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The map label for this gene is ggt [H]

Identifier: 147674349

GI number: 147674349

Start: 2725235

End: 2727001

Strand: Reverse

Name: ggt [H]

Synonym: VC0395_A2574

Alternate gene names: 147674349

Gene position: 2727001-2725235 (Counterclockwise)

Preceding gene: 147673550

Following gene: 147673771

Centisome position: 90.18

GC content: 55.29

Gene sequence:

>1767_bases
ATGGAGATGGGCATGAATTGGACTCATACCCCCTTGGCGCTTTCTGCGCTGATGTTTGCGATGGCTGCACAAGCTACCCC
GAATCAAGCCACCGATGCGGTTGCGCCAGAACAAGCCACTGGCTTTGAGCACAAATCGTTAGTCAAAGCCAAAAACTGGA
TGGTCACGGCGGCTAACCCACTGGCGAGCGAAGCAGGGGCTTCGATTTTACGCCAAGGCGGTAATGCGATAGATGCCATG
GTGACGACACAACTGATGCTGGGCTTGGTTGAGCCGCAATCATCCGGCATTGGCGGTGGCTCGTTTTTGGTCTACTGGGA
TGCCAAGAAAAAAGCGCTCACTACGTTCGATGGCCGCGAAACCGCGCCACTCAACGCCACACCTGAACTATTTTTAGATA
GTACAGGTCAGCCAATGAAATTTTACGATGCCGTGGTCGGCGGTCGCTCGGTTGGTACTCCCGGCACGGTCAAACTGCTG
TGGGAAACCCATCGTCAATACGGCAAGCTGGAATGGGCGCGCTTGATTGAACCTGTCGCCAAACTCGCCGAGCAAGGCTT
TGAGGTAAGTCCTCGCCTCGCGGCACTCATTGCAGAAGATAAAGAGCGTTTAGGCCGTTTTCCTGCCACCAAAGCCTATT
TCTTTGATGCACAAGGTGAACCCCTCACAGCCGGCACTTTACTGAAAAACCCGGACTACGCCGCCACACTCAGAGCCATC
GCACAGCAAGGCGCCTCCGCCTTCTATCAAGGTGACATCGCCAAAGACATCATCGCCACGGTGCAAAATGCGCCGGGCAA
TCCCGGAGTGCTCGCTCAGCAAGATTTTGATACGTACCAAGTCAAACAGCGTGCGCCCGTGTGTGCGGCTTATCAAAGCT
ATCAAGTCTGCGGCATGGGGTTACCCAGCTCAGGTGGCCTGACGGTGGGACAAATTCTCGCCCTCACCGAACAATACGAT
CTCAAAGGTTGGGGCGCGCAGGATGTGAAATCATGGCAAGTGCTGGGGGATGCCTCACAACTGGCGTTTGCCGATCGCGG
CTTGTACATGGCCGATCAAGATTATGTGCCCGTTCCGACCCAAGGCTTATTGGATAAAACCTATCTGGCCGAGCGCGCTA
AACTGATCCAACCCGGCAAAGCGCTGACCAGTGCGCCAGCAGGCAATCCGCCTTGGCATCATGCGCAGCTACGCAGCCCC
GATCAGTCGATAGAACTGCCCTCCACCAGCCACTTCAACATTGTTGACCGTGAAGGCAACGTGGTTTCCTTCACCACCTC
GATCGAAAACGCGTTCGGTTCACGCTTGTTGGTGCGCGGCTTTTTGCTCAACAACGAACTGACCGATTTTTCGTTTGCCA
CGCAAAGTGAAGGTCGCCCGATTGCCAATCGCTTAGAGCCGGGCAAACGCCCACGTTCATCGATGGCACCGACCATTGTC
TTGCAGGATAACCAACCCTATTTGGCGATTGGCTCACCCGGTGGCAGCCGAATTATTGGCTATGTGGCGCAAGCAATCGT
TGCTCACACCCAATGGGGCATGAACATTCAAGCCGCGATCAATCAACCGCATGTGCTGAATCGTTTTGGCGAAATCGAGC
TCGAACAAGGCACCTCCGCCGAGCAGTTCAAGCCAGCGCTAGAAAGTTTGGGGGCAAAGGTCGGGATCAAAGAGCTCAAC
TCTGGCCTGCACGCCATTCGTATTACTGCACAAGGTCTTGAGGGAGCCGCTGACCCTCGCCGTGAAGGCGTCGCCATCGG
CGAGTAA

