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The map label for this gene is gmhB

Identifier: 147674205

GI number: 147674205

Start: 458718

End: 459278

Strand: Direct

Name: gmhB

Synonym: VC0395_A0430

Alternate gene names: 147674205

Gene position: 458718-459278 (Clockwise)

Preceding gene: 147673743

Following gene: 147673437

Centisome position: 15.17

GC content: 49.02

Gene sequence:

>561_bases
TTGGCCAAACCCGCCGTATTTCTTGATCGTGATGGCGTGATCAACGTCGATCATGGTTACGTGCATGATGAGCACGATTT
CCAATTTATTGAAGGTGTATTTGAAGCGACTGCGGCTTTGCAGCGTATGGGGTATTTGTTGGTGCTGGTTACCAACCAAT
CCGGTATTGCGCGTGGCAAATTTAGCGAAGAGCGTTTCATTTCTCTCACCCAGTGGATGGACTGGAACTTTGCCGATAAT
GGCGTTGAGTTTGATGGTATCTATTATTGTCCGCACCATGCTGAACATGGCATTGGGCAATACAAAGAAGAGTGTGATTG
CCGCAAACCTAAGCCGGGCATGTTTCTCTCGGCGCGCGATTTCCTGAACATCGACATGGCCAATTCGGTGATGGTCGGTG
ATAAAGCCGAAGATATGATGGCAGCTGAAGCGGCGGGTGTAGGCACTAAGATTTTGGTGCGCACCGGTAAGCCAATCACA
GAGCAAGGTGAAGCCTTAGCGACCGTGGTGCTCGATAGCATTCGCGATGTGCCTCATTATCTACTGCGAGTGAAAAAATA
A

Upstream 100 bases:

>100_bases
ACGAGAAGGTTATTAGATAGTGACGAAAAAAATATAGATAGTGATGAAAAAAATAAAGCGTGCAATAATTCGCGCAAAGT
GACTTGAAAGAGACAGCATT

Downstream 100 bases:

>100_bases
GGTCGCGTCAGTGGCCTTATTGACCGCTCATTCTTTTCTTATCAATGAATACCAATACAAACGCATGAATCGAAAACTGA
CTATTTTAGACATTGCTAGA

Product: D,D-heptose 1,7-bisphosphate phosphatase

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MAKPAVFLDRDGVINVDHGYVHDEHDFQFIEGVFEATAALQRMGYLLVLVTNQSGIARGKFSEERFISLTQWMDWNFADN
GVEFDGIYYCPHHAEHGIGQYKEECDCRKPKPGMFLSARDFLNIDMANSVMVGDKAEDMMAAEAAGVGTKILVRTGKPIT
EQGEALATVVLDSIRDVPHYLLRVKK

Sequences:

>Translated_186_residues
MAKPAVFLDRDGVINVDHGYVHDEHDFQFIEGVFEATAALQRMGYLLVLVTNQSGIARGKFSEERFISLTQWMDWNFADN
GVEFDGIYYCPHHAEHGIGQYKEECDCRKPKPGMFLSARDFLNIDMANSVMVGDKAEDMMAAEAAGVGTKILVRTGKPIT
EQGEALATVVLDSIRDVPHYLLRVKK
>Mature_185_residues
AKPAVFLDRDGVINVDHGYVHDEHDFQFIEGVFEATAALQRMGYLLVLVTNQSGIARGKFSEERFISLTQWMDWNFADNG
VEFDGIYYCPHHAEHGIGQYKEECDCRKPKPGMFLSARDFLNIDMANSVMVGDKAEDMMAAEAAGVGTKILVRTGKPITE
QGEALATVVLDSIRDVPHYLLRVKK

Specific function: Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family

Homologues:

Organism=Escherichia coli, GI1786399, Length=188, Percent_Identity=61.7021276595745, Blast_Score=251, Evalue=3e-68,
Organism=Escherichia coli, GI87082027, Length=150, Percent_Identity=34, Blast_Score=84, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHB_VIBCH (Q9KTJ4)

Other databases:

- EMBL:   AE003852
- PIR:   D82266
- RefSeq:   NP_230555.1
- ProteinModelPortal:   Q9KTJ4
- SMR:   Q9KTJ4
- GeneID:   2614199
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC0908
- TIGR:   VC_0908
- HOGENOM:   HBG613347
- OMA:   VVLDSIA
- ProtClustDB:   PRK08942
- GO:   GO:0005737
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543
- Gene3D:   G3DSA:3.40.50.1000
- TIGRFAMs:   TIGR00213
- TIGRFAMs:   TIGR01662
- TIGRFAMs:   TIGR01656

Pfam domain/function: PF00702 Hydrolase; SSF56784 SSF56784

EC number: 3.1.1.-

Molecular weight: Translated: 20829; Mature: 20698

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPAVFLDRDGVINVDHGYVHDEHDFQFIEGVFEATAALQRMGYLLVLVTNQSGIARGK
CCCCCEEECCCCEEECCCCEEECCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCC
FSEERFISLTQWMDWNFADNGVEFDGIYYCPHHAEHGIGQYKEECDCRKPKPGMFLSARD
CCHHHHEEHHHHCCCCCCCCCEEECEEEECCCCCCCCCHHHHHHHCCCCCCCCEEEECCC
FLNIDMANSVMVGDKAEDMMAAEAAGVGTKILVRTGKPITEQGEALATVVLDSIRDVPHY
EEEEECCCEEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
LLRVKK
HHEECC
>Mature Secondary Structure 
AKPAVFLDRDGVINVDHGYVHDEHDFQFIEGVFEATAALQRMGYLLVLVTNQSGIARGK
CCCCEEECCCCEEECCCCEEECCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCC
FSEERFISLTQWMDWNFADNGVEFDGIYYCPHHAEHGIGQYKEECDCRKPKPGMFLSARD
CCHHHHEEHHHHCCCCCCCCCEEECEEEECCCCCCCCCHHHHHHHCCCCCCCCEEEECCC
FLNIDMANSVMVGDKAEDMMAAEAAGVGTKILVRTGKPITEQGEALATVVLDSIRDVPHY
EEEEECCCEEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
LLRVKK
HHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301; 12101286