Click here to switch to the map view.

The map label for this gene is cytR [H]

Identifier: 147674191

GI number: 147674191

Start: 2397911

End: 2398918

Strand: Reverse

Name: cytR [H]

Synonym: VC0395_A2250

Alternate gene names: 147674191

Gene position: 2398918-2397911 (Counterclockwise)

Preceding gene: 147674045

Following gene: 147673934

Centisome position: 79.33

GC content: 52.48

Gene sequence:

>1008_bases
ATGGCGACAATGAAGGATGTTGCCCAGCTTGCTGGAGTTTCAACCGCGACCGTGTCTCGTGCGTTGATGAATCCAGAGAA
AGTCTCGTCGTCCACTCGTAAACGAGTGGAAGAGGCCGTGCTGGAAGCGGGTTACTCACCCAATTCTTTGGCGCGCAATT
TGCGCCGTAATGAATCGAAAACCATCGTTGCTATCGTGCCAGATATCTGTGATCCCTACTTTTCTGAGATCATTCGCGGT
ATTGAAGATGCCGCGATGGAGCACGGTTATCTGGTGCTGTTGGGGGATAGTGGTCAACAGAAGCGTCGGGAGAACTCGTT
CGTTAATCTGGTGTTTACCAAACAGGCAGACGGTATGTTGCTGCTGGGGACAGATTTGCCGTTTGATGTGAGTAAACCTG
AGCAGAAAAACCTACCGCCTATGGTGATGGCGTGTGAATTTGCGCCAGAGCTGGAATTGCCAACGGTACACATTGATAAC
CTGACCTCGGCATTTGAGGCGGTAAACTATCTCACTCAGCTTGGGCACAAACGGATTGCGCAGATCTCAGGTCCACAACA
TGCTGCGCTGTGCCAATTCCGTCATCAAGGCTATCAACAGGCGTTGCGTCGTGCTGGCATCACCATGAACCCGACTTACT
GCACTTTTGGCGATTTCACTTTTGAAGCCGGGGCAAAAGCGGTGCGTCAGCTGTTGGCATTGCCTGAGCAGCCGACCGCG
ATTTTCTGTCATAACGATACGATGGCGATTGGCGCAATTCAGGAAGCGAAGCGACTTGGCTTGCGCGTACCGCAAGATCT
CTCTGTGGTCGGTTTTGACGATATTCAGTTTGCCCAGTACTGCGATCCCCCATTAACCACCATTTCGCAGCCGCGTTATG
AGATTGGCCGTCAAGCCATGCTGATGATGCTTGAGCTGCTTCGCGGACACGATGTACGTGCTGGATCGCGTCTTTTGGAG
ACCAAGCTGGTCGTGCGTGAGAGTGCTGCGCCGCCAAGCAAGAAGTAA

Upstream 100 bases:

>100_bases
CATGAACAAGATTTACTGATTGCAGGTTAAGTCTTACAAGATCAGTCATCATGAGTGTGATGCTCAACATCACTCGATAG
AGAAAAGAGGGTAAAAATAC

Downstream 100 bases:

>100_bases
CCCACCTTCGAAACCGAGTTTCATGCTTGAAAGGTTTGAACTCGGTTCCTTTTTTCGTTCCTGTCGCAGCGCTGAGATCG
GCGATAAGGCCAGTTGTTTG

Product: DNA-binding transcriptional regulator CytR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MATMKDVAQLAGVSTATVSRALMNPEKVSSSTRKRVEEAVLEAGYSPNSLARNLRRNESKTIVAIVPDICDPYFSEIIRG
IEDAAMEHGYLVLLGDSGQQKRRENSFVNLVFTKQADGMLLLGTDLPFDVSKPEQKNLPPMVMACEFAPELELPTVHIDN
LTSAFEAVNYLTQLGHKRIAQISGPQHAALCQFRHQGYQQALRRAGITMNPTYCTFGDFTFEAGAKAVRQLLALPEQPTA
IFCHNDTMAIGAIQEAKRLGLRVPQDLSVVGFDDIQFAQYCDPPLTTISQPRYEIGRQAMLMMLELLRGHDVRAGSRLLE
TKLVVRESAAPPSKK

Sequences:

>Translated_335_residues
MATMKDVAQLAGVSTATVSRALMNPEKVSSSTRKRVEEAVLEAGYSPNSLARNLRRNESKTIVAIVPDICDPYFSEIIRG
IEDAAMEHGYLVLLGDSGQQKRRENSFVNLVFTKQADGMLLLGTDLPFDVSKPEQKNLPPMVMACEFAPELELPTVHIDN
LTSAFEAVNYLTQLGHKRIAQISGPQHAALCQFRHQGYQQALRRAGITMNPTYCTFGDFTFEAGAKAVRQLLALPEQPTA
IFCHNDTMAIGAIQEAKRLGLRVPQDLSVVGFDDIQFAQYCDPPLTTISQPRYEIGRQAMLMMLELLRGHDVRAGSRLLE
TKLVVRESAAPPSKK
>Mature_334_residues
ATMKDVAQLAGVSTATVSRALMNPEKVSSSTRKRVEEAVLEAGYSPNSLARNLRRNESKTIVAIVPDICDPYFSEIIRGI
EDAAMEHGYLVLLGDSGQQKRRENSFVNLVFTKQADGMLLLGTDLPFDVSKPEQKNLPPMVMACEFAPELELPTVHIDNL
TSAFEAVNYLTQLGHKRIAQISGPQHAALCQFRHQGYQQALRRAGITMNPTYCTFGDFTFEAGAKAVRQLLALPEQPTAI
FCHNDTMAIGAIQEAKRLGLRVPQDLSVVGFDDIQFAQYCDPPLTTISQPRYEIGRQAMLMMLELLRGHDVRAGSRLLET
KLVVRESAAPPSKK

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=327, Percent_Identity=65.4434250764526, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1790194, Length=307, Percent_Identity=39.0879478827362, Blast_Score=218, Evalue=4e-58,
Organism=Escherichia coli, GI1787948, Length=333, Percent_Identity=34.2342342342342, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1789202, Length=333, Percent_Identity=31.8318318318318, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1788474, Length=331, Percent_Identity=33.8368580060423, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1789068, Length=340, Percent_Identity=32.6470588235294, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI48994940, Length=311, Percent_Identity=29.903536977492, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786540, Length=344, Percent_Identity=30.5232558139535, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790715, Length=312, Percent_Identity=26.6025641025641, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787580, Length=315, Percent_Identity=27.6190476190476, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1787906, Length=304, Percent_Identity=27.3026315789474, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1789456, Length=318, Percent_Identity=27.6729559748428, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1786268, Length=315, Percent_Identity=22.2222222222222, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790689, Length=310, Percent_Identity=26.1290322580645, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790192, Length=313, Percent_Identity=24.2811501597444, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37019; Mature: 36888

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATMKDVAQLAGVSTATVSRALMNPEKVSSSTRKRVEEAVLEAGYSPNSLARNLRRNESK
CCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
TIVAIVPDICDPYFSEIIRGIEDAAMEHGYLVLLGDSGQQKRRENSFVNLVFTKQADGML
EEEEECCHHCCHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHCCCEEEEEEEECCCCEE
LLGTDLPFDVSKPEQKNLPPMVMACEFAPELELPTVHIDNLTSAFEAVNYLTQLGHKRIA
EEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
QISGPQHAALCQFRHQGYQQALRRAGITMNPTYCTFGDFTFEAGAKAVRQLLALPEQPTA
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCE
IFCHNDTMAIGAIQEAKRLGLRVPQDLSVVGFDDIQFAQYCDPPLTTISQPRYEIGRQAM
EEEECCCEEHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCHHHHHHHHH
LMMLELLRGHDVRAGSRLLETKLVVRESAAPPSKK
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ATMKDVAQLAGVSTATVSRALMNPEKVSSSTRKRVEEAVLEAGYSPNSLARNLRRNESK
CCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
TIVAIVPDICDPYFSEIIRGIEDAAMEHGYLVLLGDSGQQKRRENSFVNLVFTKQADGML
EEEEECCHHCCHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHCCCEEEEEEEECCCCEE
LLGTDLPFDVSKPEQKNLPPMVMACEFAPELELPTVHIDNLTSAFEAVNYLTQLGHKRIA
EEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
QISGPQHAALCQFRHQGYQQALRRAGITMNPTYCTFGDFTFEAGAKAVRQLLALPEQPTA
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCE
IFCHNDTMAIGAIQEAKRLGLRVPQDLSVVGFDDIQFAQYCDPPLTTISQPRYEIGRQAM
EEEECCCEEHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCHHHHHHHHH
LMMLELLRGHDVRAGSRLLETKLVVRESAAPPSKK
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]