Upstream 100 bases:

>100_bases
CAATCCTGAGACATTGCTGCATAAATCATCGATTTAGCCAACAAGCCGCTAGAACAAAACTTTAACCCAACGTTAACATG
ATCTCTTCATAACAACGAAA

Downstream 100 bases:

>100_bases
GCGTTAACTCAAAAAGTGATGGGCAGAGTCTGCCCATCATTTTTTACTCGCACCTCATTTTTCCCACCCACGCGAAGAGG
CACTGATCATTTTTTACAAG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 588

Protein sequence:

>588_residues
MEMGMNWTHTPLALSALMFAMAAQATPNQATDAVAPEQATGFEHKSLVKAKNWMVTAANPLASEAGASILRQGGNAIDAM
VTTQLMLGLVEPQSSGIGGGSFLVYWDAKKKALTTFDGRETAPLNATPELFLDSTGQPMKFYDAVVGGRSVGTPGTVKLL
WETHRQYGKLEWARLIEPVAKLAEQGFEVSPRLAALIAEDKERLGRFPATKAYFFDAQGEPLTAGTLLKNPDYAATLRAI
AQQGASAFYQGDIAKDIIATVQNAPGNPGVLAQQDFDTYQVKQRAPVCAAYQSYQVCGMGLPSSGGLTVGQILALTEQYD
LKGWGAQDVKSWQVLGDASQLAFADRGLYMADQDYVPVPTQGLLDKTYLAERAKLIQPGKALTSAPAGNPPWHHAQLRSP
DQSIELPSTSHFNIVDREGNVVSFTTSIENAFGSRLLVRGFLLNNELTDFSFATQSEGRPIANRLEPGKRPRSSMAPTIV
LQDNQPYLAIGSPGGSRIIGYVAQAIVAHTQWGMNIQAAINQPHVLNRFGEIELEQGTSAEQFKPALESLGAKVGIKELN
SGLHAIRITAQGLEGAADPRREGVAIGE

Sequences:

>Translated_588_residues
MEMGMNWTHTPLALSALMFAMAAQATPNQATDAVAPEQATGFEHKSLVKAKNWMVTAANPLASEAGASILRQGGNAIDAM
VTTQLMLGLVEPQSSGIGGGSFLVYWDAKKKALTTFDGRETAPLNATPELFLDSTGQPMKFYDAVVGGRSVGTPGTVKLL
WETHRQYGKLEWARLIEPVAKLAEQGFEVSPRLAALIAEDKERLGRFPATKAYFFDAQGEPLTAGTLLKNPDYAATLRAI
AQQGASAFYQGDIAKDIIATVQNAPGNPGVLAQQDFDTYQVKQRAPVCAAYQSYQVCGMGLPSSGGLTVGQILALTEQYD
LKGWGAQDVKSWQVLGDASQLAFADRGLYMADQDYVPVPTQGLLDKTYLAERAKLIQPGKALTSAPAGNPPWHHAQLRSP
DQSIELPSTSHFNIVDREGNVVSFTTSIENAFGSRLLVRGFLLNNELTDFSFATQSEGRPIANRLEPGKRPRSSMAPTIV
LQDNQPYLAIGSPGGSRIIGYVAQAIVAHTQWGMNIQAAINQPHVLNRFGEIELEQGTSAEQFKPALESLGAKVGIKELN
SGLHAIRITAQGLEGAADPRREGVAIGE
>Mature_588_residues
MEMGMNWTHTPLALSALMFAMAAQATPNQATDAVAPEQATGFEHKSLVKAKNWMVTAANPLASEAGASILRQGGNAIDAM
VTTQLMLGLVEPQSSGIGGGSFLVYWDAKKKALTTFDGRETAPLNATPELFLDSTGQPMKFYDAVVGGRSVGTPGTVKLL
WETHRQYGKLEWARLIEPVAKLAEQGFEVSPRLAALIAEDKERLGRFPATKAYFFDAQGEPLTAGTLLKNPDYAATLRAI
AQQGASAFYQGDIAKDIIATVQNAPGNPGVLAQQDFDTYQVKQRAPVCAAYQSYQVCGMGLPSSGGLTVGQILALTEQYD
LKGWGAQDVKSWQVLGDASQLAFADRGLYMADQDYVPVPTQGLLDKTYLAERAKLIQPGKALTSAPAGNPPWHHAQLRSP
DQSIELPSTSHFNIVDREGNVVSFTTSIENAFGSRLLVRGFLLNNELTDFSFATQSEGRPIANRLEPGKRPRSSMAPTIV
LQDNQPYLAIGSPGGSRIIGYVAQAIVAHTQWGMNIQAAINQPHVLNRFGEIELEQGTSAEQFKPALESLGAKVGIKELN
SGLHAIRITAQGLEGAADPRREGVAIGE

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=542, Percent_Identity=29.8892988929889, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI73915090, Length=542, Percent_Identity=29.8892988929889, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI73915096, Length=542, Percent_Identity=29.8892988929889, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI73915094, Length=542, Percent_Identity=29.8892988929889, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI113429324, Length=538, Percent_Identity=29.182156133829, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI113429326, Length=542, Percent_Identity=28.5977859778598, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI109148539, Length=538, Percent_Identity=27.6951672862454, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI153266885, Length=510, Percent_Identity=26.8627450980392, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI153266901, Length=511, Percent_Identity=26.8101761252446, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI30581157, Length=184, Percent_Identity=33.695652173913, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI30581155, Length=184, Percent_Identity=33.695652173913, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI171543825, Length=203, Percent_Identity=29.5566502463054, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1789856, Length=550, Percent_Identity=35.8181818181818, Blast_Score=308, Evalue=6e-85,
Organism=Caenorhabditis elegans, GI72000294, Length=531, Percent_Identity=31.8267419962335, Blast_Score=218, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI212646519, Length=531, Percent_Identity=31.8267419962335, Blast_Score=218, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI193208245, Length=517, Percent_Identity=29.4003868471954, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI193208247, Length=517, Percent_Identity=29.4003868471954, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17542894, Length=555, Percent_Identity=29.7297297297297, Blast_Score=189, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17506189, Length=498, Percent_Identity=27.1084337349398, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17564448, Length=460, Percent_Identity=25.4347826086956, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI72001497, Length=235, Percent_Identity=28.5106382978723, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI72001495, Length=235, Percent_Identity=28.5106382978723, Blast_Score=100, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323330, Length=494, Percent_Identity=29.9595141700405, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI18859893, Length=478, Percent_Identity=30.5439330543933, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI161077496, Length=544, Percent_Identity=27.0220588235294, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI45551474, Length=552, Percent_Identity=26.6304347826087, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24642670, Length=552, Percent_Identity=26.6304347826087, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24642666, Length=552, Percent_Identity=26.6304347826087, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI161077878, Length=552, Percent_Identity=26.6304347826087, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI161077880, Length=552, Percent_Identity=26.6304347826087, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI18859741, Length=486, Percent_Identity=23.4567901234568, Blast_Score=109, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 63077; Mature: 63077

