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The map label for this gene is apt

Identifier: 147673655

GI number: 147673655

Start: 612850

End: 613395

Strand: Direct

Name: apt

Synonym: VC0395_A0571

Alternate gene names: 147673655

Gene position: 612850-613395 (Clockwise)

Preceding gene: 147673072

Following gene: 147674747

Centisome position: 20.27

GC content: 48.53

Gene sequence:

>546_bases
ATGACAACTGAAACTCTTTCACTGATCAAATCCAGCATCAAAAGTATTCCTGACTACCCGAAAAAAGGCATTCTGTTTCG
TGATGTGACCAGCTTGCTGGAAGATGCCCAAGCCTACCAAGCGACCATTCAACTTCTGGTTGAAAAGTACAAAGACATGG
GTTTTACCAAGGTTGTGGGCACAGAAGCGCGTGGTTTCTTATTTGGTGCTCCTCTAGCACTAGAACTGGGTGTCGGCTTT
GTGCCTGTGCGTAAGCCGGGTAAATTGCCGCGTCAAACCGTCGCTCAATCTTATGAGCTGGAATACGGTACTGATACGCT
CGAAATTCATGTGGATGCGATCAAACCGGGCGACAAAGTACTGGTGGTGGATGACCTGCTGGCGACCGGTGGTACGATTG
AAGCGACCACTAAGCTTATCCGTCAATTAGGGGGAGAAGTCGAGCACGCTGCCTTCGTGATCAACTTGCCAGAAATTGGT
GGTGATAAGCGCCTTGAAGGGTTAGGCTTGCAGGTTTACAGCATCTGTGAATTTGAAGGTCACTAA

Upstream 100 bases:

>100_bases
GGGCTTTGTTTTTTCAGTGCTGTCGTTCCCTTGTGGCAGACGGCTCCGAAATTGTTCTGTCATCACCTAAGGTGATGAAG
CAACTGAAGTTAAAGTAACT

Downstream 100 bases:

>100_bases
CCGACAACGGATATTGGAATGAGTTATCTTGCTTTAGCACGCAAATGGCGTCCGACACGATTTAGCGAAGTGGTCGGACA
ATCCCATGTTTTAACCGCTT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MTTETLSLIKSSIKSIPDYPKKGILFRDVTSLLEDAQAYQATIQLLVEKYKDMGFTKVVGTEARGFLFGAPLALELGVGF
VPVRKPGKLPRQTVAQSYELEYGTDTLEIHVDAIKPGDKVLVVDDLLATGGTIEATTKLIRQLGGEVEHAAFVINLPEIG
GDKRLEGLGLQVYSICEFEGH

Sequences:

>Translated_181_residues
MTTETLSLIKSSIKSIPDYPKKGILFRDVTSLLEDAQAYQATIQLLVEKYKDMGFTKVVGTEARGFLFGAPLALELGVGF
VPVRKPGKLPRQTVAQSYELEYGTDTLEIHVDAIKPGDKVLVVDDLLATGGTIEATTKLIRQLGGEVEHAAFVINLPEIG
GDKRLEGLGLQVYSICEFEGH
>Mature_180_residues
TTETLSLIKSSIKSIPDYPKKGILFRDVTSLLEDAQAYQATIQLLVEKYKDMGFTKVVGTEARGFLFGAPLALELGVGFV
PVRKPGKLPRQTVAQSYELEYGTDTLEIHVDAIKPGDKVLVVDDLLATGGTIEATTKLIRQLGGEVEHAAFVINLPEIGG
DKRLEGLGLQVYSICEFEGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=182, Percent_Identity=41.2087912087912, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=47.3684210526316, Blast_Score=122, Evalue=2e-28,
Organism=Escherichia coli, GI1786675, Length=180, Percent_Identity=73.8888888888889, Blast_Score=269, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI17509087, Length=164, Percent_Identity=43.9024390243902, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=40.4907975460123, Blast_Score=114, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=161, Percent_Identity=37.2670807453416, Blast_Score=91, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17136334, Length=177, Percent_Identity=44.6327683615819, Blast_Score=139, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_VIBC3 (A5F2N2)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F2N2
- SMR:   A5F2N2
- STRING:   A5F2N2
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A0571
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   VCHO345073:VC0395_A0571-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19693; Mature: 19562

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTETLSLIKSSIKSIPDYPKKGILFRDVTSLLEDAQAYQATIQLLVEKYKDMGFTKVVG
CCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
TEARGFLFGAPLALELGVGFVPVRKPGKLPRQTVAQSYELEYGTDTLEIHVDAIKPGDKV
CCCCCEEEECCEEEECCCCEEECCCCCCCCHHHHHHHHCCCCCCCEEEEEEEEECCCCEE
LVVDDLLATGGTIEATTKLIRQLGGEVEHAAFVINLPEIGGDKRLEGLGLQVYSICEFEG
EEEEHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEECCC
H
C
>Mature Secondary Structure 
TTETLSLIKSSIKSIPDYPKKGILFRDVTSLLEDAQAYQATIQLLVEKYKDMGFTKVVG
CHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
TEARGFLFGAPLALELGVGFVPVRKPGKLPRQTVAQSYELEYGTDTLEIHVDAIKPGDKV
CCCCCEEEECCEEEECCCCEEECCCCCCCCHHHHHHHHCCCCCCCEEEEEEEEECCCCEE
LVVDDLLATGGTIEATTKLIRQLGGEVEHAAFVINLPEIGGDKRLEGLGLQVYSICEFEG
EEEEHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEECCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA