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The map label for this gene is bisZ [H]

Identifier: 147673939

GI number: 147673939

Start: 1653442

End: 1655889

Strand: Reverse

Name: bisZ [H]

Synonym: VC0395_A1538

Alternate gene names: 147673939

Gene position: 1655889-1653442 (Counterclockwise)

Preceding gene: 147673410

Following gene: 147675040

Centisome position: 54.76

GC content: 52.33

Gene sequence:

>2448_bases
ATGACTAAAATCACCCGCCGTGGATTTTTAAAAGGCACTGGTATGGCTGCCGGTGCAATGGCTTTCACTTCATTTTCACC
ACTCTCGATTGCCAGTGATAACGCACGTGGTAAAGGCGTGTTAACGGCTGGACGTATGGGGCCACTTCTCTGTGAAGTGC
AAGATGGCAAAATGGTGGCGACCAAAAATGCGCTGGCGCAAACTGTACCGAACAGCTTGCAATCGACAGGCCCCGATCAG
GTGTATACCCAAGCGCGGGTTAAATACCCTATGGTTCGTAAAGGCTTTTTAGCGAACCCTGCCGCACCGAAAGGAGTGCG
TGGCAGTGATGAGTTTGTGCGCGTATCGTGGGATGACGCGTATCGCTTAATCCATGAGCAGCATATGCGCATTCGCAAAA
CCTATGGTCCAGCTTCGGTGTTTGCTGGCTCTTATGGTTGGCGCTCCAGTGGCGTGCTGCATAAAGCTCAAACTTTATTG
CAACGCTATATGAGTATGGCGGGCGGCTATTCAGGCCACTTGGGAGATTACTCAACCGGCGCGGCGCAAATCATCATGCC
GCACGTGGTTGGTTCGATTGAAGTGTATGAGCAGCAAACCACTTACCCCGTAGTGCTAGAGCACAGTGATGTGGTGGTTC
TGTGGGGGTTAAACCCGATCAACACATTGAAAATTGCGTGGAGCTCGACCGACTGTGCAGGCCTTGAATTCTTCCATCAA
CTGAAAAAATCCGGCAAAACCATTATCGGCATTGACCCGATCCGCTCTGAAACCATCGAGTTTTTCGGTGAGCAAGCCCA
ATGGATTGCCCCACACCCAATGACAGATGTGGCGATGATGATGGGCATCGCGCACTCGCTGATCAAGCAAGGTAAGCACG
ATAAAGCCTTCTTGGACAAATACACCGTAGGCTACGATCGCTTTGAAGCGTATTTGCTGGGTAAAGAAGATGGCGTTGAA
AAGTCCGCGCAATGGGCAGAAGGCATTTGTGGCGTACCAGCCAAGCAACTAGAAACGCTGGCTGAGATTTTCAGCAACCA
TCGCACTATGCTAATGGCAGGCTGGGGTATGCAGCGTCAACAATATGGTGAGCAGCGTCACTGGATGGTGGTCACCTTAG
CCGCGATGTTGGGGCAAATTGGCTTGCCGGGCGGTGGTTTTGGTTTCTCCTACCATTACTCGAATGGCGGGAACCCAGCG
CGTGACGCGGGAGTTCTGCCTGCCATTTCGGCAGCTATTGGTGGTGGCTCTTCGGCGGGGAATGATTGGGCGATTTCAGG
GGCGACGCAAAGTTTCCCGGTCGCGCGTATTGTGGAAGCGTTGGAGAATCCGGGCGGGGCCTATCAACACAATGGTCACA
CGCTGACCTTCCCTGAAATCAAGATGATCTGGTGGGCGGGTGGTGCCAACTTTACCCACCATCAAGACACCAATCGTCTG
ATCAAAGCGTGGCAAAAGCCTGAGCTGATTGTAATTTCAGAGCCGTATTGGACAGCGGCGGCGAAGCATGCCGATATCGT
ACTGCCGATCACCACAACGTTTGAGCGTAATGACTTGACCATGACGGGTGACTACAGTAACCAACACTTGGTGCCGATGA
AACAGGTGGTGGAGCCACAAGGCGAAGCGCGTAACGACTTTGATGTGTTTGCCGATATGGCGGAAATGATCCGTCCCGGA
GGCCGTGATGTGTTTACCGAAGGCAAAACCGAGATGGAATGGTTGTACGGTTTCTACAAAACCGCGCAGAAGAGCGGCCG
TGCAGCACGAGTGGCGATGCCGAATTTCAGTAAGTTCTGGGAAGATAACCAGCTGATTGAAATGAAGTGGAACGCGAAAA
ATGCTCAGTTTGTGCGTTACGCCGATTTTCGCGCGGATCCGATCCTCAATCCATTAGGTACACCGAGCGGCAAGATTGAG
ATTTACTCTAAAACTCTGGCGGGCTTTAATTTGCCTGATTGTCCAGCCCATCCAACCTGGTTGGCTCCTGATGAATTTAC
AGGTAATGCGAAGCAGGGCGAGTTGCAATTAATGACGGCGCACGCGGCGCACCGTTTGCACAGTCAATTCAACTACGCTC
AATTGCGGGAAGAGTATGCGATTGCTAACCGTGAGCCGATCTGGATCCACCCAGAAGATGCGGCATCACGCGGCATTCAA
ACGGGCGATTTGGTTCGTGCCTATAACCAGCGTGGCCAAGTACTGGTCGGCGCTTTGGTGACGGATCGCATCAAACAAGG
CTCAGTCTGTATTCACGAAGGCGGCTGGCCAGATCTTGATCCGCAAACCGGCTTATGTAAAAACGGTGGTGCGAATGTGC
TGACTTCAGACATTCCGACTTCACGTTTGGCGAATGGCTGTGCGGCGAACTCTTCTCTGGTGCGTATTGAAAAGTACACA
GGGCCAGCGTTGGAACTGACGGCGTTTATGCCACCGAAAAATGGCTAA

Upstream 100 bases:

>100_bases
ACGGATATTTCCGCTGAGAATCTGGAGATTCTCACCAAGTTCTTCCAGCACCATGCCAAAGATATGGTTAGCCACTGAGT
ATAAGTAGAGGGATAACGTT

Downstream 100 bases:

>100_bases
TCGCGAGTGATAAGAAAACACTAATAGAAAGCCGAGGCGAGTGCCTCGGCTTTTTGCGTTCTTAACCGACTTGCTGCTTT
GGCTGAAGCCTAAGCCGAGG

Product: biotin sulfoxide reductase

Products: NA

Alternate protein names: TMAO reductase 2; Trimethylamine oxidase 2 [H]

Number of amino acids: Translated: 815; Mature: 814

Protein sequence:

>815_residues
MTKITRRGFLKGTGMAAGAMAFTSFSPLSIASDNARGKGVLTAGRMGPLLCEVQDGKMVATKNALAQTVPNSLQSTGPDQ
VYTQARVKYPMVRKGFLANPAAPKGVRGSDEFVRVSWDDAYRLIHEQHMRIRKTYGPASVFAGSYGWRSSGVLHKAQTLL
QRYMSMAGGYSGHLGDYSTGAAQIIMPHVVGSIEVYEQQTTYPVVLEHSDVVVLWGLNPINTLKIAWSSTDCAGLEFFHQ
LKKSGKTIIGIDPIRSETIEFFGEQAQWIAPHPMTDVAMMMGIAHSLIKQGKHDKAFLDKYTVGYDRFEAYLLGKEDGVE
KSAQWAEGICGVPAKQLETLAEIFSNHRTMLMAGWGMQRQQYGEQRHWMVVTLAAMLGQIGLPGGGFGFSYHYSNGGNPA
RDAGVLPAISAAIGGGSSAGNDWAISGATQSFPVARIVEALENPGGAYQHNGHTLTFPEIKMIWWAGGANFTHHQDTNRL
IKAWQKPELIVISEPYWTAAAKHADIVLPITTTFERNDLTMTGDYSNQHLVPMKQVVEPQGEARNDFDVFADMAEMIRPG
GRDVFTEGKTEMEWLYGFYKTAQKSGRAARVAMPNFSKFWEDNQLIEMKWNAKNAQFVRYADFRADPILNPLGTPSGKIE
IYSKTLAGFNLPDCPAHPTWLAPDEFTGNAKQGELQLMTAHAAHRLHSQFNYAQLREEYAIANREPIWIHPEDAASRGIQ
TGDLVRAYNQRGQVLVGALVTDRIKQGSVCIHEGGWPDLDPQTGLCKNGGANVLTSDIPTSRLANGCAANSSLVRIEKYT
GPALELTAFMPPKNG

