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The map label for this gene is galK [H]

Identifier: 147673567

GI number: 147673567

Start: 1260635

End: 1261852

Strand: Reverse

Name: galK [H]

Synonym: VC0395_A1197

Alternate gene names: 147673567

Gene position: 1261852-1260635 (Counterclockwise)

Preceding gene: 147674295

Following gene: 147675555

Centisome position: 41.73

GC content: 51.97

Gene sequence:

>1218_bases
TTGAGCGGCGCAGCACCAACGCCAGCGTCGCTCTCCCCATTTAAAGTGAGAAGCCCTATGTCTGAATTAATCCAAAACGT
GACTACAACCTTTGCACAACTCTTTGGCTATGATGCTACGCACCTTGTGCAAGCTCCGGGGCGGGTCAATTTGATCGGCG
AGCACACCGACTACAACGATGGCTTTGTGCTGCCTTGCGCGATTAACTACCAAACCGTCGTGGCTGCAGCCAAACGGGAA
GACTTTCTAGTGCGTTTGGTCGCCGTCGATTACGACAATGACACGGACGAATTTGACCTGCGAGAAGAGATTGCCTTTCA
GCCTAAAAAAATGTGGTCGAACTATATTCGCGGTGTAATCAAGTGCTTGATTGAACGTGGTTTTGAGTTTAATGGGGCAG
ATATTGTGGTCTCAGGTAACGTACCTCAAGGGGCGGGTCTCAGTTCCTCGGCGGCTTTAGAAGTCGTGATTGGGCAAACT
TTTAAAGAGCTTTACCAGCTAAAAATCAGTCAGGCGGAGATCGCCCTCAATGGCCAGCAAGCGGAGAACCAGTTTGTCGG
TTGTAACTGCGGCATTATGGATCAGATGATCTCGGCGCAGGGGCAAGCGAACCATGCCATGTTGCTTGATTGTCGTAGCT
TGCAAACCGAGGCCGTTGCGATGCCAGAGCAGATGGCAGTGGTGATCCTCAATTCCAATAAAAAACGCGGCTTGGTGGAG
AGTGAATACAATACCCGTCGTCAGCAATGCGAAGCCGCAGCCAAAACTTTTGGTGTGAAAGCGCTACGCGATGTCACTTT
GGCGCAATTGACTGCAAAGCAGGCCGAACTTGATCCTGTGGTGGCCAAACGTGCGCGCCATGTCATCACGGAAAATGAAC
GCACTTTACATGCCGCTCAGGCCCTGCGTGAAGGAAACATGCCGCGCTTAGGCGAGTTAATGGCCGCTTCTCACGCTTCG
ATGCGTGATGATTTTGAAATCACTGTCAAGGAGATAGATACGCTGGTCGAGATTGTTCAATCTGTGATTGGCGATCAAGG
CGGTGTGCGGATGACTGGCGGCGGCTTTGGTGGTTGTGTGGTGGCCCTTGTACACCCGAAGCAAGTAGAAGCGGTGCAGC
AAGCGGTGGCTGAACACTATGAAGCTGCGACAGGGCTGAAGGCATCGATCTATGTCTGCCATGCAACTTCGGGCGCGGGA
TTGGTTGAGCTTGCATAA

Upstream 100 bases:

>100_bases
AAAGCCAACGTGATTTAACCGCAGAGCAGGCCGCAGAGCGTTTACGCGCGGTGAGTGATATTCACTACAAAGAACAGCAT
AACCATCAATAACAGATATT

Downstream 100 bases:

>100_bases
GGTTAGAGATGAACGCGTTATTCACCAGCATGACAGCACAGGTCGCCTATGATGGTCAGCCTGCCAAGCTTATTGAGCTC
ACTAACCGCCGCGGTATGCG

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MSGAAPTPASLSPFKVRSPMSELIQNVTTTFAQLFGYDATHLVQAPGRVNLIGEHTDYNDGFVLPCAINYQTVVAAAKRE
DFLVRLVAVDYDNDTDEFDLREEIAFQPKKMWSNYIRGVIKCLIERGFEFNGADIVVSGNVPQGAGLSSSAALEVVIGQT
FKELYQLKISQAEIALNGQQAENQFVGCNCGIMDQMISAQGQANHAMLLDCRSLQTEAVAMPEQMAVVILNSNKKRGLVE
SEYNTRRQQCEAAAKTFGVKALRDVTLAQLTAKQAELDPVVAKRARHVITENERTLHAAQALREGNMPRLGELMAASHAS
MRDDFEITVKEIDTLVEIVQSVIGDQGGVRMTGGGFGGCVVALVHPKQVEAVQQAVAEHYEAATGLKASIYVCHATSGAG
LVELA

Sequences:

