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The map label for this gene is galM [H]

Identifier: 147675555

GI number: 147675555

Start: 1259574

End: 1260626

Strand: Reverse

Name: galM [H]

Synonym: VC0395_A1196

Alternate gene names: 147675555

Gene position: 1260626-1259574 (Counterclockwise)

Preceding gene: 147673567

Following gene: 147674953

Centisome position: 41.69

GC content: 51.38

Gene sequence:

>1053_bases
ATGAACGCGTTATTCACCAGCATGACAGCACAGGTCGCCTATGATGGTCAGCCTGCCAAGCTTATTGAGCTCACTAACCG
CCGCGGTATGCGTGTGGTAGTGATGGACATCGGTGCCACTTGGCTCAGTTGCACTCTACCGATGGGCGATGAATCAAGAG
AAGTGCTACTTGGCGTAAGCAGCATGGATGATTTTGTGCGCCAAGGCAGTTATTTAGGCGCAACGGTGGGGCGTTATGCC
AATCGGATTGCGCGTGGCGAACTCAAGATAGGGACACAAACGTATGCTTTGTCGGTCAATCAAGCTGGCAATACGTTACA
CGGTGGCGTTGTAGGGTTTGATCGTCGTCGCTGGCAAATCACGCAGCAAAGCGCACAGCATGTGACCTTTCAACTGCTTT
CTGCTGACGGAGAACAAGGCTTTCCGGGCAACCTCCACGTTGCAGTGACCTACCGGTTGGATGAGCAAGGTGGGGTGAAT
ATCGACTACCAAGCCACCACCGATCGTGCGACCGCCGTGAATCTAACGAACCACGCCTACTTTAATTTGAATGGCGCTGA
GCAAGGTAGTGATTGCCTCAATCATCAGCTCTGGATTGATGCAAAGCAGTTCTTACCAACGGATGCCTCGGGTATCCCGC
TCGGGGAGTTGCAATCGGTACTGGGTAGCGGTTTTGATTTCACTCAACCGAAAAGGGTTGGGGAGGATTTGCTTCAAGAT
AAACAGCAAATCCGTGCGAAAGGCTATGACCACAGTTATTTCTTTGCGCCAGAGCGAGATATGCACACGCCTATCGCTAA
GGTGTGGTCTGCCGATGAGAAAGTGCAACTGCTCGTCAGTACGGATAAACCTGCTATGCAGCTTTATACCGGTAATTGGT
TGGCGGGAACACCCAATCGCCTTGGTTCGCACTACAAGGATTACGCTGGCCTCGCTTTAGAAACGCAGTTTTTACCCGAT
TCCCCTCATCATCCAGAATGGCTGCAACCGAGCTGCATCCTGCAACCCGGAGAAGTCTATCGCTATCAAACGCGCTATCA
GTTTGTTTTTTAA

Upstream 100 bases:

>100_bases
TGGCTGAACACTATGAAGCTGCGACAGGGCTGAAGGCATCGATCTATGTCTGCCATGCAACTTCGGGCGCGGGATTGGTT
GAGCTTGCATAAGGTTAGAG

Downstream 100 bases:

>100_bases
CATCTTGGGCATAAGACTCAGCACTGAATCGGTAAATCTGCTGCTGAGTCATTCTCTTTCTCGCTGTCGGCAACCACTTG
ATTACGTCCTGCTTCTTTTG

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MNALFTSMTAQVAYDGQPAKLIELTNRRGMRVVVMDIGATWLSCTLPMGDESREVLLGVSSMDDFVRQGSYLGATVGRYA
NRIARGELKIGTQTYALSVNQAGNTLHGGVVGFDRRRWQITQQSAQHVTFQLLSADGEQGFPGNLHVAVTYRLDEQGGVN
IDYQATTDRATAVNLTNHAYFNLNGAEQGSDCLNHQLWIDAKQFLPTDASGIPLGELQSVLGSGFDFTQPKRVGEDLLQD
KQQIRAKGYDHSYFFAPERDMHTPIAKVWSADEKVQLLVSTDKPAMQLYTGNWLAGTPNRLGSHYKDYAGLALETQFLPD
SPHHPEWLQPSCILQPGEVYRYQTRYQFVF

Sequences:

>Translated_350_residues
MNALFTSMTAQVAYDGQPAKLIELTNRRGMRVVVMDIGATWLSCTLPMGDESREVLLGVSSMDDFVRQGSYLGATVGRYA
NRIARGELKIGTQTYALSVNQAGNTLHGGVVGFDRRRWQITQQSAQHVTFQLLSADGEQGFPGNLHVAVTYRLDEQGGVN
IDYQATTDRATAVNLTNHAYFNLNGAEQGSDCLNHQLWIDAKQFLPTDASGIPLGELQSVLGSGFDFTQPKRVGEDLLQD
KQQIRAKGYDHSYFFAPERDMHTPIAKVWSADEKVQLLVSTDKPAMQLYTGNWLAGTPNRLGSHYKDYAGLALETQFLPD
SPHHPEWLQPSCILQPGEVYRYQTRYQFVF
>Mature_350_residues
MNALFTSMTAQVAYDGQPAKLIELTNRRGMRVVVMDIGATWLSCTLPMGDESREVLLGVSSMDDFVRQGSYLGATVGRYA
NRIARGELKIGTQTYALSVNQAGNTLHGGVVGFDRRRWQITQQSAQHVTFQLLSADGEQGFPGNLHVAVTYRLDEQGGVN
IDYQATTDRATAVNLTNHAYFNLNGAEQGSDCLNHQLWIDAKQFLPTDASGIPLGELQSVLGSGFDFTQPKRVGEDLLQD
KQQIRAKGYDHSYFFAPERDMHTPIAKVWSADEKVQLLVSTDKPAMQLYTGNWLAGTPNRLGSHYKDYAGLALETQFLPD
SPHHPEWLQPSCILQPGEVYRYQTRYQFVF

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=324, Percent_Identity=38.2716049382716, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1786971, Length=342, Percent_Identity=50.2923976608187, Blast_Score=342, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17557428, Length=331, Percent_Identity=29.3051359516616, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI115533334, Length=331, Percent_Identity=29.3051359516616, Blast_Score=171, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6324399, Length=350, Percent_Identity=26.8571428571429, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6322004, Length=356, Percent_Identity=27.5280898876405, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6319493, Length=307, Percent_Identity=28.6644951140065, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24668278, Length=332, Percent_Identity=36.7469879518072, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI24583720, Length=331, Percent_Identity=35.6495468277946, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24659048, Length=345, Percent_Identity=34.4927536231884, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24668282, Length=336, Percent_Identity=31.25, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24641876, Length=359, Percent_Identity=27.0194986072423, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38987; Mature: 38987

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALFTSMTAQVAYDGQPAKLIELTNRRGMRVVVMDIGATWLSCTLPMGDESREVLLGVS
CCCHHHCCEEEEEECCCCCEEEEECCCCCCEEEEEECCCEEEEEECCCCCCCCEEEEEEH
SMDDFVRQGSYLGATVGRYANRIARGELKIGTQTYALSVNQAGNTLHGGVVGFDRRRWQI
HHHHHHHCCCCCHHHHHHHHHHHHCCEEEECCEEEEEEECCCCCEEECCEEECCCCEEEE
TQQSAQHVTFQLLSADGEQGFPGNLHVAVTYRLDEQGGVNIDYQATTDRATAVNLTNHAY
HHHHHHHEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCEEEEEECCCCEEEEEECCEEE
FNLNGAEQGSDCLNHQLWIDAKQFLPTDASGIPLGELQSVLGSGFDFTQPKRVGEDLLQD
EEECCCCCCHHHHCCEEEEEHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHH
KQQIRAKGYDHSYFFAPERDMHTPIAKVWSADEKVQLLVSTDKPAMQLYTGNWLAGTPNR
HHHHHHCCCCCCEEECCCCCCCCCHHHHHCCCCEEEEEEECCCCCEEEEECCEECCCCHH
LGSHYKDYAGLALETQFLPDSPHHPEWLQPSCILQPGEVYRYQTRYQFVF
HHHHHHHHCCEEEEEEECCCCCCCCCCCCCCEEECCCHHEEEEEEEEEEC
>Mature Secondary Structure
MNALFTSMTAQVAYDGQPAKLIELTNRRGMRVVVMDIGATWLSCTLPMGDESREVLLGVS
CCCHHHCCEEEEEECCCCCEEEEECCCCCCEEEEEECCCEEEEEECCCCCCCCEEEEEEH
SMDDFVRQGSYLGATVGRYANRIARGELKIGTQTYALSVNQAGNTLHGGVVGFDRRRWQI
HHHHHHHCCCCCHHHHHHHHHHHHCCEEEECCEEEEEEECCCCCEEECCEEECCCCEEEE
TQQSAQHVTFQLLSADGEQGFPGNLHVAVTYRLDEQGGVNIDYQATTDRATAVNLTNHAY
HHHHHHHEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCEEEEEECCCCEEEEEECCEEE
FNLNGAEQGSDCLNHQLWIDAKQFLPTDASGIPLGELQSVLGSGFDFTQPKRVGEDLLQD
EEECCCCCCHHHHCCEEEEEHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHH
KQQIRAKGYDHSYFFAPERDMHTPIAKVWSADEKVQLLVSTDKPAMQLYTGNWLAGTPNR
HHHHHHCCCCCCEEECCCCCCCCCHHHHHCCCCEEEEEEECCCCCEEEEECCEECCCCHH
LGSHYKDYAGLALETQFLPDSPHHPEWLQPSCILQPGEVYRYQTRYQFVF
HHHHHHHHCCEEEEEEECCCCCCCCCCCCCCEEECCCHHEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]