Sequences:

>Translated_815_residues
MTKITRRGFLKGTGMAAGAMAFTSFSPLSIASDNARGKGVLTAGRMGPLLCEVQDGKMVATKNALAQTVPNSLQSTGPDQ
VYTQARVKYPMVRKGFLANPAAPKGVRGSDEFVRVSWDDAYRLIHEQHMRIRKTYGPASVFAGSYGWRSSGVLHKAQTLL
QRYMSMAGGYSGHLGDYSTGAAQIIMPHVVGSIEVYEQQTTYPVVLEHSDVVVLWGLNPINTLKIAWSSTDCAGLEFFHQ
LKKSGKTIIGIDPIRSETIEFFGEQAQWIAPHPMTDVAMMMGIAHSLIKQGKHDKAFLDKYTVGYDRFEAYLLGKEDGVE
KSAQWAEGICGVPAKQLETLAEIFSNHRTMLMAGWGMQRQQYGEQRHWMVVTLAAMLGQIGLPGGGFGFSYHYSNGGNPA
RDAGVLPAISAAIGGGSSAGNDWAISGATQSFPVARIVEALENPGGAYQHNGHTLTFPEIKMIWWAGGANFTHHQDTNRL
IKAWQKPELIVISEPYWTAAAKHADIVLPITTTFERNDLTMTGDYSNQHLVPMKQVVEPQGEARNDFDVFADMAEMIRPG
GRDVFTEGKTEMEWLYGFYKTAQKSGRAARVAMPNFSKFWEDNQLIEMKWNAKNAQFVRYADFRADPILNPLGTPSGKIE
IYSKTLAGFNLPDCPAHPTWLAPDEFTGNAKQGELQLMTAHAAHRLHSQFNYAQLREEYAIANREPIWIHPEDAASRGIQ
TGDLVRAYNQRGQVLVGALVTDRIKQGSVCIHEGGWPDLDPQTGLCKNGGANVLTSDIPTSRLANGCAANSSLVRIEKYT
GPALELTAFMPPKNG
>Mature_814_residues
TKITRRGFLKGTGMAAGAMAFTSFSPLSIASDNARGKGVLTAGRMGPLLCEVQDGKMVATKNALAQTVPNSLQSTGPDQV
YTQARVKYPMVRKGFLANPAAPKGVRGSDEFVRVSWDDAYRLIHEQHMRIRKTYGPASVFAGSYGWRSSGVLHKAQTLLQ
RYMSMAGGYSGHLGDYSTGAAQIIMPHVVGSIEVYEQQTTYPVVLEHSDVVVLWGLNPINTLKIAWSSTDCAGLEFFHQL
KKSGKTIIGIDPIRSETIEFFGEQAQWIAPHPMTDVAMMMGIAHSLIKQGKHDKAFLDKYTVGYDRFEAYLLGKEDGVEK
SAQWAEGICGVPAKQLETLAEIFSNHRTMLMAGWGMQRQQYGEQRHWMVVTLAAMLGQIGLPGGGFGFSYHYSNGGNPAR
DAGVLPAISAAIGGGSSAGNDWAISGATQSFPVARIVEALENPGGAYQHNGHTLTFPEIKMIWWAGGANFTHHQDTNRLI
KAWQKPELIVISEPYWTAAAKHADIVLPITTTFERNDLTMTGDYSNQHLVPMKQVVEPQGEARNDFDVFADMAEMIRPGG
RDVFTEGKTEMEWLYGFYKTAQKSGRAARVAMPNFSKFWEDNQLIEMKWNAKNAQFVRYADFRADPILNPLGTPSGKIEI
YSKTLAGFNLPDCPAHPTWLAPDEFTGNAKQGELQLMTAHAAHRLHSQFNYAQLREEYAIANREPIWIHPEDAASRGIQT
GDLVRAYNQRGQVLVGALVTDRIKQGSVCIHEGGWPDLDPQTGLCKNGGANVLTSDIPTSRLANGCAANSSLVRIEKYTG
PALELTAFMPPKNG

Specific function: Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N-oxide and biotin sulfoxide (BSO), but with a lower catalytic

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081994, Length=809, Percent_Identity=69.5920889987639, Blast_Score=1188, Evalue=0.0,
Organism=Escherichia coli, GI145693196, Length=774, Percent_Identity=63.4366925064599, Blast_Score=1060, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=790, Percent_Identity=42.6582278481013, Blast_Score=622, Evalue=1e-179,
Organism=Escherichia coli, GI87081797, Length=858, Percent_Identity=31.8181818181818, Blast_Score=316, Evalue=3e-87,
Organism=Escherichia coli, GI1787870, Length=860, Percent_Identity=29.8837209302326, Blast_Score=278, Evalue=7e-76,
Organism=Escherichia coli, GI171474008, Length=851, Percent_Identity=28.9071680376028, Blast_Score=256, Evalue=6e-69,
Organism=Escherichia coli, GI3868721, Length=717, Percent_Identity=21.8967921896792, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.7.2.3 [H]

Molecular weight: Translated: 89441; Mature: 89309

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKITRRGFLKGTGMAAGAMAFTSFSPLSIASDNARGKGVLTAGRMGPLLCEVQDGKMVA
CCCCCCCCCCCCCCCCHHHHHHCCCCCCEEECCCCCCCEEEEECCCCCEEEEECCCCEEE
TKNALAQTVPNSLQSTGPDQVYTQARVKYPMVRKGFLANPAAPKGVRGSDEFVRVSWDDA
EHHHHHHHCCHHHHCCCCHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEHHHH
YRLIHEQHMRIRKTYGPASVFAGSYGWRSSGVLHKAQTLLQRYMSMAGGYSGHLGDYSTG
HHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
AAQIIMPHVVGSIEVYEQQTTYPVVLEHSDVVVLWGLNPINTLKIAWSSTDCAGLEFFHQ
HHHEEHHHHHCCEEEEECCCCCEEEEECCCEEEEECCCCCCEEEEEECCCCCHHHHHHHH
LKKSGKTIIGIDPIRSETIEFFGEQAQWIAPHPMTDVAMMMGIAHSLIKQGKHDKAFLDK
HHHCCCEEEEECCCHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
YTVGYDRFEAYLLGKEDGVEKSAQWAEGICGVPAKQLETLAEIFSNHRTMLMAGWGMQRQ
HHCCHHHEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHH
QYGEQRHWMVVTLAAMLGQIGLPGGGFGFSYHYSNGGNPARDAGVLPAISAAIGGGSSAG
HHCCCCCCHHEEHHHHHHCCCCCCCCCCEEEEECCCCCCCHHCCCCHHHHHHHCCCCCCC
NDWAISGATQSFPVARIVEALENPGGAYQHNGHTLTFPEIKMIWWAGGANFTHHQDTNRL
CCEEECCCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCEEEEEEECCCCCCCCCHHHHH
IKAWQKPELIVISEPYWTAAAKHADIVLPITTTFERNDLTMTGDYSNQHLVPMKQVVEPQ
HHHCCCCCEEEEECCCHHHHCCCCEEEEEEEEEEECCCEEEECCCCCCCCCCHHHHHCCC
GEARNDFDVFADMAEMIRPGGRDVFTEGKTEMEWLYGFYKTAQKSGRAARVAMPNFSKFW
CCCCCHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHC
EDNQLIEMKWNAKNAQFVRYADFRADPILNPLGTPSGKIEIYSKTLAGFNLPDCPAHPTW
CCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCC
LAPDEFTGNAKQGELQLMTAHAAHRLHSQFNYAQLREEYAIANREPIWIHPEDAASRGIQ
CCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCCHHHHCCCC
TGDLVRAYNQRGQVLVGALVTDRIKQGSVCIHEGGWPDLDPQTGLCKNGGANVLTSDIPT
CHHHHHHHCCCCCEEEEEHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCH
SRLANGCAANSSLVRIEKYTGPALELTAFMPPKNG
HHHHCCCCCCCCEEEEEECCCCEEEEEEECCCCCC
>Mature Secondary Structure 
TKITRRGFLKGTGMAAGAMAFTSFSPLSIASDNARGKGVLTAGRMGPLLCEVQDGKMVA
CCCCCCCCCCCCCCCHHHHHHCCCCCCEEECCCCCCCEEEEECCCCCEEEEECCCCEEE
TKNALAQTVPNSLQSTGPDQVYTQARVKYPMVRKGFLANPAAPKGVRGSDEFVRVSWDDA
EHHHHHHHCCHHHHCCCCHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEHHHH
YRLIHEQHMRIRKTYGPASVFAGSYGWRSSGVLHKAQTLLQRYMSMAGGYSGHLGDYSTG
HHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
AAQIIMPHVVGSIEVYEQQTTYPVVLEHSDVVVLWGLNPINTLKIAWSSTDCAGLEFFHQ
HHHEEHHHHHCCEEEEECCCCCEEEEECCCEEEEECCCCCCEEEEEECCCCCHHHHHHHH
LKKSGKTIIGIDPIRSETIEFFGEQAQWIAPHPMTDVAMMMGIAHSLIKQGKHDKAFLDK
HHHCCCEEEEECCCHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
YTVGYDRFEAYLLGKEDGVEKSAQWAEGICGVPAKQLETLAEIFSNHRTMLMAGWGMQRQ
HHCCHHHEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHH
QYGEQRHWMVVTLAAMLGQIGLPGGGFGFSYHYSNGGNPARDAGVLPAISAAIGGGSSAG
HHCCCCCCHHEEHHHHHHCCCCCCCCCCEEEEECCCCCCCHHCCCCHHHHHHHCCCCCCC
NDWAISGATQSFPVARIVEALENPGGAYQHNGHTLTFPEIKMIWWAGGANFTHHQDTNRL
CCEEECCCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCEEEEEEECCCCCCCCCHHHHH
IKAWQKPELIVISEPYWTAAAKHADIVLPITTTFERNDLTMTGDYSNQHLVPMKQVVEPQ
HHHCCCCCEEEEECCCHHHHCCCCEEEEEEEEEEECCCEEEECCCCCCCCCCHHHHHCCC
GEARNDFDVFADMAEMIRPGGRDVFTEGKTEMEWLYGFYKTAQKSGRAARVAMPNFSKFW
CCCCCHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHC
EDNQLIEMKWNAKNAQFVRYADFRADPILNPLGTPSGKIEIYSKTLAGFNLPDCPAHPTW
CCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCC
LAPDEFTGNAKQGELQLMTAHAAHRLHSQFNYAQLREEYAIANREPIWIHPEDAASRGIQ
CCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCCHHHHCCCC
TGDLVRAYNQRGQVLVGALVTDRIKQGSVCIHEGGWPDLDPQTGLCKNGGANVLTSDIPT
CHHHHHHHCCCCCEEEEEHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCH
SRLANGCAANSSLVRIEKYTGPALELTAFMPPKNG
HHHHCCCCCCCCEEEEEECCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]