>Translated_405_residues
MSGAAPTPASLSPFKVRSPMSELIQNVTTTFAQLFGYDATHLVQAPGRVNLIGEHTDYNDGFVLPCAINYQTVVAAAKRE
DFLVRLVAVDYDNDTDEFDLREEIAFQPKKMWSNYIRGVIKCLIERGFEFNGADIVVSGNVPQGAGLSSSAALEVVIGQT
FKELYQLKISQAEIALNGQQAENQFVGCNCGIMDQMISAQGQANHAMLLDCRSLQTEAVAMPEQMAVVILNSNKKRGLVE
SEYNTRRQQCEAAAKTFGVKALRDVTLAQLTAKQAELDPVVAKRARHVITENERTLHAAQALREGNMPRLGELMAASHAS
MRDDFEITVKEIDTLVEIVQSVIGDQGGVRMTGGGFGGCVVALVHPKQVEAVQQAVAEHYEAATGLKASIYVCHATSGAG
LVELA
>Mature_404_residues
SGAAPTPASLSPFKVRSPMSELIQNVTTTFAQLFGYDATHLVQAPGRVNLIGEHTDYNDGFVLPCAINYQTVVAAAKRED
FLVRLVAVDYDNDTDEFDLREEIAFQPKKMWSNYIRGVIKCLIERGFEFNGADIVVSGNVPQGAGLSSSAALEVVIGQTF
KELYQLKISQAEIALNGQQAENQFVGCNCGIMDQMISAQGQANHAMLLDCRSLQTEAVAMPEQMAVVILNSNKKRGLVES
EYNTRRQQCEAAAKTFGVKALRDVTLAQLTAKQAELDPVVAKRARHVITENERTLHAAQALREGNMPRLGELMAASHASM
RDDFEITVKEIDTLVEIVQSVIGDQGGVRMTGGGFGGCVVALVHPKQVEAVQQAVAEHYEAATGLKASIYVCHATSGAGL
VELA

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=399, Percent_Identity=42.3558897243108, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI48527957, Length=414, Percent_Identity=28.9855072463768, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI4503897, Length=414, Percent_Identity=28.9855072463768, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1786972, Length=378, Percent_Identity=64.2857142857143, Blast_Score=513, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI71989053, Length=405, Percent_Identity=26.1728395061728, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319494, Length=278, Percent_Identity=28.0575539568345, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320212, Length=265, Percent_Identity=29.0566037735849, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24661292, Length=429, Percent_Identity=29.1375291375291, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21355577, Length=429, Percent_Identity=29.1375291375291, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24661285, Length=429, Percent_Identity=29.1375291375291, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 43817; Mature: 43686

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGAAPTPASLSPFKVRSPMSELIQNVTTTFAQLFGYDATHLVQAPGRVNLIGEHTDYND
CCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHCCCHHHEEECCCCEEEEECCCCCCC
GFVLPCAINYQTVVAAAKREDFLVRLVAVDYDNDTDEFDLREEIAFQPKKMWSNYIRGVI
CEEEEEECCHHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHH
KCLIERGFEFNGADIVVSGNVPQGAGLSSSAALEVVIGQTFKELYQLKISQAEIALNGQQ
HHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCHHEEEECCCC
AENQFVGCNCGIMDQMISAQGQANHAMLLDCRSLQTEAVAMPEQMAVVILNSNKKRGLVE
CCCCEECCCCCHHHHHHHCCCCCCCEEEEEHHHCCHHHHCCCCCEEEEEEECCCCCCCCC
SEYNTRRQQCEAAAKTFGVKALRDVTLAQLTAKQAELDPVVAKRARHVITENERTLHAAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHH
ALREGNMPRLGELMAASHASMRDDFEITVKEIDTLVEIVQSVIGDQGGVRMTGGGFGGCV
HHHCCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEE
VALVHPKQVEAVQQAVAEHYEAATGLKASIYVCHATSGAGLVELA
EEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCEEEEC
>Mature Secondary Structure 
SGAAPTPASLSPFKVRSPMSELIQNVTTTFAQLFGYDATHLVQAPGRVNLIGEHTDYND
CCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHCCCHHHEEECCCCEEEEECCCCCCC
GFVLPCAINYQTVVAAAKREDFLVRLVAVDYDNDTDEFDLREEIAFQPKKMWSNYIRGVI
CEEEEEECCHHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHH
KCLIERGFEFNGADIVVSGNVPQGAGLSSSAALEVVIGQTFKELYQLKISQAEIALNGQQ
HHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCHHEEEECCCC
AENQFVGCNCGIMDQMISAQGQANHAMLLDCRSLQTEAVAMPEQMAVVILNSNKKRGLVE
CCCCEECCCCCHHHHHHHCCCCCCCEEEEEHHHCCHHHHCCCCCEEEEEEECCCCCCCCC
SEYNTRRQQCEAAAKTFGVKALRDVTLAQLTAKQAELDPVVAKRARHVITENERTLHAAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHH
ALREGNMPRLGELMAASHASMRDDFEITVKEIDTLVEIVQSVIGDQGGVRMTGGGFGGCV
HHHCCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEE
VALVHPKQVEAVQQAVAEHYEAATGLKASIYVCHATSGAGLVELA
EEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]