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The map label for this gene is treR [H]

Identifier: 147673437

GI number: 147673437

Start: 459343

End: 460293

Strand: Direct

Name: treR [H]

Synonym: VC0395_A0431

Alternate gene names: 147673437

Gene position: 459343-460293 (Clockwise)

Preceding gene: 147674205

Following gene: 147675677

Centisome position: 15.19

GC content: 49.21

Gene sequence:

>951_bases
ATGAATCGAAAACTGACTATTTTAGACATTGCTAGACTCTCAGGCGTCGGTAAATCTACCGTTTCGCGCGTGTTAACCAA
TGATCCTAAAGTGAAGCCTGAAACCCGCGCTAAAGTAGAGCAGGTGATTGCAGAGTCGGGGTATGTGCCCTCTAAATCGG
CACAAACCATGCGTGGTGGTAGTCAGAAAGTCGTGGGCATCATTATTTCACGTCTGGATTCCCCTTCTGAAAACAAAGCA
GTCAGTACTATGCTGCAAGCTTTCTATGCTCACGGCTACGATGTGGTGATCATGGAAAGCCAATTTAGCCGCGAAAAAAC
CAATGCTCACTTAAAAGTGCTCGCCAAGCGGCAAGTGGATGGCGTCATTGTGTTTGGCTTTACCGATATCGATCATGATG
CCTTGCTCAGTTGGCAGCACCGCTGTGTACTCTTGGCCATGCACAGTGATGAGATTTCCTCTATCAATTATGACAATGCT
GGGGTGATTGAGCGTGCGCTGCAGCATTTGGCACAAAAACAGTTACGCGATATTGCCTTCATTGGGGTCGACCCACGTGA
CAAAACCACGGGTGAGCAGCGGCTCAACGCCTATCTCAATTGGTGTGTTGAGCATGAGATTGTGGCGAATTACCAAACCG
GACAACTGCATCATGAAAGTGCTTATCTGCTGGTAGATAAAGTGCTGACTGAGCAAACCCAAGCGATTGTGTGCGCGAGT
GATACTTTGGCGCTCGGTGTGATTAAGCGTTTGCAAGAGCTGCAGCGAGATGACGTAGTGGTGACGGGGGTGGGTGGTAA
TGAGTTGCTCTCTTTCCTGTTTCCGAACATATTCAGTGTCGATCCTGGTTATCGTGAGGCCGGAAAACTGGCGGCAGATC
TGCTGATTGAGCAGCTATGCGGCTCTGACCATGGCTGTGTGCATTTGACCCAAATGCCAGTGTCACGCTAA

Upstream 100 bases:

>100_bases
GATGTGCCTCATTATCTACTGCGAGTGAAAAAATAAGGTCGCGTCAGTGGCCTTATTGACCGCTCATTCTTTTCTTATCA
ATGAATACCAATACAAACGC

Downstream 100 bases:

>100_bases
GCCTATTCTTTCTTTAATTCGGTGCTTTCATTCGGCTCCTCATCAGTGGCTTTTTCGCCACTTTCGTGATTTTGCCTCTC
TTTTTACTACACTAAATTGA

Product: trehalose repressor

Products: NA

Alternate protein names: Trehalose operon repressor [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MNRKLTILDIARLSGVGKSTVSRVLTNDPKVKPETRAKVEQVIAESGYVPSKSAQTMRGGSQKVVGIIISRLDSPSENKA
VSTMLQAFYAHGYDVVIMESQFSREKTNAHLKVLAKRQVDGVIVFGFTDIDHDALLSWQHRCVLLAMHSDEISSINYDNA
GVIERALQHLAQKQLRDIAFIGVDPRDKTTGEQRLNAYLNWCVEHEIVANYQTGQLHHESAYLLVDKVLTEQTQAIVCAS
DTLALGVIKRLQELQRDDVVVTGVGGNELLSFLFPNIFSVDPGYREAGKLAADLLIEQLCGSDHGCVHLTQMPVSR

Sequences:

>Translated_316_residues
MNRKLTILDIARLSGVGKSTVSRVLTNDPKVKPETRAKVEQVIAESGYVPSKSAQTMRGGSQKVVGIIISRLDSPSENKA
VSTMLQAFYAHGYDVVIMESQFSREKTNAHLKVLAKRQVDGVIVFGFTDIDHDALLSWQHRCVLLAMHSDEISSINYDNA
GVIERALQHLAQKQLRDIAFIGVDPRDKTTGEQRLNAYLNWCVEHEIVANYQTGQLHHESAYLLVDKVLTEQTQAIVCAS
DTLALGVIKRLQELQRDDVVVTGVGGNELLSFLFPNIFSVDPGYREAGKLAADLLIEQLCGSDHGCVHLTQMPVSR
>Mature_316_residues
MNRKLTILDIARLSGVGKSTVSRVLTNDPKVKPETRAKVEQVIAESGYVPSKSAQTMRGGSQKVVGIIISRLDSPSENKA
VSTMLQAFYAHGYDVVIMESQFSREKTNAHLKVLAKRQVDGVIVFGFTDIDHDALLSWQHRCVLLAMHSDEISSINYDNA
GVIERALQHLAQKQLRDIAFIGVDPRDKTTGEQRLNAYLNWCVEHEIVANYQTGQLHHESAYLLVDKVLTEQTQAIVCAS
DTLALGVIKRLQELQRDDVVVTGVGGNELLSFLFPNIFSVDPGYREAGKLAADLLIEQLCGSDHGCVHLTQMPVSR

Specific function: Repressor of the treBC operon. Binds trehalose 6- phosphate as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790689, Length=301, Percent_Identity=49.5016611295681, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1790194, Length=312, Percent_Identity=28.2051282051282, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790369, Length=313, Percent_Identity=23.3226837060703, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787906, Length=265, Percent_Identity=24.5283018867925, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787948, Length=310, Percent_Identity=21.2903225806452, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI48994940, Length=326, Percent_Identity=22.3926380368098, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787580, Length=320, Percent_Identity=26.25, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786540, Length=309, Percent_Identity=25.2427184466019, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786268, Length=309, Percent_Identity=23.3009708737864, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789068, Length=264, Percent_Identity=24.2424242424242, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789202, Length=257, Percent_Identity=23.7354085603113, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761
- InterPro:   IPR012771 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 34935; Mature: 34935

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKLTILDIARLSGVGKSTVSRVLTNDPKVKPETRAKVEQVIAESGYVPSKSAQTMRGG
CCCEEEEEEHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCC
SQKVVGIIISRLDSPSENKAVSTMLQAFYAHGYDVVIMESQFSREKTNAHLKVLAKRQVD
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHCCHHCCHHHHEEEECCCC
GVIVFGFTDIDHDALLSWQHRCVLLAMHSDEISSINYDNAGVIERALQHLAQKQLRDIAF
EEEEEEEECCCHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEE
IGVDPRDKTTGEQRLNAYLNWCVEHEIVANYQTGQLHHESAYLLVDKVLTEQTQAIVCAS
EECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHCEEEEEC
DTLALGVIKRLQELQRDDVVVTGVGGNELLSFLFPNIFSVDPGYREAGKLAADLLIEQLC
CHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
GSDHGCVHLTQMPVSR
CCCCCEEEEECCCCCC
>Mature Secondary Structure
MNRKLTILDIARLSGVGKSTVSRVLTNDPKVKPETRAKVEQVIAESGYVPSKSAQTMRGG
CCCEEEEEEHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCC
SQKVVGIIISRLDSPSENKAVSTMLQAFYAHGYDVVIMESQFSREKTNAHLKVLAKRQVD
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHCCHHCCHHHHEEEECCCC
GVIVFGFTDIDHDALLSWQHRCVLLAMHSDEISSINYDNAGVIERALQHLAQKQLRDIAF
EEEEEEEECCCHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEE
IGVDPRDKTTGEQRLNAYLNWCVEHEIVANYQTGQLHHESAYLLVDKVLTEQTQAIVCAS
EECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHCEEEEEC
DTLALGVIKRLQELQRDDVVVTGVGGNELLSFLFPNIFSVDPGYREAGKLAADLLIEQLC
CHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
GSDHGCVHLTQMPVSR
CCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9148912; 7610040; 9278503; 7608078; 9865945 [H]