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMGMNWTHTPLALSALMFAMAAQATPNQATDAVAPEQATGFEHKSLVKAKNWMVTAANP
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHCCEEEEECCC
LASEAGASILRQGGNAIDAMVTTQLMLGLVEPQSSGIGGGSFLVYWDAKKKALTTFDGRE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEECCCCC
TAPLNATPELFLDSTGQPMKFYDAVVGGRSVGTPGTVKLLWETHRQYGKLEWARLIEPVA
CCCCCCCCHHEECCCCCCHHHHHHHHCCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHH
KLAEQGFEVSPRLAALIAEDKERLGRFPATKAYFFDAQGEPLTAGTLLKNPDYAATLRAI
HHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEECCCEECCCCHHHHHHHH
AQQGASAFYQGDIAKDIIATVQNAPGNPGVLAQQDFDTYQVKQRAPVCAAYQSYQVCGMG
HHHCCHHHHCCCHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHCCCHHHHHHCCCEECCC
LPSSGGLTVGQILALTEQYDLKGWGAQDVKSWQVLGDASQLAFADRGLYMADQDYVPVPT
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHEECCHHHHHHHHCCCEEECCCCCCCCC
QGLLDKTYLAERAKLIQPGKALTSAPAGNPPWHHAQLRSPDQSIELPSTSHFNIVDREGN
CHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCC
VVSFTTSIENAFGSRLLVRGFLLNNELTDFSFATQSEGRPIANRLEPGKRPRSSMAPTIV
EEEEEEHHHHHHCCHHHHHHHHHCCCCCCCEECCCCCCCCCHHHCCCCCCCCCCCCCEEE
LQDNQPYLAIGSPGGSRIIGYVAQAIVAHTQWGMNIQAAINQPHVLNRFGEIELEQGTSA
EECCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHCCCCEEECCCCCH
EQFKPALESLGAKVGIKELNSGLHAIRITAQGLEGAADPRREGVAIGE
HHHHHHHHHCCCCCCHHHHCCCCEEEEEEECCCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MEMGMNWTHTPLALSALMFAMAAQATPNQATDAVAPEQATGFEHKSLVKAKNWMVTAANP
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHCCEEEEECCC
LASEAGASILRQGGNAIDAMVTTQLMLGLVEPQSSGIGGGSFLVYWDAKKKALTTFDGRE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEECCCCC
TAPLNATPELFLDSTGQPMKFYDAVVGGRSVGTPGTVKLLWETHRQYGKLEWARLIEPVA
CCCCCCCCHHEECCCCCCHHHHHHHHCCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHH
KLAEQGFEVSPRLAALIAEDKERLGRFPATKAYFFDAQGEPLTAGTLLKNPDYAATLRAI
HHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEECCCEECCCCHHHHHHHH
AQQGASAFYQGDIAKDIIATVQNAPGNPGVLAQQDFDTYQVKQRAPVCAAYQSYQVCGMG
HHHCCHHHHCCCHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHCCCHHHHHHCCCEECCC
LPSSGGLTVGQILALTEQYDLKGWGAQDVKSWQVLGDASQLAFADRGLYMADQDYVPVPT
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHEECCHHHHHHHHCCCEEECCCCCCCCC
QGLLDKTYLAERAKLIQPGKALTSAPAGNPPWHHAQLRSPDQSIELPSTSHFNIVDREGN
CHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCC
VVSFTTSIENAFGSRLLVRGFLLNNELTDFSFATQSEGRPIANRLEPGKRPRSSMAPTIV
EEEEEEHHHHHHCCHHHHHHHHHCCCCCCCEECCCCCCCCCHHHCCCCCCCCCCCCCEEE
LQDNQPYLAIGSPGGSRIIGYVAQAIVAHTQWGMNIQAAINQPHVLNRFGEIELEQGTSA
EECCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHCCCCEEECCCCCH
EQFKPALESLGAKVGIKELNSGLHAIRITAQGLEGAADPRREGVAIGE
HHHHHHHHHCCCCCCHHHHCCCCEEEEEEECCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA