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The map label for this gene is fabB [H]

Identifier: 147674185

GI number: 147674185

Start: 1819246

End: 1820457

Strand: Reverse

Name: fabB [H]

Synonym: VC0395_A1693

Alternate gene names: 147674185

Gene position: 1820457-1819246 (Counterclockwise)

Preceding gene: 147675722

Following gene: 147673968

Centisome position: 60.2

GC content: 49.92

Gene sequence:

>1212_bases
ATGAAACGAGTCGTCATCACCGGTATGGGTATTATTTCGAGTATCGGTAACAACGTCGAAGAAGTTTTGGCCTCACTAAA
AGCTGGCAAGTCAGGCATCACCGCCTCTGAACAGTTTAAAGAGCATGGTTTGCGTTCACAGGTTTGGGGCGATTTAAAAA
TCAACCCAGAAGAACATATCGATCGTAAGCAAATGCGCTTTATGGGTGATGCGGCTGCGTATGCATACCTATCTCTTGAA
CAAGCGATTGCTGATGCGGGTTTAACCCCTGAGCAAGTGTCGAACGACCGTACTGGTATCGTTGCTGGCTCTGGTGGCGC
ATCTTCTGAAAACCAAGTTATCGCAGTCGATACTCAGCGTGAAAAAGGCGTAAAACGCGTGGGTCCTTACATGGTGCCTC
GTACCATGTCTTCTACCGTTTCTGCGTGTTTGGCTACGCCATTCAAAATTCGCGGTGTGAACTACTCAATCAGCTCAGCT
TGCGCGACTTCGGCGCACTGTATTGGTAACGCGGTTGAGCTTATCCAACTGGGCAAGCAAGACATCGTGTTTGCTGGTGG
TGGTGAAGAGCTGTACTGGTCACAAACCATGATGTTTGATGCGATGGGCGCACTATCCACCAAATACAACGAAACACCAG
AAAAAGCGTCGCGCACTTACGATGCCGATCGTGATGGTTTCGTGATCTCTGGCGGCGGCGGCATGGTGGTGGTTGAAGAG
TTGGAACACGCTCTGGCGCGCGGCGCAAAAATTTACGGTGAAATCGTCGGTTACGGCGCGACTTCCGATGGCTACGACAT
GGTTGCTCCATCGGGTGAAGGCGCTATCCGTTGTATGAAAATGGCGATGCAAGGCGTGGATAAGATTGATTACATCAACA
CCCACGGCACATCAACCCCAGTCGGTGATGTGAAAGAACTGGGTGCAATCCAAGAAGTGTTTGGCGGCAATAGCCCAGCG
ATTTCTGCAACCAAAGCGATGACCGGTCACGCATTGGGCGCTGCGGGTGTGCATGAAGCCATCTACTCAACACTGATGCT
GCACCACGGCTTTATCGCTCCAAGTATTAACATTGATACCTTGGATGAAGCGGCGCAAGGTCTGGATATTGTGACGGAAC
TGCGTGAGCAAGAGCTGACTACTGTGATGTCTAACAGCTTTGGTTTTGGTGGTACAAACGCAACTTTGGTTATCAAAAAA
TACCAAGGTTAA

Upstream 100 bases:

>100_bases
TGAATATGGCTCGAGATTGTACGAATTTATGGGAAAGCTGACCACTTCTGTTATCCTTCTTCGATATCATCTAGCCAAAT
TTACATAATAGGAATGTTAC

Downstream 100 bases:

>100_bases
GCGCACCAGATCCAACACAGTTTCCAGAACAGATTAGTTTCGCTAATCGAACAGACGCAGACTCTGTCCCATGGAGAGCG
GGATAGGATCCTTTTGTTCT

Product: 3-oxoacyl-(acyl-carrier-protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKRVVITGMGIISSIGNNVEEVLASLKAGKSGITASEQFKEHGLRSQVWGDLKINPEEHIDRKQMRFMGDAAAYAYLSLE
QAIADAGLTPEQVSNDRTGIVAGSGGASSENQVIAVDTQREKGVKRVGPYMVPRTMSSTVSACLATPFKIRGVNYSISSA
CATSAHCIGNAVELIQLGKQDIVFAGGGEELYWSQTMMFDAMGALSTKYNETPEKASRTYDADRDGFVISGGGGMVVVEE
LEHALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMAMQGVDKIDYINTHGTSTPVGDVKELGAIQEVFGGNSPA
ISATKAMTGHALGAAGVHEAIYSTLMLHHGFIAPSINIDTLDEAAQGLDIVTELREQELTTVMSNSFGFGGTNATLVIKK
YQG

Sequences:

>Translated_403_residues
MKRVVITGMGIISSIGNNVEEVLASLKAGKSGITASEQFKEHGLRSQVWGDLKINPEEHIDRKQMRFMGDAAAYAYLSLE
QAIADAGLTPEQVSNDRTGIVAGSGGASSENQVIAVDTQREKGVKRVGPYMVPRTMSSTVSACLATPFKIRGVNYSISSA
CATSAHCIGNAVELIQLGKQDIVFAGGGEELYWSQTMMFDAMGALSTKYNETPEKASRTYDADRDGFVISGGGGMVVVEE
LEHALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMAMQGVDKIDYINTHGTSTPVGDVKELGAIQEVFGGNSPA
ISATKAMTGHALGAAGVHEAIYSTLMLHHGFIAPSINIDTLDEAAQGLDIVTELREQELTTVMSNSFGFGGTNATLVIKK
YQG
>Mature_403_residues
MKRVVITGMGIISSIGNNVEEVLASLKAGKSGITASEQFKEHGLRSQVWGDLKINPEEHIDRKQMRFMGDAAAYAYLSLE
QAIADAGLTPEQVSNDRTGIVAGSGGASSENQVIAVDTQREKGVKRVGPYMVPRTMSSTVSACLATPFKIRGVNYSISSA
CATSAHCIGNAVELIQLGKQDIVFAGGGEELYWSQTMMFDAMGALSTKYNETPEKASRTYDADRDGFVISGGGGMVVVEE
LEHALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMAMQGVDKIDYINTHGTSTPVGDVKELGAIQEVFGGNSPA
ISATKAMTGHALGAAGVHEAIYSTLMLHHGFIAPSINIDTLDEAAQGLDIVTELREQELTTVMSNSFGFGGTNATLVIKK
YQG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=35.0835322195704, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI41872631, Length=429, Percent_Identity=27.039627039627, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI223972627, Length=168, Percent_Identity=42.8571428571429, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1788663, Length=405, Percent_Identity=75.0617283950617, Blast_Score=613, Evalue=1e-177,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=39.6135265700483, Blast_Score=256, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI71983541, Length=420, Percent_Identity=35.7142857142857, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=39.3258426966292, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI212642053, Length=353, Percent_Identity=26.628895184136, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=344, Percent_Identity=26.1627906976744, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=31.4606741573034, Blast_Score=189, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24644341, Length=417, Percent_Identity=37.8896882494005, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI19920632, Length=382, Percent_Identity=26.7015706806283, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221330659, Length=382, Percent_Identity=26.7015706806283, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24581345, Length=425, Percent_Identity=22.8235294117647, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42571; Mature: 42571

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVITGMGIISSIGNNVEEVLASLKAGKSGITASEQFKEHGLRSQVWGDLKINPEEHI
CCEEEEECHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHCCCEEECHHHHH
DRKQMRFMGDAAAYAYLSLEQAIADAGLTPEQVSNDRTGIVAGSGGASSENQVIAVDTQR
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCCCCCCCCEEEEECHH
EKGVKRVGPYMVPRTMSSTVSACLATPFKIRGVNYSISSACATSAHCIGNAVELIQLGKQ
HCCHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCCC
DIVFAGGGEELYWSQTMMFDAMGALSTKYNETPEKASRTYDADRDGFVISGGGGMVVVEE
CEEEECCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEECCCCEEEHHH
LEHALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMAMQGVDKIDYINTHGTSTP
HHHHHHCCHHHHHHHEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCC
VGDVKELGAIQEVFGGNSPAISATKAMTGHALGAAGVHEAIYSTLMLHHGFIAPSINIDT
CCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
LDEAAQGLDIVTELREQELTTVMSNSFGFGGTNATLVIKKYQG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MKRVVITGMGIISSIGNNVEEVLASLKAGKSGITASEQFKEHGLRSQVWGDLKINPEEHI
CCEEEEECHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHCCCEEECHHHHH
DRKQMRFMGDAAAYAYLSLEQAIADAGLTPEQVSNDRTGIVAGSGGASSENQVIAVDTQR
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCCCCCCCCEEEEECHH
EKGVKRVGPYMVPRTMSSTVSACLATPFKIRGVNYSISSACATSAHCIGNAVELIQLGKQ
HCCHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCCC
DIVFAGGGEELYWSQTMMFDAMGALSTKYNETPEKASRTYDADRDGFVISGGGGMVVVEE
CEEEECCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEECCCCEEEHHH
LEHALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMAMQGVDKIDYINTHGTSTP
HHHHHHCCHHHHHHHEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCC
VGDVKELGAIQEVFGGNSPAISATKAMTGHALGAAGVHEAIYSTLMLHHGFIAPSINIDT
CCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
LDEAAQGLDIVTELREQELTTVMSNSFGFGGTNATLVIKKYQG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]