

Downstream 100 bases:

>100_bases
GAAAAATACAGCAACATTAACGCGCCATCGAAAAGAGCCTATACATTATGCGTTTCAACATTCCTAACCTTCTCTCCTTG
CTCAGATTATTTCTGATCCC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MSTQFDSAPFLKTVTNQPGVYRMYNAEAEVIYVGKAKDLKKRLTSYFRKNLDSEKTKALVSNIAKIDVTVTHTETEALIL
EHNYIKQYLPKYNVLLRDDKSYPYIFLSAHKHPRLSSHRGAKKRRGEYFGPYPDSGAVRETLHLIQKIFPVRQCEDTVYS
NRTRPCLMYQIGRCAGPCVKGLISDQGYQEIVHYLRLFLQGKDNQVLSILVEKMEQASRELRFEDAAKARDQIQAIRRVQ
EQQFVSDDSLEDLDVLGFAQENGIACIHILMIRQGKVLGSRSHFPKIPSDTSQVEVFESFLSQYYLSHSEARSIPARIIL
NRGLTEETEALQIAISELAGRKVTFHVNPTGTRGRYLKLANTNALTAITTKMNHKMTISQRFKALQEELGMDAITRMECF
DISHTMGESTMASCVVFNQEGPLKQEYRRYNITGITGGDDYAAMAQVLERRYSKQLDSSKIPDIIFIDGGKGQLNRAYEI
ISSCWQDWPKYPKIIGIAKGVTRKPGLETLITIDGDEFHLPSDAPALHLIQHIRDESHNHAIAGHRAQRGKTRRTSTLEG
IEGVGPKRRQALLKYLGGMQELKRASVEEIAKVPGISHALAENIYQALKQ

Sequences:

>Translated_610_residues
MSTQFDSAPFLKTVTNQPGVYRMYNAEAEVIYVGKAKDLKKRLTSYFRKNLDSEKTKALVSNIAKIDVTVTHTETEALIL
EHNYIKQYLPKYNVLLRDDKSYPYIFLSAHKHPRLSSHRGAKKRRGEYFGPYPDSGAVRETLHLIQKIFPVRQCEDTVYS
NRTRPCLMYQIGRCAGPCVKGLISDQGYQEIVHYLRLFLQGKDNQVLSILVEKMEQASRELRFEDAAKARDQIQAIRRVQ
EQQFVSDDSLEDLDVLGFAQENGIACIHILMIRQGKVLGSRSHFPKIPSDTSQVEVFESFLSQYYLSHSEARSIPARIIL
NRGLTEETEALQIAISELAGRKVTFHVNPTGTRGRYLKLANTNALTAITTKMNHKMTISQRFKALQEELGMDAITRMECF
DISHTMGESTMASCVVFNQEGPLKQEYRRYNITGITGGDDYAAMAQVLERRYSKQLDSSKIPDIIFIDGGKGQLNRAYEI
ISSCWQDWPKYPKIIGIAKGVTRKPGLETLITIDGDEFHLPSDAPALHLIQHIRDESHNHAIAGHRAQRGKTRRTSTLEG
IEGVGPKRRQALLKYLGGMQELKRASVEEIAKVPGISHALAENIYQALKQ
>Mature_609_residues
STQFDSAPFLKTVTNQPGVYRMYNAEAEVIYVGKAKDLKKRLTSYFRKNLDSEKTKALVSNIAKIDVTVTHTETEALILE
HNYIKQYLPKYNVLLRDDKSYPYIFLSAHKHPRLSSHRGAKKRRGEYFGPYPDSGAVRETLHLIQKIFPVRQCEDTVYSN
RTRPCLMYQIGRCAGPCVKGLISDQGYQEIVHYLRLFLQGKDNQVLSILVEKMEQASRELRFEDAAKARDQIQAIRRVQE
QQFVSDDSLEDLDVLGFAQENGIACIHILMIRQGKVLGSRSHFPKIPSDTSQVEVFESFLSQYYLSHSEARSIPARIILN
RGLTEETEALQIAISELAGRKVTFHVNPTGTRGRYLKLANTNALTAITTKMNHKMTISQRFKALQEELGMDAITRMECFD
ISHTMGESTMASCVVFNQEGPLKQEYRRYNITGITGGDDYAAMAQVLERRYSKQLDSSKIPDIIFIDGGKGQLNRAYEII
SSCWQDWPKYPKIIGIAKGVTRKPGLETLITIDGDEFHLPSDAPALHLIQHIRDESHNHAIAGHRAQRGKTRRTSTLEGI
EGVGPKRRQALLKYLGGMQELKRASVEEIAKVPGISHALAENIYQALKQ

