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The map label for this gene is uvrY [H]

Identifier: 147673828

GI number: 147673828

Start: 849006

End: 849689

Strand: Direct

Name: uvrY [H]

Synonym: VC0395_A0833

Alternate gene names: 147673828

Gene position: 849006-849689 (Clockwise)

Preceding gene: 147674946

Following gene: 147674383

Centisome position: 28.07

GC content: 47.66

Gene sequence:

>684_bases
GTGGGTGCAGAGCCAATAGATAAGTGTGGAGATACAAGTTTGATTAGTGTTTTCCTTGTAGATGATCACGAGCTGGTTCG
CACAGGGATACGACGTATTATTGAAGACGTCCGTGGAATGAAAGTAGCAGGGGAAGCTGACAGCGGTGAAGAAGCAGTAA
AATGGTGCCGTACTAACCATGCGGATGTCATTTTAATGGATATGAACATGCCGGGTATTGGTGGCTTGGAAGCAACCAAG
AAGCTGTTGCGTGTTAATCCGGACATTAAAATTATCGTATTGACGGTACATACCGAAAATCCGTTCCCAACCAAAGTGAT
GCAAGCGGGTGCCGCAGGTTATCTCACGAAGGGCGCGGCACCGGATGAAATGGTCAATGCGATCCGTATCGTTCACAGCG
GTCAGCGTTACATTTCTCCAGAAATTGCGCAGCAAATGGCGTTGAGTCAGTTTTCGCCCGCCTCTGAAAATCCTTTTGCT
GATCTCTCCGAGCGTGAATTGCAGATCATGTTAATGATCACCAAAGGCCAGAAGGTGACGGACATTTCCGAACAGCTCAG
TTTGAGCCCGAACACCGTCAACAGCTACCGCTACCGTTTGTTCGCCAAGCTGAATATCAACGGTGATGTGGAATTAACCC
ACTTAGCTATCCGACACGGGATCTTAGATACTGAGAAGTTATAG

Upstream 100 bases:

>100_bases
AAAAATAAGTGCTTGCTAAAGTGTAGGTTTCAGATCATATTCACGGGAGAAAAGTTGCCCGCGTTGGTTTGGGGTAGCTT
CGCTGTAATCCACTGTCTCG

Downstream 100 bases:

>100_bases
TGTCGACACAGTTTGATTCTGCCCCTTTTCTTAAGACAGTCACCAACCAGCCCGGCGTATACCGAATGTATAACGCTGAG
GCTGAAGTGATTTATGTCGG

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MGAEPIDKCGDTSLISVFLVDDHELVRTGIRRIIEDVRGMKVAGEADSGEEAVKWCRTNHADVILMDMNMPGIGGLEATK
KLLRVNPDIKIIVLTVHTENPFPTKVMQAGAAGYLTKGAAPDEMVNAIRIVHSGQRYISPEIAQQMALSQFSPASENPFA
DLSERELQIMLMITKGQKVTDISEQLSLSPNTVNSYRYRLFAKLNINGDVELTHLAIRHGILDTEKL

Sequences:

>Translated_227_residues
MGAEPIDKCGDTSLISVFLVDDHELVRTGIRRIIEDVRGMKVAGEADSGEEAVKWCRTNHADVILMDMNMPGIGGLEATK
KLLRVNPDIKIIVLTVHTENPFPTKVMQAGAAGYLTKGAAPDEMVNAIRIVHSGQRYISPEIAQQMALSQFSPASENPFA
DLSERELQIMLMITKGQKVTDISEQLSLSPNTVNSYRYRLFAKLNINGDVELTHLAIRHGILDTEKL
>Mature_226_residues
GAEPIDKCGDTSLISVFLVDDHELVRTGIRRIIEDVRGMKVAGEADSGEEAVKWCRTNHADVILMDMNMPGIGGLEATKK
LLRVNPDIKIIVLTVHTENPFPTKVMQAGAAGYLTKGAAPDEMVNAIRIVHSGQRYISPEIAQQMALSQFSPASENPFAD
LSERELQIMLMITKGQKVTDISEQLSLSPNTVNSYRYRLFAKLNINGDVELTHLAIRHGILDTEKL

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=215, Percent_Identity=74.8837209302326, Blast_Score=344, Evalue=3e-96,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=33.5, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1788521, Length=205, Percent_Identity=33.6585365853659, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1786747, Length=201, Percent_Identity=24.8756218905473, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=28.9617486338798, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788712, Length=210, Percent_Identity=24.2857142857143, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1788546, Length=205, Percent_Identity=25.8536585365854, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25025; Mature: 24894

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAEPIDKCGDTSLISVFLVDDHELVRTGIRRIIEDVRGMKVAGEADSGEEAVKWCRTNH
CCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCC
ADVILMDMNMPGIGGLEATKKLLRVNPDIKIIVLTVHTENPFPTKVMQAGAAGYLTKGAA
CCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHCCCCCCCCCCCC
PDEMVNAIRIVHSGQRYISPEIAQQMALSQFSPASENPFADLSERELQIMLMITKGQKVT
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCEEC
DISEQLSLSPNTVNSYRYRLFAKLNINGDVELTHLAIRHGILDTEKL
CHHHHHCCCCCCCCCEEEEEEEEEECCCCEEEEHHHHHHCCCCCCCC
>Mature Secondary Structure 
GAEPIDKCGDTSLISVFLVDDHELVRTGIRRIIEDVRGMKVAGEADSGEEAVKWCRTNH
CCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCC
ADVILMDMNMPGIGGLEATKKLLRVNPDIKIIVLTVHTENPFPTKVMQAGAAGYLTKGAA
CCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHCCCCCCCCCCCC
PDEMVNAIRIVHSGQRYISPEIAQQMALSQFSPASENPFADLSERELQIMLMITKGQKVT
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCEEC
DISEQLSLSPNTVNSYRYRLFAKLNINGDVELTHLAIRHGILDTEKL
CHHHHHCCCCCCCCCEEEEEEEEEECCCCEEEEHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]