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=611, Percent_Identity=63.9934533551555, Blast_Score=819, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_VIBC3 (A5F1X2)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F1X2
- STRING:   A5F1X2
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A0834
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   VCHO345073:VC0395_A0834-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69110; Mature: 68979

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQFDSAPFLKTVTNQPGVYRMYNAEAEVIYVGKAKDLKKRLTSYFRKNLDSEKTKALV
CCCCCCCCCHHHHHCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHHH
SNIAKIDVTVTHTETEALILEHNYIKQYLPKYNVLLRDDKSYPYIFLSAHKHPRLSSHRG
HHHHHEEEEEEECCCCEEEEEHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCCCCCC
AKKRRGEYFGPYPDSGAVRETLHLIQKIFPVRQCEDTVYSNRTRPCLMYQIGRCAGPCVK
CHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
GLISDQGYQEIVHYLRLFLQGKDNQVLSILVEKMEQASRELRFEDAAKARDQIQAIRRVQ
HHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
EQQFVSDDSLEDLDVLGFAQENGIACIHILMIRQGKVLGSRSHFPKIPSDTSQVEVFESF
HHHHCCCCCCCCHHHEEECCCCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
LSQYYLSHSEARSIPARIILNRGLTEETEALQIAISELAGRKVTFHVNPTGTRGRYLKLA
HHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEE
NTNALTAITTKMNHKMTISQRFKALQEELGMDAITRMECFDISHTMGESTMASCVVFNQE
CCCCEEEEEECCCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHEEEEEECCC
GPLKQEYRRYNITGITGGDDYAAMAQVLERRYSKQLDSSKIPDIIFIDGGKGQLNRAYEI
CCHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHH
ISSCWQDWPKYPKIIGIAKGVTRKPGLETLITIDGDEFHLPSDAPALHLIQHIRDESHNH
HHHHHHHCCCCCCCEEHHCCCCCCCCCCEEEEECCCCEECCCCCHHHHHHHHHHCCCCCC
AIAGHRAQRGKTRRTSTLEGIEGVGPKRRQALLKYLGGMQELKRASVEEIAKVPGISHAL
CCCCCHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHH
AENIYQALKQ
HHHHHHHHCC
>Mature Secondary Structure 
STQFDSAPFLKTVTNQPGVYRMYNAEAEVIYVGKAKDLKKRLTSYFRKNLDSEKTKALV
CCCCCCCCHHHHHCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHHH
SNIAKIDVTVTHTETEALILEHNYIKQYLPKYNVLLRDDKSYPYIFLSAHKHPRLSSHRG
HHHHHEEEEEEECCCCEEEEEHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCCCCCC
AKKRRGEYFGPYPDSGAVRETLHLIQKIFPVRQCEDTVYSNRTRPCLMYQIGRCAGPCVK
CHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
GLISDQGYQEIVHYLRLFLQGKDNQVLSILVEKMEQASRELRFEDAAKARDQIQAIRRVQ
HHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
EQQFVSDDSLEDLDVLGFAQENGIACIHILMIRQGKVLGSRSHFPKIPSDTSQVEVFESF
HHHHCCCCCCCCHHHEEECCCCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
LSQYYLSHSEARSIPARIILNRGLTEETEALQIAISELAGRKVTFHVNPTGTRGRYLKLA
HHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEE
NTNALTAITTKMNHKMTISQRFKALQEELGMDAITRMECFDISHTMGESTMASCVVFNQE
CCCCEEEEEECCCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHEEEEEECCC
GPLKQEYRRYNITGITGGDDYAAMAQVLERRYSKQLDSSKIPDIIFIDGGKGQLNRAYEI
CCHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHH
ISSCWQDWPKYPKIIGIAKGVTRKPGLETLITIDGDEFHLPSDAPALHLIQHIRDESHNH
HHHHHHHCCCCCCCEEHHCCCCCCCCCCEEEEECCCCEECCCCCHHHHHHHHHHCCCCCC
AIAGHRAQRGKTRRTSTLEGIEGVGPKRRQALLKYLGGMQELKRASVEEIAKVPGISHAL
CCCCCHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHH
AENIYQALKQ
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA